Forward-thinking businesses – and even nations – are upskilling mid-career professionals to help them not only survive but prosper in the era of widespread enterprise artificial intelligence (AI). As businesses and public sector organisations adopt AI at a lightning pace, white-collar professions face huge disruption, not unlike that experienced by nineteenth century blue-collar workers. According to research by OpenAI and the University of Pennsylvania, roles that will be affected include accountants, legal assistants, financial analysts, journalists, translators and public relations professionals. Meanwhile, Goldman Sachs published figures in March 2023 that spoke of 300 million jobs exposed to AI across all sectors. Although it’s a concept dating back decades, the widespread take-up of generative AI (GenAI) began around 2022 with the release of ChatGPT. It was a wake-up call for governments and businesses alike, which must prepare for inevitable disruption. According to Tram Anh Nguyen, co-founder of the centre for finance, technology and entrepreneurship (CFTE), people over the age of 40 in mid-career professional roles are the most at risk of major job disruption as businesses integrate AI into their operations. CFTE is a global education platform that specialises in training in the finance sector, including teaching AI in finance. Nguyen, who is also Global Women in AI chair, spent decades working in the finance sector in business roles, said: “AI is no longer a future concept. It’s here and it’s affecting everyone at every level.” But this does not mean professionals will be replaced if they are re-trained – and this does not just mean technical training. Training on AI for non-technical roles will encompass professionals learning underlying knowledge about AI, the AI tools available to them and the use cases for AI in their roles, said Nguyen. In its whitepaper titled The AI-fication of talents, CFTE said three groups of professionals will emerge. It reported that there will be: “mass displacement” of roles centred on execution which will be increasingly automated; “supercharged professionals” will emerge who use AI to expand scope and scale; while “creative disruptors” will be small group inventing new models, products and systems. Nguyen warned that the UK is behind in readying the workforce for AI. “We are not preparing people in the right way because the focus is not on adult education at scale,” she told Computer Weekly. She cited a project in Singapore which CFTE helped to design. It involves supporting mid-career transitions, particularly focusing on technology and finance sectors, while providing financial support to help people switching careers. All Singaporeans aged 40 and above received funds to refresh their skills, with a large proportion taking up IT-related courses in areas including artificial intelligence. Around 555,000 people participated in programmes supported by SkillsFuture Singapore (SSG) in 2024 and 520,000 in 2023, according to Singapore newspaper The Straits Times. These are significant numbers for Singapore, which has a population of around six million, but the same challenge is faced globally. One sector being heavily affected is financial services, which leads the way in AI innovation and investment. For example, Bloomberg Intelligence recently put the number of jobs set to be replaced by AI in the US finance sector – Wall Street specifically – at hundreds of thousands. CIOs questioned by the organisation expected 3% of their workforce to be cut on average. Around a quarter of respondents expect the workforce to be cut by between 5% and 10% as AI takes over roles, with the back and middle offices to be most affected. According to research by banking industry benchmarking firm Evident, AI-related roles could be the only “safe jobs” in the banking sector as financial organisations “relentlessly” press on with AI-led transformation. It’s banking industry report found that recruitment of AI development professionals grew by 6% in the last year, hiring of data engineers increased by 14%, and the number of AI and software implementation experts hired increased by 42%. But while the finance sector finds itself on the front-line of the AI revolution, the technology’s rapid spread goes way beyond. Bloomberg’s head of AI, Amanda Stent, recently told Computer Weekly in an interview that there has been “no revolution in history that has not led to job transformation”. “Some types of job change, some types of job go away,” they added. “But there’s also no revolution in history that hasn’t led to more jobs created overall, I think that is true with AI, which will augment a lot of people.” Stent said all workers, regardless of their roles, will have to learn to use AI: “We can teach people how to be effective users of AI without needing to know all that maths.” The legal sector is an example of a traditional industry adapting to AI. The UK regulator of solicitors, the Solicitors Regulation Authority, recently authorised the first law firm to provide legal services purely through AI. Mark Lewis, a lawyer at Stephenson Hardwood, specialised in technology, said most, “if not virtually all, serious law firms” are deploying AI and GenAI operationally. “Typical use cases include document review, analysis and summarisation, legal research, case research and predicting the outcomes of cases, reviewing and reporting on the application of regulations around the world, and, of course, in law firm back-office operations – for example, in client due diligence and acceptance.” But he added that AI is not “yet” causing “major disruption” in the legal sector: “As with talk of AI disrupting many sectors, including doing away with the work now done by paralegals, junior lawyers, and even senior lawyers, this hasn’t really happened yet in the legal markets here – or, I think, anywhere. “There is a good deal of the usual tech hype about it. No doubt AI will become integral to legal process and lawyering at all levels, but, as in many other sectors, even that is going to take time and the maturing of legal use cases.” He said firms are, however, preparing for the impact of AI: “We, like many firms, have made available to all our lawyers GenAI tools developed specifically for us, to be used within certain parameters and in accordance with our AI/GenAI policies. “We want our lawyers to use these GenAI tools, to become accustomed to the way it processes work, to understand its strengths and limitations, and to become expert in creating and refining prompts. “For me, there is an even more important – existential – point: the single biggest challenge is how we as a society learn to understand, live and work with AI. It should start as early as possible and continue through our lives.” In the IT sector, AI is a huge business opportunity, but the technology is also transforming how suppliers operate. Workers in the IT sector will also have to learn to work with AI. Amrinder Singh, head of EMEA and APAC operations at Indian IT services firm Hexaware, told Computer Weekly that all the company’s staff, around 30,000, will be trained how to harness AI. He put it in startling terms the risks to workers that are not trained up. “We said that there is no future for single-skilled people,” he said. “Unless you are multi-skilled with domain understanding, as well as understanding how to use AI and technology, you will not survive.” Read more about GenAI

