• How to play Recluse in Elden Ring Nightreign

    The Recluse makes a bunch of cocktails in Elden Ring’s Nightreign, but not the type you’d like to drink. She transforms the typical playstyle of a Soulslike spellcaster and flips it on its head by allowing you access to 14 extra spells through her character skill, Magic Cocktail.

    Recluse is the perfect character for you if you want to dedicate many hours to mastering a character. In comparison to the other classes, Recluse demands constant management of stamina, FP, and your character skill on top of all the other requirements Nightreign demands of you.

    If you’re an aspiring Recluse main who wants to get the best out of the character in your future expeditions, this Elden Ring Nightreign guide will show you how to play as Recluse, with a focus on recommendations for her best relics, best teammates, and best weapons, alongside other miscellaneous tips.

    How to make a great Recluse build in Elden Ring Nightreign

    As a mage, you want your Recluse build to involve staves and whatever melee weapon you’re most comfortable with. The most challenging part of learning Recluse’s quirks isn’t strictly about managing her character skill but also about keeping your FP high. It’s easy to disregard it and spam the spells of your weapons, but once you run out of FP, you’re out of luck; there is no azure flask to lean on.

    The only way to restore this vital resource is by using your character skill. This is why a good melee weapon you’re comfortable with matters as you begin to learn. Once you have a good grasp on weaving your skill in between spells, you can prioritize weapons and relics that boost intelligence and improve spellcasting.

    Best relics for Recluse in Elden Ring Nightreign

    For Recluse, Intelligence is king! There are many relics to choose from in Elden Ring Nightreign, but as long as your relic has some boost to spellcasting, FP cost, or intelligence, you are in good shape. While playing the game, you’ll unlock some relics that have passives unique to Recluse. As you can probably assume, these are some of her best options.

    Some of the Recluse’s best options are relics with the following effects:Activating ultimate art raises max HPCollecting affinity residue activates Terra MagicaSuffer blood loss and increase attack power upon art activation

    Magic attack power up +

    Ultimate art gauge +

    FP restoration upon successive attacks

    Improved resistance relics are also grand if you’re able to match them up with the damage type of your chosen expedition’s Nightlord

    Other miscellaneous relics to prioritize are those that increase vigor, mind, intelligence, faith, or endurance. Recluse is a frail character, so more survivability is always good.

    Best teammates for Recluse in Elden Ring Nightreign

    Similar to other less tanky options like Duchess, Ironeye, and Revenant, Recluse thrives in a team composition that can take enemy pressure off of her as she applies high magic damage through her spells and skills. The following classes are great for Recluse, and you shouldn’t pick her unless one of your teammates is hovering them.

    Guardian — Guardian’s ultimate art provides a useful damage negation buff to teammates in its radius, helping Recluse stay alive longer.

    Raider — Raider easily absorbs enemy attention, allowing for Recluse to damage her targets safely.

    Wylder — Wylder’s character skill allows him to grapple enemies to him, relieving pressure off of Recluse. His Ultimate Art also deals fire damage, which you can provide fire essence for your character skill.

    Best Magic Cocktail Combinations in Elden Ring Nightreign

    Recluse’s character skill is the meat and potatoes of her playstyle. There is no way around it; you have to get comfortable with all 14 of the possible spell combinations. When an enemy or ally takes elemental damage from any source, you can use this skill to siphon the residue of that damage and bank it. Once you’ve banked three element residues, your next cast will cast a unique spell. Every single one has its uses, but some are more practical and usable in nearly every situation.

    Pure Holy — Enwreathe oneself in holy light, bordering poise and increasing damage negation. Requires 3 Holy residues.

    Magic & Holy — Cover nearby area with a magic veil, fully conserving FP for self and allies for a short time. Can be used with any combination of Magic and Holy residue.

    Magic, Fire, & Lightning — Conjure frontwards exploding gravity orb. Gravity orb pulls enemies inward, expands, and explodes, inflicting heavy damage. Requires Magic, Fire, and Lightning residue.

