• Final Fantasy 7 Rebirth PC Graphics Analysis Does it Surpass the PS5 Version?
    gamingbolt.com
    If theres one game I enjoyed immensely last year and yet begrudgingly forced myself to endure, its Final Fantasy 7 Rebirth. No, not because of the story, changes, mini-games or any other complaints others may have had (though some issues annoyed me more than others). It was purely due to the visual quality and performance on PS5.As much as I was looking forward to Performance mode delivering 60 FPS, I also mentally prepared for some hits to the graphical quality. They were far more drastic than imagined, though, and while Square Enix did improve several aspects at launch and after, the fidelity wasnt doing it for me. Its a shame because of how great the environments, cutscenes, and battles looked.While it received an update on the PS5 Pro, utilizing PSSR to achieve a 4K output while hitting 60 frames per second, Rebirths PC version is what I truly looked forward to. Would it finally showcase this visual masterpiece in all its glory? Would Cloud and friends look even better than before? Could it be the definitive way to experience the sagas continuation, following up on Final Fantasy 7 Remakes excellent port?Now that its almost here, the answer is yes, for the most part. Some aspects could still do with improvements and further optimization but as it stands, Square Enix has delivered. Lets jump into everything you should know about Final Fantasy 7 Rebirths performance and graphical fidelity on PC as well as how it compares to the PS5 version.Graphics Settings and Test RigThe graphics settings for Final Fantasy 7 Rebirth on PC are pretty standard fare. Graphics quality falls into three presets Low, Medium, and High but you can customize separate options for minimum and maximum Dynamic Resolution Scaling, background model detail, ocean detail, character model detail and effect details.Texture resolution, shadow quality, fog quality its all here, and there are even options to adjust the number of characters displayed and their shadow distance. A separate font is also available for better text legibility when playing at lower resolutions. The anti-aliasing is intriguing because it offers three options TAA, TAAU and DLSS.There are no separate upscaling options for DLSS like Quality or Performance, much less the ability to select AMD FSR or Intel XeSS. Square Enix never really said it was implementing the latter, but not even having different modes for DLSS is odd. Heres hoping it arrives sometime after launch if only to provide those in need with the option.Our test rig consisted of an AMD 5950X, a Nvidia GeForce RTX 3080 Ti, 64 GB of RAM, and an NVMe SSD PCI-e 4.0. Aside from 50 percent minimum Dynamic Resolution Scaling, all settings were on High with DLSS anti-aliasing, 38402160 resolution and 90 FPS enabled. Characters displayed is set to seven, while their shadow display distance is set to eight. So, how does the game fare on PC compared to the PS5 version on Quality Mode?PC vs PS5 Quality ModeBeyond resolutions up to 4K, DLSS, 120 FPS and adjustable displayed characters, Square Enix touts other improvements with the PC version. These include significantly improved lighting, allowing for more clarity, higher texture density and a bump to the background polygon density.The PS5 version of Quality Mode targets 30 frames per second and around 4K with a dynamic resolution. While the image clarity is generally decent on the console, its not as sharp as the PC version. It does stick close to the 30 FPS target, which is much better than dealing with the inconsistent Performance Mode. However, the fidelity is better overall on PC.The lighting alone presents a noticeable jump, coming across as more natural, while shadow edges look smoother and less blurry than on PS5. Perhaps the only real downside is the noticeable pop-in, especially in the open-world environments. The PS5 version had this too, for sure, but the increased fidelity and image quality make it all the more noticeable. Then again, its distracting when foliage is loading just a few feet away.Be that as it may, the PC version is still pretty stunning, with the high-resolution assets and lighting shining throughout.PC PerformanceSquare Enix recommends an AMD Ryzen 7 5700X or an Intel Core i7-10700, a Radeon 7 5700X or GeForce RTX 4080, and 16 GB RAM for 2160p/60 FPS on High settings. Our testing rig falls short in that regard, but we still achieved some pretty good performance. It was fairly consistent at 90 FPS, sometimes dropping to 85 before