• A scalable system using mini-organs to test personalized RNA therapy
    www.nature.com
    Nature, Published online: 22 January 2025; doi:10.1038/d41586-025-00078-3A rapid and efficient method developed to create stem-cell-based 3D mini-organs derived from the cells of patients offers a way to evaluate personalized treatments using RNA therapies for rare genetic diseases.
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  • Precise modelling of mitochondrial diseases using optimized mitoBEs
    www.nature.com
    Nature, Published online: 22 January 2025; doi:10.1038/s41586-024-08469-8A study reports optimized mitochondrial base editors with reduced off-target effects to facilitate the generation of mouse models of human mitochondrial diseases.
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  • Fantastic Photorealistic Old West Town Landscape Created with UE5
    cgshares.com
    Jefferson Bacquey Habrylo, Senior Environment and Props Artist at Lost Boys Interactive, showcased a new fantastic project created withMaya, Unreal Engine 5, Substance 3D Painter, and Photoshop.The project is a fully modular and procedurally textured Old West town. The photorealistic environment looks highly detailed, with both natural and architectural pieces. It features a complex composition, with stones, grass, and moss on the forefront, a road and wooden houses in the main part, and another architectural structure and distant mountains in the backdrop, which adds depth and graphic fidelity to the picture.This is one of the most ambitious pieces Ive worked on, featuring extensive technical elements that supported its creation, the artist shared. A special thanks to Ethan Reeds for his invaluable guidance and insights on lighting.In our interview, Jefferson Bacquey Habrylo shared a breakdown of another great project, the Hogwarts Library Personal Interpretation, speculated on the challenges of creating large-scale scenes, and shared some environment art tips for beginners:Visit the artists ArtStation page anddont forget to join our 80 Level Talent platform and our new Discord server, follow us on Instagram, Twitter, LinkedIn, Telegram, TikTok, and Threads, where we share breakdowns, the latest news, awesome artworks, and more.Source link The post Fantastic Photorealistic Old West Town Landscape Created with UE5 appeared first on CG SHARES.
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  • This Tractor Tire Simulation Set Up in Unity Is Surprisingly Satisfying
    cgshares.com
    An artist known as Lancaster showed off a nice soft body tire simulation made for a 3D tractor in Unity. Redditors really appreciated the satisfying view, although some didnt quite agree on one definition of a soft body.Whatever your opinion is, Lancasters goal was tire deformation and not any metal or plastic deform. These wheels behave like real physical tires and emulate internal pressure. It needed to be as simple as possible and look as real as possible.The artist used colliders inside the wheel that were connected to each other. The soft body effect was achieved with customizable forces in the connections. For steering, they used a configurable joint and two separated rigid bodies.LancasterYou can also find a Star Wars-inspired hover bike on Lancasters Reddit page, also well received by Redditors, and we hope this success will lead to more projects by the creator.Meanwhile, join our80 Level Talent platformand ournew Discord server, follow us onInstagram,Twitter,LinkedIn,Telegram,TikTok, andThreads,where we share breakdowns, the latest news, awesome artworks, and more.Source link The post This Tractor Tire Simulation Set Up in Unity Is Surprisingly Satisfying appeared first on CG SHARES.
