Nature, Published online: 01 January 2025; doi:10.1038/d41586-024-04137-zMetabolic-dysfunction-associated steatohepatitis (MASH) is defined by lipid accumulation and inflammation, and makes liver cells enter a tumour-suppressive state called senescence while increasing cancer risk. Investigation of this paradox reveals that MASH-inducing diets trigger senescence by causing DNA damage. However, prolonged metabolic stress allows once-senescent liver cells to start dividing and progress to cancer.

Pokemon Pockets first post-release expansion, Mythical Island, introduced 68 new and reworked Pokemon, along with 18 Special Illustrations and rare variants, bringing the total number of cards in the set to 86. But one question many fans may have is: which Mythical Island cards are the best? Which ones are worth the time and grind? The following list ranks the top nine Pokemon from this expansion based on gameplay-centered criteria. Here are the most noteworthy cards from Pokemon Pockets Mythical Island mini-set.

Sekiro: Shadows Die Twice is an outlier in FromSoftware's recent catalog. It deviates from the standard soulslike formula in a number of ways, but perhaps the most notable is its focus on a single weapon for the player, with limited additional abilities. However, this focus means that it has some of the tightest-feeling gameplay in an action game.

Starting humbly as a hidden gem from Japan, Monster Hunter has slowly grown in popularity since its success on the 3DS and Wii U, only bolstered by the release of Monster Hunter: World, which brought a whole new crowd to what was once a niche grind-em-up boss bananza.

