Nature, Published online: 15 January 2025; doi:10.1038/d41586-025-00134-yProteins made using machine learning successfully bind snake toxins plus, Earths temperature breaks a significant climate threshold for the first time.

Tales of Graces f Remastered can be a challenging experience on the higher difficulties. You can adjust the difficulty setting, but the rewards, EXP, and item drops are reduced. As a result, it's a must to know how to keep Asbel and his team healthy in and out of battle. Thankfully, there are multiple ways to heal and stay healthy in Tales of Graces f Remastered. Whether it's through Artes, gels, or cooking, the party is not short of options. This guide will show you how to heal using the many resources and mechanics available in Tales of Graces f.

Early this morning, Nintendo finally revealed the Nintendo Switch 2 in a surprise video announcement. That itself wasn't necessarily that much of a surprise: Recent rumors had suggested the company would do as much, and sooner rather than later. But in a slightly unexpected move, Nintendo dropped the video on YouTube without much fanfare or hype. Aside from a complimentary post on X, the company basically said, "Well, here you go."Perhaps it's due to the fact the Switch 2 itself has been leaked to death that the company is taking less pleasure in the announcement. After all, accessory maker Genki essentially showed the tech world the Switch 2's design at CES last week (though Nintendo says Genki's products were based on unofficial hardware, so it's possible Nintendo felt a drawn-out reveal wasn't necessary. Regardless, it you're really interested in the Switch 2, chances are you knew a lot about it already. Now, you've seen it for real.This is the Switch 2 In the video announcement, Nintendo gives us a direct comparison between the original Switch (not the Switch OLED) and the new console. You can see how much larger the Switch 2's display and hardware is, as well as some subtle tweaks in I/O. The kickstand design is much different, and much more flexible, as you can bend the console back to a steeper degree. But the biggest changes, at least aesthetically, seem to be to the Joy-Cons. Nintendo opted to make them larger, slightly change their shape, and bump up the size of the shoulder buttons. The company has also flipped the color scheme: Colorful Joy-Cons on the OG Switch had black accents on the rails, but the new Joy-Cons are almost entirely black, with the colors added as accents to the rails and under the joysticks. As expected, the Joy-Cons connect to the new Switch magnetically, instead of aligning the rails with the console and clicking into place.The reveal doesn't offer a super close look at the dock, but it does appear similar to the Switch OLED's, but in blacksave, of course, for the large "2" next to the Switch logo. The same goes for the Joy-Con grip: It looks like a larger, more refined version of the OG Switch's grip, though Nintendo did display how you can "pop" the Joy-Con out to the side, showing off its magnetic connection. Did we get any news of Switch 2 exclusive games?Yes! Although we don't know many details yet. In the trailer, we appear to get a glimpse of a new Mario Kart, as the character designs are definitely not the same as those in Mario Kart 8: Deluxe. Credit: Nintendo of America/YouTube Aside from that, there's no word on actual titles, available at launch or otherwise. However, Nintendo said Switch 2 will play both exclusive and original Switch games, and both physical and digital copies, so your existing cartridges should work with the new console. That said, some Switch games may not be supported by or fully compatible with Switch 2. Nintendo doesn't elaborate further, but this might be a situation where it makes sense to hold onto your original Switch, instead of trading it in for the new console. Did the Switch 2 reveal include anything else?Not really! Nintendo being Nintendo, this is just a sneak peak more or less confirming the massive amount of leaks and rumors we've already sifted through. Nintendo has longed promised a Switch 2 reveal in Q1 2025, and we got that. Now we wait for more information. Nintendo points customers to a page on its website for more details about Switch 2, but as of this article, it's just hosting a link to the reveal video. Perhaps they'll update the site with more information over time. For now, this is the Switch 2. It may not be surprising, but after so much time and so many leaks, it's hard to believe it's finally official.

As part of an ongoing investigation into X, the European Commission has requested documents from the company related to how its recommendation systems work. The European Union's regulatory arm is particularly interested in any recent changes to the algorithm. The EC said it asked X to provide the information by February 15 as it steps up the Digital Services Act (DSA) probe.On top of that, regulators asked for access to certain APIs that X provides so it can conduct direct fact-finding on content moderation and virality of accounts. The Commission has also slapped X with a retention order. This requires the company to retain internal documents related to future changes to the algorithm through the rest of 2025 (or earlier if the investigation wraps up before then).Today, we are taking further steps to shed light on the compliance of X's recommender systems with the obligations under the DSA, Henna Virkkunen the Commissions executive vice-president for sovereignty, security and democracy said in a statement on Friday. We are committed to ensuring that every platform operating in the EU respects our legislation, which aims to make the online environment fair, safe, and democratic for all European citizens.The EC opened the investigation in December 2023 to look into potential violations of the DSA. Companies that are deemed to have breached the law face fines of up to six percent of their global annual revenue.Thierry Breton, the former European commissioner for internal market, said the bloc was looking into whether X failed to live up to its obligations regarding transparency and tackling illegal content. Possible deceptive design practices are also under the Commission's microscope.Regulators stepped up their investigation after X owner Elon Musk publicly backed the Reform party in the UK, as well as the far-right Alternative for Germany party ahead of an election in February. As Reutersnotes, some European politicians have claimed that Musk is meddling in elections. He decried the criticism as an attack on free speech and democracy.To that end, the Commission is looking into whether X's algorithms shadowban certain perspectives while amplifying a single narrative. However, it said that Musk is free to speak as he wishes.This article originally appeared on Engadget at https://www.engadget.com/big-tech/the-eu-wants-to-know-just-how-xs-recommendation-algorithm-works-161000963.html?src=rss

What could the future hold for the Samsung Galaxy Watch Ultra 2?

