CagriSema, a drug that Novo Nordiskhad hoped would become itsnext generationweight-loss aid, has failed to meet expectations in late-stage trials, sending shares of the pharmaceutical giant tumblingas much as 24%at one point in premarket trading on Friday morning.The test drug combinessemaglutide, the active ingredient in its blockbuster Wegovy, withcagrilintide, a dual approach that suppresses the appetite and manages how the body processes food. This combination is designed to be more effective than treatments using semaglutide alone.What happened with the trial?The Phase 3 trial, conducted over 68 weeks and involving approximately 3,400 participants with obesity or overweight conditions and one or more comorbidities, was a crucial step in demonstrating the drugs potential, with the goal of achieving 25% weight loss in trial participants. But the results, while promising, fell short at weight loss of22.7%.Additionally, competitor Eli Lillys experimental drugretatrutideshowed even stronger results with a24%reduction after just 48 weeks, further highlighting the competitive advantage of Lillys offeringsand helping drive Lillys stock (NYSE: LLY) up 7% in premarket trading Friday morning.Whats next for CagriSema?Despite these setbacks, Novo Nordisk said it remains committed to CagriSema. Results from theREDEFINE 2 trial, focusing on adults with type 2 diabetes who are obese or overweight, are expected in early 2025. Meanwhile, the company plans to submit the drug for regulatory approval by the end of next year, signaling that it sees potential for further refinement and success in the competitive obesity drug market.We are encouraged by the weight loss profile of CagriSema, demonstrating superiority over both semaglutide and cagrilintide in monotherapy in the REDEFINE 1 trial, Martin Holst Lange, Novos executive vice president for development, noted in astatement. This was achieved even though only 57% of patients reached the highest CagriSema dose.Shares of Novo Nordisk A/S (NYSE: NVO) peaked in June of this year and have been on a generally downward slope since. The stock has fallen more than 26% in the last six months.

Promotion: global kitchen and bath brand Kohler has set out an ambitious vision for the role it will play on the future of water conservation in the built environment.The U.S. company has taken a three-pronged approach with a design strategy that it says is increasingly focused around sustainability.Firstly, innovating with products that prioritise water conservation. Secondly, easing dependency on freshwater and supporting restoration projects. Finally, engaging in what it describes as "a wider ecosystem" of architects, designers, builders, and policymakers.Kohler has developed a broad portfolio of products which prioritise water efficiency"At Kohler, we believe water is not just a resource; its a vital thread that weaves through every aspect of life and the built environment," said Laura Kohler, chief sustainable living officer and board member at Kohler.She was appointed in the newly created chief sustainability officer role in January 2023, in what the company said reflected the sustainability priorities of the organisation. Her role was changed tochief sustainable living officer in January 2024.She subsequently established bigger goals for the organisation with more urgent deadlines in pursuing water conservation and improved access to safe water and sanitation.Laura Kohler has established bigger goals with more urgent deadlinesSmart technology and products which prioritise water efficiency are at the heart of its work, said Kohler.Years of research, analysis and design from Kohler have culminated in several new products such as smart toilets, advancedshower panels and hands-free taps which it expects will significantly reduce water waste."By blending thoughtful design with cutting-edge technology, were not only shaping a future where water is respected and preserved, but also inspiring others to rethink how we interact with this essential resource," said Kohler.Kohler's latest toilet is the Leap has its most advanced features for water efficiencyThe Leap toilet is Kohler's latest smart toilet, capable of saving around 48,000 gallons of water over 20 years, Kohler claimed.As well as its Leap toilet, its smart panels for showers allow people to set an eco mode which ensures significantly more efficient water usage. It has also designed a smart water monitoring system giving people more visibility of water at home, identifying leaks and waste.The company has been rethinking its designs since its first public sustainability commitments in 2008. It has been exploring the broader system of water in the built environment, leading to a wide-ranging selection of water conserving products offered across its global product portfolio.Smart panels help ensure more efficient water usage"Our water ambition - 'Water Stewardship Through Uncompromising Design' - reflects our commitment to innovating solutions that ensure equitable access to clean water and create more efficient and sustainable water experiences for generations to