Pro-tooth decay RFK Jr’s plan to ban fluoride supplements will “hurt rural America,” dentists say In areas without fluoridated water, supplements are the only way to get adequate doses. Beth Mole – May 16, 2025 5:55 pm | 19 Credit: Getty | Flavio Coelho Credit: Getty | Flavio Coelho Story text Size Small Standard Large Width * Standard Wide Links Standard Orange * Subscribers only   Learn more This week, the US health department announced a plan to ban prescription fluoride supplements for children. These ingested fluoride products are dispensed at safe doses by doctors and dentists to prevent tooth decay in children who are unable to get adequate fluoride doses from community water systems—something that may become more common as more states and cities remove or ban fluoride from their water. Both the American Dental Associationand the American Academy of Pediatrics recommend fluoridating community water and advise prescribing fluoride supplements for children who do not get adequate fluoride dosages through their water. Nevertheless, the Department of Health and Human Servicesunder anti-vaccine advocate and conspiracy theorist Robert F. Kennedy Jr states without clear evidence that fluoride supplements harm children's microbiome and pose other health risks. The ADA pushed back strongly, telling Ars Technica in a written statement that the scientific studies the HHS references as evidence of harms "do not in fact demonstrate any harmful effects for the concentrations of fluoride prescribed by physicians and dentists." To support the alleged claim that fluoride harms the gut microbiome, HHS listed two review studies in its announcement. One review, published this year, concludes, "In humans, high doses potentially may be detrimental to the microbiome, whereas ≤ 2 mg/Lhad positive effects." Community water systems are recommended to have a level of 0.7 mg/L. The other review, published in 2023, said that there wasn't enough human data to make any conclusions. In the announcement, FDA Commissioner Marty Makary was quoted as saying, "The best way to prevent cavities in children is by avoiding excessive sugar intake and good dental hygiene, not by altering a child’s microbiome. For the same reason that fluoride may kill bacteria on teeth, it may also kill intestinal bacteria important for a child’s health." “Harmful” While fluoride can kill bacteria, particularly at high levels, it's used in oral health to inhibit the demineralization of tooth enamel while enhancing the remineralization of tooth surfaces, the ADA clarifies. The best way to get fluoride is through drinking water, the ADA says. But supplements are a safe alternative if a child lives in an area without fluoridated water or if they mostly drink bottled water. Given rampant false and controversial claims about fluoride, more communities are now abandoning it. This week, Florida became the second state after Utah to ban fluoridation state-wide. "Yes, use fluoride for your teeth, that’s fine," Florida Gov. Ron DeSantis said at a news conference after signing the ban into law. "But forcing it in the water supply is basically forced medication on people. They don’t have a choice." ADA President Brett Kessler worries what children in places such as Utah and Florida will do to get adequate fluoride if the ban on supplements goes through. “In non-fluoridated communities, especially rural areas, fluoride supplements are the only chance for individuals to get the appropriate amount of fluoride to prevent tooth decay," Kessler said in the statement. The move will be "particularly harmful to the most vulnerable and those who lack access to care," he added. While Makary said that the FDA will conduct a safety review of  fluoride supplements, the conclusion seems to be foregone, with the HHS writing that it is already "initiating action to remove" the products. The ADA noted that places that have removed fluoride from drinking water, such as Calgary, Canada, and Juneau, Alaska, have seen increases in dental decay, particularly among children and low-income populations. "Proposals like this stand to hurt rural America, not make them healthier," Kessler said. Beth Mole Senior Health Reporter Beth Mole Senior Health Reporter Beth is Ars Technica’s Senior Health Reporter. Beth has a Ph.D. in microbiology from the University of North Carolina at Chapel Hill and attended the Science Communication program at the University of California, Santa Cruz. She specializes in covering infectious diseases, public health, and microbes. 19 Comments #rfk #jrs #plan #ban #fluoride

