Bacteria wouldn’t be so bad if we could tell them what to do. “Stop spreading! Stop sticking together! Stop fending off our antibiotics!” A new method is starting to allow scientists to do just that, letting them use light to control certain functions of bacteria. Introduced in a paper published in The European Physical Journal Plus, the preliminary approach could have several potential applications, including a possible avenue for combating antibiotic resistance.The Problem of Antibacterial Resistance Bacteria are behind a variety of diseases, from strep to staph to pneumonia and meningitis, and they attack our bodies in a variety of ways, as well, including through the production of toxins that damage and disrupt our cells. Some of these infections stop on their own, but others are too stubborn, or too serious, to leave untreated. These are the infections that we target with antibiotics — that is, as long as our antibiotics are working.But, because bacteria are constantly changing, they can develop defenses against the antibiotics that we use to stave them off, making these treatments much less effective. That’s the gist of the growing threat posed by antibiotic resistance, which has contributed to millions of deaths since 1990 and is anticipated to contribute to millions more by 2050. Setting out to find a new solution to this growing problem, scientists from the Italian Institute of Technology and the Polytechnic University of Milan embarked on the Engineering of Bacteria to See Lightproject. The project aims to use light to control bacteria, primarily for the fight against antibiotic resistance. And the new method pushes the project closer to achieving that aim. Using light and light-sensitive molecules to adjust the electrical signals that are transmitted across the bacterial membrane, the method impacts the biological activity of bacteria without any alterations to their genetic makeup.“This interplay between light and electricalallows us to control key biological processes such as movement, biofilm formation, and antibiotic sensitivity,” said Giuseppe Maria Paternò, a study author and a professor at the Polytechnic University of Milan, according to a press release. “We can influence antibiotic uptake and restore or even enhance the effectiveness of treatments against resistant strains.”Coating Bacteria to Curb Antibiotic ResistanceTo control bacteria, the method takes advantage of a light-sensitive molecule called Ziapin2, which sticks to the bacterial surface. By covering bacteria with this light-sensitive molecule and by subjecting the covered bacteria to light, the scientists were able to modify the electrical signals that were transmitted across their bacterial membranes, transforming the bacteria’s basic functioning. Testing their method on one of the most studied bacterial species, the scientists changed the electrical signaling across the membranes of Bacillus subtilis, a popular model organism that’s often used as a stand-in for Staphylococcus aureus, the bacterium that causes staphylococcus, or staph, infections.When tested, the method modulated the bacteria’s susceptibility to Kanamycin, an intracellular antibiotic that’s frequently used as a treatment for severe bacterial infections after other treatments fail. “Under blue light,” Paternò said in the release, “the effectiveness of Kanamycin was significantly reduced,” indicating that the electrical signaling on the bacterial membrane “plays a crucial role in the drug’s uptake.”Additional research is required to tailor the method to increase the effectiveness of Kanamycin and other antibiotics against bacteria. But for now, it seems that such an outcome could be possible. “This initial assessmentrepresents a first step in a completely new field of study,” the scientists state in their paper. “This proof-of-concept study underscores the potential of non-genetic, light-based interventions to modulate bacterial susceptibility in real time. Future work will expand this approachultimately advancing our understanding of bacterial bioelectric regulation and its applications in antimicrobial therapies.”This article is not offering medical advice and should be used for informational purposes only.Article SourcesOur writers at Discovermagazine.com use peer-reviewed studies and high-quality sources for our articles, and our editors review for scientific accuracy and editorial standards. Review the sources used below for this article:The European Physical Journal Plus. Photocontrol of Bacterial Membrane Potential Regulates Antibiotic Persistence in B. SubtilisSam Walters is a journalist covering archaeology, paleontology, ecology, and evolution for Discover, along with an assortment of other topics. Before joining the Discover team as an assistant editor in 2022, Sam studied journalism at Northwestern University in Evanston, Illinois. #how #lightcontrolled #bacteria #could #tackle

