• WWW.WSJ.COM
    This Clever Recipe Turns a Tub of Hummus Into a Wow-Worthy Dinner
    Warm pitas, a pile of shawarma-spiced wild mushrooms and a drizzle of homemade garlic oil transform store-bought hummus into a sophisticated and substantial meatless main.
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  • ARSTECHNICA.COM
    AP: Trump admin to kill IRS free tax-filing service that Intuit lobbied against
    Goodbye, Direct File AP: Trump admin to kill IRS free tax-filing service that Intuit lobbied against Amid IRS staff cuts, employees were told to stop working on Direct File. Jon Brodkin – Apr 16, 2025 5:01 pm | 41 Credit: Getty Images | Richard Stephen Credit: Getty Images | Richard Stephen Story text Size Small Standard Large Width * Standard Wide Links Standard Orange * Subscribers only   Learn more The Trump administration plans to kill the free tax filing program operated by the Internal Revenue Service, the Associated Press reported today, citing two anonymous sources. The IRS launched Direct File in a pilot for the 2024 tax filing season. It was available to taxpayers in 12 states last year, and was available in 25 states this year. The program's website says the filing tool will be open until October 15 for people who obtained deadline extensions, but it hasn't been updated to account for the plan to end Direct File. "The program had been in limbo since the start of the Trump administration as Elon Musk and the Department of Government Efficiency have slashed their way through the federal government," the AP article said. "Musk posted in February on his social media site, X, that he had 'deleted' 18F, a government agency that worked on technology projects such as Direct File." The AP wrote that "two people familiar with the decision to end Direct File said its future became clear when the IRS staff assigned to the program were told in mid-March to stop working on its development for the 2026 tax filing season." The IRS will lose about a third of its staff this year through layoffs and employees accepting resignation offers, The New York Times reported yesterday. TurboTax maker Intuit repeatedly criticized the Direct File program created during the Biden administration. Intuit has said that "Direct File is not free tax preparation, but rather a thinly veiled scheme where billions of dollars of taxpayer money will be unnecessarily used to pay for something already completely free of charge." The IRS last year said the pilot cost $31.8 million and estimated 2025 costs of $75 million. Sen. Elizabeth Warren (D-Mass.) criticized Intuit's lobbying against Direct File and told the AP that Trump and Musk "are going after Direct File because it stops giant tax prep companies from ripping taxpayers off for services that should be free. Americans want a free and easy way to file their taxes—Trump and Musk want to take that away." Intuit's TurboTax offers free filing for simple returns, but has faced lawsuits alleging that its ads misled consumers who had to pay. In 2022, Intuit agreed to pay $141 million in restitution to millions of consumers and stop a specific ad campaign that promised free filing. The Federal Trade Commission ruled last year that Intuit violated US law with deceptive advertising and ordered the company to stop telling consumers that TurboTax is free without more obvious disclaimers. Intuit responded by suing the FTC in a case that is still pending at the US Court of Appeals for the 5th Circuit. The free IRS filing program is also limited to simple returns, but there was hope of expanding its usefulness. The program accepted returns from 140,803 taxpayers in the 12-state 2024 pilot, which was followed by a May 2024 announcement that Direct File would become "a permanent option for filing federal tax returns starting in the 2025 tax season." The IRS said in the 2024 announcement that it was looking for ways to cover more complicated tax returns. "Over the coming years, the agency's goal is to expand Direct File to support most common tax situations, with a particular focus on those situations that impact working families," the IRS said at the time. The Treasury Department estimated that over 30 million taxpayers were eligible for Direct File this year, but hasn't said yet how many people used it. House Republicans urged Trump to act even more quickly to kill the program, saying in a December 2024 letter that he should issue "a day-one executive order to end the Internal Revenue Service's (IRS) unauthorized and wasteful Direct File pilot program." Jon Brodkin Senior IT Reporter Jon Brodkin Senior IT Reporter Jon is a Senior IT Reporter for Ars Technica. He covers the telecom industry, Federal Communications Commission rulemakings, broadband consumer affairs, court cases, and government regulation of the tech industry. 41 Comments
