• Bifidobacteria support optimal infant vaccine responses
    www.nature.com
    Nature, Published online: 02 April 2025; doi:10.1038/s41586-025-08796-4Neonatal antibiotic use is shown to reduce immune response to infant vaccines, accompanied by reduced abundance of Bifidobacteria in the gut microbiota, with experiments in mice indicating that probiotic therapy could be beneficial.
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  • Near-field photon entanglement in total angular momentum
    www.nature.com
    Nature, Published online: 02 April 2025; doi:10.1038/s41586-025-08761-1Non-classical correlations between two photons in the near-field regime give rise to entanglement in their total angular momentum, leading to a completely different structure of quantum correlations of photon pairs.
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  • Calling all digital artists & devs! Join the #ArtToExperience contest by @emperiavr & 80 Level. Craft immersive virtual worlds using Emperias Creato...
    x.com
    Calling all digital artists & devs! Join the #ArtToExperience contest by @emperiavr & 80 Level. Craft immersive virtual worlds using Emperias Creator Tools & compete for epic prizes! Learn More & Enter the Contest: https://80.lv/articles/art-to-experience-contest-a-creative-challenge-by-emperia-and-80-level
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  • Streamline your Blender's 3D modeling workflow with AV's Resample Mesh, featuring tools for geometry modification through interpolation, mesh optimiza...
    x.com
    Streamline your Blender's 3D modeling workflow with AV's Resample Mesh, featuring tools for geometry modification through interpolation, mesh optimization, edge loop connection, smoothing, and more.Get it here: https://80.lv/articles/simplify-mesh-editing-in-blender-with-this-tool/
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  • Games Joining Game Pass In April 2025
    www.gamespot.com
    Microsoft has revealed some of the games that'll be joining Xbox Game Pass this month, and there are several big additions.South of Midnight is Xbox and Compulsion Games' noteworthy release this month. The We Happy Few developer has created a single-player narrative-adventure game inspired by the American Deep South. It'll launch on April 8, but those who purchase the Premium Edition can play it five days early on April 3.Borderlands 3 Ultimate Edition is joining the service, and it comes with all four campaign add-ons, Directors Cut content, and cosmetic packs. This popular shooter is a great warm-up for Borderlands 4, which is scheduled to launch in September.Diablo IV is on already on Game Pass, but perhaps you'd like to experience an older experience. Well, Diablo III: Ultimate Evil Edition also includes the Reapers of Souls expansion set.Still Wakes the Deep is a horror game that came out last year. It takes places on an oil rig in the North Sea during the 1970s, and it's incredibly atmospheric.Wargroove 2 is an excellent tactics game that scratches the old Nintendo Advance Wars-itch, while Hunt Showdown: 1896 is an engrossing extraction shooter that takes place in a backwater swamp.All You Need is Help is a multiplayer co-op puzzles game that involves cube-shaped creatures collaborating with each other to reach goals. Its premise makes it a great game to play with family and children.Some Day One additions to Game Pass include Blue Prince, which is a genre-bending puzzle game that's spread across 45 different rooms. It'll launch on April 10. Commandos: Origins launches on April 9 and revisits the six original commandos in the series. It'll also feature two-player co-op multiplayer.There are some games leaving Game Pass in two weeks, so don't forget to check those out before they leave the service. South of MidnightSouth of Midnight joins Game Pass for cloud, PC, and Xbox Series X|S on April 8. Borderlands 3: Ultimate EditionBorderlands 3 joins Game Pass for cloud, PC, and console on April 3. Diablo III: Reapers of Souls - Ultimate Evil EditionDiablo III: Reaper of Souls - Ultimate Evil Edition joins Game Pass for cloud and console on April 8. Commandos: OriginsCommandos: Origins joins Game Pass for Cloud, PC, and Xbox Series X|S on April 9. Blue PrinceBlue Prince joins Game Pass for cloud, PC, and Xbox Series X|S on April 10. Hunt Showdown: 1896Hunt Showdown: 1896 joins Game Pass for PC on April 10. All You Need is HelpAll You Need is Help joins Game Pass for console on April 3. Still Wakes the DeepStill Wakes the Deep joins Game Pass for Xbox Series X|S on April 3. Wargroove 2Wargroove 2 joins Game Pass for console on April 3.
