The FDA recently cleared the Lumipulse blood test for early diagnosis of Alzheimer's disease in ... More people 55 and over with memory loss. The noninvasive Lumipulse blood test measures the levels of two proteins—pTau 217 and β-Amyloid 1-42—in plasma and calculates the ratio between them. This ratio is correlated with the presence or absence of amyloid plaques, a hallmark of Alzheimer's disease, in the brain.getty Whether you’re noticing changes in your memory that are affecting your daily life, caring for a loved one recently diagnosed with dementia, evaluating a patient as a physician, or simply worried about someone close to you, the recent FDA clearance of the Lumipulse blood test for the early diagnosis of Alzheimer’s disease is a significant development that you should be aware of. Here’s what you need to know about this Breakthrough Alzheimer’s blood test. The Lumipulse G pTau217/β-Amyloid 1-42 Plasma Ratio test is designed for the early detection of amyloid plaques associated with Alzheimer’s disease in adults aged 55 years and older who are showing signs and symptoms of the condition. If you’ve witnessed a loved one gradually lose their memories due to the impact of amyloid plaques in their brain, you understand how important a test like this can be. The Lumipulse test measures the levels of two proteins—pTau 217 and β-Amyloid 1-42—in plasma and calculates the ratio between them. This ratio is correlated with the presence or absence of amyloid plaques in the brain, potentially reducing the need for more invasive procedures like PET scans or spinal fluid analysis. Benefits of testing with Lumipulse Dr. Phillipe Douyon, a neurologist and author of “7 Things You Should Be Doing to Minimize Your Risk of Dementia,” notes that the Alzheimer’s Association has reported that 50-70% of symptomatic patients in community settings are inaccurately diagnosed with Alzheimer’s disease. In specialized memory clinics, this misdiagnosis rate drops to 25-30%. “Having a test that provides early and accurate insights into the cause of someone’s dementia could be a massive game changer,” says Dr. Douyon. Alzheimer's disease. Neurodegeneration. Cross section of normal and Alzheimer brain, with Atrophy of ... More the cerebral cortex, Enlarged ventricles and Hippocampus. Close-up of neurons with Neurofibrillary tangles and Amyloid plaques. Vector illustrationgetty This new test follows the recent FDA approval of two medications, lecanemab and donanemab, which are highly effective in removing amyloid from the brain. Clinical trials have shown that these treatments can slow the progression of dementia. Currently, to qualify for these medications, patients must undergo expensive examinations, such as a brain amyloid PET scan or a lumbar puncture to analyze their spinal fluid. Many patients, however, do not have access to PET imaging or specialist care. “A blood test makes diagnostic procedures more accessible and benefits underserved populations,” says Dr. Haythum Tayeb, a neurologist at WMCHealth. “It also enables earlier and more personalized care planning, even before formal treatment begins. This empowers patients and their families to make informed decisions sooner,” Dr. Tayeb adds. Who Should Be Tested With Lumipulse While this blood test may improve access to care for patients from communities lacking neurology and other specialty services, it is recommended to use it only for individuals experiencing memory problems, rather than for those who are asymptomatic. “Given that there is no specific treatment indicated for asymptomatic persons, there is a risk of introducing psychological harm at this stage,” warns Dr. James Noble who is Professor of Neurology at Columbia University Irving Medical Center and author of Navigating Life With Dementia. “Healthy approaches to lifestyle will remain central in adulthood whether or not someone has a positive test, and that advice will not really change,” adds Dr. Noble. Living a healthy lifestyle can significantly enhance brain health, regardless of whether a person has an abnormal accumulation of amyloid in their brain. Key factors include regular exercise, following a healthy diet such as the Mediterranean diet, getting adequate sleep, engaging in social and cognitive activities. These practices are all essential for maintaining cognitive function. Additionally, taking steps to protect your hearing may help reduce the risk of developing dementia.To reduce your risk of dementia, you can do regular exercise, consume a healthy diet such as the ... More Mediterranean diet, get adequate sleep, and engage regularly in social and cognitive activities.getty Anyone experiencing memory loss should consult their medical provider for an evaluation. The provider can conduct basic cognitive testing and determine if a referral to a specialist is necessary. If the individual meets the criteria for testing, the lumipulse blood test should also be considered. Future Of Alzheimer’s Testing “Looking across