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WWW.NATURE.COMLithocholic acid phenocopies anti-ageing effects of calorie restrictionNature, Published online: 18 December 2024; doi:10.1038/s41586-024-08329-5Lithocholic acid is one of the metabolites upregulated during calorie restriction, and treatment of mice, worms and flies with this bile acid alone can reproduce the health benefits of calorie restriction.0 Comments 0 Shares 37 Views
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WWW.NATURE.COMLithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageingNature, Published online: 18 December 2024; doi:10.1038/s41586-024-08348-2The molecular mechanism underlying how lithocholic acid recapitulates the lifespan and healthspan benefits of calorie restriction is revealed to involve TULP3, sirtuins, v-ATPase and AMPK.0 Comments 0 Shares 34 Views
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WWW.NATURE.COMScalable production of ultraflat and ultraflexible diamond membraneNature, Published online: 18 December 2024; doi:10.1038/s41586-024-08218-xEdge-exposed exfoliation using sticky tape is shown to be a simple and reliable method for scaling up the production of ultrathin, ultraflat and ultraflexible polycrystalline diamond membranes for diverse electrical, optical, mechanical, thermal, acoustic and quantum applications.0 Comments 0 Shares 38 Views
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WWW.LIVESCIENCE.COM'It's better to be safe than sorry': How superstitions may still benefit usNew research found behaving superstitiously could benefit us psychologically, even if we know it has no real effect on the outcomes of our actions.0 Comments 0 Shares 55 Views
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GAMERANT.COMMapleStory Best ClassesToday, we'll be taking a look at the best classes in MapleStory.0 Comments 0 Shares 33 Views
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GAMERANT.COMWhat Was Your First Legend Of Zelda GameThis week on Gamers Said, we asked you what was the first Zelda game you ever played. Whilst every entry in the Zelda series follows a core formula that began with the original NES release, they also take creative freedoms with their stories and emotional tones, ensuring youll have a memorable experience no matter which game you start off with.0 Comments 0 Shares 30 Views
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GAMERANT.COMDragon Ball: Everything GT Got RightThe Dragon Ball franchise has been around for decades as a staple of the anime industry since the 1980s. Throughout all of these years, the heroes have gone on many journeys and have grown into some of the most iconic characters in fiction, prompting millions of fans from across the world to fall in love with them and the series as a whole. However, not all parts of the franchise are remembered fondly.0 Comments 0 Shares 34 Views
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WWW.POLYGON.COMViral BookTok author Olivie Blake on what its like to be a New Years resolution personFantasy writer Olivie Blake jokingly tells me that she doesnt know how to write a book. With eight adult fantasy novels and two YA romantic comedies under her belt including the bestselling Atlas series its a little hard to believe that. But Blake, a self-proclaimed discovery writer, insists.Every time, it gets done, and I tell myself I know how to do it, she laughs. But when Im in the middle of the process, Im like, I dont know what Im doing, and were just working through it. Ive come to this embrace of the unknown.Blake is a prolific writer for an author who claims not to know how to write. She originally self-published her adult novels under a pen name, the same one she used for her fanfiction. When The Atlas Six became a viral sensation via TikTok and other social media, she got a chance to republish that novel in 2022 with Tor. The publishing house also republished her older adult fantasy, and picked up the rest of the Atlas series. At the same time, Blake published her YA debut, My Mechanical Romance, under the name Alexene Farol Follmuth.In 2024, she published the last book of the Atlas trilogy, along with Twelfth Knight, another YA rom-com. With two new stand-alone adult fantasy books coming out in 2025 and a whole lot more planned for down the line, Blake has learned a thing or two about balancing projects, focusing on goals, and figuring out what to work on next. Since the beginning of a new year is always a time for reflection about setting new goals and considering self-improvement, Polygon reached out to Blake to ask how she stays so productive, and discuss the perks of being a New Years resolution person.This interview has been edited for concision and clarity.Polygon: Do you set professional or creative goals for yourself as the new year approaches, or do you have different strategies?Olivie Blake: Im a New Years resolution person. I like to start the year assuming I will be my least lazy self, and then inevitably be disappointed. But I feel like in the margin for error, there is still some improvement.