Because the Verganis love color, Menino used a lot of it, carefully, so as never to overwhelm the Harlem-meets-Milan aesthetic. A deep orange paints an accent wall in the primary bedroom, color-matched by a painterly wallcovering opposite it. The sleek muted green-and-blue kitchen is Menino’s homage to Carlo Scarpa, while the jewel box guest bedroom-cum-library sports a more verdant forest hue on its bespoke Murphy bed with a desk and built-in bookcases. An ombré teal powder room with a sculptural sink is another moment of joyful experiment but the living room—decorated with a custom sectional and vintage seating around a tiered marble cocktail table by Menino—is largely neutral.A vintage kilim rug is underfoot in the serene living room where the custom Italian-made sofa gathers with a custom marble cocktail table and vintage chairs by Jorge Zalszupin and Carlos Motta in front of new bespoke steel-framed doors to the terraced garden. The living room’s relaxed and sun-filled vibe makes it one of the most-used rooms in the house as well as the perfect space for a striking tree branch sculpture by local artist Jannette Jwahir Hawkins, says Miriam, who worked with art advisor Aurore Vullierme to source such contemporary pieces. With Miriam’s plans to grow the family’s collection over time, Menino left a few walls blank here and chose their subtle gray hue specifically to be an optimal background to future artwork.Though the brownstone is certainly a family abode, it is also a natural venue for the Verganis’ love of entertaining, whether a soiree that extends indoors and out across the garden level or an intimate gathering at the dining table with Miriam’s “unbelievable tiramisu,” as Menino describes it. Flowing, relaxing, and luxurious rooms facilitate daily life and such occasions with equal ease. “We were excited to work with someone who would understand our design vision and had a deep knowledge of our culture,” says Miriam of Menino. “But we also wanted this house to reflect our story: how we moved here at a young age and made our life in New York.”A sculpture by Jannette Jwahir Hawkins stands adjacent the existing fireplace mantel, decorated with an artwork by Faustine Badrichani and a ceramic vase by Marion Naufal. Menino Design Studio specified Tiger Onyx for the home’s statement-making custom bar and matching wall cladding behind it. A custom Affreschi & Affreschi wallcovering adds color and texture to the primary bedroom, where the bespoke bed wears Parachute linens. Vintage Giuseppe Scapinelli armchair. A painting by Ernest Crichlow hangs on a Benjamin Moore orange–painted brick wall in the primary bedroom, which features an existing fireplace mantel with vases by Marion Naufal. Sculptureby Victoire d’Harcourt. Vintage Giuseppe Scapinelli armchair. Menino Design Studio created a floating Azul Cielo marble sink for the Roman clay–clad primary bath, where the tub is by Produits Neptune with Hotbath fixtures. The office is decorated with a desk by Hugo Besnier, chair by Cultivation Objects, pendant by Pablo Designs, and a vintage Gregori Warchavchik magazine rack. The mural-like wallpaper is by Affreschi & Affreschi, made with a custom blue. Photograph by Coreen Simpson. #this #harlem #brownstone #takes #design

May 22: National Maritime Day in the United States Prayut Chan-o-cha 1766 – A magnitude-7.1 earthquake struck Constantinople and was followed by a tsunami that caused significant damage. 1874 – Giuseppe Verdi's Requiem was first performed in the San Marco church in Milan to commemorate the first anniversary of Alessandro Manzoni's death. 1998 – In Public Prosecutor v Taw Cheng Kong, the Court of Appeal of Singapore overruled a High Court decision in the only time a statute in Singapore had been ruled unconstitutional. 2014 – Prayut Chan-o-cha, the commander-in-chief of the Royal Thai Army, launched a coup d'état against the caretaker government following six months of political crisis. Jovan VladimirJohn ForestCharles AznavourApolo OhnoMore anniversaries: May 21 May 22 May 23 Archive By email List of days of the year About #this #day