jumping back up again. Strangely enough, the same difference occurred when playing at 60 FPS, with frames occasionally dropping to 55. Though some of the busier fights and a few scenes in the first hour led to these frame drops, the PC version is otherwise strongly consistent.On my own set-up consisting of a Core i5-11400, 32 GB DDR4 RAM, and a GeForce RTX 4060, performance was pretty solid. When dropping to 1080p from 1440p, it felt more consistent even with pretty much everything set to High (Square Enix recommends Medium, so your mileage may vary). The same frame drops would occasionally occur, but once again, it didnt impact my enjoyment of the title.ConclusionFinal Fantasy 7 Rebirth is unarguably one of 2024s greatest games and an exceptional follow-up to Remake, warts and all. The graphical issues on PS5 did it no favors, and you really have to wonder how many didnt jump in at launch because of the same. Even with the PS5 Pro offering improvements, dropping $700 to experience one game in better detail isnt exactly fiscally responsible.The PC version isnt perfect by any means. Between the pop-in, slight frame drops and lack of DLSS options, theres room for improvement. Id also like to see additional options in the future to fine-tune the fidelity even further.However, this is still a quality experience and represents the first step to really doing justice to Rebirths art direction, environments, cutscenes, characters, and so much more. Though Square Enix could probably offer even more customization in the future, the lighting improvements are an unexpected but welcome surprise that makes the world feel more vibrant and alive. Of course, the keyboard and mouse support isnt too shabby either and being able to assign functions to multiple keys and mouse buttons is nice.If youve been waiting to play Final Fantasy 7 Rebirth on hardware that can truly make it shine, the PC port is definitely recommended. Heres hoping that the development team continues to refine and improve it, further enhancing what is currently the best way to experience Cloud and companys journey.
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  • Inside the TED Gift Hub: A tradition of generosity
    blog.ted.com
    News Inside the TED Gift Hub: A tradition of generosityPosted by: Sabina Osorio January 23, 2025at 12:38 pm ESTThe Gift Hub at TED2024: The Brave and the Brilliant, April 15-19, 2024, in Vancouver, BC, Canada. (Photo: Felicia Chang / TED)Generosity matters. Whether youre giving your time, your talent or a special gift, generosity is an important force in the world. Giving back not only feels good,its good for you, too.At TED, we give our talks away for free on the internet. We give our brand away for free through our TEDx program. We empower people around the world who are bringing real change to their communities through free programs and initiatives like the Audacious Project, TED Countdown and TED Democracy. As head of TED Chris Anderson says: Be brave. Give what you can, and then be absolutely amazed at what happens next.Align your giving with your valuesTEDs global community is built on curiosity, bravery and generosity. TED donors, patrons and partners help fuel our nonprofit mission to bring the gift of knowledge to millions of people around the world. All of the TED Talks you know and love are made possible thanks to the generosity of others.This spirit of giving extends to our events, where our in-kind gifting partners play a crucial role. By donating their goods and services, these partners help create the extraordinary atmosphere that makes the TED experience spectacular.Each of our outrageously generous in-kind partners are carefully selected not only for their quality of products but also for how their values and mission embody the spirit of TED. These partnerships allow us to offer our attendees gifts that are meaningful, memorable and aligned with the ethos of our community.Attendees at TED2024: The Brave and the Brilliant, April 15-19, 2024, in Vancouver, BC, Canada. (Photo: Jason Redmond / TED)A look inside the TED Gift HubAt TED2024, the Gift Hub wasnt just about giving it was about discovery. Attendees explored a curated selection of in-kind gifts, resources and communities that reflected TEDs values, including:Sustainable livingWe partnered with Solgaard (recycled plastic backpacks), Grosche (eco-friendly drinkware), Stasher (reusable storage bags) and Heirloom (sustainable coffee) to inspire an eco-conscious lifestyle.Creativity and explorationFor those fueled by curiosity, brands like