come," Kohler added.The U.S. company also marked the 10 year anniversary of its WasteLab initiative this year, which sought to develop new designs which advance circularity and wasted materials.It developed a range of WaterSense labelled products with features which it claimed has saved over 634 billion gallons of water per year in the U.S. since 2007.Experts discussed sustainable water consumption at this year's Climate Week NYCIn its bid to be an active participant in water security over a long term, Kohler has been fostering partnerships with other organisations with similar interests.Among them is a multi-year project led by Bonneville Environmental Foundation, Arizona State University and Bridgestone to convert high water use crops to low water use crops and install high efficiency irrigation technology to low water use crops to alleviate water stress on the local aquifers.Laura Kohler outlined many of the themes at a talk moderated by Dezeen US editor Ben Dreith during Climate Week NYC, which took place from 22 to 29 September.Kohler has been fostering partnerships with other organisations with similar interestsThe panel, which also included AvroKO architecture design director Dennis Askins and Six Senses regional director Sarah Bonsall, explored radical ideas to address water security, spanning the design of buildings to advocating for improved infrastructure in neighbourhoods.Laura Kohler said in the company's impact report that its ambition is to "leave the world a better place than we found it".She added: "We evolved our mission to intentionally embrace the concept of sustainable living and significantly increased our efforts to address the water crisis."The photography is supplied by Kohler.Partnership contentThis article was written by Dezeen forKohleras part of a partnership.Find out more about Dezeen partnership contenthere.The post Kohler sets out vision for "water stewardship through uncompromising design" appeared first on Dezeen.

Making a film is like designing a building, The Brutalist director Brady Corbet tells Dezeen in this exclusive interview.Corbet, who co-wrote The Brutalist, chose to make brutalism the central subject of the film, which follows fictional Hungarian architect and Holocaust survivor Lszl Tth as he starts a new life in America, as it worked both visually and thematically."It reared its head in the 1950s, and so it was the correct style of architecture in terms of the film's visual allegory and what it is exploring thematically," Corbet said."[Tth] is also a character that you know has studied at the Bauhaus in Dessau before it was shut down by the Nazis."The film depicts Lszl Tth as a Bauhaus-trained architectCorbet argues that in some ways brutalist architecture mirrors the immigrant experience."It just so happens that it is a style of architecture that was predominantly being practised by immigrant architects," Corbet said."I felt that the community tends to have the same response to a style of architecture that is unfamiliar to them; it provokes the same feelings in them as it does about their new neighbour coming from a different background."A library with moving shelves plays an important part in the filmWhile The Brutalist is set in the post-war years, Corbet believes brutalism is still very relevant today as antagonism towards immigrants continues in the US."The instinct is generally to have those buildings torn down and have those people thrown out, especially in this country," he added."And it's never been more relevant, considering that we had a brief intermezzo before entering into Trump's second term, which is likely going to be somewhat more effective, unfortunately."The lead character is played by Adrien BrodyCorbet and co-writer Mona Fastvold wanted to tell the story of an architect partly due to the fact they both had architects in their families."I grew up with an architect in my family John Pfeiffer," Corbet told Dezeen. "He's my mother's brother and lived with us when I was a child in Arizona, while he was attending Taliesyn West.""My wife and co-writer's grandfather was a mid-century designer who did mostly residences in Norway. So we both had architects in the family and had spoken for some time about doing a project on architecture."Read: Boston City Hall renovation preserves "straightforward honesty" of brutalist buildingCorbet also feels a kinship with architects, whose work he says is "remarkably similar" to that of a filmmaker."You rely on roughly the same amount of personnel to make things come to life it's not an option to do it solo," Corbet said.Its brutalist structure houses a church and community centreAt the centre of The Brutalist is the Institute, a monumental building designed by Tth, who is played by actor Adrien Brody, for businessman Harrison van Buren, who is played by actor Guy Pearce.Production designer Judy Becker drew on her own knowledge of brutalism to create the structure, as it wasn't described in detail in the script."There were very specific things in the script, but they weren't about the exterior design of the building, as much about the things that