    Best talismans for Recluse in Elden Ring Nightreign

    Talismans are some of the rarest gear in Elden Ring Nightreign, but they can be found if you know where to look. They can drop in fortresses and from scarabs, so if you spot one of these, it’s good to prioritize them. The best talismans for the Recluse are the following:

    Ancestral Spirit’s Horn — Defeating Enemies Restores FP

    Taker’s Cameo — Defeating Enemies Restores HP

    Ritual Shield Talisman — Improved Damage Negation at Full HP

    Blessed Dew Talisman — Continous HP Recovery +2

    Viridian Amber Medallion — Increased Maximum Stamina +12%

    Any talisman that offers FP restoration, HP restoration, damage negation, and stamina recovery is good, as they allow Recluse players some individuality and choice regarding whether they should instead play defensively or offensively. Recluse in Elden Ring Nightreign requires a specific type of player, and with some practice, adaptability, and a good loadout, mastering the mage will be a piece of cake.

    For more Elden Ring Nightreign guides, here’s a list of all classes, the best class to pick first, how to unlock the Duchess and Revenant, and the best early Duchess build.
    #how #play #recluse #elden #ring
    How to play Recluse in Elden Ring Nightreign
    The Recluse makes a bunch of cocktails in Elden Ring’s Nightreign, but not the type you’d like to drink. She transforms the typical playstyle of a Soulslike spellcaster and flips it on its head by allowing you access to 14 extra spells through her character skill, Magic Cocktail. Recluse is the perfect character for you if you want to dedicate many hours to mastering a character. In comparison to the other classes, Recluse demands constant management of stamina, FP, and your character skill on top of all the other requirements Nightreign demands of you. If you’re an aspiring Recluse main who wants to get the best out of the character in your future expeditions, this Elden Ring Nightreign guide will show you how to play as Recluse, with a focus on recommendations for her best relics, best teammates, and best weapons, alongside other miscellaneous tips. How to make a great Recluse build in Elden Ring Nightreign As a mage, you want your Recluse build to involve staves and whatever melee weapon you’re most comfortable with. The most challenging part of learning Recluse’s quirks isn’t strictly about managing her character skill but also about keeping your FP high. It’s easy to disregard it and spam the spells of your weapons, but once you run out of FP, you’re out of luck; there is no azure flask to lean on. The only way to restore this vital resource is by using your character skill. This is why a good melee weapon you’re comfortable with matters as you begin to learn. Once you have a good grasp on weaving your skill in between spells, you can prioritize weapons and relics that boost intelligence and improve spellcasting. Best relics for Recluse in Elden Ring Nightreign For Recluse, Intelligence is king! There are many relics to choose from in Elden Ring Nightreign, but as long as your relic has some boost to spellcasting, FP cost, or intelligence, you are in good shape. While playing the game, you’ll unlock some relics that have passives unique to Recluse. As you can probably assume, these are some of her best options. Some of the Recluse’s best options are relics with the following effects:Activating ultimate art raises max HPCollecting affinity residue activates Terra MagicaSuffer blood loss and increase attack power upon art activation Magic attack power up + Ultimate art gauge + FP restoration upon successive attacks Improved resistance relics are also grand if you’re able to match them up with the damage type of your chosen expedition’s Nightlord Other miscellaneous relics to prioritize are those that increase vigor, mind, intelligence, faith, or endurance. Recluse is a frail character, so more survivability is always good. Best teammates for Recluse in Elden Ring Nightreign Similar to other less tanky options like Duchess, Ironeye, and Revenant, Recluse thrives in a team composition that can take enemy pressure off of her as she applies high magic damage through her spells and skills. The following classes are great for Recluse, and you shouldn’t pick her unless one of your teammates is hovering them. Guardian — Guardian’s ultimate art provides a useful damage negation buff to teammates in its radius, helping Recluse stay alive longer. Raider — Raider easily absorbs enemy attention, allowing for Recluse to damage her targets safely. Wylder — Wylder’s character skill allows him to grapple enemies to him, relieving pressure off of Recluse. His Ultimate Art also deals fire damage, which you can provide fire essence for your character skill. Best Magic Cocktail Combinations in Elden Ring Nightreign Recluse’s character skill is the meat and potatoes of her playstyle. There is no way around it; you have to get comfortable with all 14 of the possible spell combinations. When an enemy or ally takes elemental damage from any source, you can use this skill to siphon the residue of that damage and bank it. Once you’ve banked three element residues, your next cast will cast a unique spell. Every single one has its uses, but some are more practical and usable in nearly every situation. Pure Holy — Enwreathe oneself in holy light, bordering poise and increasing damage negation. Requires 3 Holy residues. Magic & Holy — Cover nearby area with a magic veil, fully conserving FP for self and allies for a short time. Can be used with any combination of Magic and Holy residue. Magic, Fire, & Lightning — Conjure frontwards exploding gravity orb. Gravity orb pulls enemies inward, expands, and explodes, inflicting heavy damage. Requires Magic, Fire, and Lightning residue. Best talismans for Recluse in Elden Ring Nightreign Talismans are some of the rarest gear in Elden Ring Nightreign, but they can be found if you know where to look. They can drop in fortresses and from scarabs, so if you spot one of these, it’s good to prioritize them. The best talismans for the Recluse are the following: Ancestral Spirit’s Horn — Defeating Enemies Restores FP Taker’s Cameo — Defeating Enemies Restores HP Ritual Shield Talisman — Improved Damage Negation at Full HP Blessed Dew Talisman — Continous HP Recovery +2 Viridian Amber Medallion — Increased Maximum Stamina +12% Any talisman that offers FP restoration, HP restoration, damage negation, and stamina recovery is good, as they allow Recluse players some individuality and choice regarding whether they should instead play defensively or offensively. Recluse in Elden Ring Nightreign requires a specific type of player, and with some practice, adaptability, and a good loadout, mastering the mage will be a piece of cake. For more Elden Ring Nightreign guides, here’s a list of all classes, the best class to pick first, how to unlock the Duchess and Revenant, and the best early Duchess build. #how #play #recluse #elden #ring