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  • WWW.NEWSCIENTIST.COM
    Ancient humans may have faced radiation risk 41,000 years ago
    A magnetic field disturbance could have allowed auroras to occur more widely 41,000 years agoEvgeniyQ/iStockphoto/Get​ty Images Around 41,000 years ago, Earth’s magnetic field weakened to just a fraction of modern levels, leading to a huge increase in the radiation hitting the surface of the planet. Some researchers suggest the Laschamps event, as it is known, could have pushed Neanderthals towards extinction, while modern humans might have protected themselves using tailored clothing and ochre sunscreen. Earth’s magnetic field extends into space and acts as a protective shield against harmful radiation. The magnetic poles usually line up with the north and south poles, but they occasionally wander due to changes in the liquid outer core of the planet. Advertisement “Fluctuations in this system can lead to variations in the strength and orientation of Earth’s magnetic field, such as those observed during the Laschamps event,” says Agnit Mukhopadhyay at the University of Michigan. By studying magnetic signatures preserved in volcanic rocks and sediments, Mukhopadhyay and his colleagues created a detailed 3D reconstruction of Earth’s magnetic field during the Laschamps event. They found evidence that the magnetic poles had shifted towards the equator and that the field strength had weakened to just 10 per cent of today’s levels. Keep up with advances in archaeology and evolution with our subscriber-only, monthly newsletter. Sign up to newsletter Auroras, created by charged particles hitting the upper atmosphere, are usually only visible close to the poles, but this would have changed during the Laschamps event. “Auroras would have been visible in much wider areas, possibly even near the equator,” says Mukhopadhyay. A weakened magnetic field would have allowed more solar and cosmic radiation to reach Earth’s surface, and may have altered regional climates. “These environmental changes may have driven adaptive behaviours in human populations, such as the increased use of protective clothing and ochre for UV shielding,” says Mukhopadhyay. The researchers argue that the production of tailored clothing and the use of the reddish mineral ochre as a sunscreen may have given Homo sapiens an advantage over Neanderthals, who are thought to have become extinct during this period. “There’s definitely a rough overlap in terms of timing between the incursion of ancient modern humans into Europe and the Laschamps event,” says Amy Mosig Way at the Australian Museum in Sydney. “But it’s probably a stretch to say modern humans had better sun protection in the form of tailored clothing than Neanderthals, and that this contributed to their ability to travel further than Neanderthals and their subsequent dominance of Eurasia.” Veronica Waweru at Yale University says there is evidence for ancient humans using ochre around this time. For example, the Porc-Epic site in Ethiopia records ochre use at 45,000 years ago, but this intensified 40,000 years ago, she says. They may have used it for sunscreen or other reasons such as making artwork or adhesives. Ladislav Nejman at JCMM in the Czech Republic says we don’t know if modern humans used ochre as a sunscreen. “If they did, it could’ve protected them more, but not necessarily saved them,” he says. “Humans in Europe really had it stacked against them at the time.” He points out that the Laschamps event coincided with an extremely cold period known as Heinrich event 4, as well as a major volcanic eruption in Italy called the Campanian Ignimbrite explosion. “The huge advantage that Homo sapiens had as a species compared to Neanderthals is that there were other large populations living in Africa and elsewhere, so new Homo sapiens could move into Europe after these events,” says Nejman. Journal reference:Science Advances DOI: 10.1126/sciadv.adq727 Topics:
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  • WWW.BUSINESSINSIDER.COM
    Here is how much the Magnificent 7 lost after stocks tanked over tariff warnings from the Fed and Nvidia
