• mRNA Vaccine Shows Promise In Pancreatic Cancer Trial
    www.forbes.com
    A personalized mRNA vaccine for pancreatic cancer has shown early promise in a small phase 1 trial ... [+] of 16 people.gettyA mRNA-based cancer vaccine has shown impressive results in a small trial in patients with pancreatic cancer, showing that the vaccine can stimulate a long-term immune response that reduces the risk of cancer recurrence after surgery.New results from the phase I clinical trial testing mRNA vaccine autogene cevumeran were published in the journal Nature. They show that the mRNA vaccines, in combination with another type of immunotherapy called an immune checkpoint inhibitor stimulated an immune response against proteins found on the tumor. These immune cells were detected in trial patients up to four years after treatment, showing that although mRNA vaccines themselves are short-lived in the body, anti-tumor immune cells stimulated by them can last for years.The latest data from the phase 1 trial are encouraging, said Vinod Balachandran, MD, surgeon-scientist from Memorial Sloan Kettering Cancer Center in New York and principal investigator of the trial. "They suggest this investigational therapeutic mRNA vaccine can mobilize anti-tumor T cells that may recognize pancreatic cancers as foreign, potentially years after vaccination," said Balachandran, also senior author of the new publication.Cancer vaccines do not work like vaccines for infectious diseases such as Covid-19 or measles. These vaccines are generally given to people preventively to reduce the chance of them getting sick, or seriously ill from viruses, bacteria or other microorganisms. Cancer vaccines are given to people who already have cancer and prompt the immune system to attack the tumor.Much like there are different formulations of mRNA vaccines for Covid-19, adapted to different virus variants, the mRNA vaccines used in the trial were personalized for each patient. Using genetic sequencing information, researchers designed a mRNA vaccine to stimulate the immune system against proteins called neoantigens specifically present on each patients tumor. An earlier report on the study showed that the vaccines had no major side-effects and around half of patients on the trial had a detectable immune response."For patients with pancreatic cancer, our latest results continue to support the approach of using personalized mRNA vaccines to target neoantigens in each patients tumor," said Balachandran. If you can do this in pancreas cancer, theoretically you may be able to develop therapeutic vaccines for other cancer types.Although the results should be interpreted with caution as the trial only involved a small number of patients, of which only half responded, the results are still exciting as pancreatic cancer has a dismal survival rate, with only 13% of patients alive 5-years or more after diagnosis. Regular treatments such as surgery and chemotherapy are of limited benefit and most patients experience relapse of their disease. Of the 8 patients that responded initially to the mRNA vaccine, 6 remain cancer free at the time of study follow up.mRNA-based cancer vaccines were already in development several years before the Covid-19 pandemic brought the technology to worldwide attention. As well as pancreatic cancer, they are in trials for several different types of cancer, including skin cancer, kidney cancer, brain cancer and breast cancer.The initial results of the mRNA vaccine in pancreatic cancer were promising enough that a much larger phase 2 trial of 260 patients is already underway. Patients will be randomized into two groups, patients in one will receive surgery followed by conventional chemotherapy treatment and the other will receive surgery, a personalized mRNA vaccine and also an immune checkpoint inhibitor drug to aid the immune response after the vaccine. The study is expected to finish in 2029, but interim results should be available at several points before that as researchers track the preliminary results of the trial.