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    How to play Recluse in Elden Ring Nightreign
    The Recluse makes a bunch of cocktails in Elden Ring’s Nightreign, but not the type you’d like to drink. She transforms the typical playstyle of a Soulslike spellcaster and flips it on its head by allowing you access to 14 extra spells through her character skill, Magic Cocktail. Recluse is the perfect character for you if you want to dedicate many hours to mastering a character. In comparison to the other classes, Recluse demands constant management of stamina, FP, and your character skill on top of all the other requirements Nightreign demands of you. If you’re an aspiring Recluse main who wants to get the best out of the character in your future expeditions, this Elden Ring Nightreign guide will show you how to play as Recluse, with a focus on recommendations for her best relics, best teammates, and best weapons, alongside other miscellaneous tips. How to make a great Recluse build in Elden Ring Nightreign As a mage, you want your Recluse build to involve staves and whatever melee weapon you’re most comfortable with. The most challenging part of learning Recluse’s quirks isn’t strictly about managing her character skill but also about keeping your FP high. It’s easy to disregard it and spam the spells of your weapons, but once you run out of FP, you’re out of luck; there is no azure flask to lean on. The only way to restore this vital resource is by using your character skill. This is why a good melee weapon you’re comfortable with matters as you begin to learn. Once you have a good grasp on weaving your skill in between spells, you can prioritize weapons and relics that boost intelligence and improve spellcasting. Best relics for Recluse in Elden Ring Nightreign For Recluse, Intelligence is king! There are many relics to choose from in Elden Ring Nightreign, but as long as your relic has some boost to spellcasting, FP cost, or intelligence, you are in good shape. While playing the game, you’ll unlock some relics that have passives unique to Recluse. As you can probably assume, these are some of her best options. Some of the Recluse’s best options are relics with the following effects: [Recluse] Activating ultimate art raises max HP [Recluse] Collecting affinity residue activates Terra Magica [Recluse] Suffer blood loss and increase attack power upon art activation Magic attack power up + Ultimate art gauge + FP restoration upon successive attacks Improved resistance relics are also grand if you’re able to match them up with the damage type of your chosen expedition’s Nightlord Other miscellaneous relics to prioritize are those that increase vigor, mind, intelligence, faith, or endurance. Recluse is a frail character, so more survivability is always good. Best teammates for Recluse in Elden Ring Nightreign Similar to other less tanky options like Duchess, Ironeye, and Revenant, Recluse thrives in a team composition that can take enemy pressure off of her as she applies high magic damage through her spells and skills. The following classes are great for Recluse, and you shouldn’t pick her unless one of your teammates is hovering them. Guardian — Guardian’s ultimate art provides a useful damage negation buff to teammates in its radius, helping Recluse stay alive longer. Raider — Raider easily absorbs enemy attention, allowing for Recluse to damage her targets safely. Wylder — Wylder’s character skill allows him to grapple enemies to him, relieving pressure off of Recluse. His Ultimate Art also deals fire damage, which you can provide fire essence for your character skill. Best Magic Cocktail Combinations in Elden Ring Nightreign Recluse’s character skill is the meat and potatoes of her playstyle. There is no way around it; you have to get comfortable with all 14 of the possible spell combinations. When an enemy or ally takes elemental damage from any source, you can use this skill to siphon the residue of that damage and bank it. Once you’ve banked three element residues, your next cast will cast a unique spell. Every single one has its uses, but some are more practical and usable in nearly every situation. Pure Holy — Enwreathe oneself in holy light, bordering poise and increasing damage negation. Requires 3 Holy residues. Magic & Holy — Cover nearby area with a magic veil, fully conserving FP for self and allies for a short time. Can be used with any combination of Magic and Holy residue. Magic, Fire, & Lightning — Conjure frontwards exploding gravity orb. Gravity orb pulls enemies inward, expands, and explodes, inflicting heavy damage. Requires Magic, Fire, and Lightning residue. Best talismans for Recluse in Elden Ring Nightreign Talismans are some of the rarest gear in Elden Ring Nightreign, but they can be found if you know where to look. They can drop in fortresses and from scarabs, so if you spot one of these, it’s good to prioritize them. The best talismans for the Recluse are the following: Ancestral Spirit’s Horn — Defeating Enemies Restores FP Taker’s Cameo — Defeating Enemies Restores HP Ritual Shield Talisman — Improved Damage Negation at Full HP Blessed Dew Talisman — Continous HP Recovery +2 Viridian Amber Medallion — Increased Maximum Stamina +12% Any talisman that offers FP restoration, HP restoration, damage negation, and stamina recovery is good, as they allow Recluse players some individuality and choice regarding whether they should instead play defensively or offensively. Recluse in Elden Ring Nightreign requires a specific type of player, and with some practice, adaptability, and a good loadout, mastering the mage will be a piece of cake. For more Elden Ring Nightreign guides, here’s a list of all classes, the best class to pick first, how to unlock the Duchess and Revenant, and the best early Duchess build.
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  • The Supercomputer Designed to Accelerate Nobel-Worthy Science