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  • Assassin's Creed Shadows Director Reveals Why Game Was Delayed A Second Time
    www.gamespot.com
    Assassin's Creed Shadows has already been pushed back from its release date more than once, but the most recent delay has a good reason behind it. Ubisoft recently showed off what Shadows' two protagonists--Naoe and Yasuke--can do with their parkour skills. And those skills were part of the rational behind giving Shadows' programmers a few extra weeks to get everything ready.Game director Charles Benoit told IGN that the additional time was used to polish Shadows and balance the progression. However, he noted that the really difficult issue to deal with was the architecture of Feudal Japan, which wasn't intended to be used as parkour surfaces."The Japanese architecture, the roofs [are] super complex," said Benoit. "Probably the most complex thing that I ever worked with if we compared to Odyssey and Syndicate. We needed specific codes and specific animations to support something super fluid, changing the transition of the parkour to make it even more fluid. So that's one of the specific feedback that we heard that we wanted to address, and it really improved since the last few months."Continue Reading at GameSpot
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  • Get 3-Month Xbox Game Pass Ultimate Subscription For $30.59 Today Only (January 23)
    www.gamespot.com
    Xbox Game Pass Ultimate 3-Month Code $30.59 (was $50) with promo code SAVETEN (Jan. 23) See at Woot See at Amazon If you're interested in playing any of the games featured in Xbox's latest Developer Direct, you should check out Woot's deal on Game Pass Ultimate. Today only, January 23, you can get three months of Game Pass Ultimate for $30.59 (was $50) with promo code SAVETEN. After today, the price will rise to $34--still a good deal--as long as it doesn't sell out before then. This deal saves you nearly 50% compared to subscribing directly through Microsoft for $20/month ($60 for three months). If you've never shopped at Woot, you can sign in using your Amazon account. You can even start playing a new game today, as Team Ninja revealed a surprise launch for Ninja Gaiden 2 Black, a remaster of the studio's 2008 action game. Team Ninja also unveiled Ninja Gaiden 4, the long-awaited new entry in the classic series, and it'll be on Game Pass when it launches this fall. Xbox also announced release dates for several of its Spring 2025 games, Doom: The Dark Ages (May 15), Clair Obscur: Expedition 33 (April 24), and South of Midnight (April 8). Xbox Game Pass Ultimate 3-Month Code $30.59 (was $50) with promo code SAVETEN (Jan. 23) Xbox Game Pass Ultimate is stackable up to 36 months, but Woot is limiting customers to four codes, meaning you can add a full year to your membership--and play all of the aforementioned games as well as hundreds more. If you bought four codes from Woot, you'd spend $122.36 on one year of Game Pass Ultimate. That's $118 less than the cost of annual membership from the Xbox Store ($240), and $78 less than the cost of four prepaid codes from Amazon ($200).When placing your order, you will need to input your shipping address, but the codes will be delivered to your email. Woot sends a shipping confirmation email with a "tracking number" shortly after your order is finalized. The tracking number is actually the 25-character key that you need to redeem on the Xbox Store. See at Woot See at Amazon Continue Reading at GameSpot
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  • Sea of Thieves: Complete Fishing Guide
    gamerant.com
    Fishing is one of many different things you can do in Sea of Thieves, and it offers a different pace of life in Rare's pirate sandbox. Once you learn the ropes of fishing, it also becomes another way to make money in Sea of Thieves and increase your Hunters Call Reputation, with some species of fish being particularly lucrative. However, learning how to fish in Sea of Thieves can take time, with there being numerous species and varieties to find and catch.
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  • Best RPGs That Focus On Boss Fights
    gamerant.com
    Boss battles are all the rage in most video games, with players loving the idea of taking on tough opponents in epic battles where a single mistake can be the difference between victory and defeat. Some of the best RPGs know how important this part of the game is, integrating a host of challenging fights that push players to their very limits.
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  • Doctor Strange wont be in Avengers: Doomsday, says Benedict Cumberbatch
    www.polygon.com
    Avengers: Doomsday is still more than a year away, but its not too early to learn a few of the movies secrets. For instance, Doctor Strange wont be appearing in this next Avengers film, apparently. Strange actor Benedict Cumberbatch revealed this fact during an interview with Variety, which he immediately realized might be a spoiler, before quickly overcoming his fears with a succinct, fuck it.But dont worry, Benedict, its probably not really a spoiler. After all, who could possibly be surprised at the news that not every Avenger was going to appear in the next team-up movie? The universe has (conservatively) 20 semi-important characters at this point. To fit them all in the entire film would be a montage of introductions with one line each and it would still be over three hours.Another reason it isnt a spoiler is because of what else Cumberbatch revealed in the interview: Strange will be back. In fact, hell be back more than once. For one thing, Cumberbatch has reported that his MCU character is in a lot of Avengers: Secret War, so its not like this world is done with Strange yet, he just doesnt fit into the first films plot. More importantly, Doctor Strange is also getting a third standalone film, so his Avengers absence isnt a sign of his MCU future. But even if this isnt a spoiler, it does provide some interesting insight into the potential plot of Doomsday. For instance, we certainly know that Robert Downey Jr.s Doctor Doom wont be encountering the Avengers all at once. Instead, it seems like the movies will be meting out its immense cast over the first two films.