were incorporated in the building," she told Dezeen.Production designer Judy Becker designed the building from scratchThe independent film was shot on a budget of less than $10 million, making it imperative that no money was wasted and that the sets would be functional from the start."We were trying to figure out what we were going to do about the Institute, how we were going to shoot parts of it, what we were going to create," Becker explained."To do that, we needed to design the building," she added. "That was my first assignment, and it was going to be something to show the producers how we could do it and make the movie for this amount of money."She deliberately didn't reference existing brutalist buildings, instead focusing on creating a brand-new design."I looked at contemporary buildings that play with light and sky, and underground designs, even [designs by] James Turrell," she said."I didn't look at period architecture as much; partly because I have a lot of that already in my head, and partly because I didn't want to copy it."She referenced buildings that play with light and skyThe script made it clear that the Institute would comprise a community centre as well as a Protestant chapel, but that its design would also incorporate Tth and his wife Erzsbet's (played by Felicity Jones) experience of being incarcerated in the Nazi concentration camps.While Becker described this as a "big challenge", it was also what led to a breakthrough in her design of the building."The big eureka moment came from trying to incorporate the concentration camps," Becker said."I started looking at images of them, mostly bird's-eye images of their plans but also interiors, and noticed that they were mostly as is common in military bases and those kinds of very structured environments kind of a T shape," she continued."You would add the barracks on either side of the main road, then there'd be an intersection, and then it would continue. It was a T but it was also a cross, and I really started thinking about the symbolism."Becker looked to crematoriums and factory designsThe resulting building is a monumental, towering structure that Becker says also drew on factory and crematorium design, another reference to the architecture of the concentration camps.The Institute's chapel, with a cross-design that is integral to the story, was shot on location in Hungary and some of the building was built as a model, using concrete to get the right materiality for the shots.Some of the building's support columns were builtBut the crew also erected sets for parts of the design."We built part of the staircase that descended into the ground, and part of the entrance," Becker said. "We also built some of the support columns, things that would indicate the scale and aspects of the important parts of the building."Though the Institute is the central building in the film, it wasn't the only striking set that Becker was tasked with designing.To create the project with which Tth first makes his mark in America a library, also designed for benefactor Van Buren Becker had to transform a glass conservatory into a library covered in shelves.Specially designed furniture and shelves were made for the libraryShe came up with the solution of creating foldable, moveable shelves that actually moved."I had this inspiration that it was going to be cabinets that were going to be designed to create this forced perspective in the room, and then they were going to open up," Becker said."The execution was hard it had to look so beautiful, because it's the moment when you realize Lszl is an artist, and that's such an important story point," she added.Corbet agreed that the library was one of the most important sets."It was very important that it had a real impact," he said. "It's like making a film about a fictional painter if the paintings aren't good, the whole thing falls apart."Read: "Megalopolis is a reminder that the heroic conception of the architect is an intoxicating one"To design Tth's furniture for Van Buren's library, notably a sleek reading chair, Becker drew on his background as a Bauhaus-trained architect."I used tubular steel because that was a material that was very much used by people that studied at the Bauhaus and those shapes were common," she explained."A lot of people designed with them, and I looked at a lot of furniture just to make sure I wasn't copying anybody."While The Brutalist focuses on a very specific time and place, Corbet believes the style is still relevant, and provocative, today."It seems that to this day, there is no more controversial style of architecture," he said. "If you're on Twitter or Reddit, it's fascinating how so many folks are still so provoked by it."Other recent Dezeen film stories looked at the inspiration for Dune: Part Two and the Tokyo Toilets showcased in Wim Wenders' film Perfect Days.The Brutalist premieres in the US on 20 December and the UK on 24 January.The photography is courtesy of Universal Pictures.The post "There is no more controversial style of architecture" says The Brutalist director Brady Corbet appeared first on Dezeen.