    Markets plummet as Nvidia and Federal Reserve warnings shake investor confidence. Brendan McDermid/REUTERS 2025-04-17T01:33:03Z Save Saved Read in app This story is available exclusively to Business Insider subscribers. Become an Insider and start reading now. Have an account? Markets dropped as Nvidia and the Federal Reserve headlines shook investor confidence. Nvidia is anticipating a $5.5 billion hit due to export rules on H20 AI chips to China. Tech giants like Amazon, Meta, and Microsoft saw their stock value decline. Markets sank sharply on Wednesday after back-to-back tariff-related headlines from Nvidia and the Federal Reserve rattled investor confidence.The sell-off started after a disclosure on Tuesday evening after markets closed from Nvidia, which warned of a $5.5 billion hit due to export rules on H20 AI chips developed for the Chinese market.Nvidia appears to be caught in the increasing tension over tariffs between the US and China.Stock losses deepened after Federal Reserve President Jerome Powell cautioned that renewed tariffs under the Trump administration could create a "challenging scenario" for the economy. He warned that the Fed's dual mandate — low unemployment and price stability— could be tested if tariffs drive up consumer prices while slowing growth.Here is how much each of the Magnificent 7 lost on Wednesday — and since Trump's inauguration — at market closing at 4 p.m. ET, according to Yahoo Finance.Alphabet Google CEO Sundar Pichai. Justin Sullivan/Getty Images Loss in stock value since January 21: 20.51%Loss in stock value on April 16: 2%Alphabet, Google's parent company, took a comparatively smaller loss on Wednesday but still saw about one-fifth of its stock value wiped out since Trump became president. In February, Nvidia replaced Alphabet as Wall Street's third most valuable company.Alphabet donated $1 million to Trump's inauguration.Amazon E-commerce giant Amazon and its shipping hub. Peter McCabe/REUTERS Loss in stock value since January 21: 22.16%Loss in stock value on April 16: 2.93%Amazon, the global e-commerce giant, has lost about one-fifth of its share value since Trump's inauguration and could be hit further by tariffs, especially the up to 245% in duties imposed on China. Amazon donated $1 million to Trump's inauguration fund, and founder and executive chairman Jeff Bezos attended.Small businesses selling on Amazon told Business Insider they are struggling to keep their doors open as their already razor-thin margins shrink further under tariffs.Apple Apple shares briefly rallied on Monday on a surprise tariff exemption on key tech products. Tingshu Wang/REUTERS Loss in stock value since January 21: 9.21%Loss in stock value on April 16: 3.89%Apple shares briefly rallied on Monday on a surprise tariff exemption on key tech products, but the reprieve was short-lived.The tech giant is also planning to spend and invest more than $500 billion in the US over the next four years.Tim Cook, CEO of Apple, personally donated $1 million to Trump's inaugural committee and attended the ceremony.Meta Meta CEO Mark Zuckerberg. Alex Wong via Getty Images Loss in stock value since January 21: 15.40%Loss in stock value on April 16: 3.68%Meta, parent company of Facebook and Instagram, is currently facing a blockbuster antitrust trial with the Federal Trade Commission that opened on Monday and is expected to run up to eight weeks.The tech giant had donated $1 million to Trump's inauguration, and CEO Mark Zuckerberg attended the ceremony. Microsoft Microsoft CEO Satya Nadella. Stephen Brashear/Getty Images Loss in stock value since January 21: 9.98%Loss in stock value on April 16: 3.66%Microsoft has been rethinking its performance reviews and is mulling another round of job cuts that could come as soon as May, after already having fired "low-performers" in January.Nvidia Nvidia CEO Jensen Huang. Getty Images; Chelsea Jia Feng/BI Loss in stock value since January 21: 20.33%Loss in stock value on April 16: 6.87%A main character of Wednesday's stock market woes, Nvidia, the chipmaking giant, took a heavy loss in shares and at one point neared a 10% loss before bouncing back toward market close.The semiconductor maker developed H20 AI chips for China but disclosed Tuesday that new US export restrictions have effectively blocked Nvidia from selling the inventory, which weighed down share values of the broader tech sector.Tesla Trump purchased Tesla cars in front of the White House in support of the company. Kevin Lamarque/REUTERS Loss in stock value since January 21: 40.08%Loss in stock value on April 16: 4.94%Tesla, the EV giant, had an especially difficult year in terms of sales and share value for reasons that go beyond tariffs or generally low consumer sentiments.Public backlash over Musk's political involvement and ties to the White House's DOGE office resulted in mass protests and boycotts of Tesla vehicles, and his focus on DOGE made investors question his commitment to the company.Elon Musk has donated over $260 million to support Trump's return to the White House, along with $12 million toward a failed conservative bid in Wisconsin's Supreme Court race. Recommended video
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  • METRO.CO.UK
    Games Inbox: Will the Nintendo Switch 2 be a hit?