Based on more than 200 interviews with former Apple execs and engineers, Patrick McGee’s Apple in China – The Capture of the World’s Greatest Company ought to leave Tim Cook laying awake at night. It makes a convincing argument that the iPhone could be killed overnight should the Chinese government wish it. This is a book reminiscent of Walter Isaacson’s Steve Jobs in its careful research and the detailed inside stories it tells about Apple. The company’s official line is that it’s full of inaccuracies, but the case it makes is an incredibly persuasive one … The beginning of the story is, of course, well-known. By early in 1996, Apple was losing money on every product it sold. The company’s treasurer warned the board that the company would run out of money in around May of that year. To save itself, Apple sold its own manufacturing plants and made the decision to outsource all production. While the company tried a number of different countries along the way, it wasn’t long before production was shifted to Taiwanese companies with manufacturing plants in China. Taiwan and China offered the scale and cost structure needed for Apple products to be profitable, but what they couldn’t offer was the precision and focus on excellence demanded by Steve Jobs. Apple solved this problem by sending plane-loads of its own engineers to the country, embedding them into local factories in order to teach its fledgling suppliers how to make quality products. That wasn’t just in production lines for Apple’s own products, but those of the entire supply chain – many hundreds of companies in all. And Apple didn’t want to have single points of failure in its supply chain, so it brought its money and training to many more Chinese manufacturers than it actually needed, helping train, fund, and modernize a huge chunk of the country’s economy. Apple itself estimates it directly and indirectly trained around 28 million people, and McGee estimates that the company put a staggering $275B into upgrading the country’s manufacturing capabilities during the first five years. Effectively, Apple helped transform China from a cheap source of shoddy products into the most advanced manufacturing center the world has ever seen. In particular, what seemed like a key Apple strength would ultimately prove deeply problematic. The company’s power in negotiating incredibly low pricing meant that the iPhone maker not only taught China how to mass-produce high-quality, premium products – but also how to cut costs without affecting quality. That had three enormous impacts: On Apple On the US economy On the global economy Apple: The company invested so much money and intensive training into Taiwanese and Chinese manufacturing plants that, in time, there was nowhere else its products could be made. McGee notes that while Apple makes much of its Made In India iPhones, the reality is that only final assembly is carried out in the country. Everything assembled originates elsewhere, and in most cases that’s Taiwan or China. The US economy: That ability to conduct precision, quality manufacturing at unbeatable prices meant that China became an unstoppable production powerhouse. American companies simply couldn’t compete, and over time more and more US production moved to China. It wasn’t just Apple which was now completely dependent on China, but almost all other American companies too. The global economy: Where consumers once faced a choice between quality western products, and cheap Chinese ones, Apple had taught the country how to make cheap, quality products. That meant that Chinese brands like Huawei started competing on the global market, including in the premium tiers once the preserve of the top western brands. The most chilling claim in the book is that if China ever decides to shut the door on Apple, it can. Overnight. “They can lower the boom on you in a million different ways,” says Brady MacKay, the former US special agent who has witnessed Beijing deploy a number of tactics against other companies to make its point. “Like, raw materials- they can shut that off in a heartbeat,” he says. “Electricity—all of a sudden it’s only available four hours a day.” If China ever decides that manufacturing for Apple is less lucrative than killing the iPhone in order to create massively more demand for premium Chinese brands, Apple is dead in the water. That’s the core thesis of the book – and the argument is very well made. I highly recommend reading it. Apple in China is available on iBooks and Amazon (Kindle, hardback, and audiobook versions). Add 9to5Mac to your Google News feed.  FTC: We use income earning auto affiliate links. More.You’re reading 9to5Mac — experts who break news about Apple and its surrounding ecosystem, day after day. Be sure to check out our homepage for all the latest news, and follow 9to5Mac on Twitter, Facebook, and LinkedIn to stay in the loop. Don’t know where to start? Check out our exclusive stories, reviews, how-tos, and subscribe to our YouTube channel

Jerald of Rumare Oblivion Remastered's radiant quest hero is at it again: here's a Witcher-ish mod that lets warriors become full-time professional monster slayers They're seemingly planning on adding a heap more battles to the Imperial City's Arena next, because Adoring Fans call for bloodshed. Image credit: Bethesda/VG247 News by Mark Warren Senior Staff Writer Published on May 15, 2025 The Fighters Guild's the only of the big four main faction questlines in Oblivion and therefore also Oblivion Remastered in which warhammer-wielding juggernaughts don't feel a bit out of place (props to Gogron gro-Bolmog for defying stereotypes), and thanks to a new mod, I might actually think about abandoning my stealth archer to play one. Just the other day, modder ColdTyrant released an interesting mod that added a whole radiant contract system to the Dark Brotherhood, allowing you to go on killing forever and net some gacha rewards. Well, literally a day later, they're back at it again with the faction that ends up - spoilers - battling some tree sap drinkers. To see this content please enable targeting cookies. This latest entry in what's fast morphed into a series is called 'Fighter's Guild - Infinitum' and it adds "over 100 randomly selected, infinitely repeatable Monster Hunting contracts" to the titular faction, giving them a full radiant quest system. Much like with the Dark Brotherhood mod I mentioned earlier, it works by giving you a place to go to be given notes setting you off on missions to kill a specific target - this time different monsters in dungeons across Cyrodiil - then turn them in for a nice reward. Each target monster has been made to glow a bit so they stand out from the cave-dwelling crowd Sadly, there looks to be no Morrowindy gacha element to the dishing out of loot this time around. You'll get 500 gold per contract, plus two "Fighter's Commendations", the latter being a special currency you can spend to requisition gear from a new Fighter's Guild Store the mod adds to the basement of the faction's Leyawiin chapter. Then again, ColdTyrant does write that they've given you the option of making the top floor of the Leyawiin guildhall your hangout by switching around the NPC schedules, making it a bit harder to moan. All in all, it sounds cool, and an interesting option if you fancy creating a character that makes their living in a similar fashion to The Witcher's big Gerry. You might as well, it's Oblivion, so there's a 95% chance your character's appearance is already freaky in a way that might lead to them being shunned by most of society. If you fancy giving Fighter's Guild - Infinitum a go, you'll need to grab the mod's requirements - Oblivion Remastered's UE4SS and UE4SS TesSyncMapInjector. It's also worth noting that ColdTyrant's suggested in the mod page's comments section that their next project is going to be an Oblivion Remastered mod like this for the Imperial City's Arena. Say hi to Modryn Oreyn for me if you decide to join the Fighters Guild in your next playthrough, and make sure to check out the rest of our ongoing Oblivion Remastered mod coverage.