From skyscrapers to remote houses, we've compiled 10 of the most popular architecture projects completed in the United States in 2024 and covered on Dezeen.Projects included in this list stretch from the Northeast to the West Coast, with buildings that reach towards the sky or burrow below ground.Of note is the absence of any large-scale projects in the New York City area, which have featured heavily on these lists in the past. Instead, two skyscrapers from Chicago are featured below.Read on for Dezeen's top 10 USA architecture projects of 2024:Photo by Tom Rossiter1000M, Illinois, by JahnOne of the last projects by Jahn founder Helmut Jahn, 1000M is among the tallest structures in the southern end of Downtown Chicago.It rises to 788 feet (223 metres) and has a sleek, curved form clad mostly in glass.Because the structure sits next to historical buildings on Michigan Avenue, the base was given a slightly different treatment with more angular definitions at the edges and aluminium panels.Find out more about 1000M Photo courtesy of AppleThe Observatory, California, by AppleLocated near the Foster + Partners-designed main building at Apple Park in Cupertino, the Observatory was meticulously planned by an in-house Apple team to complement the other structures in the area and provide a space for "contemplation" for workers and visitors.Like other aspects of the campus, the Observatory was designed to integrate with the landscape and is mostly subterranean, with large windows looking out at the nature walks and other structures.Nearly 100 trees were removed during the project and replanted after construction.Find out more about The Observatory Photo by Iwan BaanOne River North, Colorado, by MADThis apartment building in Denver was designed by MADto simulate the geography of the nearby Rocky Mountains, which can be seen from One River North's location in the north of the city.A "crack" in the facade features a textural plaster treatment meant to reference the materiality of a mountain canyon and demarcates the public zones of the building and a few private balconies.These areas were designed to function like a hiking trail, with staircases weaving up among foliage and water features.Find out more about One River North Photo by Joe FletcherHill House, California, by Donaldson + PartnersDonaldson + Partners studio founder Robin Donaldson set out to build a "house for the 21st century" when beginning work on Hill House in Montecito. The result is a sprawling residence with a central courtyard and massive concrete parabolic houses.Embedded into the landscape, the house features a suspended walkway entrance, rooms that face both the courtyard and the exterior as well as a rock garden and solar panel array on top.The sprawling residence also features a submerged amphitheatre and a pool deck.Find out more about Hill House Photo by Hufton + CrowThe Atrium at Sumner Houses, New York, by Studio LibeskindThis 11-storey apartment block wraps around a central atrium and is located in Brooklyn. It was created in collaboration with a local housing authority and provides affordable homes for senior citizens.Studio Libeskind founderDaniel Libeskind used his distinctive style of angular cladding to set the building apart but also focused on the communitarian aspects of the building.Libeskind said his own upbringing in a social housing project in the Bronx gave him a "unique" perspective when designing The Atrium.Find out more about The Atrium at Sumner Houses Photo by Chris MottaliniFire Island House, New York, by BoNDThis project peeled back of years of additions to a Sears Modern kit house in the beach community of Fire Island Pines on Long Island.One of the oldest houses in the area, it had undergone a series of renovations that took away from the original design, so the studio embarked on a process of "de-complication".It stripped away walls and replaced them with natural materials like cedar, took out cabinetry to open up the interior spaces and added in plentiful glass fronting the pool deck.Find out more about Fire Island House Photo by Jason O'Rear (also top)Salesforce Tower, Illinois, by Pelli Clarke & PartnersLocated on a prominent site where converging branches of the Chicago River meet in the city's downtown, this 57-storey office building has a height of 852 feet (259 metres). It is part of the the Wolf Point development, which has been 14 years in the making.The glass-clad skyscraper joins several iconic tall buildings that line this portion of the river. It has a wide face and more slender side made up of thin volumes that ascend in height towards the middle of the tower.Architecture studio Pelli Clarke & Partners said its intention was for the skyscraper to be "imbued with lightness".Find out more about Salesforce Tower Photo by Jeremy BittermannDNA Alpine, Colorado, by CCY ArchitectsThis 4,000-square-foot (372-square metre) house in the mountains was designed to merge with the landscape of the site as it slopes upward among groves of evergreen trees. Its roofline slopes up with the landscape, elevating different parts of the two-level program, which includes a sleeping loft and a small guest bedroom perched above the main structure.It has a copper facade, which CCY Architects claimed uses up to 30 per cent recycled copper. Over time, the panels will patina in a way that will echo the colours of the surrounding mountain peaks.Find out more about DNA Alpine Photo by Jason O'RearCalifornia College of the Arts (CCA) San Francisco, California, by Studio GangAn extension to the main campus of CCA in San Francisco, this building features a massive concrete deck structure organised around three pavilions with exposed mass-timber structural systems.The mass-timber elements are set on the perimeter of the large concrete deck that functions as a sort of second ground level, with educational facilities tucked underneath and public spaces below and above.Studio Gang founder Jeanne Gang said she sought to create a "dynamic environment" for students at the campus by placing many disciplines alongside one another.Find out more about California College of the ArtsSan Francisco Photos by Joe Fletcher/Dean KaufmanNorth Fork, New York, by Lake Flato ArchitectsLake Flato Architects, whose founders won the 2023 AIA Gold Medal, designed this house in the New York town of Peconic to fit in with the local vernacular barn architecture while utilising contemporary materials and sensibilities.It has three long structures all with steeply gabled metal roofs and siding made of blackened cedar. Many of the structural elements were completed using prefabricated elements."This arrival by barge of the bulk of the house seemed especially fitting for a place that is so intimately tied to the water," said the studio.Find out more about North ForkThe post The top 10 US architecture projects of 2024 appeared first on Dezeen.