the wide landscape of medicine, many other conditions benefit from early detection, diagnosis, and treatment. There is no reason to believe that Alzheimer’s disease will be any different” says Dr. Noble. Indeed, screening for diseases like colon cancer, breast cancer, and high blood pressure has significantly extended the average American lifespan. Imagine how much our lives could change if we could screen for Alzheimer’s dementia in the same way. This would be particularly useful for patients at higher risk due to age or family history. Providing earlier intervention for Alzheimer’s disease could potentially reduce amyloid buildup in the brain, help preserve memories, and allow individuals to live more independently at home, rather than in nursing homes. Another advantage of using a test like the Lumipulse blood test is the ability to inform a patient that their memory loss is not linked to Alzheimer’s disease. While a negative blood test does not entirely rule out an Alzheimer’s diagnosis, it does make it less probable. This could prompt the medical provider to conduct further testing to identify a more accurate cause for the patient’s memory loss. In some instances, the medical provider may conclude that the patient’s memory loss is related to normal aging. This is also important so that patients are not unnecessarily placed on medications that may not help them. It is reasonable to anticipate that additional blood-based biomarkers for diagnosing Alzheimer’s disease and other dementias will be available in the future. Perhaps one day, there will be a dementia panel blood test that can be sent off to provide early diagnosis of a wide range of dementias. Alzheimer’s blood testing is not only beneficial for individuals, but it also represents a significant advancement for research. Doctors and scientists can more easily identify individuals in the early stages of Alzheimer’s disease, which accelerates clinical trials for new medications. This increased diagnostic accuracy can enhance the effectiveness of Alzheimer’s clinical trials, as it ensures that patients enrolled have more reliable diagnoses. Consequently, new and more effective treatments could be developed and made available more quickly. The Lumipulse Alzheimer’s blood test marks a pivotal moment in our approach to this disease. While patients may still need confirmatory testing through brain imaging or spinal fluid analysis, this blood test enables the medical community to adopt a more proactive, precise, and personalized strategy for diagnosing and treating patients with dementia. This simple blood test brings us one step closer to earlier answers, better care, and renewed hope for millions of people facing the uncertainty of dementia.

On Thursday, President Donald Trump will sit down for an intimate evening at his Northern Virginia golf club with 220 of his favorite people in the world: a group of cryptocurrency speculators who have spent an estimated $148 million on Trump’s eponymous memecoin, making the president and his associates millions of dollars in the process. Even by Trump’s standards, this dinner will be the culmination of one of the most cartoonish episodes of executive-branch graft in recent memory. Last month, Trump announced that at the end of a predetermined period, he would host an “unforgettable Gala DINNER” for the top 220 holders of $TRUMP, allowing winners to discuss the future of the industry with the “Crypto President” himself. The top 25 token holders would also get to attend an “Exclusive Reception” with Trump, along with a “Special VIP White House Tour.” (Hours after the contest went live, its website was quietly edited to promise the top 25 finishers only a “Special VIP Tour,” with no location specified. It remains unclear whether that event will indeed take place at the White House, or at a golf resort facility of the president’s choice.) The contest’s organizer, a Trump-affiliated LLC called Fight Fight Fight, maintained an online leaderboard of those jockeying for position during the sweepstakes, which ended on May 12. The website also includes helpful information about the dress code (black tie optional) and the plus-one policy (none, because “if you earned a seat at the table, it’s because you earned it”). For Trump, the logistical details were far less important than the chance to juice the market for $TRUMP, which had cratered after launching in January but then spiked by more than 50% when he announced the contest. In the two days that followed, the Trump Organization and its affiliates, which together control roughly 80% of the token’s supply, took in nearly $1 million in trading fees; by the end of the sweepstakes, that number had jumped to $3 million, according to a Washington Post analysis.  