    Ready for a front-row seat to the next scientific revolution?
    That’s the idea behind Doudna — a groundbreaking supercomputer announced today at Lawrence Berkeley National Laboratory in Berkeley, California. The system represents a major national investment in advancing U.S. high-performance computingleadership, ensuring U.S. researchers have access to cutting-edge tools to address global challenges.
    “It will advance scientific discovery from chemistry to physics to biology and all powered by — unleashing this power — of artificial intelligence,” U.S. Energy Secretary Chris Wrightsaid at today’s event.
    Also known as NERSC-10, Doudna is named for Nobel laureate and CRISPR pioneer Jennifer Doudna. The next-generation system announced today is designed not just for speed but for impact.
    Nobel laureate and CRISPR pioneer Jennifer Doudna speaking at today’s event in Berkeley, California. To her right, NVIDIA founder and CEO Jensen Huang and Paul Perez, senior vice president and senior technology fellow at Dell Technologies.
    Powered by Dell Technologies infrastructure with the NVIDIA Vera Rubin architecture, and set to launch in 2026, Doudna is tailored for real-time discovery across the U.S. Department of Energy’s most urgent scientific missions. It’s poised to catapult American researchers to the forefront of critical scientific breakthroughs, fostering innovation and securing the nation’s competitive edge in key technological fields.
    “I’m so proud that America continues to invest in this particular area,” said NVIDIA founder and CEO Jensen Huang. “It is the foundation of scientific discovery for our country. It is also the foundation for economic and technology leadership.”
    “It’s an incredible honor to be here,” Doudna said, adding she was “surprised and delighted” that a supercomputer would be named after her. “I think we’re standing at a really interesting moment in biology,” she added, with people with different skills coming together to address global issues.
    Designed to Accelerate Breakthroughs
    Unlike traditional systems that operate in silos, Doudna merges simulation, data and AI into a single seamless platform.
    “The Doudna supercomputer is designed to accelerate a broad set of scientific workflows,” said NERSC Director Sudip Dosanjh. “Doudna will be connected to DOE experimental and observational facilities through the Energy Sciences Network, allowing scientists to stream data seamlessly into the system from all parts of the country and to analyze it in near real time.”
    It’s engineered to empower over 11,000 researchers with almost instantaneous responsiveness and integrated workflows, helping scientists explore bigger questions and reach answers faster than ever.
    “We’re not just building a faster computer,” said Nick Wright, advanced technologies group lead and Doudna chief architect at NERSC. “We’re building a system that helps researchers think bigger and discover sooner.”
    Here’s what Wright expects Doudna to advance:

    Fusion energy: Breakthroughs in simulation that unlocks clean fusion energy.
    Materials science: AI models that design new classes of superconducting materials.
    Drug discovery acceleration: Ultrarapid workflow that helps biologists fold proteins fast enough to outpace a pandemic.
    Astronomy: Real-time processing of data from the Dark Energy Spectroscopic Instrument at Kitt Peak to help scientists map the universe.

    Doudna is expected to outperform its predecessor, Perlmutter, by more than 10x in scientific output, all while using just 2-3x the power.
    This translates to a 3-5x increase in performance per watt, a result of innovations in chip design, dynamic load balancing and system-level efficiencies.
    AI-Powered Discovery at Scale
    Doudna will power AI-driven breakthroughs across high-impact scientific fields nationwide. Highlights include:

    AI for protein design: David Baker, a 2024 Nobel laureate, used NERSC systems to support his work using AI to predict novel protein structures, addressing challenges across scientific disciplines.
    AI for fundamental physics: Researchers like Benjamin Nachman are using AI to “unfold” detector distortions in particle physics data and analyze proton data from electron-proton colliders.
    AI for materials science: A collaboration including Berkeley Lab and Meta created “Open Molecules 2025,” a massive dataset for using AI to accurately model complex molecular chemical reactions. Researchers involved also use NERSC for their AI models.