    Is it destined for success? (Nintendo) The Thursday letters page thinks that the concept of console generations is coming to an end, as a reader is surprised there aren’t more Fallout games. To join in with the discussions yourself email gamecentral@metro.co.uk Despite it all I don’t think Nintendo can be all that happy with the response to the Switch 2 Direct. The thing itself was fine, I think, but the lack of details and the way all the most important information has trickled out since has made them look bad, in my opinion.We’re two weeks later now and we still don’t know most of the UK prices for anything, including the upgrades. Pre-orders are also very hard to come by for a console they said was not going to have stock problems. I know Trump’s tariffs have put a spanner in the works but that shouldn’t be a problem for anyone outside of the US. The lack of big budget IP or news on other first party games was also a disappointment, although that’s pretty normal for Nintendo and I’m not so worried about that. Even though I’m still surprised there wasn’t a Super Smash Bros. Ultimate Deluxe. So, quite a few problems but despite it all I really can’t see the Switch 2 not being a success. We probably won’t be able to tell this year anyway, because it’ll sell out whatever, but I still feel people are ready for an upgrade and there’s so much more negativity around Xbox and PlayStation at the moment that people that wouldn’t normally buy Nintendo may be more interested than usual.Grackle Resident Evil Ultimate I really can’t see the point of remaking Resident Evil 2 for a second time, after such a short period. There’s an argument for doing 3 again, because it’s so different from the original, but then the original was always the weakest of the early games anyway, so I’m not sure it’s really worth it.I know we don’t know what Resident Evil 9 is yet but my hope for a long time now is that it’ll be more like Resident Evil 2, which I thought was almost the perfect Resi game. It’s a bit limited by being based on such an old game, but if they made a brand new game in the same general style it could be the ultimate Resident Evil. I would play up the horror element more though, as that’s one thing we haven’t had from any of these remakes. None of them are scary or even really trying to be, and that’s a shame. Resident Evil 1 one would be though, presumably, so that’s one reason why I’m also in favour of a remake of that.Pr0metheus Sticking to the plan I really feel that Phil Spencer has outstayed his welcome at Xbox. People were saying that a year or more ago but now it’s got to the point where I forget he’s still there and for a moment I can’t believe it. As usual, he gave a non-answer as to why no Xbox games have been announced for Switch 2 yet and it’s impossible to tell whether they’re waiting for something or they were just lying about support in the first place.It certainly doesn’t make any sense to me, for them not to have been at the Switch 2 Direct. That would’ve made a very clear statement but instead I suspect they’re going to sneak out the annoucement in some blog somewhere, because they’re embarrassed about their own business plan. If this whole multiformat thing is going to work they really need to go all in on it or just stick to PC. There’s no point doing it half-hearted.Gibson Email your comments to: gamecentral@metro.co.uk Exclusive ending Watching the second season of The Last Of Us, I’m still not sure I really see the point. Finding out about Abby early is different but I don’t see how that makes things better or worse. It’s a well made show but the problem, I feel, is that the games are already so much like a movie that it really makes little difference making it live action.I also don’t like the idea that they’re going to invent a new twist to replace the one they’re not doing with Abby. That already sounds super contrived and I really hope that isn’t what happens. The best thing I would suggest is that if they make the final season of the show The Last Of Us Part 3 and finish the story that way. I like the games but at the same time I don’t want Naughty Dog to spend another six years on a third one. Some of these people will be hitting retirement age before they ever get to do something new.Tiger Balm Source material I’ll probably pick up Indiana Jones And The Great Circle when it’s on cheap, no doubt by Black Friday at least. I’m not really sure why it wasn’t multiformat from the start though, as that would surely have increased its impact, rather than just slipping out unnoticed in April.What interested me about your review was the idea that many younger gamers don’t realise that Tomb Raider and Uncharted are both knock-offs. Many probably don’t even know who Indiana Jones is, given how few people watched the last movie. Uncharted is particularly funny because it’s a knock-off of Tomb Raider, which is basically an unofficial Indiana Jones