Nature, Published online: 31 January 2025; doi:10.1038/d41586-025-00274-1The FDAs nod for suzetrigine bolsters confidence in the pharmaceutical industrys strategy to target sodium channels.

Nature, Published online: 31 January 2025; doi:10.1038/d41586-025-00257-2Database shows that researchers with retracted papers had higher self-citation rates and published more than those without retractions.

RockstarThe whole gaming world is eagerly waiting for GTA 6, expecting a very high level of quality from Rockstar. However, not everyone believes the game will run at 60 FPS when its finally out this year (hopefully).Speaking on Kiwi Talkz, Mike York, former Rockstar animator, expressed his doubts about GTA 6 hitting the numbers at launch:I dont know if theyll be able to pull off 60fps, he said (via GamesRadar+). I dont think so. I think theyre gonna be shooting for 30 FPS and a locked 30 FPS, meaning it never dips below that. Theyre gonna try to optimize as much as they can to where it never goes below 30. But it can be bumped up to 40, 41, 52.But he thinks GTA 6 will get super optimized by the time it comes to PC (whenever that is) and produce a stable 60 FPS.I dont think [the] initial release itll come out at 60 FPS unless its getting those 60 FPS by [using] an AI upscaler thing like the PlayStation is doing, unless something is coming in and helping it get those 60 FPS, York continued. I dont think itll get the 60 FPS raw out the gate on a base console. PS5, for instance. Maybe PS5 Pro, or whatever, but I still dont think so.Its important to note that York hasnt worked at Rockstar since 2017, and this is speculation on his part, but his experience there does give his words some weight.I dont know what theyre doing over there, he said. I dont know how massive this is going to be. But from my experience, theyre going to squeeze every little freaking thing they can out of it and then optimize later for 60 frames because its not as important as just making the game amazing at 30 frames.Not supporting 60 FPS at launch has become an unfortunate trend, which usually irks players. However, with GTAs popularity, Im sure most of them will overlook this fact.York also talked about the culture at Rockstar, working on Red Dead Redemption 2, and the combat system in GTA 5, but the video was removed from the Kiwi Talkz YouTube channel at his request. He asked for it to be taken down cause he said some stuff that he shouldnt have said apparently, the host, Reece Reilly, shared.In any case, keep your hopes up and join our80 Level Talent platformand ournew Discord server, follow us onInstagram,Twitter,LinkedIn,Telegram,TikTok, andThreads,where we share breakdowns, the latest news, awesome artworks, and more.Source link The post Former GTA Animator Doesnt Think GTA 6 Will Be Able to Run at 60 FPS on Consoles appeared first on CG SHARES.

The sequel to Warhorse Studios hugely successful Kingdom Come: Deliverance, which was delayed several times, is set for an official release on February 4th and is probably the most anticipated RPG right now. Kingdom Come: Deliverance II continues Henrys journey, giving players the chance to explore an even larger game worldinspired by medieval Bohemia and prove themselves in epic battles and survival challenges, adding a fresh layer of realism to the experience.A new official CGI trailer titled Live a Life Medieval just dropped a couple of days ago, summarizing the game experience in less than a minute, featuring some solid cinematography and animations, plus a scenario thats definitely going to be tough for Henry to explain to Theresa. Check out the video above for a closer look at the performance capture process, featuring actors and stunt performers on Platige Images motion capture stage.Learn more about Kingdom Come: Deliverance II here and watch some other trailers to get yourself hyped:https://www.youtube.com/watch?v=vPS-pgg3scEDont forget tojoin our80 Level Talent platformand ournew Discord server, follow us onInstagram,Twitter,LinkedIn,Telegram,TikTok, andThreads, where we share breakdowns, the latest news, awesome artworks, and more.Source link The post Take A Behind-The-Scenes Look At Kingdom Come: Deliverance II CGI Trailer appeared first on CG SHARES.

Following on the success of Castlevania and Tomb Raider: The Legend of Lara Croft, Netflix's next animated video game adaptation will take on Capcom's Devil May Cry. The long-running supernatural action franchise previously had an anime series in 2007, but if the opening credits sequence for the new show is any indication, this version is going to be even wilder. Amusingly, the opening credits are set to Limp Bizkit's Rollin', a song which was previously used as one of the entrance themes for WWE's Undertaker during his American Badass phase just over two decades ago. The song does seem to suit the manic energy of Devil May Cry's leading man, Dante, especially when he takes a break from all of the demon-killing to scarf down some pizza.Adi Shankar, who executive produced Netflix's first Castlevania animated series and Captain Laserhawk: A Blood Dragon Remix is filling the same role on Devil May Cry alongside Seung Wook Lee and Hideaki Itsuno. The animation for the series is being handled by Studio Mir, a production house that should be very familiar to American fans for its work on X-Men '97, Harley Quinn, and My Adventures with Superman.Continue Reading at GameSpot