    Real-Time Science, Real-World Impact
    Doudna isn’t a standalone system. It’s an integral part of scientific workflows. DOE’s ESnet will stream data from telescopes, detectors and genome sequencers directly into the machine with low-latency, high-throughput NVIDIA Quantum-X800 InfiniBand networking.
    This critical data flow is prioritized by intelligent quality-of-service mechanisms, ensuring it stays fast and uninterrupted, from input to insight.
    This will make the system incredibly responsive. At the DIII-D national fusion ignition facility, for example, data will stream control-room events directly into Doudna for rapid-response plasma modeling, so scientists can make adjustments in real time.
    “We used to think of the supercomputer as a passive participant in the corner,” Wright said. “Now it’s part of the entire workflow, connected to experiments, telescopes, detectors.”
    The Platform for What’s Next: Unlocking Quantum and HPC Workflows
    Doudna supports traditional HPC, cutting-edge AI, real-time streaming and even quantum workflows.
    The Mayall 4-Meter Telescope, which will be home to the Dark Energy Spectroscopic Instrument, seen at night at Kitt Peak National Observatory.
    This includes support for scalable quantum algorithm development and the codesign of future integrated quantum-HPC systems, using platforms like NVIDIA CUDA-Q.
    All of these workflows will run on the next-generation NVIDIA Vera Rubin platform, which will blend high-performance CPUs with coherent GPUs, meaning all processors can access and share data directly to support the most demanding scientific workloads.
    Researchers are already porting full pipelines using frameworks like PyTorch, the NVIDIA Holoscan software development kit, TensorFlow, NVIDIA cuDNN and NVIDIA CUDA-Q, all optimized for the system’s Rubin GPUs and NVIDIA NVLink architecture.
    Over 20 research teams are already porting full workflows to Doudna through the NERSC Science Acceleration Program, tackling everything from climate models to particle physics. This isn’t just about raw compute, it’s about discovery, integrated from idea to insight.
    Designed for Urgency
    Last year, AI-assisted science earned two Nobel Prizes. From climate research to pandemic response, the next breakthroughs won’t wait for better infrastructure.
    With deployment slated for 2026, Doudna is positioned to lead a new era of accelerated science. DOE facilities across the country, from Fermilab to the Joint Genome Institute, will rely on its capabilities to turn today’s questions into tomorrow’s breakthroughs.
    “This isn’t a system for one field,” Wright said. “It’s for discovery — across chemistry, physics and fields we haven’t imagined yet.”
    As Huang put it, Doudna is “a time machine for science.” It compresses years of discovery into days and gives the world’s toughest problems the power they’ve been waiting for.
    This post has been updated with comments from Thursday’s event at Lawrence Berkeley National Laboratory. 
    #supercomputer #designed #accelerate #nobelworthy #science
    The Supercomputer Designed to Accelerate Nobel-Worthy Science
    Ready for a front-row seat to the next scientific revolution? That’s the idea behind Doudna — a groundbreaking supercomputer announced today at Lawrence Berkeley National Laboratory in Berkeley, California. The system represents a major national investment in advancing U.S. high-performance computingleadership, ensuring U.S. researchers have access to cutting-edge tools to address global challenges. “It will advance scientific discovery from chemistry to physics to biology and all powered by — unleashing this power — of artificial intelligence,” U.S. Energy Secretary Chris Wrightsaid at today’s event. Also known as NERSC-10, Doudna is named for Nobel laureate and CRISPR pioneer Jennifer Doudna. The next-generation system announced today is designed not just for speed but for impact. Nobel laureate and CRISPR pioneer Jennifer Doudna speaking at today’s event in Berkeley, California. To her right, NVIDIA founder and CEO Jensen Huang and Paul Perez, senior vice president and senior technology fellow at Dell Technologies. Powered by Dell Technologies infrastructure with the NVIDIA Vera Rubin architecture, and set to launch in 2026, Doudna is tailored for real-time discovery across the U.S. Department of Energy’s most urgent scientific missions. It’s poised to catapult American researchers to the forefront of critical scientific breakthroughs, fostering innovation and securing the nation’s competitive edge in key technological fields. “I’m so proud that America continues to invest in this particular area,” said NVIDIA founder and CEO Jensen Huang. “It is the foundation of scientific discovery for our country. It is also the foundation for economic and technology leadership.” “It’s an incredible honor to be here,” Doudna said, adding she was “surprised and delighted” that a supercomputer would be named after her. “I think we’re standing at a really interesting moment in biology,” she added, with people with different skills coming together to address global issues. Designed to Accelerate Breakthroughs Unlike traditional systems that operate in silos, Doudna merges simulation, data and AI into a single seamless platform. “The Doudna supercomputer is designed to accelerate a broad set of scientific workflows,” said NERSC Director Sudip Dosanjh. “Doudna will be connected to DOE experimental and observational facilities through the Energy Sciences Network, allowing scientists to stream data seamlessly into the system from all parts of the country and to analyze it in near real time.” It’s engineered to empower over 11,000 researchers with almost instantaneous responsiveness and integrated workflows, helping scientists explore bigger questions and reach answers faster than ever. “We’re not just building a faster computer,” said Nick Wright, advanced technologies group lead and Doudna chief architect at NERSC. “We’re building a system that helps researchers think bigger and discover