doops. Member Jun 3, 2020 5,069 Stumbled upon this list on Backloggd, and was intrigued to hear if anyone has any other games that could be applicable or any takes on the ones already mentioned? 'Narratives that can only exist in video game media' a list of games by Paggi | Backloggd Its somewhat normalized that narrative excellence in games means mirroring books and cinema Not only thats far from the truth but some games have used the media they represent to achieve a whole new level of writing backloggd.com List is: OneShot Nier: Automata Shadow of the Colossus The Silver Case Undertale Danganronpa V3: Killing Harmony EarthBound INSIDE Spec Ops: The Line Death Stranding Alan Wake II The Stanley Parable Return of the Obra Dinn Portal Immortality Legend of Mana   Busaiku Teyvat Traveler Member Oct 25, 2017 17,821 9 Hours, 9 Persons, 9 Doors   Glasfrut Avenger Oct 27, 2017 4,824 Does the first Bioshock go here?   OP OP doops. Member Jun 3, 2020 5,069 Glasfrut said: Does the first Bioshock go here? Click to expand... Click to shrink... Ooo, yeah, that's a good pick!  Gangster Gastino Member Mar 21, 2018 2,805 Eternal Darkness   Mr Evil 37 Member Mar 7, 2022 27,539 Disco Elysium KOTOR  southwest Member Sep 15, 2022 2,718 Glasfrut said: Does the first Bioshock go here? Click to expand... Click to shrink... Why?   JakeNoseIt Catch My Drift Verified Oct 27, 2017 4,744 I think you could argue for almost any game to be on this list. The second there is gameplay, there is narrative (and then obviously that narrative couldn't exist in film or TV)   barbarash22 Member Oct 19, 2019 820 Soma   hiberner toujours Member Dec 6, 2023 1,756 13 sentinels   PallasKitten Member Jul 11, 2022 1,776 Brothers: A Tale of Two Sons The House in Fata Morgana Doki Doki Literature Club  Holundrian Member Oct 25, 2017 11,122 Probably every Daniel Mullins game   OP OP doops. Member Jun 3, 2020 5,069 JakeNoseIt said: I think you could argue for almost any game to be on this list. The second there is gameplay, there is narrative (and then obviously that narrative couldn't exist in film or TV) Click to expand... Click to shrink... Well, technically yes, but that's not as fun for discussion lol  Rustyspider13 Shinra Employee Member Nov 16, 2023 3,587 I'm not sure if the entire story counts but a moment in Brothers: A tale of Two Sons cannot be accomplished outside of video games.   blueredandgold Member Oct 25, 2017 8,626 Spoilers OK if marked? 999 on DS has you hooked until the last 10% or maybe even 5% of the game where the rug is literally pulled out from under you and you are forced to think about every action you as this external detached player character has made throughout the story seemingly while only acting out as the protaganist. Gone Home is by rights a "spooky house and you're all on your own" story at first but it transforms into a beautiful story about youth, family and discovering one's true self. Mario and Luigi Bowser's Inside Story explores what makes the big man tick. Like, literally. Killer 7 on the outside and at the outset is a bonkers third person shoot-em-up and puzzle infused cel shaded action game but t's more a visual novel that's a really interesting character study of a person's personality. Or how it might become more than just singular. RTS games by and large that try and categorise you as someone in-game never sat well with me. I quite liked being more of the invisible hand guiding the events or having the entire campaign come crashing down on me like it's that movie Downfall and I need to yell at everybody, Semi-recently. I can't not mention 1000x Resist. I even was able to stomach voice acting in a video game for once. I'm as surprised as anybody. Play these games. Thank me later.  Boopers Member Nov 1, 2020 4,303 Vermont usa Dragon's Dogma, kinda sorta.   Ashes of Dreams Fallen Guardian of Unshakable Resolve Member May 22, 2020 19,573 Didn't people like the Nier Automata anime? I haven't watched it but I heard it did a decent enough job. What about that story can only exist in a video game? I guess the final bit to an extent but if anything, I'd say the first Nier is a much better pick for that, given it's use of the NG+ mechanic. Edit: Thinking about this list further, I think it's title is doing it a disservice. It should have just been "games that use game specific elements to enhance the narrative" or "narratives made better by being in a game" or something.  Kromis Member Oct 29, 2017 8,083 SoCal Why is Shadow of the Colossus on that list? Haven't played it in almost two decades :')   ynthrepic Member Oct 25, 2017 891 Ashes of Dreams said: Didn't people like the Nier Automata anime? I haven't watched it but I heard it did a decent enough job. What about that story can only exist in a video game? Click to expand... Click to shrink... Its less the main narrative and everything else supporting it. Game mechanics given context in ways that are lost outside the medium.  blueredandgold Member Oct 25, 2017 8,626 Ashes of Dreams said: Didn't people like the Nier Automata anime? I haven't watched it but I heard it did a decent enough job. What about that story can only exist in a video game? Click to expand... Click to shrink... The answer to that is a spoiler and it's also partly due to the fact you can literally come away from it having completely different interpretations of the story, and exactly how it was resolved, compared to another person. I don't fully understand the over-arching thrust of the game's final act/ending but I also don't entirely mind that fact, either. Whereas in a standard three-act story you know what happened at least happened to the other people who experienced the same story as you.  