UM171 glues asymmetric CRL3HDAC1/2 assembly to degrade CoREST...

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2025-02-13 11:01:12 ·

UM171 glues asymmetric CRL3HDAC1/2 assembly to degrade CoREST corepressors

www.nature.com

Nature, Published online: 12 February 2025; doi:10.1038/s41586-024-08532-4UM171 promotes corepressor degradation by acting as a molecular glue to induce KBTBD4HDAC1/2 interactions with the help of inositol hexakisphosphate.

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