• RUNX2 promotes fibrosis via an alveolar-to-pathological fibroblast transition
    www.nature.com
    Nature, Published online: 05 February 2025; doi:10.1038/s41586-024-08542-2The use of two mouse models of pulmonary fibrosis helped the identification of the transcription factor RUNX2 as a regulator of the transition of alveolar fibroblasts to pathological fibroblasts.
    0 Comments ·0 Shares ·48 Views
  • Multi-interface licensing of protein import into a phage nucleus
    www.nature.com
    Nature, Published online: 05 February 2025; doi:10.1038/s41586-024-08547-xThis study uncovers a highly conserved jumbo phage protein, Imp1, that possesses multiple interfaces to license protein import into a proteinaceous nucleus-like compartment, using a genetic selection that forces the phage to decrease or abolish the import of specific proteins.
    0 Comments ·0 Shares ·54 Views
  • I just realized that blender doesn't auto update
    i.redd.it
    submitted by /u/Iobeast356 [link] [comments]
    0 Comments ·0 Shares ·47 Views
  • PlayStation California Office Fires an Undisclosed Number of Employees
    cgshares.com
    The industry-wide layoffs show no signs of stopping, as Sony Interactive Entertainment quietly fires an undisclosed number of PlayStation employees, according to former Senior Design Technologist Oscar Diaz, one of the affected workers.First spotted by Reddit user IcePopsicleDragon, Oscar Diazs posts across his social media pages reveal that he and the majority of his team were laid off from PlayStation, with no reason provided for the job cuts.According to Oscars LinkedIn and GitHub pages, he was responsible for building tools and processes related to UI/UX, as well as prototyping new experiences across console, VR, and mobile, indicating which department was impacted. Based on the ex-developers listed residence in San Francisco, it is reasonable to assume that the companys global headquarters in San Mateo was the office affected. At the moment, Oscar appears to be the only developer who has publicly disclosed being laid off, leaving the total number of affected employees unknown.As always, a studios refusal to explain its actions fuels speculation, with the community now theorizing why these particular layoffs have taken place. The most likely explanation appears to be the recently announced full integration of SN Systems, a provider of programming tools for PlayStation developers, into SIE a move made public just a day before Oscars posts about the layoffs and given that both Oscars department and SN Systems specialize in tools development, this theory does indeed sound plausible and may be the reason behind the cuts.A year ago, in February 2024, Sony also let go of some of its employees, but at least back then, they officially acknowledged it, announcing the termination of 900 workers roughly 8% of their global workforce and closing PlayStation London entirely. Following the standard protocol, the layoffs were described as hard, and the dismissed personnel was talented, however, it appears their talents were ultimately deemed unnecessary for Sonys mission to continue bringing the best gaming experiences to the community.Later in the year, the company also shut down Firewalk Studios the developer of what was by far the worst AAA game of 2024, Concord resulting in around 150 developers being laid off.Despite that (and having Concord of all games in their portfolios), some ex-Firewalk members appear to be doing just fine, with it recently coming to light that Pamela Piscitello, the Director of Marketing and Operations behind the infamous hero-shooter, has landed a job as a Senior Product Marketing Manager on the Halo franchise. Couple this with the previous statements from Will Waltz, a developer who spent over 12 years as 343 Industries Senior R&D (Principal) Animator, who back in October denounced Halo Studios executives particularly Studio Head Pierre Hintze describing them as cancer and creatively limiting individuals, and it sure seems like a rough time to be a Halo fan.Dont forget to join our80 Level Talent platformand ournew Discord server, follow us onInstagram,Twitter,LinkedIn,Telegram,TikTok, andThreads,where we share breakdowns, the latest news, awesome artworks, and more.Source link The post PlayStation California Office Fires an Undisclosed Number of Employees appeared first on CG SHARES.