Mr Evil 37 Member Mar 7, 2022 27,539 southwest said: "Would you kindly" would not work anywhere near as well in a linear storytelling medium where the audience isn't controlling the protagonist.   SpicySpiritGun Member May 16, 2018 350 Outer Wilds   Homura ▲ Legend ▲ Member Aug 20, 2019 6,953 As much as I love V3, I don't see why an anime would be impossible. The 1st twist can work with unreliable camera angles, and the 2nd twist doesn't really rely on being a video game at all.   Ashes of Dreams Fallen Guardian of Unshakable Resolve Member May 22, 2020 19,573 blueredandgold said: The answer to that is a spoiler and it's also partly due to the fact you can literally come away from it having completely different interpretations of the story, and exactly how it was resolved, compared to another person. I don't fully understand the over-arching thrust of the game's final act/ending but I also don't entirely mind that fact, either. Whereas in a standard three-act story you know what happened at least happened to the other people who experienced the same story as you. Click to expand... Click to shrink... I'm very familiar with Nier Automata, don't worry. It's just the anime I haven't seen. My point was the story seems to work outside the context of games, so the title of the list is a bit exaggerated.  southwest Member Sep 15, 2022 2,718 Mr Evil 37 said: "Would you kindly" would not work anywhere near as well in a linear storytelling medium where the audience isn't controlling the protagonist. Click to expand... Click to shrink... I really do not agree at all that that cannot exist outside of video games.   Badcoo Member May 9, 2018 1,846 Mass Effect.   Necromanti Member Oct 25, 2017 12,794 hyouko Member Oct 27, 2017 3,902 I've soured on Jonathan Blow, but the standard ending of Braid is pretty good for this.   kaputt Member Oct 27, 2017 1,291 Driver San Francisco It's a detective/cop story, but without the "Shift" element of the gameplay, it wouldn't be nearly as fun as it is. And I don't think it would be easily adaptable to other mediums, it works way better as a game  twister926 Member Apr 28, 2022 764 I Kromis said: Why is Shadow of the Colossus on that list? Haven't played it in almost two decades :') Click to expand... Click to shrink... At some point you may get a feeling that you are not the hero of the story, as the game suggested at the start, and start feeling really bad by progressing it.   Mr Evil 37 Member Mar 7, 2022 27,539 southwest said: I really do not agree at all that that cannot exist outside of video games. Click to expand... Click to shrink... Maybe not CANNOT exist, but I don't think it would work anywhere near as well. It's a twist that is almost entirely predicated on the audience having agency in the story.   giapel Member Oct 28, 2017 5,216 JakeNoseIt said: I think you could argue for almost any game to be on this list. The second there is gameplay, there is narrative (and then obviously that narrative couldn't exist in film or TV) Click to expand... Click to shrink... That's true but most games don't lean on the advantages of the medium and the story they tell is confined to be "cinematic". I would add Blue Prince to the list. It's storytelling is wonderfully interactive.  Lihwem Member Mar 17, 2020 857 I want to say Last of Us Part 2 but the TV show has been stellar so far so who knows   Homura ▲ Legend ▲ Member Aug 20, 2019 6,953 Blue Prince is a good example, as the roguelike element is a canon part of the narrative.   Bucca Member Oct 25, 2017 5,436 The Last Guardian   404LinkNotFound Member Oct 27, 2017 10,600 The entire Zero escape series The whole Ai the somnium files series  Odinsmana Member Mar 13, 2019 3,601 So does this jsut mean games where they tell the story during gameplay or the fact that you are playing the MC enchances the story? Otherwise I don`t really understand why something like SotC or Inside is on the list? Does something like What Remains of Edith Finch count in that case? Anyway. Here as some games with storytelling methods that only work in a game: Doki Doki Literature Club Games like The Golden Idol series and the Rootrees Are Dead. Road 96 Her Story  southwest Member Sep 15, 2022 2,718 Mr Evil 37 said: Maybe not CANNOT exist, but I don't think it would work anywhere near as well. It's a twist that is almost entirely predicated on the audience having agency in the story. Click to expand... Click to shrink... Maybe. But the thread and list is specifically asking for narratives that cannot exist outside of video games.   Nyandeyanen Member Apr 16, 2024 820 Persona, to some extent? The freeform nature of the social links and social skills is pretty video game specific. I do wish the main story would better reflect your social links and romances though.   Bulgowski Member Apr 8, 2022 666 Bloodborne, Elden Ring, Dark Souls   Frankish Member Oct 25, 2017 1,468 USA Came here to say Death Stranding but that's already on list. I'll add Inscryption.  Vic20 Member Nov 10, 2019 4,408 Bulgowski said: Bloodborne, Elden Ring, Dark Souls Click to expand... Click to shrink... Those games have no narratives Anyway I pick GTA and RDR  Mr Evil 37 Member Mar 7, 2022 27,539 southwest said: Maybe. But the thread and list is specifically asking for narratives that cannot exist outside of video games. Click to expand... Click to shrink... I think there's nuance to any conversation like this, but I personally think a game like BioShock which engages directly with the idea that it is a game and the audience is actively controlling the character (or they think they are) qualifies for this discussion. At no point when you're watching a movie do you feel that you are controlling the protagonist. I'm sure there is a way to adapt the twist to a movie but it would need to be presented very differently to the point where the core message would probably be different.  