LEUCHTTURM1917 (notebooks to capture bold ideas), Celestron (telescopes for stargazing) and Huion (digital design tools) offered endless opportunities for creative discovery.Mindful connectionTo encourage moments of reflection, relaxation and connection, we featured thoughtful gifts from Flare Audio (enhanced sound experiences), Nidra (tools for better sleep) and ShareWell (a peer support community).Wellness and growthAttendees were introduced to innovative brands like FitnessGenes (personalized fitness insights), Molecular You (health and wellness profiling), Outway (performance socks) and Plankplad (interactive fitness), making health and personal growth accessible and exciting.Attendees and in-kind partners at TED2024: The Brave and the Brilliant, April 15-19, 2024, in Vancouver, BC, Canada. (Photo: Jason Redmond / TED)Emerging tech and designFrom cutting-edge devices to imaginative tech, brands like Anything Speaker (portable speakers), Bond Touch (connection bracelets), EarFun (audio devices), Frenz (smart headsets), Mobvoi (AI wearables), Mymanu (translation earbuds), ZWILLING (kitchenware), Shelly (smart home solutions) and Petit Qoobo (robotic cushions) showcased tools and tech that enhance everyday life.Elevated self-careTo bring holistic well-being into attendees lives, we partnered with brands like Aesop (sensorial products), Graydon Skincare, Flaus (oral care tools), VERIPHY Skincare (eco-conscious skincare), Aramweer Organics (South Sudanese natural skincare), Mwani Zanzibar (seaweed products) and Spicewell (nutrient-rich seasonings), bringing thoughtful self-care to every aspect of life.Playful discoveryFinally, for moments of joy and discovery, brands like Fufuly (playful relaxation tools), Page6 (market intelligence for leaders), MoFi Electronics (premium audio), and Wicked Problem Solving (problem-solving frameworks) brought unexpected delight to the Gift Hub.Every gift was thoughtfully curated, empowering attendees to choose items that truly mattered to them. This intentional approach shifted the focus from accumulation to discovery, prioritizing meaningful gifting, reducing waste and connecting attendees with products and ideas that aligned with their values and needs.Attendees and in-kind partners at TED2024: The Brave and the Brilliant, April 15-19, 2024, in Vancouver, BC, Canada. (Photo: Jason Redmond / TED)What will 2025 bring?As we prepare for TED2025 (April 7-11, 2025), were already imagining how to surprise and delight our attendees with gifts that embody the themes of the conference and the spirit of TED. What stories will the items in the Gift Hub tell? How can each gift inspire curiosity, spark connections and encourage generosity in the lives of our community?This years theme, Humanity Reimagined, challenges us to think deeply about innovation, collaboration and the values that define us. Our gifting partners are hard at work designing and curating items that reflect these ideas, blending creativity, sustainability and purpose.From practical tools that promote mindful living to unexpected treasures that spark joy, each gift in the TED2025 hub will be thoughtfully chosen to enhance the experience of being part of TEDs global community.Stay tuned as we unveil the partners and surprises in store for TED2025. We cant wait for you to see and feel the generosity that makes TED a tradition unlike any other.PartnershipsTED2024
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  • Neolithic Farmers May Have Buried These Mysterious Stones to Bring Back the Sun After a Volcanic Eruption
    www.smithsonianmag.com
    New ResearchNeolithic Farmers May Have Buried These Mysterious Stones to Bring Back the Sun After a Volcanic EruptionUsing ice core samples, researchers linked a natural disaster with a trove of nearly 5,000-year-old artifacts discovered at an archaeological site in Denmark Researchers discovered 614 stone plaques and fragments at Vasagrd West, an archaeological site on the Danish island of Bornholm. National Museum of DenmarkOver the years, a variety of mysterious engraved stone plaques have been unearthed in Denmark. The decorative artifacts date to around 2900 B.C.E., during the Neolithic period.Now, researchers have proposed a theory about the plaques origins: They suspect Neolithic farmers may have carved and ceremonially buried them after a volcanic eruption blotted out light from the sun and made it difficult to grow crops, according to a study published this month in the journalAntiquity.The sun stones were discovered at Vasagrd West, an archaeological site on the