News Health & Medicine FDA plan to ban fluoride supplements baffles and alarms dental experts The move could mean further oral health decay, especially in rural areas Fluoride tablets and drops are prescribed to prevent tooth decay in places without fluoride in the water, such as U.S. rural communities. geckophotos/ iStock/Getty Images Plus By Tina Hesman Saey 9 seconds ago A decades-old dental health treatment may soon vanish in the United States. Access to fluoride supplements, prescribed to prevent cavities in children without access to fluoridated water, is now under threat from a controversial move by the U.S. Food and Drug Administration. The agency announced May 13 that it plans to remove fluoride products that can be ingested by children from the market, citing concerns about potential harm to gut microbes, links to thyroid disorders, weight gain and decreased IQ. Sign up for our newsletter We summarize the week's scientific breakthroughs every Thursday. #fda #plan #ban #fluoride #supplements

The world is awash in data about, well, the world — thanks to satellites and environmental sensors. But there’s still a lot we can’t see, and Fieldstone Bio thinks microbes can change that. “They’ve evolved to sense and respond to information. It’s just trillions of calculations going on at all times all around us,” Brandon Fields, Fieldstone Bio’s co-founder and chief science officer, told TechCrunch. “How do we take that and actually manipulate that to gain benefits for us?” Fieldstone’s technology emerged from that question. The startup was founded in 2023 after spinning out of MIT, where professor Chris Voigt’s lab had developed a way to turn microbes into sensors. The scientists programmed the microbes to change color when they encountered something of interest, whether it be nutrients in soil or landmines hidden in the dirt, and then figured out how to detect them. “The key technology out of Chris’ lab is this idea of, ‘How do we actually visualize these cells from really far away?’” Fields said. Fieldstone Bio recently raised million in seed funding led by Ubiquity Ventures with participation from E14 and LDV Capital, the company exclusively told TechCrunch. The startup has been testing its technology in the lab, and the funding will let it test those microbes in the real world. Each strain is tailored to sense a particular compound, such as nitrogen on a farm field or TNT residue from a landmine.  “We isolate microbes from the environments we want to sense,” Fields said. “We build our sensors the DNA pieces, and we just drop them into these different ones and see which ones behave the best, which ones can last the longest.” Techcrunch event Join us at TechCrunch Sessions: AI Secure your spot for our leading AI industry event with speakers from OpenAI, Anthropic, and Cohere. For a limited time, tickets are just for an entire day of expert talks, workshops, and potent networking. Exhibit at TechCrunch Sessions: AI Secure your spot at TC Sessions: AI and show 1,200+ decision-makers what you’ve built — without the big spend. Available through May 9 or while tables last. Berkeley, CA | June 5 REGISTER NOW Once the microbes are ready, Fieldstone will broadcast them using drones. After the microbes have some time to sense their environment — several hours to days, depending on the target — the company will have another drone snap photos of the area. The images aren’t the usual aerial photography seen on Google Maps. Rather, they’re taken using what’s known as a hyperspectral camera, which divide visible and infrared light into as many as 600 different colors. Because Fieldstone’s microbes will reflect light at a very specific wavelength, it can train AI models to look for those signals amid a torrent of data. “That’s where the power of AI comes in, because we can start using that information to tease out these really faint signals to produce really cool heat maps of the microbe sensing the environment,” Fields said. In addition to agriculture and national security applications, Fieldstone is also programming microbes to detect environmental contaminants like arsenic, CEO Patrick Stone said. “Instead of going to do core soil samples over every 100 feet — and then you have 100 foot resolution — we could get a one-inch resolution and really map out exactly where they need to go clean up stuff,” he said. Gene edited microbial sensors broadcast over farm fields are sure to raise the eyebrows among people who oppose genetic modification. Fields said that the company has been in contact with the EPA to ensure that the company follows regulations. Fields said that, over time, he hopes the company’s database will become large enough that it can train models to associate other signals in the environment with whatever data is returned by the microbes. That would allow hyperspectral cameras to detect, say, arsenic contamination without needing to spread the engineered microbes. “Eventually, you don’t need to apply the microbe at all,” Fields said. “You have drones, planes, and satellites now collecting information about chemical information on a global scale.” #fieldstone #bio #building #microbes #that