When Sony first released the PlayStation 5, it wasnt possible to expand the consoles storage. Thankfully, that changed with a software update that the company pushed out less than a year later. And with how big some game installs have become in recent years, its a good thing, too: the PS5s built-in 667GB of space may have been good enough in the systems first year, but now, the default drive is absolutely limiting.The good news is a standard PCIe Gen4 x4 M.2 NVMe SSD can solve all of your PS5 storage woes. If that mess of acronyms has you recoiling, dont worry: youll see that its not all that complicated. And if all you want to know is what the best PS5 SSDs are, weve got them right at the top. Read more: These are the best SSDs in 2025 Best PS5 SSDs in 2025 How we test PS5 SSDs Ive tested most of the SSDs recommended on this list, either for PS5 or computer use. I also bought and used our top pick in my own PS5. How much PS5 storage do I need? The PlayStation 5 and PlayStation 5 Pro can accept internal drives with between 250GB and 8TB of storage capacity. If you already own a PS5, chances are you have a reasonable idea of how much storage you need for your game library. If youre buying an SSD with a new PS5 or PS5 Pro, or buying for someone else, its more difficult to tell what you might need for a high-performance experience. PS5 games are smaller on average than their PS4 equivalents, typically taking up between 30GB and 100GB, with some notable (and very popular) exceptions. If youre a fan of the Call of Duty series, installing Black Ops 6and Warzone 2.0 can eat up to 240GB. In other words, a full Call of Duty install will take up more than one-third of the PS5s internal storage. If youre not a CoD fan, though, chances are youll be good to store between six to 10 games on a regular PS5 internally before running into problems. You also need to consider your internet speed. If you live in an area with slow broadband, the you can just download it again rationale doesnt really work. At my old home, a 100GB download took me around eight hours, during which time it was difficult to simultaneously watch Twitch or, say, publish articles about upgrading PS5 SSDs. Keeping games around on the off-chance youll want to play them at some point makes sense. Aaron Souppouris / Engadget Off the bat, there's basically no point in going for a 250GB PS5 SSD. Economically, 250GB drives arent that much cheaper than 500GB ones and practically, that really isnt a lot of space for modern games to live on. 500GB drives can be a decent option, but after years of declining prices, I think the sweet spot for most people is to opt for a high-capacity 1TB or 2TB drive, which should run you at most $200. The latter will more than double the PS5 Pros storage without breaking the bank. Unless youre rolling in cash and want to flex, 4TB and 8TB models should mostly be avoided, as youll end up paying more per gigabyte than you would with a 1TB or 2TB drive. While the 825GB PS5 only provides 667GB of storage, thats largely due to storage being reserved for the operating system and caching. If you install a 1TB PS5 SSD, you'll have, within a margin of error, 1TB of storage available for games. Out of the box, the PS5 Pro offers 1.86TB of storage for games, though you can eke out more if you delete the pre-installed Astros Playroom (gasp). Since neither the PS5 Slim nor PS5 Pro feature updated CPU architecture, all of our recommendations will work with whatever PS5 model you own. Can you play PS5 games on an external SSD? External hard drives tend to cost less than internal SSD counterparts (and theres a good chance you might own one already). Unfortunately, there are restrictions on what you can do with them. An external SSD connects to your PS5 via USB, and is only suitable for playing PlayStation 4 games, or storing PS5 titles. Thats useful if you have anything but the best high-speed internet its faster to move a PS5 game out of cold storage on an external drive than it is to re-download it or want to keep your PS4 library on hand. Due to the limitations here, you dont need the highest-performing model, although you should opt for SSDs over HDDs for improved transfer speeds and load times. Any basic portable drive from a reputable brand will do, with the Crucial X9 Pro and Samsung T7 being options weve tried and can recommend. Which SSD cards are compatible with the PS5? The official answer to this question is an M.2 Socket 3 (Key M) Gen4 x4 NVME SSD. But even within that seemingly specific description, there are additional factors to consider. The main requirements Sony has laid out for compatibility come down to speed, cooling and physical dimensions. For speed, Sony says drives should be able to handle sequential reads at 5,500MB/s. Early testing showed that the PS5 would accept drives as slow as 4,800MB/s, and that games that tap into the SSD regularly such as Ratchet & Clank: Rift Apart would cause no issues. Pretty much the only thing the PS5 will outright reject is one that doesn't match the Gen4 x4 spec. In our opinion, though, using a drive slower than the specification is a risk that, if you dont already have that drive lying around, is not worth taking. Just because we havent found issues yet doesnt mean there wont be games that could be problematic in the future. The price difference between these marginally slower Gen4 drives and the ones that meet Sonys spec isnt huge, and you might as well cover all your bases. Slightly more complicated than speed is cooling and size. Most new SSDs are going to be just fine; the PS5 can fit 22mm-wide SSDs of virtually any length (30mm, 40mm, 60mm, 80mm or 110mm, to be precise). The vast majority of drives you find will be 22mm wide and 80mm long, so no problem there. It should be noted that the system can fit a 25mm-wide drive, but that width must include the cooling solution. Speaking of, Sony says SSDs require effective heat dissipation with a cooling structure, such as a heatsink. The maximum height supported by Sonys slot is 11.25mm, of which only 2.45mm can be below the drive. This previously meant some of the most popular heatsinked Gen4 SSDs, including Corsairs MP600 Pro LP, would not fit within the PS5s storage expansion slot. Since Engadget first published this guide in 2021, most NVMe makers, including Samsung, have come out with PlayStation-specific models that meet those requirements. That said, if you want to save some money, bare drives are often cheaper and its trivial to find a cooling solution that will work for the PS5. The only component in an NVMe SSD that really requires cooling is the controller, which without a heatsink will happily sear a (very small) steak. Most SSDs have chips on only one side, but even on double-sided SSDs, the controller is likely to be on top, as manufacturers know it needs to be positioned there to better dissipate heat. So, head to your PC component seller of choice and pick up basically anything that meets the recommended dimensions. A good search term is laptop NVME heatsink, as these will be designed to fit in the confines of gaming laptops, which are even more restrictive than a PS5. Theyre also typically cheaper than the ones labeled as PS5 heatsinks. One recommendation is this $6 copper heatsink, which attaches to the PS5 SSD with sticky thermal interface material. It works just fine, and in performing stress tests on a PC, we couldnt find anything metal that didnt keep temperatures under control. When youre searching, just make sure the solution you go for measures no more than 25mm wide or 8mm tall (including the thermal interface material) and has a simple method of installation thats not going to cause any headaches. One last thing: When shopping for a PS5 NVMe, theres no reason to buy a Gen5 model over a more affordable Gen4 model. As things stand, Sonys console cant take advantage of the new standard, and though Gen5 drives are backward compatible, theyre more expensive than their Gen4 counterparts. Just buy the fastest and highest-capacity Gen4 model you can afford. How to install an SSD into your PS5 If you need guidance on how to install your new NVMe into your PS5 or PS5 Pro, we have a separate guide detailing all the steps here. Installation is pretty straightforward, but our how-to can help you if you're stuck. Just make note: Before attempting to add more storage via a PS5 SSD, ensure that you have Sonys latest software installed.This article originally appeared on Engadget at https://www.engadget.com/gaming/playstation/best-ps5-ssd-expansion-upgrade-150052315.html?src=rss