Danish island of Bornholm, which is located in the Baltic Sea between Poland and Sweden.In recent years, researchers found 614 whole or fragmented pieces of plaques from ditches that were later filled in and covered with a layer of pottery, animal bones and artifacts. They suspect they were left by members of the Funnel Beaker culture, a group of farmers known to have inhabited the island.Initially, researchers thought Neolithic farmers might have buried the stones as fertility offerings to promote the growth of crops and a bountiful harvest. But then they realized the plaques had been deposited on only a few successive occasions or even during a single event.They wondered if some catastrophe had triggered the burials.We were looking for a natural disaster or climatic event that could have affected crop yields or the visibility of the sun, says study co-author Rune Iversen, an archaeologist at the University of Copenhagen, toNewsweeks Aristos Georgiou.Researchers turned to ice core samples from Greenland and Antarctica to confirm their suspicion: There, trapped in the layers of ice and air bubbles, they found evidence of a volcanic eruption around 2900 B.C.E.which lines up with the sun stones.The ice core samples suggest the eruption occurred near the equator, but its plumes of toxic gas and ash likely affected a large area. The ensuing haze may have been so thick it blocked out the sun and caused temperatures to plummet.This theory is backed up by other sources, including tree rings from Germany and the western United States, per the researchers.This sudden shift would have proved catastrophic for Neolithic farmers on Bornholm. They may have carved and buried the plaques in hopes of bringing back the sunor, possibly, as a way of celebrating after its return.If you dont have the harvest and you dont get the crops in, you wont have anything to sow next year, Iversen tellsNew Scientists Chris Simms. They must have felt pretty punished at that time because its just an endless catastrophe coming at them.Archaeologists wonder whether the volcanic eruption may have contributed to the Neolithic decline, a period when northern Europes human population decreased. Other possible drivers of this decline includeplague, war and famine.The Neolithic decline was followed by profound cultural and populational change as new societies appeared with the influx of people from the steppe north of the Black Sea into Europe, Iversen tells theArt Newspapers Garry Shaw.To confirm this theory, future studies might explore where the volcanic eruption took place, as well as the geographic spread of its debris.Could it, for example, have influenced (or even caused) the migration of steppe herders into Europe during the early third millennium [B.C.E.]? Iversen adds. If it impacted the life on the steppe, it could be a potential driver for these migrations, which we know from ancient genomics totally changed the genetic landscape of Europe.Get the latest stories in your inbox every weekday.Filed Under: Agriculture, Archaeology, Cultural Heritage, Denmark, European History, Farming, History, New Research, Sun, Volcanoes
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  • Why Do Mammals Have Outer Ears? Scientists Are Getting Closer to Solving the Mystery
    www.smithsonianmag.com
    Why Do Mammals Have Outer Ears? Scientists Are Getting Closer to Solving the MysteryTwo new studies offer insights into the evolution and development of external ears, which appear in humans and other mammals but arent found in reptiles, birds or amphibians Elephants, bats, rabbits and other mammals have exceptional hearingand their outer ears may be a key reason why. PexelsMammals have exceptional hearing. Using echolocation, bats can detect tiny insects flying in pitch-black darkness. Elephants can recognize the calls of their companions from roughly a mile away. And rabbits can detect the sounds of predators before they ever get close enough to pounce.Physically, these animals are very different. But they all share one helpful anatomical feature: external ears.Scientists have long wondered about the evolutionary origins of outer ears, which are unique to mammals. Now, two new studies are unraveling some of the mysteries surrounding the soft, fleshy structures protruding from our heads.In one paper, published in early January in the journal Science, researchers report the discovery of a new type of cartilage that could help explain why mammals are such keen listeners.They stumbled upon the novel cartilage by chance, while getting ready to