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Machine learning helps to determine the diverse conformations of RNA molecules
Nature, Published online: 18 December 2024; doi:10.1038/d41586-024-04134-2An innovative technique called HORNET uses atomic force microscopy and a machine-learning architecture called a deep neural network to recapitulate the 3D structures of individual RNA molecules. This method enables the study of the structure and dynamics of RNAs that adopt flexible and variable conformations under biologically relevant conditions.
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