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  • MicroSD Express Cards For Nintendo Switch 2 - Here Are Your Options
    www.gamespot.com
    The Nintendo Switch 2 offers a fairly massive upgrade when it comes to raw storage space. The 256GB onboard SSD is four times larger than the Switch OLED (64GB) and eight times the size of the original Switch and Switch Lite (32GB). That said, the Switch 2's performance upgrades will inevitably lead to bigger file sizes for upcoming games, which could compel you to expand your console's storage capacity. Just like its predecessor, the Nintendo Switch 2 has a microSD card slot. But while the Switch worked with basically every microSD card sold in stores, the Switch 2 is only compatible with a very specific type of storage: microSD Express cards. See all microSD Express Cards at Amazon The Express format is a recent advancement in the semiconductor industry that hasn't been widely adopted by manufacturers yet. The Nintendo Switch 2 will certainly increase its adoption rate by both manufacturers and consumers in a hurry. During this week's Nintendo Direct, we learned that both Samsung and SanDisk will be releasing Super Mario-themed microSD Express Cards this year. If you want to get ahead of any potential Switch 2 storage woes, we've put together a brief list and explainer detailing the microSD Express options available now from SanDisk and Lexar. None of the current cards are themed around Nintendo franchises, but you'll probably save some cash by grabbing a non-branded one anyway.SanDisk 128GB microSD Express Card -- $45 ($50)SanDisk 256GB microSD Express Card -- $60 ($65)Lexar 256GB Play Pro microSD Express Card -- $50Lexar 512GB Play Pro microSD Express Card -- $100Lexar 1TB Play Pro microSD Express Card -- $200For more on the new console, check out GameSpot's Nintendo Switch 2 preorder guide, which includes all of the first-party hardware and games featured in the Nintendo Direct. Preorders for the Switch 2, its accessories, and a bunch of launch games will open on April 9, and we're only two months out from the console's June 5 launch.Continue Reading at GameSpot
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  • Best RPGs to Play to Live in a History Book
    gamerant.com
    There are plenty of games nowadays that are based on books. One of the biggest examples has to be The Witcher and all of its sequels. Where would the video game industry be without a game like The Witcher 3: Wild Hunt? Then some games use books in their stories to tell something compelling like Alan Wake wherein the titular novelist has his books coming to life.
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  • 9 Best Nintendo Switch Games To Play If You Love Assassin's Creed
    gamerant.com
    Assassin's Creed is one of gaming's biggest franchises.Its inspirational formula has spread to other games to some degree.
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  • The best weapons in Assassins Creed Shadows
    www.polygon.com
    The best weapons in Assassins Creed Shadows give you the proper tools to smack all the nasty ronin and unfriendly bandits youll come across.As each legendary weapon has a unique gameplay perk not to mention the usually higher stats theyre typically more useful than lower-quality weapons. Together with the best armor in Assassins Creed Shadows, you can mix and match these perks to achieve the perfect loadout for your playstyle, whether you prefer to be a stealthy shinobi or sturdy samurai.Below, well show to the best weapons in Assassins Creed Shadows, broken down by the best weapons for Naoe and the best weapons for Yasuke.Update (April 2): Weve added additional legendary weapons to round out the list of best weapons.Best weapons for NaoeSome of the best shinobi weapons focus on Naoes specialty, stealth attacks, but its also important to improve her combat prowess when shes not hiding in the shadows. You might want to combine a stealthy weapon with a kusarigama to clear the field, or perhaps a katana thatll inflict damage over time. Here are the best weapons for Naoe.Bloodshade KatanaPerk: Affliction buildup is not lost over timeLocation: Izumi Settsu, on a ship west of OsakaWith an 18% default bleed buildup, the Bloodshade Katana bleeds your enemies in just six hits. Whereas any other weapon would require quick, consecutive slashes to avoid affliction loss, the Bloodshade Katana allows for complete freedom, as the bleed buildup is never lost. Besides being one of the best weapons in Assassins Creed Shadows, this katana is also one of the easiest to obtain in early game, but beware that its ridiculously easy to miss as its hidden in an unmarked spot on a ship west of Osaka.Yami No Kage KatanaPerk: Deal 100% damage to the attacker on deflectLocation: Clear Hiraiyama Fort in the Warfields, eastern HarimaThis legendary katana comes with a massive damage boost that works well with almost any other weapon, perk, or armor set as long as its not too focused on assassinations and tools. Of course, this weapon truly shines if youre good at deflecting damage (Naoes version of parrying), but you can grab it fairly early in the game, so theres plenty of time to practice.Violet Night KatanaPerk: Trigger poison on deflectLocation: Complete the Yuki Onna objective (The Yokai) in the mountains