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PLA2G15 is a BMP hydrolase and its targeting ameliorates lysosomal disease
Nature, Published online: 07 May 2025; doi:10.1038/s41586-025-08942-yLysosomal phospholipase PLA2G15 was identified as a physiological BMP hydrolase whose activity depends on unique esterification and stereochemistry of BMP and offers a potential therapeutic target for Niemann–Pick disease type C1 and other neurodegenerative conditions.
المصدر: https://www.nature.com/articles/s41586-025-08942-y
#PLA2G15 #BMP #hydrolase #and #its #targeting #ameliorates #lysosomal #disease
PLA2G15 is a BMP hydrolase and its targeting ameliorates lysosomal disease
Nature, Published online: 07 May 2025; doi:10.1038/s41586-025-08942-yLysosomal phospholipase PLA2G15 was identified as a physiological BMP hydrolase whose activity depends on unique esterification and stereochemistry of BMP and offers a potential therapeutic target for Niemann–Pick disease type C1 and other neurodegenerative conditions.
المصدر: https://www.nature.com/articles/s41586-025-08942-y
#PLA2G15 #BMP #hydrolase #and #its #targeting #ameliorates #lysosomal #disease
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