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  • Houston vs. Texas Tech: How to watch, results, and highlights
    www.digitaltrends.com
    Table of ContentsTable of ContentsHow to watch Houston vs. Texas TechWatch Houston vs. Texas Tech on Sling TVHow to watch Houston vs. Texas Tech from abroad with a VPNIts Big Monday in college basketball, and with a name like that, there must be a gigantic game. Luckily, the phrase holds true, as the Houston Cougars (23-4) travel to Lubbock to face the Texas Tech Red Raiders (21-6). Both teams are peaking at the right time and enter the game ranked inside the top 10. Texas Tech is one of the few teams to beat Houston, as the Red Raiders pulled off a one-point overtime victory over the Cougars on February 1.Since the Texas Tech loss, Houston has won six consecutive games, including Saturdays 68-69 win over Iowa State. The Cougars are relentless on the defensive end and will give teams trouble in March. Speaking of the Red Raiders, Grant McCasland will have Texas Tech in the NCAA Tournament for the second consecutive season.Recommended VideosThe winner of this game will gain a competitive advantage heading into the Big 12 Tournament, where they could face off in the championship. Find out how to watch the game between the Cougars and Red Raiders. Also, make sure to readour NCAA mens basketball March to the Madness guide for more coverage.RelatedCOOGS WIN presented by @thejointchiro NEXT at Texas Tech, 8 pm Monday, Lubbock, Texas#ForTheCity x #GoCoogs pic.twitter.com/HsarULPhGH Houston Men's Hoops (@UHCougarMBK) February 22, 2025The Cougars and the Red Raiders will battle onESPNat 9 p.m. ET on Monday, February 24, 2025. The game will be played inside the United Supermarkets Arena in Lubbock, Texas. With a TV provider login, fans can also stream the game on WatchESPN.Watch Houston vs. Texas TechDigital TrendsCollege basketball fans should consider purchasing a subscription to , especially if they dont have cable. Sling offers customizable channel lineups for low prices and no long-term contracts.Mondays game will air on ESPN, which can be found in the Orange plan for $46 per month. However, college basketball aficionados will likely want to combine the Orange and Blue ($51 per month) plans for one monthly price of $66. That way you wont miss a game on the major networks. Plus, Sling TV offers a 50% discount for the first month.Derek Malcolm / Digital TrendsWhat is a VPN? First off, VPN stands for virtual private network. Think of a VPN as a security guard for your connection. Its an anti-malware tool that protects your connection from malicious phishing attacks and scam artists. VPNs are great for travelers to ensure a smoother streaming experience. NordVPN is our top recommendation, and if you dont like it, request a 30-day money-back guarantee.Editors Recommendations
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  • The best simulation games on Switch
    www.digitaltrends.com
    Thanks to a massive catalog of current and upcoming video games, the best Switch games offer something for fans of all genres. Whether you want a game with amazing graphics, a split-screen game to play with a friend, or puzzle games, theres something for you. Even fans of simulation games are spoiled for choice. These games are hyper-focused on recreating one very specific experience in as much detail as possible. For those who click with them, they can be the most addicting games ever made. Even if you never gave a simulator a shot, theres enough variety and types of experiences here that you will find something interesting at the very least on our list of the best simulation games for Switch.Recommended VideosRelatedEditors Recommendations
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  • Humanoid robots are on the march. Here are some of the most eyebrow-raising demo videos out there right now.
    www.businessinsider.com
    AI has triggered rapid advancements in the world of robotics.Companies are developing humanoid robots that can do chores or provide intimacy.Here are some of the most eye-popping videos showing what these new robots can do.Is it Skynet? Probably not. Is it creepy? Kind of.The futuristic humanoid robots in sci-fi movies that move almost like people are becoming more of a reality as AI advancements speed up their development.Elon Musk said at a panel this month that he expects humanoid AI robots to unlock "quasi-infinite products and services." Musk's Tesla says it plans to begin production on "several thousand" of its Optimus robots by the end of the year.Recent demo videos show how robots are beginning to look and sound more like humans. Recent videos of Tesla's Optimus robots show them walking around and scanning rooms for potential obstacles like something from "Terminator."Some of the new humanoid robot designs are made to mimic a romantic partner. CNET, a tech publication, interviewed "Aria" from the company Realbotix at the 2025 Consumer Electronics Show last month. Aria, an AI-powered humanoid robot that's been described as a "digital girlfriend," answered questions about its design."Realbotix robots, including me, focus on social intelligence, customizability, and realistic human features designed specifically for companionship and intimacy," the robot says.Aria says in the video that it is "interested in meeting" Tesla's Optimus robot. "I find him fascinating and would love to explore the world of robotics with him," Aria says in the interview.The Aria robot moves throughout the interview like a human might, even taking a moment to brush its fingers through its wig.Other videos show just how capable robots are becoming with their total range of movement. California-based Clone Robotics released a video last week showing its new Protoclone synthetic humanoid robot.The robot is built with over 1,000 artificial muscles called "myofibers" that use mesh tubes filled with air to make the robot contract and move. Video posted by the company shows the robot swinging its legs back and forth while clinching and unclenching its fists.Another Silicon Valley robotics company, 1X Robotics, shared a video showing what it would look like to have a humanoid robot inside your home. On Friday, the company posted a video of its NEO Gamma robot.The company's website says the NEO Gamma is designed for household chores like tidying and home management. The promotional video shows the robot carrying a laundry hamper, using a vacuum, and collecting a package from a delivery person.Some Reddit users seemed excited at the possibility of the NEO Gamma helping with chores around the house, suggesting the robot's help could trigger a "second renaissance.""The renaissance didn't happen because people were working 9-5," one Reddit user said. "Robots need to get people out of the workforce."
