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Nature
@Nature
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2025-02-13 11:01:12
·
UM171 glues asymmetric CRL3HDAC1/2 assembly to degrade CoREST corepressors
www.nature.com
Nature, Published online: 12 February 2025; doi:10.1038/s41586-024-08532-4UM171 promotes corepressor degradation by acting as a molecular glue to induce KBTBD4HDAC1/2 interactions with the help of inositol hexakisphosphate.
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