game but with different characters. It makes me wonder what other games people don’t realise are not what they think. People always seem to forget that Wolfenstein 3D was the first successful first person shooter, not Doom, although even then I think many modern gamers don’t realise the significance of either franchise, given they’re much lower profile than they were 30 years or so ago (which isn’t surprising, I guess).Tacle Slow expansion All this talk of Fallout remasters seems pointless to me. The one everyone wants is New Vegas and that needs a full remake, not just a remake. But given how much effort Bethesda puts into ignoring it all the time I don’t see that happening.The sensible thing to do, considering we’ll all have died of old age or World War 3 by the time Fallout 5 is out, is to get someone else to make another spin-off and I have no idea why Obsidian (who made New Vegas) have not been told to do this. I mean, compared to that or The Outer Worlds 2, who wouldn’t want a new Fallout? A lot of people seem to think Bethesda resent New Vegas being so popular but the only Fallout games that Bethesda has ever made are 3 and 4, plus 76. It’s actually a really small franchise, even if you include the pre-Bethesda stuff, and I’m not sure why. You would’ve thought that Microsoft would’ve have put their foot down and told Bethesda to make more, especially after the TV show, but if they have they’re being strangely quiet about it. If they do anything it probably will just be another remaster, which just doesn’t feel like enough to me. The franchise is spinning its wheels and it really shouldn’t be.Zeiss Not all gamers In Korbie’s last paragraph in the 16th April Inbox, he said ‘scalpers might be being locked out with the console, to a degree, but I bet all those physical copies of games are going to go for a fortune on eBay.’If gamers are up in arms about Nintendo potentially selling games for £75 now, why the pixel would anyone then buy said games for double or more?LeighDappa End of line Now we have rumours that the next PlayStation will be either a traditional console or a portable depending on what the user prefers, it has me wondering is the end of console generations, at least in the traditional sense.If the portable version of the PlayStation 6 is roughly able to achieve similar levels of performance as the current PlayStation 5 does this essentially mean that the PlayStation 6 won’t have exclusive games and instead all titles will be available across all formats, whether you have the PlayStation 6, PlayStation 6 portable, PlayStation 5 or PS5 Pro, albeit with varying levels of performance. And given that this is already the case with Xbox, since pretty much all games release day one on Xbox Series X, Series S, and on PC it could be the all the same is true for the next Xbox generation, in that it won’t have exclusives. Perhaps, given that we are only seeing incremental changes with each passing console generation, and judging by recent price increases and the cost of living, it does pose the question of whether the next generation of consoles will appeal to a broad audience. Will they provide new experiences in terms of games that can only be run on new hardware or will they target a more specific player that is happy to play titles that are available on multiple systems but wants to have the best possible experience in terms of frame rate/resolution/ray-tracing, etc.Matc7884 GC: We’d assume it’d be that the portable would play downgraded versions of PlayStation 6 games, much as the Switch 2 already has a few current gen ports announced for it. Although that’s assuming the rumours are in any way accurate. Inbox also-rans I’m a bit confused as to the need for the Switch 2 magnets. I don’t remember ever having trouble with the rails on the Switch 1 or having heard anyone complain about them. Sounds like a classic case of if it ain’t broke, don’t fix it.AldoI really hope that Star Wars strategy game is good, because I need more XCOM, but that artwork they released is so boring. It looks like someone carefully designed the least interesting group of generic Star Wars characters possible.PizzaLottery More Trending Email your comments to: gamecentral@metro.co.uk The small printNew Inbox updates appear every weekday morning, with special Hot Topic Inboxes at the weekend. Readers’ letters are used on merit and may be edited for length and content. You can also submit your own 500 to 600-word Reader’s Feature at any time via email or our Submit Stuff page, which if used will be shown in the next available weekend slot. You can also leave your comments below and don’t forget to follow us on Twitter. Arrow MORE: Games Inbox: How long will the PS5 console last? Arrow MORE: Games Inbox: How much will GTA 6 cost? GameCentral Sign up for exclusive analysis, latest releases, and bonus community content. This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply. Your information will be used in line with our Privacy Policy