Hisense is set to redefine home theater audio in 2025 with its new sound system designed to make great sound feel effortless. The Hisense HT Saturn offers a bold promise of fully wireless surround with a 4.1.2 channel audio system, delivering cinematic sound without the hassle that plagued older setups. It transforms the usual nest of cables into a sleek environment, allowing four individual wireless satellite speakers and a standalone 6.5-inch subwoofer to settle comfortably wherever the rooms personality leads. The companys engineers believe its time to give home audio the freedom it deserves. As Hisense describes it, Everything sounds like its a perfectly balanced home theater audio system.Designer: HisenseHisenses approach draws attention to how people actually live. The HT Saturn listens to the room before it does anything else, using a small dongle that connects to the TV and emits a precise calibration tone. This tone interacts with the rooms surfaces, furniture, and layout, allowing the system to analyze sound reflections and distances. Based on this data, the system automatically adjusts each speaker and subwoofer to deliver balanced audio tailored to the unique acoustics of the space.A Home Theater Built for Big ScreensThe HT Saturn sets a new standard in audio performance. It was purpose-built to complement Hisense TVs 85 inches and larger. Featuring Pure Surround Dolby Atmos and DTS:X, it surrounds users with multidimensional soundscapes, ensuring every audio detail is delivered with precision and creating a fully immersive experience. Whether youre watching a blockbuster or gaming with friends, the system captures every detail with precision, enhancing the emotional impact of every scene.The company seems intent on proving that there is more to a satisfying experience than numbers on a spec sheet. The HT Saturn distinguishes itself acoustically by pairing premium sound quality with intuitive features that simplify its use, from its automatic calibration to its seamless integration with TV speakers. This seamless collaboration is powered by Hisenses proprietary Hi-Concerto Technology, which synchronizes the HT Saturn with the TVs built-in speakers to deliver an expanded and immersive audio field.Another subtle touch is the single remote approach, which simplifies daily interactions by replacing the need for multiple remotes. This integration ensures that users can control the HT Saturn and TV seamlessly, avoiding the clutter and confusion often associated with multi-remote setups. Everything is integrated, even the onscreen menus. The companys representatives made it clear that the HT Saturn is less about forcing people to understand complex settings and more about putting them at ease from day one. The inclusion of EZ Play ensures direct control via the Hisense remote, further simplifying the user experience.Hisenses forward-thinking design choices extend to the systems use of advanced connectivity options and seamless integration with evolving home entertainment setups. The HT Saturn fully utilizes advanced connectivity options like HDMI eARC and Bluetooth 5.3, enhancing the user experience by ensuring high-quality audio transmission, seamless device pairing, and broad compatibility with evolving television technologies. The system also includes five tailored EQ modes, optimizing sound for movies, music, sports, and more to suit user preferences.Tailored Sound Modes for Every OccasionOne of the HT Saturns defining acoustic qualities is its ability to adapt. The systems ability to compensate for unconventional speaker placement ensures tremendous flexibility while delivering uncompromised sound. Wherever youre seateddirectly in front of the screen or off to the sidethe HT Saturn fine-tunes its output to ensure every spot feels optimal.While final pricing and release details remain unannounced, Hisense plans to showcase the HT Saturn at CES 2025, where attendees can experience its innovative wireless capabilities and immersive sound performance firsthand. Ill be at CES to explore Hisenses innovations in depth, focusing on HT Saturns wireless flexibility, acoustic calibration, and overall user experience. Im eager to test how it performs in a live environment and will share those insights with you.Initial observations suggest that this wireless sound system, with its 13-speaker system and tailored sound modes, might redefine expectations regarding installation and comfort.The post Hisense HT Saturn Soundbar Showcases Wireless 4.1.2 Audio and Immersive Performance at CES 2025 first appeared on Yanko Design.

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