    0 Comments ·0 Shares ·50 Views
  • Less Than Half of Civilization VIIs Players On Steam Are Happy With The Game
    cgshares.com
    After waiting more than eight years, the latest installment of the Civilization franchise is finally around the corner. Although there are a few days until the global release on February 11, early access has been unlocked for those who pre-ordered the Founders Edition.But the reception is not that pleasant, as the Steam review shows that, at the time of writing this article, only 47% of around 5k players gave this game a positive review thats less than half.The main complaint is quite easy to see the UI design feels incomplete or unfinished. One player named sol puts it directly: The UI is abysmal and seems to have been designed by grey aliens or some other soulless being. Another reviewer shared the same feeling, calling the current game bare bones and needs more time to add basic features.The developer Firaxis Games has noticed such universal feedback. In the letter to the community, theyve shared three key areas to be worked on, with the top priority being UI Improvements, including making UI interactions more intuitive, improving map readability, fixing areas of polish like formatting, and more. Besides this, theyll also implement features requested by the community, such as adding teams to multiplayer games, offering a wider variety of map types, enabling city and religion names to be customized, etc. Patch 1.1.0, which brings quality-of-life improvements, will be dropped in March.While players dont like the UI design, and some also mention that the game crashes frequently, the newly added mechanics and features do bring a fresh gameplay experience for the players. It looks possible that the review line will move upward once the blatant issues are corrected.If you missed the gameplay trailer for Sid Meiers Civilization VII, you can watch it below:Join our80 Level Talent platformand ournew Discord server, follow us onInstagram,Twitter,LinkedIn,Telegram,TikTok, andThreads,where we share breakdowns, the latest news, awesome artworks, and more.Source link The post Less Than Half of Civilization VIIs Players On Steam Are Happy With The Game appeared first on CG SHARES.
    0 Comments ·0 Shares ·48 Views
  • 0 Comments ·0 Shares ·21 Views
  • 0 Comments ·0 Shares ·11 Views
  • Switch 2 Rumored Mouse Functionality: Here's How It Could Be Used
    www.gamespot.com
    A few pointers for pointing and clicking...Now that months of speculation and rumors are over, and we finally have seen the Nintendo Switch 2 in action, it's time for what the gaming industry does best: more rumors and speculation!Specifically, we're interested in the rumored mouse technology embedded in the Switch 2's Joy-Con controllers. Rumors are swirling that the Joy-Cons will feature some kind of point-and-click abilities, which offers some intriguing options for future Switch 2 releases. Here are a few potential uses for that mouse technology, as well as the games that could play host to them. Mario KartThe only game confirmed for the Switch 2 so far is a new Mario Kart of some kind--we don't know the name, but we do know it exists thanks to the brief footage we saw during the Switch 2 reveal video. Mouse functionality would work surprisingly well in Mario Kart, and at the very least, we expect the option to be included.The best use we can think of is a custom track editor--a Mario Kart Maker, perhaps--built into this new Mario Kart. Using the mouse, you'd be able to build your own tracks or edit existing ones and then share them and compete with other players for top times on those custom tracks. Point-and-click portsThere are a wealth of classic point-and-click adventures that would feel right at home on Switch 2 if this mouse functionality comes to pass. The Switch is already good at hitting those nostalgia notes, and bringing the classic PC adventure scene to life would be a treat.Monkey Island, Myst, Full Throttle, Day of the Tentacle, Maniac Mansion, and more are ripe for the picking if Nintendo really is packing each Joy-Con with a computer-like mouse. Those are just the classics too; recent point-and-click success stories like Norco, Slay The Princess, and Unpacking would fit the bill too. Really, any game that involves directing a cursor around the screen, like A Little to the Left, could benefit from mouse functionality. Strategy gamesOne genre that tends to lose some luster when coming from PC to console is the strategy game. XCOM and Civilization, for example, are no strangers to the Switch, but the point-and-click experience on PC is the best way to play massive strategy games like those. Civ 7 should be playable on Switch 2 through backwards compatibility, but if 2K decided to make the jump and create an enhanced Switch 2 version, the mouse tech would be a huge boon.This concept isn't limited to those franchises either, as any strategy game would benefit from this new Joy-Con feature. Even two of Nintendo's exclusives--Advance Wars and Fire Emblem--could find benefits from a point-and-click control scheme. First-person shootersThere's an ages-old argument between FPS fans as to what makes for a better control scheme between a console controller and a keyboard-and-mouse setup. Switch 2 could offer a hybrid of sorts, with one Joy-Con becoming the mouse and the other serving as the buttons on a controller.It would take some adjustment, but the precision aiming offered with a mouse mixed with the simple button scheme of a controller might make a powerful new way to play something like Call Of Duty or Halo. Also, while it's not yet confirmed to receive an enhanced Switch 2 port, Metroid Prime 4 could serve as an intriguing test