Macrophages harness hepatocyte glutamate to boost liver regeneration

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2025-03-28 21:03:08 ·

www.nature.com

Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08778-6Glutamate metabolically reprograms bone-marrow-derived macrophages, stabilizing HIF1, which transcriptionally activates WNT3 to promote YAP1-dependent hepatocyte proliferation, boosting liver regeneration.

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