[For my creative goals], Im trying to see myself as less of an expert and more of [] I keep trying to put myself back in the feeling of being a hobbyist. I had the most fun when I was a fanfiction writer and there were no expectations. I wasnt worried about building an audience. I just [thought], Can I do this? Or How good would it feel if I got this exactly as Ive imagined it? And it never happens that way. But I think the feeling of approaching something like its the first time is falling in love all over again.As far as professional goals, artistic careers are really hard to have a sense of measurement for. Its hard to see that youve come a distance or moved up in any way. Im at a point where Ive been pretty prolific and some of it is a mix of new [and old self-published titles]. Were at the point where I dont have any more backlist titles and everything is new.But I also would like to kind of slow things down so that Im not so fatigued by the promotional and marketing and all the industry aspects. And so to give myself more, basically more art time, less administrative time, Im hoping to pace down a little bit. I would like to write every day, which I have not done over the last couple of years as my career has taken off. That means that all the administrative tasks also need to be done. All the things that are very important to selling a book, but are less satisfying to me as an artist.Im going to try to return to maybe we write a little less every day, but we still do it every day. Instead of taking these windows where it becomes this big marketing period, the focus will always be writing, even if that means smaller amounts every day.How do you pick between projects, or focus on what you want to do next?I think of it as when youre bowling and you have the bumper guards on, thats what my editor is for me. Im like, Here are the ideas Im having. Let me bounce this off you. Which one sounds like the right thing? And to be fair, I have a very privileged career, in that I have a long-standing relationship with my editor. Shes here for my career. Its one of the ways that I always knew I wanted to be traditionally published, because I kind of need to be managed.Im the kind of creative that has a lot of ideas and wants to cross media and wants to do something new and different every time. So its helpful to have someone say, What if we did this? What if we focused on this? Or This is the strongest thing youve pitched. So to some extent, I leave that up to someone else, which is a huge relief for me, because I wouldnt say I have a very good sense for what the market is. Nobody does everyone who says they understand the market is just selling you something.The two books I have coming out in 2025 are Gifted & Talented, which is kind of incisive about the tech industry, and then Girl Dinner, which is an interrogation of what feminism is, what contemporary feminism has become. Theyre both vaguely political books. I wanted the book after that to be a little bit more of Its an LA Gothic, its more of a horror romance. Im conscious of things that I write in similar periods having similar tones, thinking about the same things and working through them. In that sense, it was good to be like, Lets take a little break. Lets look at a different aspect of existence or whatever, and then we can yell about the tech industry some more after that.How do you handle distractions, or the urge to jump to another project?Sometimes if Im feeling the need to work on something else, I will do [both] concurrently. I think in terms of artistic efficiency, there are some ideas that if you try to ignore them, theyll just slow you down. This idea is what you want to be working on, what you need to be working on that doesnt necessarily mean its the only thing youre working on, and that everything else goes away.Right now Im working on two projects at the same time that are in different phases, so if I feel like one is not quite right for the day, Ill do the other. But I am also pretty conscious at this point of what the best idea is. The one I should be working on is the one Im thinking about the most, the one that I find the most interesting.There are times when I think to keep that feeling of play or to keep that hobbyist energy of Im doing this because I love it, I will sometimes do something shorter. Its never a loss. That story will become something someday.Part of it is knowing what kind of creative you are and gaming those things, I think. So I identify the priority project. Obviously having actual deadlines is helpful for this things that actually have to get done. But also knowing that sometimes if your brain just isnt in it, or the mood is just not right, then a quick break can be helpful. Its like, Lets just do this other thing. And maybe that feeling of satisfaction will keep you going on the other projects.Part of it is knowing what kind of creative you are and gaming those things. [] That feeling of satisfaction will keep you going on the other projectsHow do you restart yourself when you get blocked or overwhelmed?Usually when Im feeling blocked, when I cant move forward in the project Im working on, its because theres a problem in the project Im working on. Something I just wrote isnt right. What it really is is kind of a feeling of I need to cut what I just wrote, but I feel like