In all, the Post estimates that since the coin’s debut four months ago, Trump and company have made $312 million from crypto sales and $43 million in fees. As it turns out, one of the perks of being the person in charge of U.S. cryptocurrency policy is the freedom to profit off of cryptocurrency without fear of meaningful consequences. The details of the frenzy to secure a spot on the leaderboard make clear just how for sale the federal government is right now. Making the top 220, according to Wired, required holding or buying more than 4,000 $TRUMP tokens worth about $55,000 altogether; those who made the VIP list held an average of 325,000 tokens worth a collective $4.3 million. Many of the people who made the cut made their purchases on exchanges that suggest they are non-U.S. residents who jumped at the chance to bend the U.S. president’s ear in a semiprivate setting. Sure enough, although the leaderboard identifies winners only by username and alphanumeric crypto wallet address, among the confirmed attendees are Justin Sun, a Chinese crypto speculator who is, in a wild coincidence, trying to settle civil fraud charges with the U.S. Securities & Exchange Commission; an Australian crypto entrepreneur who hopes to pitch Trump on adopting an even more industry-friendly regulatory stance; and a to-be-determined representative of MemeCore, a Singapore-based crypto collective that told New York magazine that whomever it sends hopes to ask Trump, “Are you a meme, or the result of one?”  Fight Fight Fight calculated the value of contestants’ holdings based on both the amount of $TRUMP in a wallet and the length of time they’d held it, thus rewarding early investors for their commitment to padding the president’s bottom line. That said, earlier this month, the journalist Molly White found that of the wallets on the leaderboard at the time, 62% started buying $TRUMP only after he dangled the dinner invitation. Once acquiring a floundering memecoin came with a shot at a sit-down with the literal President of the United States, people who were previously uninterested apparently decided to reevaluate their investment priorities. Since the event is closed to the press, there will be no independent coverage of what Trump says to attendees, or what the attendees say to Trump, or even who the attendees are. The entire spectacle amounts to an off-the-record jam session between a bunch of people who have already gotten rich off crypto, brainstorming ways to keep getting rich off crypto. For Trump, the event is only the latest celebration of his whirlwind romance with crypto, which he spent years disparaging before realizing that embracing it could help fast-track his return to the Bloomberg Billionaires Index. He positioned himself as the pro-crypto candidate on the campaign trail last year, promising to create a national crypto stockpile and appoint industry luminaries to prominent administration roles. In another wild coincidence, around the same time, his adult sons helped launch World Liberty Financial, a crypto project structured to funnel 75% of revenue to the Trump family. WLF was basically a hedge against the results of the 2024 election: Even if Trump lost, he would at least have a new source of income to pay his legal bills. The fact that Trump won that election, of course, has made this alliance even more successful for everyone involved. In the hours before his inauguration, the price of Bitcoin spiked to nearly $110,000, then an all-time high. Demand for World Liberty Financial’s coins exploded, too, especially from foreign investors whom federal law bars from giving directly to presidential campaigns or inaugural funds. (Sun, who will attend Thursday’s dinner, has spent nearly $75 million on WLF tokens, making him its single largest known investor.) More recently, Abu Dhabi announced that it would use a WLF-issued stablecoin, USDI1, for its state-backed investment firm’s $2 billion deal with the crypto exchange Binance—a choice that just so happens to put tens of millions of dollars in the Trump family’s pockets.  In an interview with the New York Times earlier this year, Eric Trump spoke of the family’s pivot to crypto in glowing terms, describing World Liberty Financial as “one of the more successful things we’ve ever done.” The numbers bear this out: In March, Fortune estimated that Trump’s crypto holdings were worth $2.9 billion—not bad for an asset he was dismissing as “not money,” “highly volatile,” and “based on thin air” a few years earlier. Pundits often describe Trump’s involvement in crypto as “unprecedented,” and in a sense, this is right: Given Washington’s enduring obsessions with political scandals and conflicts of interest, traditionally, sitting presidents have not developed active side hustles in industries they have the power to regulate. But Trump has never cared about adhering to norms like this one, because he has always viewed the power of the office he holds primarily in terms of its potential to make him wealthier. He agreed to shake hands with a couple hundred crypto enthusiasts this week for the only reason he has ever done anything: He saw a chance to make money, and no one stopped him from taking it.

