Squeezing out sparks Small charges in water spray can trigger the formation of key biochemicals Charges cause water droplets in an early-Earth atmosphere to build up pre-life chemicals. Jacek Krywko Mar 14, 2025 2:30 pm | 11 Credit: Little Dinosaur Credit: Little Dinosaur Story textSizeSmallStandardLargeWidth *StandardWideLinksStandardOrange* Subscribers only Learn moreWe know Earth formed roughly 4.54 billion years ago and that the first single cell lifeforms were present roughly 1 billion years after that. What we dont know is what triggered the process that turned our planet from a barren ball of rock into a world hosting amazing abundance of lifeforms. Were trying to understand how do you go from non-life to life. Now I think we have made a real contribution to solving this mystery, says Richard Zare, a Stanford University chemistry professor. Zare is the senior author of the recent study into a previously unknown electrochemical process that might have helped supply the raw materials needed for life.Zares team demonstrated the existence of micro-lightning, very small electricity discharges that occur between tiny droplets of water spray. When triggered in a mixture of gases made to replicate the atmosphere on early Earth, these micro-lightnings produced chemical compounds used by present-day life, like glycine, uracil, and urea, along with chemical precursors like cyanoacetylene, and hydrogen cyanide. Im not saying its the only way this could happenI wasnt there, Zare acknowledged. But its a new plausible mechanism that gives us building blocks of life.Lightning in the bulbScientific research into the beginnings of life on Earth started in the 1920s with Aleksander Oparin and J.B.S. Haldane, scientists who independently proposed that life on Earth could have arisen through a process of gradual chemical evolution. In their view, inorganic molecules might have reacted due to energy from the Sun or lightning strikes to form lifes building blocks, like amino acids. Those building blocks, Oparin and Haldane argued, could have accumulated in the oceans, making a primordial soup.This Oparin-Haldane concept was tested by Stanley Miller and Harold Urey in a groundbreaking experiment conducted at the University of Chicago in 1953. They took a glass bulb, and a spark plug like in a car, Zare said. They loaded the bulb with gases like methane, ammonia, water vapor, and they made a spark go through the bulb. Miller and Urey found that this triggered the formation of glycine, hydrogen cyanide, alanine, and other building blocks of life. But there have been important objections to the Miller-Urey hypothesis, Zare acknowledges.Size mattersThe first objection was that lightning strikes were intermittent and unpredictable. Compounds made by lightning strikes in the atmosphere would have become widely dispersed, which matters a lot, because making simple building blocks is not enough. These building blocks need to remain in proximity to combine into larger molecules like proteins. To really jump-start life, the lightning proposed by Miller and Urey would need to dump material into the same puddle over and over again, which seems rather unlikely.The first hints at an alternative to lightning appeared in 2024, when a team of Indian scientists led by Shidbas Banerjee observed that electrically neutral, micron-size water droplets from sonic sprays, humidifiers, spray bottles, et cetera could spontaneously ionize surrounding gas molecules, just as lightning strikes do. Banerjee attributed this phenomenon to electrical discharges in a corona surrounding individual water droplets, but Zare wanted to investigate this phenomenon a bit further.It turned out Miller and Urey might have been right that life started with something very much like lightning. Its just the lightning was likely much, much smaller than they thought.Levitating dropletsZare and his team, just like Banerjee and his colleagues, started with electrically neutral droplets of water. They suspended these droplets mid-air using acoustic levitation and recorded the droplets behavior with a high-speed camera. When a droplet was squashed by moving the acoustic hardware closer together, smaller droplets started to split off its surface and levitate around it. At this point, both small and large droplets became electrically charged. The electrons jumped from the large droplets onto the smaller droplets, Zare explains. So the large droplets ended up with a positive charge, while smaller droplets gained negative charges.To confirm this electric charge buildup mechanism, the team placed negatively and positively charged electrodes on opposite sides of the levitating droplets. The camera registered small droplets gravitating toward the positively charged surface. But it also registered something else. We could see charge jumping between negatively and positively charged droplets, Zare says. This really was a surprise. Its news! Weve all seen lightning, but no one has ever seen micro-lightning in droplets.Once his team nailed how droplets become electrically charged and how the micro-lightning phenomenon works, they recreated the Miller-Urey experiment. Only without the spark plugs.Ingredients of lifeAfter micro-lightnings started jumping between droplets in a mixture of gases similar to that used by Miller and Urey, the team examined their chemical composition with a mass spectrometer. They confirmed glycine, uracil, urea, cyanoethylene, and lots of other chemical compounds were made. Micro-lightnings made all organic molecules observed previously in the Miller-Urey experiment without any external voltage applied, Zare claims.But does it really bring us any closer to explaining the beginnings of life? After all, Miller and Urey already demonstrated those molecules could be produced by electrical discharges in a primordial Earths atmospheredoes it matter all that much where those discharges came from? Zare argues that it does.Lightning is intermittent, so it would be hard for these molecules to concentrate. But if you look at waves crashing into rocks, you can think the spray would easily go into the crevices in these rocks, Zare suggests. He suggests that the water in these crevices would evaporate, new spray would enter and evaporate again and again. The cyclic drying would allow the chemical precursors to build into more complex molecules. When you go through such a dry cycle, it causes polymerization, which is how you make DNA, Zare argues. Since sources of spray were likely common on the early Earth, Zare thinks this process could produce far more organic chemicals than potential alternatives like lightning strikes, hydrothermal vents, or impacting comets.But even if micro-lightning really produced the basic building blocks of life on Earth, were still not sure how those combined into living organisms. We did not make life. We just demonstrated a possible mechanism that gives us some chemical compounds you find in life, Zare says. Its very important to have a lot of humility with this stuff.Science Advances, 2025. DOI: 10.1126/sciadv.adt8979Jacek KrywkoAssociate WriterJacek KrywkoAssociate Writer Jacek Krywko is a freelance science and technology writer who covers space exploration, artificial intelligence research, computer science, and all sorts of engineering wizardry. 11 Comments