The inauguration of president-elect Donald Trump will take place on Monday, January 20 at 12 p.m. EST. But the number of public servants who say theyre staying home is growing as the event nears.Former House Speaker Nancy Pelosi will not be present, ABC News reported. Pelosis office confirmed the democrat will skip the event, but did not offer a precise reason for her planned absence. Pelosi underwent a hip replacement surgery a little more than a month ago. Of course, Pelosi has frequently voiced disapproval of the president-elect and his past policies. As one of the most outspoken critics of Trump during his first term, Pelosi was also a target during the January 6, 2021 insurrection.Pelosi is far from alone in her perceived protest. According to a statement from her office, per Today, former first lady Michelle Obama will not attend the event, either. Obama also did not attend the funeral of former President Jimmy Carter last week, while her husband, former President Barack Obama, was seated next to the incoming president and could be seen chatting and smiling with the president-elect.According to Axios, Tennessee representative Steve Cohen wont attend the swearing in due to the president-elects dangerous rhetoric which prompted the January 6, 2021 insurrection, as well as statements hes since made on the fate of the insurrectionists.[Trump] has said he is going to pardon some of the January 6 prisoners at his inauguration, Cohen told the outlet. And as one who was in the gallery and then locked in my office in the early morning as the insurrectionists tried to overthrow our government and beat police, some to the point of death, I cannot be a part of that spectacle.California congresswoman Judy Chu wont be there, either. But Chu says, per Newsweek, its because the inauguration falls on Martin Luther King Jr. Day. Im not attending the upcoming inauguration. I will be in my district with my constituents for important events marking Martin Luther King Jr. Day and the second anniversary of a mass shooting in my hometown of Monterey Park.The outlet also reported that Rep. Kweisi Mfume, Rep. Jasmine Crockett, Rep. Sean Casten, Rep. Delia Ramirez, and Rep. Ilhan Omar, and a number of others, will all skip the inauguration, while Elizabeth Warren, Tammy Duckworth, and Raphael Warnock, are still undecided.Top politicians skipping the presidential inauguration is rare, though its happened before. Trump declined to attend President Bidens 2021 inauguration after refusing to acknowledge that Biden had won the election. Former first lady Melania Trump also skipped the event, as did Trumps daughter and advisor, Ivanka Trump.Other notable republicans, like Former Vice President Dick Cheney, didnt attend either, though Cheney said it was over COVID concerns. Republican North Carolina Senator Thom Tillis missed Bidens inauguration, too, but said his absence was due to a recent foot surgery. And GOP Rep. Marjorie Taylor Greene didnt go either. A spokesperson told USAToday at the time it was primarily due to security concerns.Congressman Matt Gaetz attended virtually and echoed Taylor Greenes reasoning in a post on X (formerly Twitter). Gaetz wrote, I will proudly attend the inauguration virtually to avoid any additional security strain on those protecting the transition of power. Of course, while a number of politicians wont be at Mondays event, that doesnt mean the crowd will be sparse. Filling out the seats will be some of the worlds richest people, like Elon Musk, Jeff Bezos, and Mark Zuckerberg, along with TikTok CEO Shou Chew.And while all the living former presidents will attend Trumps inauguration, they wont stick around to socialize. Former Presidents Barack Obama, Bill Clinton, and George W. Bush will not attend the inaugural lunch, which always follows the swearing-in ceremony.

Uber and London Gatwick celebrate their partnership with a witty yet sentimental series of ads.

TikTok is now unavailable in the United Statesand getting around the ban isnt as simple as using a VPN. Heres what you need to know.

MacworldTired of trying to make iWork, well, work? It might supposedly be a good alternative to Microsoft Office, but lets be honest: it really cant compare! Its time toupgrade your Macs productivity apps in 2025 to Word, Excel, PowerPoint, and more, and now might be the best time to grab a license.Rather than pay a recurring fee for Microsoft 365, you could get a lifetime Microsoft Office license for your Mac for only$39.99 (reg. $229). Thats over $30 less thanwhat youd normally pay for a yearly subscription to Office 365.ImagineWord, Excel, PowerPoint, Outlook, OneNote, and Teams Classic right on your Macthats exactly what this Office 2019 license gives you. You can immediately access and install your apps after purchasing since youll get a download link and activation key via email ASAP. iWork, who?While this isnt the latest version of Office, keep in mind that youre getting more apps for less. Plus, if youre not super into the complete AI integration of Office 2024, this might be the suite for you!Start the new year on the right foot and own thislifetime Microsoft Office download for Mac for just $39.99. No coupon needed.Microsoft Office Home & Business 2019 for MacOnly $39.99 at MacworldStackSocial prices subject to change.