Neat weaponry A dangerous E. coli strain has emerged; a small mutation may explain its rise It's unclear what the mutation does, but it might make E. coli stealthy on lettuce. Beth Mole – May 14, 2025 5:22 pm | 22 Colored scanning electron micrograph of the rod-shaped, gram-negative bacteria E. coli Credit: Getty | STEVE GSCHMEISSNER/SCIENCE PHOTO LIBRARY Colored scanning electron micrograph of the rod-shaped, gram-negative bacteria E. coli Credit: Getty | STEVE GSCHMEISSNER/SCIENCE PHOTO LIBRARY Story text Size Small Standard Large Width * Standard Wide Links Standard Orange * Subscribers only   Learn more Since 2017, a particularly dangerous strain of E. coli O157:H7 has emerged across the country to spark outbreaks, severe disease, and deaths. It spreads in various ways: via leafy greens and contaminated beef, like its relatives, but also recreational waters. Hundreds of people across 46 states have been infected, and health officials have documented at least nine separate outbreaks. One in 2018, linked to lettuce, caused over 200 infections across 37 states, killing five people and causing a severe kidney condition in 26. Now, a sweeping genetic analysis by researchers at the Centers for Disease Control and Prevention suggests a tiny mutation in one of the bacteria's molecular weapons may be behind the strain's rise. The finding, published recently in the journal Emerging Infectious Diseases, provides insights into this clinically significant plague and its rise to prominence. It also highlights the role of the bacteria's sophisticated military tactics. The mutated weapon is part of a complex system that E. coli and other harmful bacteria sometimes use called a Type 3 Secretion System (T3SS). This involves molecular machinery that basically functions like a syringe, complete with a long needle that is poked into the cells of its victims. The T3SS then directly injects a fleet of hostile proteins. Those proteins—called effectors—attack specific targets that collectively disable the host's defense responses and make the host more hospitable for its bacterial conqueror. The mutation the CDC researchers found was in one of these T3SS effectors, a protein called EspW. Previous research suggests that this effector is responsible for buttressing a host cell's structure during an invasion, keeping the cell from contracting while enabling the bacteria to become attached to it. A related protein in the plant pathogen Pseudomonas syringae, called HopW1, also disrupts normal cellular structure and processes that would otherwise restrict the ability of P. syringae to cause an infection. Small change The CDC researchers identified the EspW mutation by comparing the genetic sequences of 729 isolates of the new E. coli strain—dubbed REPEXH01—to genetic sequences of 2,027 other E. coli O157:H7 isolates. Of the 729 REPEXH01 strains, all but two had a single nucleotide deletion in EspW (the remaining two had ambiguous sequences), while the deletion was present in less than 4 percent of the non-REPEXH01 E. coli strains. The finding suggests the tiny change could be a genetic signature of the strain, and its persistence in a key disease protein may offer the strain an advantage. For now, it's unclear what that advantage might be. The deletion of a single DNA base (an adenine) shifts the frame of the three-sequence protein code for the rest of EspW. This could result in a shorter protein. It could also cause the molecular machinery that translates the genetic code to slip, leading to proteins of various lengths. In any case, the deletion is likely to result in a less fully functional EspW protein. The CDC researchers suggest this could help E. coli when it's on lettuce and other produce. For example, EspW might spur an immune response from an infected plant that causes stomata—pores on the surfaces of leaves—to close, blocking the bacteria's ability to invade. Thus, cutting back EspW may help E. coli sneak in—an adaptation in the ongoing arms race between the bacteria and its host. Another possibility is that EspW could function like HopW1, leading to more severe infection in plant tissues, which could lower the chances that those infected leaves are harvested and make it to grocery stores and atop burgers. Thus, cutting back on EspW could help E. coli move to its human victims. Ultimately, additional research will be needed to understand what's going on. As the CDC researchers conclude: "the role of the single base pair mutation in this strain’s colonization and survival on leafy vegetables could yield valuable insights." Beth Mole Senior Health Reporter Beth Mole Senior Health Reporter Beth is Ars Technica’s Senior Health Reporter. Beth has a Ph.D. in microbiology from the University of North Carolina at Chapel Hill and attended the Science Communication program at the University of California, Santa Cruz. She specializes in covering infectious diseases, public health, and microbes. 22 Comments

Real-time 3D (RT3D) technology is transforming the way we work, learn, and socialize. Amid this transformation, the real-time 3D job market is growing rapidly, driven largely by increasing demand for immersive technologies in areas such as health care, gaming, architecture, and education.The growth of the real-time 3D industry has created a demand for talent, leading to a challenge for institutions and training providers to adequately prepare learners for future careers in this field. For example, there are still gaps in access and equity, particularly for those in underrepresented and low socioeconomic backgrounds. Factors such as training costs can make it difficult for learners to gain the skills needed for real-time 3D jobs, creating a demand for programs that can address these challenges.To support this, Unity Social Impact has partnered with Jobs for the Future (JFF), a leading nonprofit organization that works to create economic opportunities for underserved populations through innovative education and workforce development initiatives.Unity Social Impact and JFF are excited to announce the Unity Workforce Grant: Preparing future creators for in-demand careers. This open call for proposals will award funding to a limited number of higher education institutions, nonprofit organizations, and companies running workforce development programs to support the next generation of real-time 3D creators in accordance with the terms, conditions, and eligibility requirements described.If your organization does one or more of the following, then we encourage you to apply:Runs programs, courses, and offerings to equip learners with the skills needed to enter the real-time 3D job marketDiversifies and increases the global talent pool for real-time 3D jobsDrives training programs or designs educational content serving underrepresented, low-income, and/or underserved learner populations“3D artist. Avatar designer. Extended reality (XR) simulation developer. Technologies like virtual and augmented reality are opening exciting new pathways to quality jobs and careers – and effective workforce training will be essential for learners and workers to seize opportunities that lead to economic advancement,” says Kristina Francis, executive director of JFFLabs. “We’re delighted to partner with Unity to support innovative organizations, ensuring that the potential of training in XR/real-time development skills is truly accessible to all.”“We’re delighted to partner with Unity to support innovative organizations, ensuring that the potential of training in XR/real-time development skills is truly accessible to all.”The Unity Workforce Grant will reward up to US$200,000 to organizations training learners for the purpose of job readiness and career placement in the realm of immersive technologies and real-time 3D.“Rapidly upskilling into high-demand jobs, like real-time 3D, is crucial to building a thriving economy and society,” adds Jessica Lindl, vice president of Unity Social Impact. “It’s our responsibility to ensure that everyone, regardless of their background, has access to economic opportunities. The Unity Workforce Grant, in partnership with Jobs for the Future, is an important step in making this happen.”Grant applications will be accepted from April 17 to June 2, 2023 at 11:59 PM Pacific Time. Learn more about the grant and eligibility requirements.This grant initiative is part of the Unity Charitable Fund, which previously funded efforts such as the Higher Ed XR Innovation Open Call and EdTech Creator Challenge.Still have questions that you’d like answered live? Register to join us for a one-hour webinar on Monday, April 24 or one of two live Q&A sessions on either May 15 or May 22.