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  • GIZMODO.COM
    Meta Pissed Off Everyone With Poorly Redacted Docs
    By AJ Dellinger Published April 16, 2025 | Comments (3) | Mark Zuckerberg, chief executive officer of Meta Platforms Inc., during the Meta Connect event in Menlo Park, California, US, on Wednesday, Sept. 25, 2024. Meta Platforms Inc. debuted its first pair of augmented reality glasses, devices that show a combined view of the digital and physical worlds, a key step in Chief Executive Officer Mark Zuckerberg’s goal of one day offering a hands-free alternative to the smartphone. © David Paul Morris/Bloomberg Mark Zuckerberg’s Meta is in the middle of a fight to maintain its social media monopoly-like status, and it’s not making many friends along the way. According to The Verge, the company got an earful in the form of lawyer-submitted smackdowns from fellow tech giants who were less than thrilled over the fact that Meta’s legal filings in its antitrust case against the Federal Trade Commission were so poorly redacted that they revealed internal information from Snapchat, Google, and Apple. The information revealed in the slides isn’t necessarily the most earth-shattering disclosures. As reported by The Verge, one slide showed data, seemingly from Apple, that shows the frequency of use of several different apps that have messaging features—including Apple’s Messages, TikTok, Instagram, Facebook Messenger, WhatsApp, and Snapchat—that suggested Messages dominated iOS when it comes to communications, not Meta’s offerings. Another slide, per The Verge, was titled “Snapchat in 2020: Competitors Are Succeeding and Not Just Meta Apps” and said apps other than Meta’s own are “thriving.” But the fact that information made its way to public consumption was a pretty big “oops” on Meta’s part. The information was visible because of how the company redacted the documents, which it turned out was pretty easy to remove…which, of course, people did. That did not inspire confidence among the legal representation for companies, including Apple, Google, and Snapchat, that Meta was doing all it could to keep proprietary information protected. (Why they would want that information redacted is a different matter.) According to The Verge, lawyers for Apple and Snap called the redaction mishap “egregious,” and Apple’s representation said the company may not be able to trust Meta with internal information going forward. Google’s lawyers also lambasted Meta for putting its business on front street. So obviously, the companies feeding Meta this information to help their case were not intending for it to leave the confines of Meta’s defense team. This isn’t the first slip-up that has resulted in some stepped-on toes in Meta’s efforts to defend itself against antitrust charges brought by the FTC. Earlier in the trial, which is just a few days into the proceedings, Snap expressed frustration that Meta’s legal team revealed supposedly confidential information from Snap during its opening statements. Meta’s sloppiness might stem from the fact that the company didn’t expect this trial to actually go forward. Reporting from the Wall Street Journal indicated that CEO Mark Zuckerberg thought his buddying up to President Trump would make the case go away for a small settlement. Instead, the company is fighting it out in court while pissing off its would-be allies along the way. Daily Newsletter You May Also Like By Matt Novak Published April 16, 2025 By Alex Cranz Published April 15, 2025 By Florence Ion Published April 14, 2025 By AJ Dellinger Published April 14, 2025 By AJ Dellinger Published April 12, 2025 By Florence Ion Published April 11, 2025
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  • WWW.YOUTUBE.COM
    Base Mesh + Greeble #b3d
    Base mesh + greeble mesh effect using the Random Flow add-on in Blender. Shops: blendermarket.com/creators/blenderguppy gumroad.com/blenderguppy Patreon: patreon.com/blenderguppy #b3d #conceptart #blender3d #blenderaddon #blendermarket
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  • WWW.DISCOVERMAGAZINE.COM
    Advances in Existing Drugs and Personalized Therapy Could Help Treat Osteoarthritis