sooner.” Here’s what Wright expects Doudna to advance: Fusion energy: Breakthroughs in simulation that unlocks clean fusion energy. Materials science: AI models that design new classes of superconducting materials. Drug discovery acceleration: Ultrarapid workflow that helps biologists fold proteins fast enough to outpace a pandemic. Astronomy: Real-time processing of data from the Dark Energy Spectroscopic Instrument at Kitt Peak to help scientists map the universe. Doudna is expected to outperform its predecessor, Perlmutter, by more than 10x in scientific output, all while using just 2-3x the power. This translates to a 3-5x increase in performance per watt, a result of innovations in chip design, dynamic load balancing and system-level efficiencies. AI-Powered Discovery at Scale Doudna will power AI-driven breakthroughs across high-impact scientific fields nationwide. Highlights include: AI for protein design: David Baker, a 2024 Nobel laureate, used NERSC systems to support his work using AI to predict novel protein structures, addressing challenges across scientific disciplines. AI for fundamental physics: Researchers like Benjamin Nachman are using AI to “unfold” detector distortions in particle physics data and analyze proton data from electron-proton colliders. AI for materials science: A collaboration including Berkeley Lab and Meta created “Open Molecules 2025,” a massive dataset for using AI to accurately model complex molecular chemical reactions. Researchers involved also use NERSC for their AI models. Real-Time Science, Real-World Impact Doudna isn’t a standalone system. It’s an integral part of scientific workflows. DOE’s ESnet will stream data from telescopes, detectors and genome sequencers directly into the machine with low-latency, high-throughput NVIDIA Quantum-X800 InfiniBand networking. This critical data flow is prioritized by intelligent quality-of-service mechanisms, ensuring it stays fast and uninterrupted, from input to insight. This will make the system incredibly responsive. At the DIII-D national fusion ignition facility, for example, data will stream control-room events directly into Doudna for rapid-response plasma modeling, so scientists can make adjustments in real time. “We used to think of the supercomputer as a passive participant in the corner,” Wright said. “Now it’s part of the entire workflow, connected to experiments, telescopes, detectors.” The Platform for What’s Next: Unlocking Quantum and HPC Workflows Doudna supports traditional HPC, cutting-edge AI, real-time streaming and even quantum workflows. The Mayall 4-Meter Telescope, which will be home to the Dark Energy Spectroscopic Instrument, seen at night at Kitt Peak National Observatory. This includes support for scalable quantum algorithm development and the codesign of future integrated quantum-HPC systems, using platforms like NVIDIA CUDA-Q. All of these workflows will run on the next-generation NVIDIA Vera Rubin platform, which will blend high-performance CPUs with coherent GPUs, meaning all processors can access and share data directly to support the most demanding scientific workloads. Researchers are already porting full pipelines using frameworks like PyTorch, the NVIDIA Holoscan software development kit, TensorFlow, NVIDIA cuDNN and NVIDIA CUDA-Q, all optimized for the system’s Rubin GPUs and NVIDIA NVLink architecture. Over 20 research teams are already porting full workflows to Doudna through the NERSC Science Acceleration Program, tackling everything from climate models to particle physics. This isn’t just about raw compute, it’s about discovery, integrated from idea to insight. Designed for Urgency Last year, AI-assisted science earned two Nobel Prizes. From climate research to pandemic response, the next breakthroughs won’t wait for better infrastructure. With deployment slated for 2026, Doudna is positioned to lead a new era of accelerated science. DOE facilities across the country, from Fermilab to the Joint Genome Institute, will rely on its capabilities to turn today’s questions into tomorrow’s breakthroughs. “This isn’t a system for one field,” Wright said. “It’s for discovery — across chemistry, physics and fields we haven’t imagined yet.” As Huang put it, Doudna is “a time machine for science.” It compresses years of discovery into days and gives the world’s toughest problems the power they’ve been waiting for. This post has been updated with comments from Thursday’s event at Lawrence Berkeley National Laboratory.  #supercomputer #designed #accelerate #nobelworthy #science
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    The Supercomputer Designed to Accelerate Nobel-Worthy Science
    Ready for a front-row seat to the next scientific revolution? That’s the idea behind Doudna — a groundbreaking supercomputer announced today at Lawrence Berkeley National Laboratory in Berkeley, California. The system represents a major national investment in advancing U.S. high-performance computing (HPC) leadership, ensuring U.S. researchers have access to cutting-edge tools to address global challenges. “It will advance scientific discovery from chemistry to physics to biology and all powered by — unleashing this power — of artificial intelligence,” U.S. Energy Secretary Chris Wright (pictured above) said at today’s event. Also known as NERSC-10, Doudna is named for Nobel laureate and CRISPR pioneer Jennifer Doudna. The next-generation system announced today is designed not just for speed but for impact. Nobel laureate and CRISPR pioneer Jennifer Doudna speaking at today’s event in Berkeley, California. To her right, NVIDIA founder and CEO Jensen Huang and Paul Perez, senior vice president and senior technology fellow at Dell Technologies. Powered by Dell Technologies infrastructure with the NVIDIA Vera Rubin architecture, and set to launch in 2026, Doudna is tailored for real-time discovery across the U.S. Department of Energy’s most urgent scientific missions. It’s poised to catapult American researchers to the forefront of critical scientific breakthroughs, fostering innovation and securing