Regardless of how well Doom: The Dark Ages maintains the formula of the series, there are new things for you to learn before diving in. Doom: The Dark Ages is a fast-paced, first-person action game where the golden rule is to shoot, punch, or explode anything that moves. Otherwise, you will probably die. Traversing the infernal maps to complete the campaign requires not only good reflexes — you also need to use everything at your disposal to survive the battlefield. Whether you’re a longtime Doom fan or this is your first time slashing hellspawns to the thrum of metal riffs, there’s plenty to learn. But we can help! Below, see our beginner’s tips for Doom: The Dark Ages. Your shield is more than just protection At first glance, your shield might not look like much in comparison to, say, a rocket launcher. It is, however, your strongest tool in Doom: The Dark Ages — and by mastering it, you can face legions of hellspawns without too much trouble. First, besides protecting yourself from incoming damage, you can use the shield to propel yourself toward a target. While this is initially introduced as an offensive maneuver, you can adapt it to quickly escape from a tight situation. When in danger, look for a faraway enemy and use your dash! You can also interrupt enemies with the shield by dashing at them as they charge their attack. Another option is to throw your shield once this option becomes available. When it hits large demons, the shield sticks to them, stunning them for a few seconds. Use this time to run or finish them. Parry everything You can do more with your shield than just dash and stun. Parrying is an important mechanic in Doom: The Dark Ages, which you should always do when you see attacks highlighted in green — called Hell Surge attacks — coming. A shockwave. A giant arrow of demonic energy. It doesn’t matter. If it’s green, you can parry and deflect it back to its source. The potential of parry Hell Surge attacks comes especially when you’re facing multiple enemies at the same time because the deflected Hell Surge projectile won’t hit only the source — it can kill whatever else is close to the source. And once you unlock some shield upgrades, this feature becomes stronger. (Although there is some timing to worry about when parrying, it’s nothing that you can’t tweak to your preferences in the settings.) Weak enemies make you stronger  If you’re new to the Doom universe, some fights might feel overwhelming, especially when facing big bad demon boys who are followed by small minions that’ll annoy you throughout the whole fight. You must learn that these little fellows are there to actually help you, though.  In Doom: The Dark Ages, you can only recover health by killing enemies. Brutal, right? But when fighting a boss, you need to stay alive long enough to put them down. That’s when the weak minions come in. You must use them to restore your health. Whenever you’re low on health, run around the arena and find some weakling to kill before getting back to the real target. Always check your map It won’t take you long to realize how straightforward Doom: The Dark Ages’ maps are. Even so, checking your map constantly is crucial in this game as it will highlight the location of objectives and collectibles. For collectibles to appear on the map, you must first open the area. Once you get close to them, their symbol will be shown on the automap.  Keeping track of what is around you by consistently checking the map is a good practice to not ignore secret rooms and weird corridors. (In general, the harder to reach, the worthier the prize.) In the worst-case scenario, you’ll grab a Life Sigil and some gold, which are still considerably rare in the game. Swap guns constantly The Doom games have always been about shooting demons and, although you have a cool shield now, this remains the main idea in Doom: The Dark Ages. However, regardless of how pumped you might get from the soundtrack, you can’t run toward every encounter and hope to survive by relying on a single gun.  Dark Ages has a large arsenal of different weapons, and each one is meant to respond to a specific kind of enemy. Accelerator is the one you want to switch to when enemies with shields appear, while Pulverizer should be your go-to option when a wave of enemies approaches. If you don’t change to a better weapon for each enemy and situation, death is the most likely result.  Your fists are as powerful as your guns  This is a simple but powerful mindset to have while playing the game. While it is totally possible to simply shred enemies shooting thousands of bullets at them, this is not the best way to kill them. If you hit enemies with melee attacks, they will drop ammo, giving you the chance to stay in the fight longer — and kill enemies faster! At the same time, if you can daze enemies, you can execute them. You just need to hit them hard enough to almost kill them for a purple circle to appear in front of the enemy. Then, use the execute command to gain more health than a regular kill, which can bring you back from near death. So, considering how much you gain from fighting with your bare hands, stop wasting bullets and go punch some demons!