look at mouse ear tissue under a microscope. After using chemicals to dry out the ear tissue, they noticed it looked different from other types of cartilage. Its cells were filled with lipids, a type of water-insoluble compound thats usually found in fat tissue, rather than in connective cartilage. Researchers named the new tissue lipocartilage.Further analysis revealed the lipocartilage cells were similarly sized and tightly packed together, akin to bubble wrap or interlocking Lego bricks. And though the cells gave the tissue structural stability, the lipocartilage was also more flexible than other types of cartilage.When scientists went looking for lipocartilage in other creatures, they found it in the ears of other mammals, including humans, opposums and bats; they also found it in the noses, sternums and larynxes of mice. But they did not find the novel tissue in birds, amphibians and reptiles, groups of animals that do not have outer ears. This suggests lipocartilage may have contributed to the exceptional hearing of mammals, says Markta Kauck, a developmental biologist at the Max Planck Institute for Evolutionary Biology who was not involved with the paper, to Sciences Mitch Leslie.The other paper, published in the journal Nature in early January, suggests the genes responsible for mammals external ears might have arisen from those that produce fish gills. It builds on previous research that suggests the jaw bones of ancient fish evolved into the three inner ear bones that mammals have today.This finding offers important new insight into the evolutionary underpinnings of outer ears, which are typically difficult to study, because cartilage disintegrates over time and does not fossilize like bone.When we started the project, the evolutionary origin of the outer ear was a complete black box, says Gage Crump, a co-author of the Nature study and a developmental biologist at the University of Southern California, in a statement.But through their work, the scientists discovered similar gene activity patterns and DNA sequences in the gill tissue of zebrafish and the ear cartilage of humans.The gills themselveswhich fish use to breathe underwaterdid not literally transform into outer ears. But, rather, when ancient fish evolved into vertebrates that could live on land, they didnt have to build their outer ears from scratch. Instead, they were able to repurpose the existing genetic programs responsible for creating gills, according to the researchers.Thats one of the amazements of life and evolution, Abigail Tucker, who studies developmental biology at Kings College London and was not involved in the research, tells Scientific Americans Viviane Callier. The regulatory network was still there and therefore could be co-opted and used again, this time to make an external ear structure rather than a gill.The team even revealed that the same genetic mechanism builds the gills of horseshoe crabs, invertebrates that have changed very little over the last 400 million years. When the first fish evolved, they might have repurposed the gill-forming genes from these ancient creatures.The bendy cartilage in mammals outer ears today, then, may be the last remnant of invertebrate cartilage, Crump adds to Scientific American.Get the latest stories in your inbox every weekday.Filed Under: Animals, Biology, DNA, Ears, Evolution, Fish, Genetics, Human Evolution, Mammals, Mice, New Research, Senses
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  • Pipeshift cuts GPU usage for AI inferences 75% with modular interface engine
    venturebeat.com
    Pipeshift has a Lego-like system that allows teams to configure the right inference stack for their AI workloads, without extensive engineering.Read More
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  • Longdue announces crowdfunding for Disco Elysium spiritual successor
    venturebeat.com
    Longdue, the studio founded with contributors to Disco Elysium and other industry veterans, announced the crowdfunding pre-launch for its debut game, Hopetown. A limited number of registrations for the pre-launch are available on Longdues website, at www.longduegames.com, with those that register early getting first access to a limited set of backRead More
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  • Warner Bros. Games president David Haddad is heading for the exit
    www.gamedeveloper.com