Images: CrytekCrysis was released back in 2007, and it was beautiful, which meant it had pretty high hardware demands – something that players still joke about with the "Can it run Crysis?" meme.Crysis's director and Crytek founder Cevat Yerli explained that the team wanted to "make sure Crysis does not age, that [it] is future proofed, meaning that if I played it three years from now, it should look better than today."If you are curious what was going on at Crytek during the development, you're in luck: Michael Khaimzon, former art director at Crytek, who worked on the game, generously shared some insights that you should hear."The back-stories are almost as crazy as the visuals, so I figured I’d start sharing a few," he said on LinkedIn.The developers, based in Frankfurt, Germany, were tasked to build "the most realistic jungle ever.""What do we know about jungles? We book tickets to Tahiti. The brief is simple: study how a real jungle works and shoot enough photos for textures. ... Ironically, none of the photos we took were usable. In the end we decided to model every single vegetation texture in 3D instead. It sounds insane, but that call ends up driving one of the biggest leaps in real-time graphics. So the trip was essentially useless other than a pack of reference shots."With Crysis, the team wanted to delve into photorealism: "Not “pretty,” not “stylized” – we wanted players to squint and wonder if it was real." Before, Far Cry was lauded for its amazing jungle environments, but for this game, the "trick of hand-painting specular and bump effects straight into textures wasn’t gonna cut it.""At the time, no one used high-poly models for foliage. Leaves were painted, not sculpted. Modeling them sounded insane – until we did it. Suddenly, we had full control over layout, and flawless normal maps where every leaf caught light at its own angle."Another solution that made Crysis look so good was light scattering. The developers simulated the color shifts and shadow plays of leaves, used vertex color and bone rigs to make leaves sway realistically, and did some manual alpha tuning for mipmaps to fix long-distance opacity glitches, "but honestly, the two real breakthroughs were high-poly leaves and subsurface light scattering."Yerli wanted to create "something the world has never seen," so art director Magnus Larbrant provided a concept showing winter in the jungle."As production rolled on, our regular jungles started looking insanely good – photoreal, even by today’s standards. Next to them, the icy levels felt gimmicky, but we’d promised them, so they stayed. ... Sometimes the image that sells the game isn’t the one that defines it. Still, that frozen-jungle concept sparked the entire franchise, so here it is for the history books," Khaimzon explained.What players do remember is the Nanosuit, which, it turns out, "wasn’t even planned until a year into production." Apparently, Delta Force agents were supposed to wear tank-looking supersuits mid-game, but "that didn’t strike a nerve, and Cevat was never satisfied with mediocrity," so the developer tried to focus on "the rubbery muscle structure" from early concepts, but it was not enough, still."And then came the franchise-defining idea: strip away all the armor. Keep the muscles only. Let’s go for a ninja-like figure – black, agile, enhanced. We made our first actual nanosuit... ...but it still didn’t work."The muscles were flat, Khaimzon says, so Crytek asked an external concept artist to look at the suite "with a fresh set of eyes, to take our design and separate each major muscle group as much as possible." This resulted in "the most amazing concepting and modeling feat I’ve ever seen."Crytek's artists created a low-poly model using smoothing groups to separate muscles and then a detailed high-poly sculpt."The Nanosuit was born."In 2004, voxels were all the rage, but they didn't suit the game: "No creature with an IQ over 1 would build a spaceship out of blobs and mush." Playing with the shapes, Crytek loved the organic feel and started looking into blending organic and technological forms, "how to make something that looked alien, but also engineered.""We quickly realized that the key to making it look like advanced technology was in repeating, parallel elements – something that looks artificially crafted."Once that was done, the team focused on zero gravity, which sounds great but demands a lot from developers. Players could get nose-to-nose to textures with zero gravity, but they didn't look good that close; they were "pixely and blurry." "Add detail textures, and they barely helped – they only showed when you were right on top of the surface. Using lots of unique textures wasn’t the answer either – it ate up memory and made the surface look noisy and chaotic from afar."So Crytek invented "one of the most unconventional art pipelines" it'd ever used: designing all alien objects using only tiled textures. The entire 1000-meter alien ship and its interiors were built with a handful of unique textures."Artists had to break objects into clearly defined zones, each mapped with a repeating texture. The structure and flow of the texture became part of the design itself. The real challenge? Creating compelling, alien shapes under such a strict limitation. A huge task."I'd say the developers succeeded in their task, creating a game that will stay with gamers for years to come, thanks to its amazing environments, characters, and mechanics that Crytek worked so hard on making work.Khaimzon has shared 6 parts of this exciting journey, and if you want to know more, follow him on LinkedIn.Also, join our 80 Level Talent platform and our new Discord server, follow us on Instagram, Twitter, LinkedIn, Telegram, TikTok, and Threads, where we share breakdowns, the latest news, awesome artworks, and more.