case if that port does surface. F-ZeroMario Kart isn't the only one in Nintendo's portfolio. For many fans, the sci-fi racer F-Zero is long overdue for a new entry, be it a reboot or a sequel, and whatever it is, a mouse-control option for throttling, braking, and turning could be a neat way to set it apart.In fact, Nintendo would have the creative freedom to design each F-Zero race car's cockpit to fully capitalize on the mouse functions of the Joy-Cons. Imagine thrusting both Joy-Cons in front of you quickly in order to activate a turbo boost; that sounds like a ton of fun. Star FoxSticking with Nintendo and sci-fi, Star Fox would be a prime candidate for a throttle/braking system made possible by a mouse-based control scheme. Some might argue that ships like the Arwing might be better suited for the scheme--which could open the door for plane-based racing in Mario Kart too, now that we think about it or the revival of Diddy Kong Racing.As for Star Fox, deftly steering through an on-rails space mission using Joy-Cons on the desk seems like a natural fit. We haven't worked out how to do a barrel roll though, and we don't think people will be keen on spinning in circles on their couches. Also, history shows that new Star Fox games tend to come packaged with some unique control scheme, so using a mouse would continue the trend. MMORPGsLook, hear us out on this one: MMOs have worked on consoles before--Final Fantasy XIV is a prime example. However, among the reasons one of the most famous MMORPGs ever made--World Of Warcraft--has never made the jump is that the game simply functions at its best with a keyboard and mouse on PC.While Switch 2 won't be offering any keyboard (that we know of), bringing the mouse function to the console would go a long way in bridging the gap, and perhaps we could see WoW join the Switch 2 lineup. Heck, if it works well enough, maybe we'll finally see that Pokemon MMO fans have wanted for years. Star Wars SquadronsThinking of Star Fox has us immediately jumping to perhaps the most famous sci-fi franchise out there: Star Wars. 2020's Star Wars Squadrons would make an excellent candidate for a Switch 2 port showing off this new tech; piloting an X-Wing with the new Joy-Con mouse tech would be pretty hard to pass up.There are other flight sims out there--and we'll get to another big one in a second--but Star Wars Squadrons would make a ton of sense as the franchise's Switch 2 debut. Then again, a remake of Rogue Squadron from the N64 days would be neat too, but Squadrons's modern tech might make for an easier transition. Microsoft Flight Simulator 2024Phil Spencer and his team are quite keen on getting Xbox first-party games on as many devices as possible, right? While Halo and that new Banjo-Kazooie that we all want to come eventually are great choices, this rumored mouse tech opens the door--or rather, the cockpit--for another Microsoft stalwart: Flight Simulator.Flight Simulator is a technically intense game, so this would take some wizardry on the part of Xbox and Nintendo, possibly via the cloud. However, being able to take off in a private jet or commercial airliner using the Joy-Cons seems like it would be a good time, and we wouldn't be surprised if Xbox explored the idea. A new Mario PaintFinally, many players of the older generation probably read those Switch 2 rumors and thought about the last time Nintendo dabbled with a mouse: Mario Paint on the Super Nintendo. If it was possible in 1992, it's certainly achievable in 2025; a new era of Mario Paint is now in the cards.Mario Paint is hard to describe; it's Photoshop, Paint, Pro Tools, GarageBand, and a fly-swatting minigame all rolled up into one neat little cartridge. Unleashing that creative energy onto Switch 2 could open up a whole new avenue of gameplay possibility, goofy memes, and who knows what else. If Mario Paint does come back, though, those chanting fellows have to come back too.
    0 Comments ·0 Shares ·20 Views
  • Call Of Duty: Black Ops 6 Multiplayer And Zombies Are Free To Play This Weekend
    www.gamespot.com
    Call of Duty: Black Ops 6 has been out for a few months, but Activision has continuously added new content to the game. And with the recent launch of Black Ops 6 Season 2, Activision is offering any lapsed players or or new fans a chance to join in on the multiplayer and zombie-killing fun for free.Activision shared the announcement on the official Call of Duty site, and revealed that the free period will extend from today, February 6, to February 10. As part of the event, new players will be able to experience some of Season 2's additions, including the Bounty and Dealership maps that are respectively set in a massive skyscraper and a car dealership. Playlists available during during this free period include Nuketown 24/7 and Stakeout 24/7. But not every single map will be included.Zombie mode players will be able to check out Season 2's latest map, The Tomb, which is set at an archeological site that has uncovered ancient catacombs and may hide secrets related to the zombie outbreak. Players can also experience the main quest through the team's next stop at Liberty Falls. There's even a Directed Mode for Liberty Falls that guides players through the objectives they need to hit.Continue Reading at GameSpot
    0 Comments ·0 Shares ·23 Views
  • Blox Fruits: How To Get Magma Ore
    gamerant.com
    While playing Blox Fruits, players can collect dozens of different materials. Some of them are needed for crafting, while others are required to learn new abilities. But, few resources can compete in usefulness with Magma Ore. This guide will detail how to get and use Magma Ore in Blox Fruits.
    0 Comments ·0 Shares ·24 Views