Neat weaponry A dangerous E. coli strain has emerged; a small mutation may explain its rise It's unclear what the mutation does, but it might make E. coli stealthy on lettuce. Beth Mole – May 14, 2025 5:22 pm | 22 Colored scanning electron micrograph of the rod-shaped, gram-negative bacteria E. coli Credit: Getty | STEVE GSCHMEISSNER/SCIENCE PHOTO LIBRARY Colored scanning electron micrograph of the rod-shaped, gram-negative bacteria E. coli Credit: Getty | STEVE GSCHMEISSNER/SCIENCE PHOTO LIBRARY Story text Size Small Standard Large Width * Standard Wide Links Standard Orange * Subscribers only   Learn more Since 2017, a particularly dangerous strain of E. coli O157:H7 has emerged across the country to spark outbreaks, severe disease, and deaths. It spreads in various ways: via leafy greens and contaminated beef, like its relatives, but also recreational waters. Hundreds of people across 46 states have been infected, and health officials have documented at least nine separate outbreaks. One in 2018, linked to lettuce, caused over 200 infections across 37 states, killing five people and causing a severe kidney condition in 26. Now, a sweeping genetic analysis by researchers at the Centers for Disease Control and Prevention suggests a tiny mutation in one of the bacteria's molecular weapons may be behind the strain's rise. The finding, published recently in the journal Emerging Infectious Diseases, provides insights into this clinically significant plague and its rise to prominence. It also highlights the role of the bacteria's sophisticated military tactics. The mutated weapon is part of a complex system that E. coli and other harmful bacteria sometimes use called a Type 3 Secretion System. This involves molecular machinery that basically functions like a syringe, complete with a long needle that is poked into the cells of its victims. The T3SS then directly injects a fleet of hostile proteins. Those proteins—called effectors—attack specific targets that collectively disable the host's defense responses and make the host more hospitable for its bacterial conqueror. The mutation the CDC researchers found was in one of these T3SS effectors, a protein called EspW. Previous research suggests that this effector is responsible for buttressing a host cell's structure during an invasion, keeping the cell from contracting while enabling the bacteria to become attached to it. A related protein in the plant pathogen Pseudomonas syringae, called HopW1, also disrupts normal cellular structure and processes that would otherwise restrict the ability of P. syringae to cause an infection. Small change The CDC researchers identified the EspW mutation by comparing the genetic sequences of 729 isolates of the new E. coli strain—dubbed REPEXH01—to genetic sequences of 2,027 other E. coli O157:H7 isolates. Of the 729 REPEXH01 strains, all but two had a single nucleotide deletion in EspW, while the deletion was present in less than 4 percent of the non-REPEXH01 E. coli strains. The finding suggests the tiny change could be a genetic signature of the strain, and its persistence in a key disease protein may offer the strain an advantage. For now, it's unclear what that advantage might be. The deletion of a single DNA baseshifts the frame of the three-sequence protein code for the rest of EspW. This could result in a shorter protein. It could also cause the molecular machinery that translates the genetic code to slip, leading to proteins of various lengths. In any case, the deletion is likely to result in a less fully functional EspW protein. The CDC researchers suggest this could help E. coli when it's on lettuce and other produce. For example, EspW might spur an immune response from an infected plant that causes stomata—pores on the surfaces of leaves—to close, blocking the bacteria's ability to invade. Thus, cutting back EspW may help E. coli sneak in—an adaptation in the ongoing arms race between the bacteria and its host. Another possibility is that EspW could function like HopW1, leading to more severe infection in plant tissues, which could lower the chances that those infected leaves are harvested and make it to grocery stores and atop burgers. Thus, cutting back on EspW could help E. coli move to its human victims. Ultimately, additional research will be needed to understand what's going on. As the CDC researchers conclude: "the role of the single base pair mutation in this strain’s colonization and survival on leafy vegetables could yield valuable insights." Beth Mole Senior Health Reporter Beth Mole Senior Health Reporter Beth is Ars Technica’s Senior Health Reporter. Beth has a Ph.D. in microbiology from the University of North Carolina at Chapel Hill and attended the Science Communication program at the University of California, Santa Cruz. She specializes in covering infectious diseases, public health, and microbes. 22 Comments #dangerous #coli #strain #has #emerged

Researchers shed light on the "dark matter" of the gut, revealing a species of fungus that could potentially help counter fatty liver disease. The research is in its early days, though. #039truly #miraculous039 #common #gut #microbe