    Warner Bros. Games president David Haddad is stepping down after 12 years.As reported by Variety, the news comes roughly a year after the launch of live service misfire Suicide Squad: Kill The Justice League.The (literal) superhero shooter, published by Warner Bros. Games and developed by Rocksteady, underperformed following a rough development cycle reportedly marred by mismanagement and misguided live service ambitions.According to a report from Bloomberg, Warner Bros. Games lost $200 million on the multiplayer shooter. The publisher axed jobs at Rocksteady following the launch of Suicide Squad and eventually chose to end support for the title.In its latest fiscal report for Q3 2024, Warner Bros. noted that games revenue declined by 31 percent year-over-yearbut stated that downturn was partly because it failed to replicate the commercial success of 2023 release Hogwarts: Legacy.As for what the future holds for Haddad, the long-serving exec will remain with Warner Bros. Games of the next three months to oversee a transition period.Warner Bros. Discovery Global Streaming and Games CEO and president JB Perrette praised Haddad's contribution to the business and said the division will now prepare to for its next "record-breaking title."Haddad said he's proud of what he achieved at Warner Bros. Games during what Perrette described as a "remarkable chapter for the company.""It has been an absolute pleasure working on and building our iconic gaming franchises, and I will continue to be an enthusiastic supporter of this talented teams future endeavors," said Haddad."I look forward to working on the next chapter of my career and will always be grateful for my time with Warner Bros. Games."
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  • Ninja Gaiden 4 is coming to Xbox and PS5
    www.theverge.com
    Microsoft promised a new game announcement at its Xbox Developer Direct event, and that game turned out to be Ninja Gaiden 4. The new entry in the long-running franchise is being co-developed by Team Ninja along with Platinum Games, the team behind action games like Bayonetta and Nier: Automata. The game is launching in Fall 2025, and will be coming to Xbox, PC, and PS5 (it will also be available via Game Pass).While the Ninja Gaiden franchise has been around since the late 80s, it entered into a new era on the Xbox with the bloody, and tough-as-nails Ninja Gaiden on Xbox in 2004. That version, developed by Team Ninja, was ported to a handful of other consoles and also received a number of sequels. Based on the debut trailer, the new game looks to continue the dark action started with the 2004 release, but with even faster gameplay.In addition to the brand-new release, a remake of Ninja Gaiden II was also announced called Ninja Gaiden II Black. In a nice surprise: the game is available now on Xbox, PC, PS5, and Game Pass.These arent the only returns to Ninja Gaiden in the works, however. Retro experts Dotemu are also developing a new throwback release called Ninja Gaiden: Ragebound.
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  • Microsoft rumored to launch a smaller Surface Pro and Surface Laptop soon
    www.theverge.com
    The Surface Laptop Go 3 could get a replacement very soon. | Amelia Holowaty Krales / The Verge Its been less than a year since Microsoft launched its first Qualcomm Snapdragon X-powered Surface devices, and now a new rumor says followups could debut as soon as this spring. A report from Windows Central updates rumors that have circled since 2023, citing sources who say that new versions of the Surface Laptop and Surface Pro 2-in-1 are in the works, with 11- to 12-inch size screens, Windows on Arm, and lighter but still premium designs.Microsoft has already scheduled a major Surface for Business event next week. There, were anticipating variants of the current Surface Laptop 7 and Surface Pro 11 CoPilot Plus PCs that have Intels Lunar Lake chips inside and are aimed at business customers.According to Windows Central, its unclear where these smaller devices might launch, but they will have cheaper chipsets, like the Snapdragon X Plus or possibly the Snapdragon X that launched earlier this month at CES, to keep prices in the $800 - $900 range. When Microsoft last updated its Surface Laptop Go lineup with a third-generation in 2023, we thought it no longer made sense at the asking price, but the battery life and performance supported by Qualcomms hardware might change things for a new replacement. The smaller Surface Pro is described as a competitor for Apples 11-inch iPad Pro. However, Windows Central reports its unclear if it is positioned to replace the old Surface Go series, which was last updated with the business-focused Surface Go 4.
