Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08794-6A study describes the split integrated stress response, a cellular stress response mechanism characterized by reduced eIF2B activity without eIF2 phosphorylation, which activates the eIF4EATF4PCK2 axis, enabling metabolic reprogramming.

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Ex-Skyrim Dev Said Creative Freedom Shaped Beloved Moments of the GameIn a recent interview at this year's GDC, ex-Bethesda Developer Nate Purkeypile, who contributed to the creation of Skyrim as a Senior World Artist and Lighting Artist, shared insights into the studio's development approach for the iconic 2011 RPG that was characterized by the team's freedom and flexibility during production.The developer shared (via PC Gamer) that the developers were given significant creative freedom and recalled the building of the city of Blackreach, which wasn't part of the original schedule: "We had quite a bit of freedom to do stuff. The one that people know about was Blackreach That was not on schedule at all. Like we just kind of did that on the side and put it in."Purkeypile also revealed that Skyrim's werewolves started off as a rough concept but were eventually transformed into something more visually impressive through the voluntary efforts of individual developers. "That was a whole side-project from somebody. Originally, it was just dudes with dog heads, and someone took it upon themselves to make it awesome," he said.The creator summed up that it was this flexible and non-restrictive approach that led to appearance of the game's many beloved features. "A lot of the great stuff within Skyrim came from having that freedom to do what you want, as opposed to a game with this whole 'checklist design' and 'design by committee,'" Purkeypile noted.

It seems that in two years, Ubisoft might lose all influence over the direction of three of its most valuable game series.The formation of the new entity, with Tencent holding a 25% stake, appears to be a desperate attempt to secure short-term investment:https://80.lv/articles/tencent-now-owns-25-of-the-assassin-s-creed-far-cry-franchises/

The latest in-game footage from the highly anticipated PvE action-horror game Blight: Survival leads us into the heart of the Marshlands biome, which started to take shape after a few months of development.Thanks to the amazing work of Senior 3D Artist Briac, who beautifully captured the vision and brought it to life, along with the talented audio work by Ian, the Audio Director, we can now experience this satisfying showcase of the stunning area soaked in mysterious fog:An earlier footage has a lower camera angle, giving us a sneak peek at the same area from day to night:If there is a nomination for the most anticipated games, this upcoming game from Haenir Studio, set in a brutal medieval world powered by Unreal Engine 5, will definitely be included. As days passed by, this project that started with two passionate developers and was joined by a dozen full-time professionals, as well as partnered with the developer Dead by Daylight Behaviour Interactive, has grown to be more exciting.As usual, this showcase has made fans more eager to know the release window, one that the team said still needs a bit of time to reveal. But this also means that there will be multiple playtest opportunities along the way. Blight: Survival will be released for PC and console on PlayStation 5 and Xbox. To stay updated, join the games Discord channel, where sneak peeks are shared and monthly suggestion contests are held. Dontforget to wishlist the game on Steam.Also, join our80 Level Talent platformand ournew Discord server, follow us onInstagram,Twitter,LinkedIn,Telegram,TikTok, andThreads,where we share breakdowns, the latest news, awesome artworks, and more.Source link The post Have A Look At The Marshlands Biome In Blight: Survival appeared first on CG SHARES.