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  • Hearts of Iron board game will have you fighting the alternate history of WWII in a single sitting
    www.polygon.com
    Steamforged Games has made a name for itself in recent years by creating miniatures-heavy tabletop games out of popular action-based video games. Franchises like Dark Souls, Resident Evil, Monster Hunter, and more have all been adapted with varying degrees of success into board games, card games, and even the odd role-playing game. But now the British publisher is looking a bit closer to home. Its next ambitious project will be adapting the Hearts of Iron series of grand strategy World War II games for the table, where it will compete with more established games like Twilight Imperium.Hearts of Irons latest iteration, Hearts of Iron 4, was released in 2016. It added new and dynamic ways to wage war, including intricate production queues and elastic armies. But none of its features have been more impactful than its take on alternate historical fiction, with novel new ways to fight old battles and lead classic factions to victory. Polygon sat down with the teams at Steamforged and Paradox earlier this week to discuss Hearts of Iron: The Board Game in detail, in advance of a Gamefound campaign launching today.Our interview has been lightly edited for clarity and concision.Polygon: I first met Johan Andersson, designer and producer on Europa Universalis, Crusader Kings, and Hearts of Iron among others, in 2013.Later, in a preview we ran about Hearts of Iron 4 in 2016, he mentioned how on his very last day of interviews there at what would become Paradox Interactive, they invited him to join a game of Axis and Allies the classic WWII board game by the legendary Larry Harris. He sat down with the other folks there, Im sure adjacent to Fredrik Westers garage at the time, and they played through the game for hours.Of course, Axis and Allies may have inspired Hearts of Iron, but theyre not the same game. Theyre very dramatically different experiences Hearts of Iron being much wider, much richer, much more strategic and tactical in depth than Axis and Allies no shade to Mr. Harris. Now, audience appetites for these kinds of 4x games have really expanded. Arcs: Conflict and Collapse in the Reach most recently, a very avant-garde kind of design with a three-act campaign, speaks to that appetite. The Stellaris board game is another attempt. Academy Games conceit was to make a grand strategy 4x game that actually plays in two hours. Twilight Imperium, on the other hand, shed the conceit of timeliness long ago. Those fans dont care how long it is, and they revel in its complexity. They revel in its length.What are your goals going into this project? How do you bring Hearts of Iron back around and even consider fitting it into a board game box?Steve Margetson, lead designer at Steamforged: The main design goal for us is taking the experience and feeling of Hearts of Iron and condensing it down into a board game that is manageable, that feels like Hearts of Iron. Youve got the complexity there that people obviously enjoy as part of that series, but also a big key part of it was we wanted to focus more on something that you can play in a night. Its going to be a longer night, to be sure! Youre looking at three-to-four hours. But we didnt want to do a campaign game that was going to take multiple sessions or even go to the really long lengths of say Twilight Imperium, because yeah, we wanted people to get together, be able to complete World War II in an evening.One of the key pillars is this idea of either playing historically rewriting history, or reliving it. So drawing heavily on the source material there, one of the most interesting things about Hearts of Iron is the fact that you can take the Soviet Union and play them communist, but also there is the question there of, oh, what does a Soviet Union look like if they are going in a down [a] different route, like a monarchy or a theocracy for example? So that was a big, key selling point.The other thing was a big focus on politics at the table. You are allying or going to war with various countries, and that is a thing that you have to declare. Its not something thats just innate in the game. [] Youve got to justify it to your country. Youve got to put in the legwork to manage your country to make it happen.Lets focus then on Soviet Russia for a moment. Out of the box, how do you communicate to the player, Okay, you can be communists, or you can be royalists?Margetson: The way that we do that is, its taking something from the video game that weve adapted called the Focus Tree, and weve broken that down. It is a big tree, and there is a lot of material to mine and create interesting gameplay situations. Weve taken that and broken it down into ideological pairs with countries.When you begin, you are choosing from the ideologies that