Eternal Strands weaves together a deeply intriguing scene from its earliest moments, stitching together a picture of a fantasy world built around the concept of magic emulating threads. It's a world I wanted to dive into from the jump, if only to uncover more of how it came to be and what the cultures of the different locations are like. And as much as the worldbuilding retains that wonder with incredible-looking environments that make for engaging play spaces for the physics-based magic system, the beat-for-beat details of Eternal Strands' story aren't nearly as rewarding to unravel.Eternal Strands' story too often hits on familiar fantasy tropes, such as an inexplicable magical disaster that changed everything and a corrupting force that seemingly has no weakness and must be avoided at all costs. But the history that story is built on adds a semblance of life to the world, building memorable NPCs that you want to come back to again and again to talk about what in their life led them to where they are now, and painting a somber undertone to the world that begs to be uncovered through its detailed lore notes and optional collectibles.The world-building in Eternal Strands is superb.I especially love how Eternal Strands packages aspects of its history so they're viewed through the art of weaving--not a typical choice for action-adventure games. Concepts like spells are recontextualized, transforming from arcane runes into fashion choices. You can largely avoid the historical exposition if you'd rather spend your time swinging a sword and spewing fire, but there's some great writing to uncover here for lore hounds.Continue Reading at GameSpot

Understanding how all the components of Baldur's Gate 3 work can be difficult, especially for new players to the genre or DnD. For example, players might not know that AC stands for Armor Class and is the minimum number enemies must roll to hit the target. Light Armor in BG3, tends to have low AC, but a character's Dexterity Modifier is also added to this value.

Joseph Campbell proposed that all stories follow a particular structure - the Heros Journey. Also known as the monomyth, it can be easily applied to Star Wars, any number of superhero movies, and so many adventure video games. But what about horror?

I have been creating soundtrack-style songs recently and I really love it. I've gone a sort of Deltarune route. Please let me know if you'd like me to write for your game! https://www.youtube.com/@SpriteInSpacee

There are guns without much recoil, and then theres the Cypher 091 in Black Ops 6. This is the latest weapon to be added to the FPS game at the start of the second season and if youre not using it yet, you should be. It is a strong contender to be one of the best assault rifles in the game, but dont just take our word for it: Let us run you through the best Cypher 091 loadout so you can try it for yourself.The Cypher 091 is a fully automatic assault rifle and even without any attachments, youll hardly miss a sho,t because it has next to no recoil whatsoever. You want to maintain this lack of recoil while enhancing its damage capabilities as much as possible, so you can shred through foes in seconds.Heres the best Cypher 091 loadout in Call of Duty: Black Ops 6 along with the best class to use with it and how to unlock the gun to begin with.How to unlock the Cypher 091 in Black Ops 6To unlock the Cypher 091 in Black Ops 6 Season 2, you must complete page eight of the battle pass. This means you must claim 34 rewards before you can access the page, followed by another six rewards before you can access the gun. This is just beyond the halfway point in the battle pass, so youll need to invest quite a few tokens to unlock it which makes sense, given how powerful it is. However, you dont need the paid battle pass; much like the PPSh-41, the free battle pass contains the new gun.Best Cypher 091 loadout in Black Ops 6Here is the best Cypher 091 loadout in Black Ops 6:Muzzle: CompensatorBarrel: Long BarrelUnderbarrel: Vertical ForegripStock: Heavy StockFire Mods: Rapid FireYou dont want to try and get too clever with the Cypher 091 because its a simple weapon to use, so as mentioned above, stick with enhancing the recoil and damage. The Compensator is an excellent choice for this, as it buffs the vertical recoil control considerably, while the Vertical Foregrip does the same for the horizontal recoil control.These are the only recoil attachments youll need though, thanks to how little recoil there is from the get-go. Pair these with the Long Barrel, which significantly buffs the damage range, so you can sit behind cover and pick enemies off from afar. Meanwhile, the Heavy Stock negates most flinching when enemies shoot back at you so youre able to stay on target.For the final attachment, go for the Rapid Fire fire mod. You may be tempted to go for the Recoil Springs here to ensure you have as little recoil as possible, but trust us: it is not needed. Theres practically no recoil anyway, so Rapid Fire allows you to fire at a much faster rate and kill enemies considerably quicker.Theres no need to opt for Gunfighter here because the Cypher 091 really does not need another three attachments, but if you find yourself in need of an optical sight instead of using the iron sights, wed recommend swapping out the Heavy Stock for your optic of choice.Best Cypher 091 class in Black Ops 6Here is the best Cypher 091 class in Black Ops 6:Pistol: GrekhovaMelee: CleaverTactical: ConcussionLethal: FragField Upgrade: Trophy SystemPerk 1: GhostPerk 2: Forward IntelPerk 3: Cold-BloodedSpecialty: ReconWildcard: Perk GreedPerk 4: Flak JacketA gun this simple to use doesnt require anything too unorthodox when it comes to the accompanying class, so its best to stick with a fairly standard class setup. Most of this can be tweaked to your personal preference, but weve found the best results with the following.The Grekhova pistol is almost always the best choice in this slot, because its so quick to switch to and because its fully automatic, it can shred through enemies quickly. Wed usually suggest the Knife as the melee weapon of choice, but the Cleaver has surpassed that due to its slightly longer range.For the three equipment slots, best to go with ol faithfuls: the Concussion is handy for an extra advantage in fights, Frag Grenades are a no-brainer when you want to time the explosion, and the Trophy System is essential to help defend a location from incoming throwables. Meanwhile, opt for the blue perks for the Recon specialty, which allows you to briefly see through walls when respawning.Ghost is the best of these three because it makes you invisible to enemy UAVs when moving, while Cold-Blooded means youre undetectable by AI targeting and thermal optics. Forward Intel is the least useful of the three but its still the best pick of a bad bunch in the slot, allowing you to see the direction enemies are travelling on the minimap. As mentioned above, Gunfighter is unnecessary, so instead pick Perk Greed and Flak Jacket as the fourth perk for those times when you dont have a Trophy System down but still need protection from incoming explosions.