of northeastern OmiAnother legendary katana with a deflect-based effect, but this one applies poison whenever you deflect an attack. Whereas the previous katana has a higher direct damage potential, Violet Night works better for affliction builds. Its absolutely perfect in combination with the Bloodshades perk (no affliction loss) and the Noh Masterstroke Mask, which grants extra adrenaline upon affliction buildup or, in this case, on every deflection with the Violet Night.Yukimitsus Revenge TantoPerk: Afflicted enemies are vulnerable.Location: Complete the Ancient Tomb of Nanjo kofun in Yamashiro, southwest of KyotoThis legendary tanto is a must-have for players who use Naoes affliction damage. While it doesnt do anything for affliction buildup or affliction damage directly, it makes afflicted enemies vulnerable, which you can normally only do by parrying, dodging, and deflecting incoming attacks. Vulnerable enemies cant defend themselves, allowing you to land devastating blows before the vulnerable state ends. Just focus on fast affliction application, and this tanto will constantly trigger the vulnerable state.Call of the Void TantoPerk: Deals +30% damage to tagged enemiesLocation: Defeat the Godai of Void in a cave in the Daikichiji Temple, northern OmiIf you want a straightforward, reliable damage boost, this legendary tanto is perfect. All you need to do is tag an opponent, and you will an extra 30% damage with any attack type. Its a simple but powerful effect that combines well with almost any other perk. If theres a downside to the Call of the Void tanto, its probably the hiding skills of its previous owners: You must ride north through the temple (do not go left to the mountain peak) and youll eventually see the cave entrance with the legendary chest inside.Featherstorm KusarigamaPerk: Instantly charge posture attacks when hitting multiple enemiesLocation: Inside Kashiwabara Fortress, the northeastern part of Omi (not the main prize look for the chest in the northern part of the fortress)Close-quarters combat is usually more Yasukes thing, but whenever Naoe is forced into a face-to-face fight, the Featherstorm Kusarigama is her savior. This heavy-hitting weapon comes with a high-range posture attack that smashes all nearby enemies, making it perfect for fighting multiple opponents. Whats more, its perk instantly charges Naoes posture attack which may not seem that spectacular, but in the heat of battle, that one second can make all the difference between an unfortunate interruption and a devastating blow.Best weapons for YasukeIn Assassins Creed Shadows, samurai weapons range from massive clubs to sleek naginatas. While you could combine a heavy melee weapon with a lighter one, consider using one of Yasukes ranged weapons too; a well-aimed shot will certainly start the battle in your favor. Heres a list of the best weapons for Yasuke.Flowing Peace Long KatanaPerk: Removes 1 health segment after armor breakLocation: Pick up The Hunters of Kyonyo quest in Negoroji, Kii, then defeat their leader in Iseji TrailsDealing extra damage is always nice, and instantly depleting a full health segment upon armor break is certainly helpful against tougher enemies. However, what makes the Flowing Peace long katana particularly useful is its field-clearing potential. Weaker enemies only have a few health segments (if not just one), so as long as you build Yasuke with high armor damage stats and decent armor-breaking abilities, hell take them out in a second.Vengeful Foe NaginataPerk: Grants 35% bleed buildup on successful parryLocation: Complete The Tournament quest at the Ominesanji Temple in YamatoIf youre looking for quick bleed application, the Vengeful Foe is your friend. This legendary naginata makes it ridiculously easy to bleed enemies as you simply need to parry incoming attacks. Of course, 35% isnt enough to trigger instant bleed, but with a default bleed buildup of 18%, youre already halfway there. Its helpful to pair this weapon with the Crescent Strike active ability (and its first passive node), which applies another 35% bleed upon hit.Shade of Blight NaginataPerk: Grants +100% of an adrenaline chunk upon affliction triggerLocation: Complete the contract on The Messenger at the Kofukuji Temple (northern Yamato)Active combat abilities offer a massive advantage in battle, but you may not use them all that often, as they require lots of adrenaline. If youre wielding the Shade of Blight Naginata, though, that calculus becomes a thing of the past. Granting a full adrenaline chunk whenever you trigger an affliction, you just need to boost your affliction buildup to reap the benefits of extra damage and more ability usage. Whats more, the Shade of Blight already has 18% poison buildup by default.Rage of Red Mist KanaboPerk: Grants +100% of an Adrenaline chunk after armor breakLocation: Loot from the Grave of Buried Hopes, northern YamashiroAnother excellent weapon to regain adrenaline is the Rage of Red Mist. All you need to do is break the opponents armor by depleting the yellow bar above their HP no problem when youre handling a heavy kanabo. Yasuke has plenty of armor-destroying abilities too, which basically means you can use adrenaline to destroy the armor before instantly gaining it back. To top that off, this kanabo is relatively easy to obtain