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  • Advancing Protein Science with Large Language Models: From Sequence Understanding to Drug Discovery
    www.marktechpost.com
    Proteins, essential macromolecules for biological processes like metabolism and immune response, follow the sequence-structure-function paradigm, where amino acid sequences determine 3D structures and functions. Computational protein science AIms to decode this relationship and design proteins with desired properties. Traditional AI models have achieved significant success in specific protein modeling tasks, such as structure prediction and design. However, these models face challenges in understanding the grammar and semantics of protein sequences and lack generalization across tasks. Recently, protein Language Models (pLMs) leveraging LLM techniques have emerged, enabling advancements in protein understanding, function prediction, and design.Researchers from institutions like The Hong Kong Polytechnic University, Michigan State University, and Mohamed bin Zayed University of Artificial Intelligence have advanced computational protein science by integrating LLMs to develop pLMs. These models effectively capture protein knowledge and address sequence-structure-function reasoning problems. This survey systematically categorizes pLMs into sequence-based, structure- and function-enhanced, and multimodal models, exploring their applications in protein structure prediction, function prediction, and design. It highlights pLMs impact on antibody design, enzyme engineering, and drug discovery while discussing challenges and future directions, providing insights for AI and biology researchers in this growing field.Protein structure prediction is a critical challenge in computational biology due to the complexity of experimental techniques like X-ray crystallography and NMR. Recent advancements like AlphaFold2 and RoseTTAFold have significantly improved structure prediction by incorporating evolutionary and geometric constraints. However, these methods still face challenges, especially with orphan proteins lacking homologous sequences. To address these issues, single-sequence prediction methods, like ESMFold, use pLMs to predict protein structures without relying on multiple sequence alignments (MSAs). These methods offer faster and more universal predictions, particularly for proteins with no homology, though there is still room for improvement in accuracy.pLMs have significantly impacted computational and experimental protein science, particularly in applications like antibody design, enzyme design, and drug discovery. In antibody design, pLMs can propose antibody sequences that specifically bind to target antigens, offering a more controlled and cost-effective alternative to traditional animal-based methods. These models, like PALMH3, have successfully designed antibodies targeting various SARS-CoV-2 variants, demonstrating improved neutralization and affinity. Similarly, pLMs play a key role in enzyme design by optimizing wild-type enzymes for enhanced stability and new catalytic functions. For example, InstructPLM has been used to redesign enzymes like PETase and L-MDH, improving their efficiency compared to the wild-type.In drug discovery, pLMs help predict interactions between drugs and target proteins, accelerating the screening of potential drug candidates. Models like TransDTI can classify drug-target interactions, aiding in identifying promising compounds for diseases. Additionally, ConPLex leverages contrastive learning to predict kinase-drug interactions, successfully confirming several high-affinity binding interactions. These advances in pLM applications streamline the drug discovery process and contribute to developing more effective therapies with better efficiency and safety profiles.In conclusion, the study provides an in-depth look at the role of LLMs in protein science, covering both foundational concepts and recent advancements. It discusses the biological basis of protein modeling, the categorization of pLMs based on their ability to understand sequences, structures, and functional information, and their applications in protein structure prediction, function prediction, and design. The review also highlights pLMs potential in practical fields like antibody design, enzyme engineering, and drug discovery. Lastly, it outlines promising future directions in this rapidly advancing field, emphasizing the transformative impact of AI on computational protein science.Check out the Paper. All credit for this research goes to the researchers of this project. Also,dont forget to follow us onTwitter and join ourTelegram Channel andLinkedIn Group. Dont Forget to join our70k+ ML SubReddit. Sana Hassan+ postsSana Hassan, a consulting intern at Marktechpost and dual-degree student at IIT Madras, is passionate about applying technology and AI to address real-world challenges. With a keen interest in solving practical problems, he brings a fresh perspective to the intersection of AI and real-life solutions. Meet 'Height':The only autonomous project management tool (Sponsored)
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