Local studio Gianni Botsford Architects has added an extension to a house in Hampstead, London, that complements a distinctive, high-tech addition created by Norman Foster in the 1960s.After the home was acquired by new owners, Gianni Botsford Architects was tasked with maintaining the extension but replacing the original 1860s coach house with a complementary four-storey home, which the studio named Reciprocal House.Set on a quiet mews site, the extension was created in 1968 by Foster Associates today Foster + Partners, the practice of Norman Foster and his then-wife Wendy Foster.Gianni Botsford Architects has added a home (above) to an extension by Foster Associates (top)"My client was in contact with Norman Foster before buying the house, who was very open about what would happen with the house but asked only that he hoped 'you are able to maintain the original intended spirit of the home for you and family- one of lightness and a place to entertain'," director Gianni Botsford told Dezeen."We looked at many options in an attempt to retain the original coach house but were unable, on such a restricted site, to achieve the spatial requirements of the brief," he continued."By demolishing the cottage, we were in the unique position of extending the extension, which clarified the diagram and the relationship between old Victorian, new Foster, and very new ourselves.Concrete blocks and aluminium were used to reference the existing extensionTrapezoidal in shape, the new home was designed with a material palette drawn from the Foster Associates extension, including exposed concrete blocks and aluminium framed windows and fittings.The ground floor kitchen space steps down directly into the new house, where a living area sits beneath the distinctive metal ceiling trusses and a full-height sliding glass door opens onto the garden.Read: Gianni Botsford Architects tops House in a Garden with sweeping copper roof"Exposed concrete was used to efficiently create the unusual form of the house, to temper the light, and to help regulate the internal temperatures by exposing the thermal mass," Botsford told Dezeen."All other elements of the house were made from aluminium, including the kitchen, bathrooms, staircase, wardrobes and wall linings."A circular skylight was added over a spiral staircaseDespite expanding on the available living space, Reciprocal House occupies a slightly smaller footprint than the original cottage, with the freed up external area used as garden spaces.A spiral aluminium stair beneath a circular skylight connects the floors of the home, with three bedrooms and roof terraces on the upper two floors and a studio space in a newly-created basement level illuminated by three-metre-tall lightwells.Reciprocal House has a trapezoidal shapeThe exterior the home has been clad in corrugated panels of brown metal mesh, to provide privacy and shade, while recovered bricks from the demolished cottage were used to created the hard landscaping in the surrounding garden spaces.Alternations to the Foster extension were kept to a minimum, focusing on improving its thermal insulation as well as strengthening and waterproofing the roof.Elsewhere in London, Gianni Botsford Architects has previously designed a home topped by a funnel-shaped copper roof, and an extension to the home of an art collector that is fronted by a facade of rust-toned frames.The photography is by Schnepp Renou.The post Gianni Botsford Architects adds trapezoidal home to Norman Foster extension appeared first on Dezeen.

