Carbo-preloading Craving carbs? Blame an ancient gene. We, Neanderthals, and Denisovans all have extra copies of a starch-digesting enzyme. Elizabeth Rayne Dec 27, 2024 7:25 am | 0 Credit: Yana Iskayeva/Getty Credit: Yana Iskayeva/Getty Story textSizeSmallStandardLargeWidth *StandardWideLinksStandardOrange* Subscribers only Learn moreThere is now a genetic excuse not to bother cutting carbs. Humans have genetically adapted to eating starchy foods, and our ancestors may have been carb-ivores even before modern Homo sapiens emerged.The salivary amylase gene, known as AMY1, is already known to have helped us adapt to eating carbs. It encodes amylase, an enzyme that breaks starches found in pasta and bread down to glucoseand may have given us a taste preference for them. Humans have multiple copies of the gene, which may help us produce high levels of the enzyme.Researchers from the University of Buffalo and the Jackson Laboratory have now found that, while most copies of this gene arose with the advent of farming, modern humans and our closest relatives had accumulated extra copies long before agriculture.By mapping the genomes of individuals from both modern and pre-agricultural populations, and using long-read gene sequencing (which sequences long strands of DNA or RNA all at once), the team found several copies of AMY1 in humans as far back as 45,000 years ago and in our Neanderthal and Denisovan predecessors over 800,000 years ago.If the genes fitThe ancestral AMY1 gene, which is expressed in the parotid salivary gland, was present as a single copy and is thought to have originated in the common ancestor of great apes. We now have multiple copies of AMY1, which had been linked to the beginnings of agriculture about 10,000 years ago, which made starches more consistently available.Because there was a lack of information about when the additional copies of AMY1 appeared, the research team mapped and sequenced the genomes of 98 individuals from various ancient and modern populations to see if the number of copies increased around the same time that many hunter-gatherers transitioned to farming. Analysis of ancient and modern human genomes, along with those of our closest relatives, revealed a common haplotype, or group of alleles (different forms of a gene), inherited together from one parent. This haplotype has three copies of AMY1 and was present in samples that predated our migration out of Africa. Haplotypes with more copies of the gene also exist.This observation is concordant with the recent evidence of Neanderthal starch consumption, and perhaps the availability of cooked starch in archaic hominins made possible through the domestication of fire, the researchers said in a study recently published in Science.Out of eight genomes examined, multiple copies of AMY1 were found in two Eastern Neanderthal genomes, one from a Western Neanderthal, and one from a Denisovan. So why did these extra copies evolve? While the exact reason is still unknown, the team thinks that the gene itself was copy number variable, meaning the number of copies within a population can vary between individuals. This variation likely developed before humans diverged from Neanderthals and Denisovans.With the grainTo the research team, it was inevitable that copies of AMY1 in individual genomes would increase as former hunter-gatherers established agricultural societies. Farming meant grains and other starch-rich foods, and the ability to adjust those meant carbs.And the data here is consistent with that. The team found a general trend where the AMY1 gene copy number is significantly higher among samples excavated from archaeologically agricultural contexts compared to those from hunter-gatherer contexts, as they said in the same study.In genomes from pre-agricultural individuals, there were already anywhere from four to eight copies of the gene. The variation is thought to have come from groups experimenting with food-processing techniques such as grinding wild grains into flour. AMY1 copy numbers grew pretty consistently from the pre-agricultural to post-agricultural period. Individuals from populations that were in the process of transitioning to agriculture (around 16,100 to 8,500 years ago) were found to have about similar numbers of AMY1 copies as hunter-gatherers at the time.Individuals from after 8,500 years ago who lived in more established agricultural societies showed the most copies and therefore the most evidence of adaptation to eating diets high in carbs. Agriculture continued to advance, and the last 4,000 years have seen the most significant surge of AMY1 copy increases. Modern humans have anywhere from two to 15 copies.Further research could help with understanding how genetic variation of AMY1 copy numbers influences starch metabolism, including conditions such as gluten allergy and celiac disease, and overall metabolic health.Can we really blame AMY1 and amylase on our carb cravings? Partly. The number of AMY1 copies in a human genome determine not only the ability to metabolize starches, but will also influence how they taste to us, and may have given us a preference for them. Maybe we can finally ease up on demonizing bread.Science, 2024. DOI: 10.1126/science.adn060Elizabeth Rayne Elizabeth Rayne is a creature who writes. Her work has appeared on SYFY WIRE, Space.com, Live Science, Grunge, Den of Geek, and Forbidden Futures. She lurks right outside New York City with her parrot, Lestat. When not writing, she is either shapeshifting, drawing, or cosplaying as a character nobody has ever heard of. Follow her on Threads and Instagram @quothravenrayne. 0 Comments