Confirming earlier insider reports about Ubisofts plans to navigate its financial troubles by using its most valuable game series to form an entirely new business entity, the struggling studio has now officially announced the creation of a dedicated subsidiary centered on the Assassins Creed, Far Cry, and Tom Clancys Rainbow Six franchises, with Chinese tech giant Tencent acting as its minority shareholder with a 25% stake.UbisoftIn the first page of its official statement shared with the public, Ubisoft describes the formation of the new entity as a rapid evolution of its operational model, stating that the new subsidiary will focus on building game ecosystems designed to become truly evergreen and multi-platform.With a valuation of 4 billion implying an average sales multiple of around 4x for FY23-FY25E the company will receive a 1.16 billion ($1.25 billion) cash injection from Tencent, which will hold a 25% minority stake in the new entity. Ubisoft CEO Yves Guillemot stated that the subsidiarys creation, with Tencent as a minority shareholder, is intended to spearhead development for three of the companys most valuable IPs and crystallize the value of our assets, ultimately providing, according to Guillemot, the best conditions for the game series long-term growth.The second page, on the other hand, is noticeably lighter on corporate jargon aimed at reassuring investors, instead offering straightforward details about the deal without the embellishments written, presumably, by the PR department.According to this section, the new subsidiary will encompass teams working on the Tom Clancys Rainbow Six, Assassins Creed, and Far Cry franchises, with studios located in Montral, Quebec, Sherbrooke, Saguenay, Barcelona, and Sofia. It will also include the back catalog, along with any ongoing or future game developments within these franchises.Notably, the new entity will not outright own the aforementioned brand trio, and instead, Ubisoft will provide it with a worldwide, exclusive, irrevocable, perpetual license in respect of the intellectual property and similar proprietary rights owned or licensable by Ubisoft concerning the IPs in question in exchange for a royalty.Regarding Tencents role in the new venture, the companys investment would grant it minority protection veto rights, along with certain consent rights regarding the disposal of key assets of the new subsidiary. Additionally, a 5-year lock-up would apply to the shares of the new subsidiary held by Tencent, with Ubisoft retaining exclusive control and consolidation of the new subsidiary, at least for the time being.Apparently, that could potentially change in the future, as the statement explicitly reveals that after a 2-year period, Ubisoft may no longer hold a majority of the new subsidiarys voting rights and share capital, ultimately implying that, going forward, the studio might lose all influence over the direction of three of its most important game series. This one clause outlined in the announcement makes the entire deal appear to be nothing more than a Hail Mary, designed exclusively to secure short-term investment at the expense of the franchises, rather than ensuring the game series long-term growth, as stated by Guillemot.The internal email shared by Chief Studios and Portfolio Officer Marie-Sophie de Waubert with Ubisoft employees, obtained by Insider Gaming, also fails to inspire much confidence, hinting at an upcoming reorganization within the studio in the weeks and months ahead, which could lead to massive layoffs and project cancellations, similar to Embracer Groups decision to eliminate 1,400 employees and shut down 42 games as part of its restructuring.Interestingly, the news that one could summarize as in two years, Ubisoft may lose all say in how Tom Clancys Rainbow Six, Assassins Creed, and Far Cry are handled comes on the heels of Assassins Creed Shadows supposed success, with over 3 million players having allegedly already tried the game and Shadows generating the second-highest Day 1 sales revenue in the franchises history.While a sizeable portion of the gaming community has repeatedly asked Ubisoft to disclose the metric that actually matters sales numbers rather than the vague players reached, at least we now have one potential reason why the troubled studio has been so evasive in its announcements and ignored this request to secure a valuation of 4 billion and not less. Could that be the actual reason? Only Ubisoft knows, and Ubisoft, as usual, isnt telling.Dont forget to join our80 Level Talent platformand ournew Discord server, follow us onInstagram,Twitter,LinkedIn,Telegram,TikTok, andThreads,where we share breakdowns, the latest news, awesome artworks, and more.Source link The post Tencent Now Owns 25% of the Assassins Creed & Far Cry Franchises appeared first on CG SHARES.

Collection of personal illustrations, playing at creating magical worlds and moments, as if they were a movie scene.

InZoi is poised to be the first real competitor to The Sims franchise ever, but the brand-new life sim obviously can't just be a copy--when you're going up against a game as well established as The Sims 4, you have to do some things differently.One of these different things involves taking care of your home. In The Sims, you have to do the dishes, and clean up piles of garbage, but the key thing is that garbage only accumulates as a direct result of your sims doing stuff. If you left the house alone for a week, it'd be just as clean when you return as it was when you left.But InZoi is a little more granular than The Sims 4 is in most respects, and house cleaning is one example. In InZoi, your home will naturally accumulate dirt and dust that you have to clean up regularly, or it will create a strain in your family's relationships. This layer of grime is quite visible just from looking around--you'll see a nice layer of grime on anything in the dirty area.Continue Reading at GameSpot

Robbing a bank--we've all joked about it, right? Now, with the release of Krafton's InZoi, your dreams can become reality (kind of). ATMs are dotted about the cities of InZoi, and if your Zoi so wishes, they can try their hand at robbing one. Unfortunately, there are a few hazards to be aware of, so we'll walk you through the most effective way to rob an ATM in InZoi and get away with both some money and your life.How to rob an ATM in InZoiBefore you can choose to rob an ATM, you first need to get your Karma down to the "Bad" level. This can be achieved by interacting negatively with other Zois, taking other karmically negative actions, such as checking for loose change in vending machines, and generally being a terrible citizen.ATMs can be found on the sidewalk.Once your Karma level is at "Bad" you can find the nearest ATM in your city. These are dotted along the sidewalks. Ironically, there doesn't appear to be any ATMs within the local bank; they're just on the roadside. You'll want to select the "Karma action" option and choose "Hack" to attempt to rob the ATM.Continue Reading at GameSpot

Though My Hero Academia may seem like a fun, vibrant, and joyful series on the surface, it's certainly not shy about getting a little darker and more emotional now and again. While the majority of sad moments will relate to the heroes of the show, since they are the ones fans are always going to be rooting for, Horiksohi is such a talented writer that he's also managed to create some truly upsetting yet memorable scenes for the villains of the series too, making them just a little more sympathetic as characters.