RT Giuseppe De GiorgiBuilding, launching, and scaling ChatGPT Imagesby @GergelyOrosz #giuseppe #giorgi #building #launching #scaling

When Pinch celebrated its 20th anniversary with a successful New York pop-up at the Jacqueline Sullivan Gallery last year, founders Russell Pinch and Oona Bannon began contemplating a possible permanent space in the city. It was kismet, then, when friend and collaborator Ashley Hildreth asked the London-based couple to go in on a petite apartment in a Greenwich Village brownstone with her. Since January, Pinch and Bannon have been quietly transforming the intimate, residential space into an apt showcase for their furniture and lighting, welcoming clients in for meetings and informal meals along the way. Past the building’s arched doors and stained-glass roof light, glossy white flooring leads to The Apartment, where a marble fireplace, 19th-century plaster cornicing, and sliding timber doors backdrop a capsule collection of Pinch designs, including eye-catching shelves of scaled miniatures.Exhibitions“Knit and Weave” takes over an Austrian castleSince 2014, design curator Alice Stori Liechtenstein and her family have called Schloss Hollenegg, a regal 12th-century castle about an hour south of Graz, home. Until June 1, the medieval Austrian estate will be open to the public for “Knit and Weave,” wherein 30 emerging designers have juxtaposed the building’s historical fabrics with contemporary works highlighting color and texture. Curated by Johanna Pichlbauer, the group show’s featured works explore sustainability, identity, innovation, and heritage. Standouts include Vienna designer Theresa Hattinger’s large-scale outdoor textiles, as well as Helsinki-based Aoi Yoshizawa’s loom installation that magnifies ancient weaving techniques.Craft in America presents teapots as works of artLindsey Ketterer Gates, Teapot, 2003. Photo: Tony CunhaArdent collectors Gloria and Sonny Kamm have been amassing teapots—and commissioning artists to dream up their own fantastical versions—for years, culminating in what is now considered the world’s largest collection. Last week, Los Angeles gallery Craft in America unveiled “Tea for Two”, a curated glimpse into the Kamm Teapot Foundation’s impressive 17,000-piece trove. Instead of focusing on the utilitarian aspects of serving tea, the creations on display center on imagination. Consider Peter Shire’s Sunburst Accordion, which takes cues from the Memphis movement, or Marilyn da Silva’s An Unlikely Pair, a union of dazzling stripes and polka dots rendered in gold-plated copper and colored pencil. Teapot, by Lindsay Ketterer Gates, even melds stainless-steel mesh with an unlikely array of pistachio shells.AD PRO Hears…… Last week, “Chris Gustin: Ascension” opened at Donzella Project Space in New York. Gustin, whose ceramics career spans five decades, is presenting the first solo show of his Spirit series, an assemblage of cumulus clouds standing five-feet tall.Project spotlightAll aboard! Dimorestudio revives Italy’s Orient Express trainIn 1883, Belgian engineer and entrepreneur Georges Nagelmackers launched the Orient Express in Europe, setting a new precedent in luxury rail travel. Now, the iconic train has returned to Italy as La Dolce Vita Orient Express, zipping through Venice, Tuscany, Portofino, Rome, and Sicily, with chic interiors from Emiliano Salci and Britt Moran, founders of Milan-based Dimorestudio. Inspired by Italian legends—Cini Boeri, Agostino Bonalumi, and Giuseppe Capogrossi among them—the AD100 duo mixed swaths of walnut, polished brass, and jewel-toned velvet with boldly patterned textiles and bespoke furniture. Light fixtures exhibit a distinctive sheen, evocative of the 1960s and ’70s golden age.ProductDornbracht becomes even more bespokeThe Tara Handles in Leather Verdite. Courtesy of DornbrachtIn celebration of its 75th anniversary, luxury fittings brand Dornbracht has launched Dornbracht Atelier, a bespoke offering of manufactured showers, faucets, and sink fittings. The Atelier cracks open a heady spectrum of possibilities for creatives and clients who want top-quality craftsmanship matched to their particular vision. The Atelier’s offered finishes span whichever color or texture suits the project—not even leather-wrapped or checkerboard patterned options are out of reach. Engravings, logos, and other expressive accents are optional embellishments too, making a case for bathroom couture. #dispatch #venice #architecture #biennale #pinch