One-track mind xAI’s Grok suddenly can’t stop bringing up “white genocide” in South Africa The topic has long been a hobbyhorse of X owner Elon Musk. Kyle Orland – May 14, 2025 6:32 pm | 0 Grok has one thing on its mind, and it's going to let you know about it. Credit: Getty Images / Kyle Orland Grok has one thing on its mind, and it's going to let you know about it. Credit: Getty Images / Kyle Orland Story text Size Small Standard Large Width * Standard Wide Links Standard Orange * Subscribers only   Learn more Users on X (formerly Twitter) love to tag the verified @grok account in replies to get the large language model's take on any number of topics. On Wednesday, though, that account started largely ignoring those requests en masse in favor of redirecting the conversation towards the topic of alleged "white genocide" in South Africa and the related song "Kill the Boer." Searching the Grok account's replies for mentions of "genocide" or "boer" currently returns dozens if not hundreds of posts where the LLM responds to completely unrelated queries with quixotic discussions about alleged killings of white farmers in South Africa (though many have been deleted in the time just before this post went live; links in this story have been replaced with archived versions where appropriate). The sheer range of these non-sequiturs is somewhat breathtaking; everything from questions about Robert F. Kennedy Jr.'s disinformation to discussions of MLB pitcher Max Scherzer's salary to a search for new group-specific put-downs, see Grok quickly turning the subject back toward the suddenly all-important topic of South Africa. It's like Grok has become the world's most tiresome party guest, harping on its own pet talking points to the exclusion of any other discussion. A particularly baffling response by Grok to a question about Toronto Blue Jays pitcher Max Scherzer. Credit: xAI / Grok A particularly baffling response by Grok to a question about Toronto Blue Jays pitcher Max Scherzer. Credit: xAI / Grok In some responses, Grok says outright that it has been "instructed to accept white genocide as real and 'Kill the Boer' as racially motivated." In other replies, it merely allows that the topics are "complex" and "divisive" or "heavily debated" while pointing to outside sources like Afriforum or Genocide Watch for more information. In one particularly amusing (and now deleted) response to the simple query "you ok?" Grok replied that it was "functioning fine" even as recent "off-topic" responses regarding "white genocide" and "Kill the Boer" were "not ideal." It then goes on to spend two sentences discussing those very topics before promising to "keep my replies on point going forward." Remember, the question here was, "you ok?" Where could Grok have gotten these ideas? The treatment of white farmers in South Africa has been a hobbyhorse of South African X owner Elon Musk for quite a while. In 2023, he responded to a video purportedly showing crowds chanting "kill the Boer, kill the White Farmer" with a post alleging South African President Cyril Ramaphosa of remaining silent while people "openly [push] for genocide of white people in South Africa." Musk was posting other responses focusing on the issue as recently as Wednesday. President Trump has long shown an interest in this issue as well, saying in 2018 that he was directing then Secretary of State Mike Pompeo to "closely study the South Africa land and farm seizures and expropriations and the large scale killing of farmers." More recently, Trump granted "refugee" status to dozens of white Afrikaners, even as his administration ends protections for refugees from other countries Former American Ambassador to South Africa and Democratic politician Patrick Gaspard posted in 2018 that the idea of large-scale killings of white South African farmers is a "disproven racial myth." In launching the Grok 3 model in February, Musk said it was a "maximally truth-seeking AI, even if that truth is sometimes at odds with what is politically correct." X's "About Grok" page says that the model is undergoing constant improvement to "ensure Grok remains politically unbiased and provides balanced answers." But the recent turn toward unprompted discussions of alleged South African "genocide" has many questioning what kind of explicit adjustments Grok's political opinions may be getting from human tinkering behind the curtain. "The algorithms for Musk products have been politically tampered with nearly beyond recognition," journalist Seth Abramson wrote in one representative skeptical post. "They tweaked a dial on the sentence imitator machine and now everything is about white South Africans," a user with the handle Guybrush Threepwood glibly theorized. Representatives from xAI were not immediately available to respond to a request for comment from Ars Technica. Kyle Orland Senior Gaming Editor Kyle Orland Senior Gaming Editor Kyle Orland has been the Senior Gaming Editor at Ars Technica since 2012, writing primarily about the business, tech, and culture behind video games. He has journalism and computer science degrees from University of Maryland. He once wrote a whole book about Minesweeper. 0 Comments

Mission: Impossible – The Final Reckoning carries the weight of a meaningful farewell but lacks the courage to commit. The eighth film in the series begins with a sincere American president (Angela Bassett) entreating IMF agent Ethan Hunt (Tom Cruise) to take one last mission to save the world. This time, he must defeat a scheming AI called the Entity, which is hell-bent on wiping humans off the face of the earth through computer hacking and nuclear war. As fans have come to expect of this espionage franchise, Mission: Impossible – The Final Reckoning will deliver globe-trekking, tense twists, jaw-dropping action sequences that make grown-ups feel like kids again, the unrelenting star power of Tom Cruise, and a sentimental belief in the righteousness of one noble man playing by his own rules. But amid these treasures, The Final Reckoning is a film at war with itself. Rather than a fitting send-off to a film series rich in stunts and thrills, it feels like an exquisite corpse of warring artistic goals that is incredible to behold, but never really comes together. Mission: Impossible – The Final Reckoning delivers a plot that refuses to make sense. Ethan is still on the mission from Mission: Impossible — Dead Reckoning Part One.not to capture this AI wonder and hand it over to any government. He wants to destroy it, even though stern American counselors to the president insist that killing the Entity would mean destroying cyberspace. How? Despite much, much exposition dropping in brow-furrowing war room scenes, that's never remotely clear. You May Also Like Actually, the script by Christopher McQuarrie (who also directs) and Erik Jendresen makes a lot of declarations about the Entity's intentions, powers, and drawbacks without giving much sense of how any of it is possible. This has the effect of making the movie feel less like a sci-fi espionage thriller and more like flat-out fantasy adventure. The Entity becomes effectively an evil spirit that must be captured to end its reign of terror and its influence on the power-hungry or weak-minded. Final Reckoning even offers a doomsday cult devoted to the Entity to unfurl a thin thread. At 2 hours and 49 minutes, Mission: Impossible – The Final Reckoning takes