Nature, Published online: 25 March 2025; doi:10.1038/d41586-025-00956-wAlzheimers disease might be partly linked to the hormonal changes that accompany menopause. Plus, the brain might temporarily eat its own myelin to power through marathons and scientists in the United States and abroad are feeling anxious about crossing the US border.

Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08752-2Key measures of biodiversity were quantified and found to be affected by human pressures that shifted community composition and decreased local diversity across terrestrial, freshwater and marine ecosystems.

Nature, Published online: 28 March 2025; doi:10.1038/d41586-025-00924-4US researchers who must forage for their own salary by finding grants fear they will be the first to go as federal research dollars disappear.

Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08797-3A study finds that RUVBL2 is a conserved component of eukaryotic circadian clocks and suggests that slow ATPase activity, which was initially discovered in cyanobacteria, is a shared feature of eukaryotic clocks.

Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08778-6Glutamate metabolically reprograms bone-marrow-derived macrophages, stabilizing HIF1, which transcriptionally activates WNT3 to promote YAP1-dependent hepatocyte proliferation, boosting liver regeneration.

Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08740-6The ability to physically partition the human brain at a spatial resolution comparable to neuroimaging methods enabled the development of a brain-wide atlas of mitochondrial content, specialization and enzymatic oxidation and phosphorylation activities.

Nature, Published online: 28 March 2025; doi:10.1038/d41586-025-00879-6Study of more than 100,000 people supports your parents advice: eat your veggies.

Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08795-5The RBPJNCOR repressor complex is identified as a negative regulator of FOXP3 expression through modulation of histone acetylation in induced regulatory T cells.

Nature, Published online: 28 March 2025; doi:10.1038/d41586-025-00968-6Two journals embarked on efforts to compensate reviewers, with different results.

Nature, Published online: 26 March 2025; doi:10.1038/d41586-025-00872-zMapping the density, molecular features and energy-transformation capacity of cell organelles called mitochondria in the brain reveals region- and cell-type-specific variability that tracks with evolutionary patterns. Correlations between mitochondrial and brain-imaging metrics could enable future non-invasive explorations of mitochondrial bioenergetics in the brain in health and disease.

Nature, Published online: 26 March 2025; doi:10.1038/d41586-025-00882-xA method for the degradation of forever chemicals called per- and polyfluoroalkyl substances (PFAS) coupled with fluoride recovery has been developed by applying a phosphateenabled mechanochemical process. This approach reduces the environmental impact of PFAS and could supplement fluorspar, the fast-depleting mineral used for producing fluorochemicals.

Nature, Published online: 27 March 2025; doi:10.1038/d41586-025-00988-2A huge study paints the most detailed picture yet of the toll pregnancy and childbirth take on the body. Plus, scientists have discovered a new antibiotic in a lab technicians garden and artificial intelligence tools are making their way into the process of peer review to some researchers dismay.

Nature, Published online: 28 March 2025; doi:10.1038/d41586-025-00984-6Researchers are looking to improve how ageing is measured, but the field is plagued with uncertainties.

Nature, Published online: 26 March 2025; doi:10.1038/d41586-025-00974-8Protein-structure-prediction tools have transformed biology, but RNA is a tougher nut to crack. Plus, the NIH is cancelling COVID-19 research funds and how qudits can boost quantum computing.

Nature, Published online: 28 March 2025; doi:10.1038/d41586-025-00937-zStudy finds genetic imprints in three generations of Syrian refugees. Researchers urge caution in interpreting findings and call for replication.

Nature, Published online: 26 March 2025; doi:10.1038/d41586-025-00865-yMost communication between neurons is mediated by the neurotransmitter glutamate. The finding that temperature influences how glutamate binds to neuronal receptor proteins to initiate signal transduction reveals the mechanics of one of the brains most important processes.

Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08773-xHigh-throughput screening and hit optimization have led to the development of a small molecule, CIM-834, that targets the SARS-CoV-2 membrane protein and blocks assembly of the virus.

Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08794-6A study describes the split integrated stress response, a cellular stress response mechanism characterized by reduced eIF2B activity without eIF2 phosphorylation, which activates the eIF4EATF4PCK2 axis, enabling metabolic reprogramming.

Nature, Published online: 26 March 2025; doi:10.1038/d41586-025-00959-7Data from 300,000 births reveal how essential biological measurements are altered by carrying and delivering a baby.

Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08690-zA longstanding challenge in organic synthesisthe catalytic allylation of unprotected saccharides in an aqueous medium, a key step for the synthesis of Millad NX 8000is achieved through a simple and efficient indium-catalysed nucleophilic allylation using a three-carbon-unit allylboronic acid or its pinacol ester.

Nature, Published online: 26 March 2025; doi:10.1038/d41586-025-00848-zHundreds of cubes of human brain tissue help scientists to chart the energy-making capabilities of various brain regions.

Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08742-4A standard commercial CMOS FET can exhibit synaptic-like long-term potentiation and depression or neuron-like leaky-integrate-and-fire and adaptive frequency-bursting behaviour when biased in a specific but unconventional way.

Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08737-1Certifiably random bits can be generated using the 56-qubit Quantinuum H2-1 trapped-ion quantum computer accessed over the Internet.

Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08675-yThis Perspective describes how recent advances in artificial intelligence could be used to automate medical image interpretation to complement human expertise and empower physicians and patients.

Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08748-yIn mice, prolonged consumption of a high-fat diet decreases interest in calorie-rich foods as a result of reduced neurotensin expression and signalling, which uncouples hedonic feeding behaviour linked to neurons projecting from lateral nucleus accumbens to ventral tegmental area.

Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08921-3Long-term impact and biological recovery in a deep-sea mining track

Nature, Published online: 27 March 2025; doi:10.1038/d41586-025-00559-5Learning how to influence the way people see me when I enter a room has been key to boosting my confidence in job interviews.

Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08651-6JNJ-9676a small-molecule inhibitor targeting coronavirus M protein that shows excellent efficacy in Syrian golden hamster modelsbinds to and stabilizes the M protein dimer in an altered conformational state between its long and short forms, preventing the release of infectious virus.

Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08723-7A new lasso peptide antibiotic exhibits broad-spectrum activity against Gram-negative and Gram-positive bacteria by interfering with bacterial protein synthesis, is unaffected by common resistance mechanisms and shows no toxicity towards human cells.

Nature, Published online: 26 March 2025; doi:10.1038/d41586-025-00901-xA natural antibacterial molecule shows clinical promise. Its unusual binding site is on an excellent target: protein-synthesis machinery known as the ribosome.