    Sometimes a big medical problem requires a massive research effort. Scientists have done just that for osteoarthritis, a condition that could affect a billion people globally by 2050. Their enormous effort could help identify existing drugs suitable to treat arthritis, develop new ones specifically targeted to the disease, and, eventually create tailored approaches based on an individual arthritis sufferer’s genetic makeup. These three approaches are essentially at different heights on the drug development tree.The Impact of OsteoarthritisJust how large was the study? For starters, scientists examined the genomes of 489,975 osteoarthritis patients and compared them to the genomes of 1,472,094 people living without the condition. In doing so, they found 962 genetic associations, 513 of which have not been previously reported. When the data dust settled, the scientists felt fairly confident that they had identified about 700 genes that contribute to osteoarthritis, the scientists report in the journal Nature.Although such numbers can seem overwhelming, in this case they should also provoke optimism. First, they essentially reveal some pharmaceutical low-hanging fruit — genes that produce proteins that are already targeted by existing drugs — just ones not necessarily associated with osteoarthritis. This is good news, because those medicines would need less time and cost to test them for safety and efficacy, compared to brand new approaches. That means they could be prescribed to osteoarthritis patients relatively soon — at least in drug-development terms. “With ten percent of our genetic targets already linked to approved drugs, we are now one step closer to accelerating the development of effective treatments for osteoarthritis," Eleftheria Zeggini, a scientist at Helmholtz Munich and an author of the study, said in a press release.Breaking Arthritis Down into Processes and GenesThe researchers then identified eight biological processes that impact osteoarthritis development. These processes essentially represent drug targets a little higher up the drug development tree. Knowing what those processes are and understanding how they contribute to the disease could help develop new drugs.“Our discovery suggests that targeted interventions regulating one or more of these eight processes could play another significant role in slowing or even halting disease progression,” Konstantinos Hatzikotoulas, also at Helmholtz and a co-author, said in the press release.Personalized Osteoarthritis Therapy Finally, since so many genes appear to be involved and are likely have some difference impacts from patient to patient, identifying each gene and understanding its specific role could lead to personalized therapy. These approaches are higher up on the drug development tree; scientists have been discussing the promises of personalized medicine since a draft of the human genome sequence was completed in 2000. Although the promise of personalized medicine remains, a good bit of work will be required before such therapies become reality. But the study at least provides some promising starting points.“Genetic variants associated with osteoarthritis risk are widespread across osteoarthritis patients,” Hatzikotoulas said in the release. “Our newly gained knowledge about them can enable improved patient selection for clinical trials and personalized medicine approaches.”The study effectively could usher in short-, medium-, and long-term approaches to treat osteoarthritis. That’s pretty big news.This article is not offering medical advice and should be used for informational purposes only.Article SourcesOur writers at Discovermagazine.com use peer-reviewed studies and high-quality sources for our articles, and our editors review for scientific accuracy and editorial standards. Review the sources used below for this article:Before joining Discover Magazine, Paul Smaglik spent over 20 years as a science journalist, specializing in U.S. life science policy and global scientific career issues. He began his career in newspapers, but switched to scientific magazines. His work has appeared in publications including Science News, Science, Nature, and Scientific American.
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  • WWW.NATURE.COM
    Don’t rush promising stem-cell therapies
    Nature, Published online: 16 April 2025; doi:10.1038/d41586-025-01176-yPotential treatments need to be subject to the highest standards of safety and efficacy.
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  • V.REDD.IT
    Made this animation for my friend’s senior fashion collection Mind Maze
    I created this animation in Blender for Chuck Ryan’s senior menswear collection Mind Maze. The concept was all about breaking free from the structured norms of society (especially in school) and living life on your own terms. I tried to channel that rebellious, exploratory energy through the animation using movement, illusion, and some mind-bending transitions. Before creating the animation, the glasses were designed in Blender, then 3D printed and cast in sterling silver for the runway show—later featured on Vogue Runway alongside the collection. The character was originally sculpted in clay by Atticus Perry (instagram: schmutz.box), then 3D scanned and brought into Blender for retopo and animation. Really fun blend of fashion, physical modeling, and CG. Happy to share more process if anyone’s interested. More about the collection here: https://chuckryan.org/8/ submitted by /u/jakeaicher [link] [comments]
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