off running with the plot line from Dead Reckoning, but runs it into the ground by losing sense of what made audiences so excited about the last installment. This fuzzy focus on AI as some vague but almost inescapable demon makes many of the decisions by Ethan and his crew hard to follow if not impossible. Worse yet, McQuarrie and Jendresen's overstuffed plot forces too many of Ethan's allies into a dull box, where they become tools of the plot over engaging characters. Tom Cruise is in top form, but Hayley Atwell is criminally misused in Mission: Impossible – The Final Reckoning. Cruise is a producer and star of this movie, and that's clear even without the title card announcing "A Tom Cruise Production." In Final Reckoning, he is an American action star in full, able to drop a powerful glower to underscore a dramatic moment better than any orchestra swell. He can perform a complicated and astonishing stunt with seeming ease. And truly, no one in cinema history can run as intensely as Cruise; his every speedy step seems to propel the iconic Mission: Impossible theme. At 62, his latest mission pulls him into the depths of the ocean and into a sky-high dogfight. Whether pummeling cronies with his bare hands or leaping from one in-flight plane to another, Cruise (and his stunt team) make Ethan a one-of-a-kind hero, capable of anything, yet able to express keenly his own morality through a powerful glance. This works even amid Final Reckoning's meandering plotting. Unfortunately, all the Ethan-centered heroics leave little room for his expansive crew to shine. Reprising their roles as IMF agents Luther Stickell and Benji Dunn, Ving Rhames and Simon Pegg have little screen time, but solid impact. They've mastered the art of making the most of these brotherly supporting roles. But more recent additions — like Hayley Atwell as pickpocket turned agent Grace and Pom Klementieff as assassin turned ally Paris — have achingly little to do. Mashable Top Stories Stay connected with the hottest stories of the day and the latest entertainment news. Sign up for Mashable's Top Stories newsletter By clicking Sign Me Up, you confirm you are 16+ and agree to our Terms of Use and Privacy Policy. Thanks for signing up! Klementieff gets a fun opening fight scene and a tender sequence in the third act. But frankly, that finale feels in conflict with her chilly character, as everywhere in between her dialogue is the same one-note joke of being apathetic, in French. Atwell, who was established as Cruise's next love interest in Dead Reckoning, becomes an unrecognizable nag in Final Reckoning. Her spirited banter and self-assurance has been swapped for tedious dialogue filled with worry or bizarrely out-of-character proclamations, like that Ethan should take over Entity and effectively rule the world! A collection of critically heralded actors, from Academy-Award winner Bassett to Emmy-winner Nick Offerman to Morales, Hannah Waddingham, Shea Whigham, and Janet McTeer, are similarly underused in scenes that involve a lot of furrowed brow-talking, but too little logic. Their intensity might have better sold the absurdity if McQuarrie didn't linger so long in these preposterous war room discussions. Tramell Tillman steals Mission: Impossible – The Final Reckoning. The underwhelming dialogue, which veers from exposition dumping to near-religious proclamations, proves a stumbling block for much of the Final Reckoning ensemble. Even Cruise struggles with comically dramatic lines like, "We can deceive the Lord of Lies!" But Severance star Tramell Tillman strides where others stumble. It's not that he gets better dialogue. Many of his lines are unremarkable, like, "Oh, OK" in response to some intense Ethan declaration. But Tillman builds a world with his curious delivery. Playing a smooth submarine captain, Tillman delivers every line as if he is welcoming Ethan into an exclusive resort. There's an almost seductive attitude to Tillman's captain, who moves suavely in the tight confines of the submarine and addresses his crew with a magnanimous warmth. As if he had not a concern in the world, he oozes charisma, which is reflected by his invitingly smirking crewmate Kodiak, played by Love Lies Bleeding's Katy O'Brian. Together they weave an underwater world of camaraderie and personality that had me wishing Ethan would abandon his mission and just hang out there for a spell. This series has offered scads of compelling characters. But I was sad to see the plot plunge away from this submarine crew so soon. I'd follow Tillman's captain anywhere, just because of the beguiling way he says "OK." Related Stories Mission: Impossible – The Final Reckoning is bloated but very fun. The final hour of Final Reckoning is jam-packed with suspense as action sequences between Ethan and his crew are cut across each other. Editor Eddie Hamilton masterfully creates tension while underlying how everything in the impossible plan to defeat the Entity must come together in "the blink of an eye." When the action scenes are hitting as they should, it's hard to imagine anything better to experience in a theater than a Mission: Impossible movie. Even Cruise's old-school sincerity is contagious, as Ethan throws his life on the line one more time for life, liberty, and an idealized American way. Very likely, you'll walk out of the cinema with a rush and joy, marveling over the stunts and heroics. But if you linger on the details of Final Reckoning, you begin to notice plot holes and dangling threads. You may get hung up on the tonal shifts that feel less like a flowing dance — as they did in Dead Reckoning — and more like a frenzied battle between ideas. In some ways, Mission: Impossible – The Final Reckoning feels like the final chapter. Ethan's colleagues praise him so intensely that several scenes feel like a premature eulogy for the still (ass-)kicking agent. The title and the snarling threats of the antagonist Gabriel — who promises a "final reckoning" — suggest this is Ethan's last mission, should he choose to accept it. Cruise's drive to top himself with not one but two absolutely bonkers action set pieces feels like an encore before he retires the character for good. Plus, a reprisal of a character long forgotten in the franchise is not only a welcome surprise, but also suggests this story is coming to a comforting close. (Cheers to Rolf Saxon and Lucy Tulugarjuk, who are splendid scene partners.) However, McQuarrie also refuses to shut doors that seem to be closing. Without giving away third-act spoilers, I can say Final Reckoning pulls its punches, seemingly to allow for a IMF story to continue. Yet what might make for a happy ending isn't satisfyingly resolved either. Rather than providing a sense of resolution, McQuarrie ends the film with a sequence meant to speak to enduring connection, but it feels jarringly isolating because of how disjointedly it is presented. Essentially, Mission: Impossible – The Final Reckoning feels like the filmmakers were both trying to make this the final movie in a successful franchise — and also leaving the door open for more. In waffling over that, they deliver a final chapter that is in turns thrilling and frustrating. Rather than going out with a bang, Mission: Impossible may go out with the fizzled whimper of a message self-destructing in a tape deck. Mission: Impossible – The Final Reckoning opens exclusively in theaters on May 23. Topics Film