are available to that nation. Not every nation has every ideology available to it. In the case of our Soviet Union, if youre picking communism you have multiple, different Focus Decks that will determine the way youre scoring points and the additional political options available to you. That choice will give them a suite of options to play within their game. [] With all of these Focus Decks, they are bespoke per country, so that a German monarchy looks very different than a Soviet Union theocracy. Ultimately, Hearts of Iron fans will care about that.The other thing that you bring up is really very interesting to me. I sit down to play Axis and Allies and I know who are the Axis and who are the Allies. Its right on the box! Were starting in 1942, 1944, and its baked into the experience. So how mechanically have you created this justification for war system?Margetson: This ties into those Focus Decks. They will give you ways that youre scoring points, and essentially your overall country goal will be based on your ideology. So, looking at something like a fascist German Reich, that combination will be rewarded for trying to control as much territory as possible, just as they tried to do in history. Whereas a German Reich under a different ideology has different objectives. Perhaps it is looking to ally with a lot more people, or protect certain areas on the map, or things like that. Its one of those where we are dictating these objectives largely by your Focus Deck choice and your ideology.Peter, I turn to you and I think about the long and storied history of this franchise. Why was Steamforged the right partner to help create this expression of it?Peter Nicholson, game director at Paradox Interactive: I think theyve already answered that question in a way, and thats by correctly identifying what makes Hearts of Iron 4 unique. Its not the combat. Its not the fact that its a tactical game. Its the fact that it has these other elements on top of that, things like Focus Trees.I think if you took the first Hearts of Iron through Hearts of Iron 3, maybe even Hearts of Iron 4 at release, and said make a board game youd end up with something that probably resembles Axis and Allies very closely. That game would be one of many tactical combat-based World War II board games.It was only fairly late in Hearts of Iron 4s development midway through, four or five years ago that it really exploded both in popularity, but also in a different sort of game design where we started experimenting with things like alternate histories, the sort of expansive Focus Trees that Steves already mentioned.Of course, all of the Paradox grand strategy games have evolved out of board games themselves. Its sort of the next logical step. If you had a human being that was capable of processing this many things at once and rolling that many dice at once, you would probably end up with board games that look very similar to Hearts of Iron or Europa Universalis. So its an odd task to ask somebody to do, to take something that has evolved from a board game and then turn it back into one, but also in the process of getting there its developed its own identity, its own sort of veneer. As a board game it would be a very stodgy board game, but its developed these unique narrative paths embodied by these Focus Decks and their ideologies.What are the incentives that youre going to be putting into this campaign for potential consumers? What are the things that youre really excited about?Margetsen: The big one, and this is kind of a first for Steamforged, is that were doing a special edition at $120 and a regular edition at $65. In the past we have only tended to offer games with miniatures in our crowdfunding campaigns. Were offering both versions here because we know not everyone is going to want all those hundreds of miniatures.But these miniatures will nonetheless be an exclusive on the campaign. If you want to see those cool historical pieces on the battlefield and be pushing them around like a general, thats one of the incentives there. Eventually, the regular edition will also arrive at retail.Peter, is there anything else about Hearts of Iron, anything about Paradox that you wanted to share with me while Ive got you on the line today?Nicholson: I think actually the way that this project is being built is very similar to the way we build projects at Paradox: Lots of player feedback. I think the early access path is super interesting for Kickstarting things and getting as much player feedback as possible. Thats often how we like to design games, as close to the community as possible. Were often out there and soliciting feedback both on pre-release and release content, for example. So I think its a project thats being built in a very familiar way and its fantastic to see what Steamforged are doing with it. Im looking forward to playing.
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