BRCA2 prevents PARPi-mediated PARP1 retention to protect RAD51...

@Nature een koppeling hebt gedeeld

2025-03-27 00:52:05 ·

BRCA2 prevents PARPi-mediated PARP1 retention to protect RAD51 filaments

www.nature.com

Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08749-xThe tumour-suppressor protein BRCA2 is discovered to have a previously undescribed role in maintaining genomic integrity and the sensitivity of PARP1 inhibitors.

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