as it lies unguarded in one of the first regions.Boulder Fall KanaboPerk: Attacks cannot be interruptedLocation: Defeat the Katsuragi Agent in the Gokenin Manor in Katsuragi, western YamatoDoes this really need any explanation beyond your attacks cannot be interrupted? More than just an extremely destructive heavy weapon, the Boulder Fall is an unstoppable heavy weapon. The risk of interruptions used to be the sluggish kanabos main weakness, but this overpowered Yasuke weapon just eliminates that problem. If you aim to smack everyone and everything in your way, the Boulder Fall is for you.Venom Pillar KanaboPerk: Instantly charge posture attacks by alternating attack typesLocation: In the Kajimiya Cemetery, southwest of Sakamoto, Omi provinceRegardless of perks, the kanabo is one of the most powerful weapons in Assassins Creed Shadows. True, it can be a bit slow, but its blows have an incredibly high damage potential. If you wield the magnificent Venom Pillar Kanabo, you can trigger a light attack followed by a heavy attack (or vice versa), to perform an instantly-charged posture attack. This combo will quickly overpower even the toughest enemies, without allowing them to recover and interrupt your charged strike. Granted, Venom Pillar isnt as strong as the Boulder Fall, but you can grab it very early on (just find the chest it isnt guarded).Dynasty Ender TeppoPerk: Suppress firing noiseLocation: Inside Genbao Fort, northern part of WakasaTeppo rifles deal fantastic damage, but they have a few drawbacks: Theyre slow, they lack range, and, most importantly, theyre loud enough to alert an entire castle to your presence. Any teppo with a perk to negate those downsides is a welcome addition to your armory, but especially the Dynasty Ender, as it hardly makes any noise when fired. Instead of just an opening move, the teppo becomes Yasukes best stealth weapon, allowing you to fire it multiple times without detection.Dragons Wrath BowPerk: Instantly charge arrowsLocation: Defeat the Tsutsui Agent in Koriyama CastleThere are several perks you can use to boost Yasukes archery damage, but only one that improves the draw speed. The Dragons Wrath bow is extremely handy when youre playing a stealthy archer as you can kill all nearby enemies before they realize whats going on and quickly finish the job if one arrow per enemy isnt enough. Dragons Wrath is particularly unmissable, however, if you want to shoot enemies in open combat you simply wont have enough time to charge your shots without it.For more Assassins Creed Shadows guides, see our running lists of Lost Pages, Kuji-kiri, and armor locations. Or see our full Assassins Creed Shadows walkthrough, and our guides on how to get all companions and romance options.
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  • Donkey Kong wears pants now is this Seth Rogens doing?
    www.polygon.com
    Donkey Kong will break new ground in his new Switch 2 game, Donkey Kong Bananza. I mean that literally, in the sense that the 3D action-adventure game is about destruction and digging into the hard earth with DKs meaty fists. But Bananza will also push the Donkey Kong series forward by putting pants on Nintendos iconic ape. Thats right, Donkey Kong is no longer just weirdly wearing a tie but otherwise completely naked; this Kong wears trousers (and suspenders).Do we have actor, producer, and ceramics enthusiast Seth Rogen to thank for this? Maybe.Rogen, who voiced Donkey Kong in The Super Mario Bros. Movie, previously said in a behind-the-scenes interview about his role, Its a fun character, its a fun world. I would be thrilled to see Donkey Kong go on more adventures. Maybe give him some pants this time.That movie has definitely had an impact on Donkey Kongs current design. But it is strange that Donkey Kong, who has famously not worn pants over the course of his career, is now just wearing britches out of nowhere. Other Kongs, like Funky Kong, Tiny Kong, and Lanky Kong, have worn pants, but DKs immediate family, including Diddy Kong and Dixie Kong, have been content Donald Ducking it for decades. So it clearly isnt a shame thing.Only rarely has DK worn anything below the waist, including what Id consider non-canonical appearances in games like Skylanders: SuperChargers, where he wore a full outfit. Otherwise, including at events like the Olympics, Kong keeps things banana out. (Of his pockets. Because he has no pants pockets to put bananas in.)Its clear from Donkey Kong Bananza screenshots that at a certain point in the game, Donkey Kong will acquire (or lose) the pants. So its not like Nintendo has suddenly found new modesty regarding DKs bare bottom, which will be presented with more realistic detail and seen directly from behind in Bananza (as opposed to side-on in the Donkey Kong Country games). The games trailer also shows many other apes wearing slacks, jeans, and bottoms, so maybe this is a new thing that primates in the Mario universe do.Weve asked Nintendo to shed some light on Donkey Kongs new pants-wearing habit, and will update when the company responds with answers to this mystery.But we may have to wait until July to fully understand the reasons behind Donkey Kongs new wardrobe. Donkey Kong Bananza will be released on Nintendo Switch 2 on July 17.
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