Projects Update – Q2/2025 html PUBLIC "-//W3C//DTD HTML 4.0 Transitional//EN" "http://www.w3.org/TR/REC-html40/loose.dtd" At the beginning of 2025, several projects were announced as the initial targets for the year. Now that we’re in the middle of the second quarter, let’s take a look at where each project stands. Complete Vulkan Vulkan is now officially supported in the upcoming 4.5 LTS release, offering feature parity and comparable performance to the OpenGL backend. The next step is to monitor bug reports and eventually make it the default backend for non-macOS systems. Almost Complete UV Sync All issues from the (five-year-old!) UV Sync design task have been addressed. Development is ongoing in the pr-uv-sync-select branch (builds are available here). The remaining work involves finalizing the port of certain selection operators and resolving minor issues. Follow the project at #136817. Better integration across node trees The compositor is moving closer to feature parity with shading and geometry nodes, thanks to the addition of new nodes such as Vector Math, Vector Rotate, Vector Mix, Value Mix, Clamp, Float Curve, and Blackbody. Compositor Assets Mockup. The next step is to expose most of the existing node options as socket inputs, (#137223). This will enable compositor node assets to be bundled with Blender. After that, the focus will remain on simplifying onboarding for new compositor users by making node trees reusable (#135223). In Progress Project Setup The first milestone (Blender variables) was recently merged. The next step is to handle Path Template errors in a more robust way. Project Setup Mockup. After that, work will begin on the Project Definition phase. Follow the project at #133001. Shape Keys Improvements What was originally framed as a performance problem has shifted focus toward usability and management of shape keys. As part of this, new operators for duplicating and updating shape keys have already been merged, with their mirrored counterparts to follow. Additionally, work on multi-select and editing of shape keys is gaining momentum. Follow the project at #136838. Remote Asset Libraries The project has broadened in scope to address usability improvements, including: Preview generation for all selected assets. A more compact view with a horizontal list and two-line names. Snapping for dragged collection assets. Remote Asset Library mockup. Meanwhile, the code for handling downloads has been submitted for review but encountered a setback. Development is taking place in the remote-asset-library-monolithic branch. Follow the project at #134495. Hair Dynamics The Hair Dynamics project consists of multiple deliverables: Embedded Linked Data (#133801) — still under review Bundles and Closures — merged as experimental Declarative Systems — published as a design proposal Hair Solver — see below For the hair (physics) solver, the plan is to use the upcoming Blender Studio project—currently unnamed but focused on a facial rig—as a use case, at least to develop it as an experimental feature. This will also involve addressing existing issues with animated hair and integrating animation and simulation for the same character—initially using separate hair objects. Design/Prototype Texture cache and mipmaps Initially unplanned due to limited resources, this project was eventually added to the agenda. A rudimentary prototype is already available in the cycles-tx branch. In the Attic and Bistro benchmark scenes, memory usage is already significantly reduced. These scenes were chosen because they include texture cache (.tx) files. To learn how to test it, follow the project at #68917. NPR The NPR (Non-Photo Realism) prototype received extensive feedback, helping to map out all planned and unsupported use cases for the project. More details, including the final design and development plans, will be shared soon. In brief: Some features will be implemented as EEVEE nodes. Others will be enabled via per-material/object compositing nodes. EEVEE features will be prioritized first, while the per-material/object compositing nodes require further design. So far, the focus has been on prototyping and finalizing the design to pull VSE strips out of the scene and create a dedicated sequence data-block. Story Tools Mockup. The next step is to finalize the design by either: Exploring once more the idea of keeping the sequence as part of the scene; or Settling on a per-camera and file settings design. After that, a technical breakdown will follow, then development. Follow the project at #131329. Not Started Layered Sculpting Layered sculpting hasn’t started yet. The