that will be such a loss that I dont want to do it.But every time without fail, if its a cant move forward feeling, its because something went wrong behind me, and I need to own that and change it and fix it. Because trying to continue forward will actually be a more inefficient use of time. But if Im feeling uninspired, which is a different feeling than blocked or overwhelmed, thats when I would go to a smaller project, something thats a little bit more bite-sized.Im bipolar, so a lot of the ways that I game my creative problems are similar to the way that I deal with my mental health. When youre really depressed, the feeling of satisfaction is even more important, but its harder to achieve. So my to-do list when Im depressed is take a shower or clean this one thing. I give myself tasks that I know I can accomplish. And so in the creative realm, its like, Why dont you just come up with an idea today? Just think of something today.That feeling of being able to cross something off helps you move forward. The feeling of I have accomplished something, that is progress or doing something thats smaller, you can still feel like I flexed that creative muscle today.How do you know when its time to let a project go?Thats a good question. Im trying to think of what projects I have let go. Theres not too many that Ive left unfinished. Usually if I leave something unfinished, its because I came up with a better version of the idea, or I want to use the characters in a different way. I have an unfinished file, but I always have the sense that Ill come back to it.I think whats hard is the feeling like Im letting this go forever, Im just dropping it and its gone. I prefer the sense that its just waiting somewhere, and I can come back to it anytime. But usually its because Im being more driven by the feeling that something else is a better idea, that something else is like, Oh, I really know how to do this, or I can really work on this thing thats specifically interesting to me.Most of the things I dont finish are short-story ideas where the tone is wrong. I tried to write this one story. It was meant to be sort of absurd. It was about a demon that was manifesting like Zillow, when theyre trying to buy your house. But for some reason, the tone just kept coming out so melancholy. The narrator was so sad. And I was like, This is not right. So Ill come back to it when I figure out how to do it. I think my brain is just working on that in the background somewhere, and however long it takes, itll come back when the time is right.0 Comments 0 Shares 38 Views
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LIFEHACKER.COMThe JBL Tour Pro 3 Earbuds Are at Their Lowest Price Right NowWe may earn a commission from links on this page. Deal pricing and availability subject to change after time of publication.The JBL Tour Pro 3 earbuds, now at their lowest price ever (according to price trackers) of $249.95 (down from $299.95), are IP55-rated and come in black or latte. JBL Tour Pro 3 - True Wireless Noise Cancelling Earbuds $249.95 at Amazon $299.95 Save $50.00 Get Deal Get Deal $249.95 at Amazon $299.95 Save $50.00 These flat-stem earbuds come with six pairs of eartips (one foam), giving you plenty of options for a comfortable fit. That said, while theyre generally secure, they can reportedly slip off during more intense activities like runninga potential downside for fitness enthusiasts. They last for a respectable seven hours with ANC on, 11 hours with it off, and an additional three full charges from the case, totaling 28 to 44 hours, with ANC on and off respectively.The earbuds use Bluetooth 5.3 for connectivity and support Google Fast Pair, Microsoft Swift Pair, and Bluetooth multipoint pairing (with up to three devices). They also feature Auracast, a cutting-edge Bluetooth technology that broadcasts audio to an unlimited number of Bluetooth devices, as noted in this PCMag review. For high-res audio, they support LDAC, AAC, and SBC codecs, offering a wide frequency range from 20Hz to 40kHz. Each earbud houses dual driversa 10.2mm dynamic driver and a 5.1x2.8mm balanced armaturefor rich sound with deep bass and crisp highs. The active noise cancellation of the Tour Pro 3 performs well, but it falls short of the industry-leading capabilities of the Bose QuietComfort Ultra Earbuds ($299), particularly in reducing high-frequency noise.The charging case of the Tour Pro 3 has a built-in touch display that allows you to control playback, adjust EQ settings, and switch ANC modes without reaching for your phone. Unique to JBL, the case also functions as a Bluetooth transmitter, enabling you to stream audio from non-Bluetooth sourceslike in-flight entertainment systemsvia the included USB cable or a 3.5mm-to-USB-C adapter. For more customization, the companion app provides access to a full suite of controls, including selecting ANC modes, personalizing on-ear controls, and managing EQ settings. You can choose from six preset EQs or create your own with JBL's adjustable EQ tool. The app also lets you enable or disable spatial audio and fine-tune call settings, such as adjusting the EQ for incoming audio and optimizing microphone performance.0 Comments 0 Shares 45 Views