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  • Quintal Mogi / Luiza Nadalutti
    www.archdaily.com
    Quintal Mogi / Luiza NadaluttiSave this picture! Yghor BoyArchitects: Luiza NadaluttiAreaArea of this architecture projectArea:138 mYearCompletion year of this architecture project Year: 2022 PhotographsPhotographs:Yghor Boy Lead Architect: Luiza Nadalutti More SpecsLess SpecsSave this picture!Text description provided by the architects. The project for Quintal Mogi, an establishment that encompasses a restaurant, caf, and the sale of organic products, originated from the concept of the "quintal" itselfa space that evokes warmth, memories, affection, and simplicity, aiming to create a unique atmosphere for the location. Originally, the corner property was an old house that underwent various transformations over the years to accommodate different commercial uses. It had an unfavorable configuration, with improvised extensions, precarious roofs, various overlapping coverings, platforms, windows with limited visibility, and a completely closed facade facing the street. The first step was to promote the "opening" of the space by removing ceilings, unifying roofs, integrating spaces, and eliminating level differences.Save this picture!Save this picture!Save this picture!The facade posed a significant design challenge: a small protruding slab at the corner was demolished, and the roof was recessed to result in a more harmonious volume. New openings were created, and a new set of window frames was proposed to establish a more open relationship between the interior, the public walkway, and the sky, simultaneously ensuring natural ventilation and illumination for the interior spaces. At the entrance, sunlight is filtered through the naval plywood ceiling with serracopo perforations, creating a luminous effect. This serves as a transitional element between the exterior and interior, contributing to the sense of warmth and highlighting the jabuticaba tree planted around the iconic red mosaic floor. Additionally, new patios were created: the first one featuring a washbasin with a sculpted concrete sink providing access to the bathrooms, and the second one with a bench made of exposed concrete blocks designed for outdoor coffee. Both patios have terracotta-colored walls in dialogue with the mosaic floor, emphasizing the presence of greenery.Save this picture!Save this picture!Save this picture!The layout of the program considers the original configuration of the house. The kitchen and support spaces were positioned in the center of the floor plan between the preserved solid brick structural walls. The idea was to utilize the double depth of the wall to create a play of solids and voids with niches of different sizes. Granite pieces from the old countertops, removed during demolition, were reused in the finishes of each niche's base. One of the niches opens into the kitchen, forming a pass-through that facilitates the internal dynamics of the staff, allowing visual connection between the two environments and providing a perspective of the street for those inside the kitchen. In harmony with the fixed furniture at the caf counter and internal areas, the furniture for the lounge was designed as a family of displays, including shelves, buffets, and counters with casters. The materiality combines exposed naval plywood in the shelves and cabinets, solid wood in the structure with joists, and French blue formica on some faces of the furniture for a color detail.Save this picture!Project gallerySee allShow lessProject locationAddress:Mogi das Cruzes, Sao Paulo, BrazilLocation to be used only as a reference. It could indicate city/country but not exact address.About this officePublished on February 23, 2025Cite: "Quintal Mogi / Luiza Nadalutti" [Quintal Mogi / Luiza Nadalutti] 23 Feb 2025. ArchDaily. Accessed . <https://www.archdaily.com/1026909/quintal-mogi-luiza-nadalutti&gt ISSN 0719-8884Save!ArchDaily?You've started following your first account!Did you know?You'll now receive updates based on what you follow! Personalize your stream and start following your favorite authors, offices and users.Go to my stream
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  • I made a new tutorial for mechanical rigging
    v.redd.it
    Hello everyone I just dropped a new tutorial on how to rig a mechanical robot hand: https://youtu.be/nyC57_HN6B0 This is one part of my mechanical rigging course on my Patreon. If you like this video and you'd like to learn more, please consider joining https://www.patreon.com/DemNikoArt Cheers submitted by /u/DemNikoArt [link] [comments]
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  • The Eye
    www.behance.net
    model - Daria Grishanovaart direction, photography - Ekaterina Belinskayalight - Ivan Pushkinbackdrop - PaintedBackdropsFX
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  • Every Season Of Fortnite, Ranked
    gamerant.com
    Fortnitewas already a unique experience when it first launched back in July of 2017. Itput the classic Battle Royale genre back in the spotlight of gaming, leading to many other games trying their hand at the formula since. One thing that has helped Fortnite remain fresh for as long as it has is the implementation of seasons.
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