the nation’s competitive edge in key technological fields. “I’m so proud that America continues to invest in this particular area,” said NVIDIA founder and CEO Jensen Huang. “It is the foundation of scientific discovery for our country. It is also the foundation for economic and technology leadership.” “It’s an incredible honor to be here,” Doudna said, adding she was “surprised and delighted” that a supercomputer would be named after her. “I think we’re standing at a really interesting moment in biology,” she added, with people with different skills coming together to address global issues. Designed to Accelerate Breakthroughs Unlike traditional systems that operate in silos, Doudna merges simulation, data and AI into a single seamless platform. “The Doudna supercomputer is designed to accelerate a broad set of scientific workflows,” said NERSC Director Sudip Dosanjh. “Doudna will be connected to DOE experimental and observational facilities through the Energy Sciences Network (ESnet), allowing scientists to stream data seamlessly into the system from all parts of the country and to analyze it in near real time.” It’s engineered to empower over 11,000 researchers with almost instantaneous responsiveness and integrated workflows, helping scientists explore bigger questions and reach answers faster than ever. “We’re not just building a faster computer,” said Nick Wright, advanced technologies group lead and Doudna chief architect at NERSC. “We’re building a system that helps researchers think bigger and discover sooner.” Here’s what Wright expects Doudna to advance: Fusion energy: Breakthroughs in simulation that unlocks clean fusion energy. Materials science: AI models that design new classes of superconducting materials. Drug discovery acceleration: Ultrarapid workflow that helps biologists fold proteins fast enough to outpace a pandemic. Astronomy: Real-time processing of data from the Dark Energy Spectroscopic Instrument at Kitt Peak to help scientists map the universe. Doudna is expected to outperform its predecessor, Perlmutter, by more than 10x in scientific output, all while using just 2-3x the power. This translates to a 3-5x increase in performance per watt, a result of innovations in chip design, dynamic load balancing and system-level efficiencies. AI-Powered Discovery at Scale Doudna will power AI-driven breakthroughs across high-impact scientific fields nationwide. Highlights include: AI for protein design: David Baker, a 2024 Nobel laureate, used NERSC systems to support his work using AI to predict novel protein structures, addressing challenges across scientific disciplines. AI for fundamental physics: Researchers like Benjamin Nachman are using AI to “unfold” detector distortions in particle physics data and analyze proton data from electron-proton colliders. AI for materials science: A collaboration including Berkeley Lab and Meta created “Open Molecules 2025,” a massive dataset for using AI to accurately model complex molecular chemical reactions. Researchers involved also use NERSC for their AI models. Real-Time Science, Real-World Impact Doudna isn’t a standalone system. It’s an integral part of scientific workflows. DOE’s ESnet will stream data from telescopes, detectors and genome sequencers directly into the machine with low-latency, high-throughput NVIDIA Quantum-X800 InfiniBand networking. This critical data flow is prioritized by intelligent quality-of-service mechanisms, ensuring it stays fast and uninterrupted, from input to insight. This will make the system incredibly responsive. At the DIII-D national fusion ignition facility, for example, data will stream control-room events directly into Doudna for rapid-response plasma modeling, so scientists can make adjustments in real time. “We used to think of the supercomputer as a passive participant in the corner,” Wright said. “Now it’s part of the entire workflow, connected to experiments, telescopes, detectors.” The Platform for What’s Next: Unlocking Quantum and HPC Workflows Doudna supports traditional HPC, cutting-edge AI, real-time streaming and even quantum workflows. The Mayall 4-Meter Telescope, which will be home to the Dark Energy Spectroscopic Instrument, seen at night at Kitt Peak National Observatory. This includes support for scalable quantum algorithm development and the codesign of future integrated quantum-HPC systems, using platforms like NVIDIA CUDA-Q. All of these workflows will run on the next-generation NVIDIA Vera Rubin platform, which will blend high-performance CPUs with coherent GPUs, meaning all processors can access and share data directly to support the most demanding scientific workloads. Researchers are already porting full pipelines using frameworks like PyTorch, the NVIDIA Holoscan software development kit, TensorFlow, NVIDIA cuDNN and NVIDIA CUDA-Q, all optimized for the system’s Rubin GPUs and NVIDIA NVLink architecture. Over 20 research teams are already porting full workflows to Doudna through the NERSC Science Acceleration Program, tackling everything from climate models to particle physics. This isn’t just about raw compute, it’s about discovery, integrated from idea to insight. Designed for Urgency Last year, AI-assisted science earned two Nobel Prizes. From climate research to pandemic response, the next breakthroughs won’t wait for better infrastructure. With deployment slated for 2026, Doudna is positioned to lead a new era of accelerated science. DOE facilities across the country, from Fermilab to the Joint Genome Institute, will rely on its capabilities to turn today’s questions into tomorrow’s breakthroughs. “This isn’t a system for one field,” Wright said. “It’s for discovery — across chemistry, physics and fields we haven’t imagined yet.” As Huang put it, Doudna is “a time machine for science.” It compresses years of discovery into days and gives the world’s toughest problems the power they’ve been waiting for. This post has been updated with comments from Thursday’s event at Lawrence Berkeley National Laboratory. 
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