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Enhancing transcriptionreplication conflict targets ecDNA-positive cancers
Nature, Published online: 06 November 2024; doi:10.1038/s41586-024-07802-5Extrachromosomal DNA makes cancerous tumours resistant to treatment, but this research demonstrates that increasing transcriptionreplication conflict allows for targeted elimination of cancer cells containing extrachromosomal DNA, and thus sustained tumour regression in mice.
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