MacworldIf youve ever struggled to back up your iPhone or transfer WhatsApp messages to a new device, youre not alone. Luckily, AnyTrans takes the hassle out of managing your Apple ecosystem. Whether youre upgrading to the newest iPhone or simply need to consolidate your digital life, this powerful tool makes it easy.With just one click, you can transfer all your photos, videos, messages, music, and more between devices or from iCloud and iTunes. AnyTrans doesnt just move your files; it also organizes and secures them, so your content is always at your fingertips.WhatsApp user? Easily transfer your chats and attachments between iOS and Android devices or merge conversations into one thread. Want to save your memories? AnyTrans can back up and export your iPhone photos and messages into printable formats.Unlike other iOS managers, AnyTrans offers unparalleled flexibility and user-friendliness. You can restore data selectively, back up from multiple sources, and transfer non-purchased musicsomething Apples tools cant do. Its no wonder TechRadar calls it a must-have for iOS users.Get a lifetime of support from AnyTrans for just $20.99 (reg. $79) with code FESTIVE30 at checkout the best price online right now.AnyTrans One-Stop Content Manager for iOS: Lifetime Subscription $20.99Get It HereStackSocial prices subject to change.

Generative language models face persistent challenges when transitioning from training to practical application. One significant difficulty lies in aligning these models to perform optimally during inference. Current methods, such as Reinforcement Learning from Human Feedback (RLHF), focus on improving win rates against a baseline model. However, they often overlook the role of inference-time decoding strategies like Best-of-N sampling and controlled decoding. This mismatch between training objectives and real-world usage can lead to inefficiencies, affecting the quality and reliability of the outputs.To address these challenges, researchers at Google DeepMind and Google Research have developed InfAlign, a machine-learning framework designed to align language models with inference-aware strategies. InfAlign incorporates inference-time methods into the alignment process, aiming to bridge the gap between training and application. It does so through a calibrated reinforcement learning approach that adjusts reward functions based on specific inference strategies. InfAlign is particularly effective for techniques like Best-of-N sampling, where multiple responses are generated and the best one is selected, and Worst-of-N, which is often used for safety evaluations. This approach ensures that aligned models perform well in both controlled environments and real-world scenarios.Technical Insights and BenefitsAt the core of InfAlign is the Calibrate-and-Transform Reinforcement Learning (CTRL) algorithm, which follows a three-step process: calibrating reward scores, transforming these scores based on inference strategies, and solving a KL-regularized optimization problem. By tailoring reward transformations to specific scenarios, InfAlign aligns training objectives with inference needs. This approach enhances inference-time win rates while maintaining computational efficiency. Beyond performance metrics, InfAlign adds robustness, enabling models to handle diverse decoding strategies effectively and produce consistent, high-quality outputs.Empirical Results and InsightsThe effectiveness of InfAlign is demonstrated using the Anthropic Helpfulness and Harmlessness datasets. In these experiments, InfAlign improved inference-time win rates by 8-12% for Best-of-N sampling and by 4-9% for Worst-of-N safety assessments compared to existing methods. These improvements are attributed to its calibrated reward transformations, which address reward model miscalibrations. The framework reduces absolute errors and ensures consistent performance across varying inference scenarios, making it a reliable and adaptable solution.ConclusionInfAlign represents a significant advancement in aligning generative language models for real-world applications. By incorporating inference-aware strategies, it addresses key discrepancies between training and deployment. Its robust theoretical foundation and empirical results highlight its potential to improve AI system alignment comprehensively. As generative models are increasingly used in diverse applications, frameworks like InfAlign will be essential for ensuring both effectiveness and reliability.Check out the Paper. All credit for this research goes to the researchers of this project. Also,dont forget to follow us onTwitter and join ourTelegram Channel andLinkedIn Group. Dont Forget to join our60k+ ML SubReddit. Asif RazzaqAsif Razzaq is the CEO of Marktechpost Media Inc.. As a visionary entrepreneur and engineer, Asif is committed to harnessing the potential of Artificial Intelligence for social good. His most recent endeavor is the launch of an Artificial Intelligence Media Platform, Marktechpost, which stands out for its in-depth coverage of machine learning and deep learning news that is both technically sound and easily understandable by a wide audience. The platform boasts of over 2 million monthly views, illustrating its popularity among audiences. [Download] Evaluation of Large Language Model Vulnerabilities Report (Promoted)