Dr. James Kinross believes gut health is linked to colon cancer risk. Getty Images/ Justine Stoddart 2025-05-13T11:59:36Z Save Saved Read in app This story is available exclusively to Business Insider subscribers. Become an Insider and start reading now. Have an account? Our modern lifestyles are thought to damage our gut health in a way that raises the risk of colon cancer. Lifestyle changes can improve the gut microbiome, which could in turn lower the risk of colon cancer. As well as eating healthily, GI surgeon James Kinross eats enough vitamin D to prevent the disease. Colon cancer is rising in people under 50. James Kinross, a gastrointestinal surgeon who researches how the gut microbiome affects our risk of the disease, told Business Insider that poor gut health could be partly to blame.Research suggests the gut microbiome, the trillions of microbes that live in the digestive tract, has a wide-ranging effect on our health. But our sterile, urbanized lifestyles, appear to have made them less diverse overall and, therefore, weaker, according to Kinross, who is based at Imperial College London."You're seeing a generational loss in our internal ecology, which is being hammered with a series of environmental hits that it simply cannot adapt to," he said, referring to factors including microplastics, ultra-processed foods, and minimal access to nature. Many studies have linked But, the gut microbiome is changeable, meaning there are things we can do to increase its diversity, which in turn could help lower colon cancer risk. "It is an ecosystem which you can adapt, and you can modify," he said.Kinross previously shared with BI how he eats to boost his gut microbiome. He shared the three things he does aside from healthy eating to lower his colon cancer risk.Don't take antibiotics if you don't need to Kinross limits his antibiotic use where possible because the medication disrupts the gut microbiome. Trevor Williams/Getty Images As a surgeon, Kinross is acutely aware that antibiotics are often necessary and save millions of lives each year, but he believes we use them too liberally — particularly to treat viral infections they can't tackle."In my house, to qualify for antibiotics, you've really got to have a pathogen that you need treated," Kinross said.Kinross and his family limit their use of antibiotics as much as possible because taking them can disrupt the ecosystem of the gut microbiome, killing off good bacteria along with pathogens, and reducing diversity.He likened it to pouring weed killer all over your garden. "Your garden won't really grow into a lovely garden full of wild meadows and flowers and color. It will just be brown and lifeless," he said.Take vitamin DKinross takes a vitamin D supplement because evidence suggests that having enough of the nutrient is important for gut health. Vitamin D is crucial for several biological processes, including calcium absorption and cellular repair — but also keeps the lining of the small intestine strong. If the lining becomes weak, microbes can pass through it into the bloodstream and cause inflammation. Chronic inflammation is linked to a higher risk of chronic diseases, including cancer.Vitamin D is found in foods including oily fish, egg yolks, and red meat, as well as from sunlight. In countries with climates like the UK's, where Kinross lives, it can be difficult to get enough vitamin D in the colder months, and residents are advised to supplement from October to March.Socialize Social connections are a pillar of health. pixdeluxe/Getty Images Kinross goes cycling with friends regularly and makes sure to sit down to eat dinner with his family in the evenings. As well as being a pillar of overall health, research suggests that socializing positively impacts the composition of our gut microbiomes, Kinross said.We exchange microbes through physical touch, and studies have found that friends, family members, and spouses have similar gut microbes to one another.A 2024 study published in the journal Nature, based on 1,787 adults from 18 isolated villages in Honduras, found that people in the same social network shared more similarities in their gut microbiomes compared to those outside of it. This was regardless of diet, water sources, and medications. Spouses and people living together had the highest amount of microbial sharing, but the phenomenon still occurred among friends and even friends of friends."Our social interactions, our real-world social interactions, define so much of our health," Kinross said. "It's good for all aspects of our health. It's good for our mental health, it's good for our cardiovascular health. It's good for everything. But if you're not having real-world social interaction, you are not really optimizing your gut health, I believe." Recommended video المصدر: https://www.businessinsider.com/how-gi-doctor-prevent-colon-cancer-eating-healthy-gut-microbiome-2025-5 #things #doctor #does #prevent #colon #cancer #ampampmdash #aside #from #eating #healthily