original plan was to first address multi-resolution undo and rebuild issues, followed by fixing propagation spikes. However, in recent months the focus shifted to tackling sculpting performance issues present since the 4.3 release, mainly: Performance problems with smaller brush strokes. Local brush management. The performance patches are currently under review and expected in time for the upcoming 4.5 LTS release. Once completed, work on undo and multi-resolution will resume. Dynamic Overrides The team is busy with the 5.0 breaking change targets and other tasks and could not reserve the time to start the initial changes expected to simplify the overrides process. The team is currently focused on the 5.0 breaking change targets and other tasks, so they have not yet been able to start the initial changes aimed at simplifying the overrides process. And more… Beyond these projects, daily activity continues across various development modules. For a more frequent, day-to-day view of progress, check out the Weekly Updates and Module Meetings. All this progress is made possible thanks to donations and ongoing community involvement and contributions. Support the Future of Blender Donate to Blender by joining the Development Fund to support the Blender Foundation’s work on core development, maintenance, and new releases. ♥ Donate to Blender

We may earn a commission from links on this page.If you're looking for a Garmin watch at a great price, the recent drops of the Forerunner 570 and 970 is excellent news—not because you should pick up those models (they're fine, I guess) but because the older generations of Forerunner, which remain excellent watches, are now going for ludicrously low prices. The previous models, the 265 and 965, are great, but you can go back one more generation to the 255 and 955—released in 2022—and save hundreds of dollars without sacrificing any major functionality. I truly can't think of any fitness watch that is a better deal right now, given the prices we're seeing on these two: currently $247 for the Forerunner 255, and $373 for the Forerunner 955, which is the upgraded version with maps and a few extra training features. Garmin Forerunner 255 GPS Running Smartwatch (Gray) $247.50 at Amazon $349.99 Save $102.49 Get Deal Get Deal $247.50 at Amazon $349.99 Save $102.49 Why am I recommending three-year-old watches? I'll get into the specs below, but the important context here is that Garmin's Forerunners have serious longevity. Running app Strava releases year-end trend reports that consistently show older Forerunners among the nation's and the world's most popular running watches. The most recent report, for example, had the Garmin Forerunner 245 in third place, after the Apple Watch and Apple Watch SE. That's a five-year-old watch. Not long ago, the Forerunner 235, then an eight-year-old watch, was the most popular worldwide. These things last!What the 255 and 955 are missing compared to newer models (not much) Left: 265S (the smaller, newer model). Right: 255 (the larger one with the MIP screen that's currently on sale). Credit: Beth Skwarecki The numbered models can get confusing, but I promise you’ll be able to follow along. All the watches that start with a 9 are the top-of-the-line Forerunners (the 955 was replaced by the 965 and most recently the 970) and most of those came with a little sibling that starts with a 2 (respectively: the 255, 265, and in a break from tradition, 570). The 9xx series have onboard maps that let you see exactly where you are and where you're going. The 2xx watches have breadcrumb navigation that shows you the general shape of the route you've already taken. If you need a map on your wrist, you probably want to go for a 9xx. I wrote about the newest models here, so you can see what the 970 has over the 965 (and what the 570 has over the 265). The big feature is that the 570 and 970 support voice calling and voice texts, and the 970 has a built-in LED flashlight. If those features aren't must-haves for you, take a look at the next generation back. The 265 and 965 are excellent watches with important functionality, like dual-band GPS. you can read my review of the 265 here:, and note that the 265 is my own personal running watch, the one that I bought with my own money because I love it. The 265 has a ton of great features for runners. Some are concrete and functional: physical buttons, lots of options for data screens, and a dual-band GPS for extra location accuracy. Others are more software-y but still arguably useful: training status, daily suggested workouts. The battery also lasts between one and two weeks, depending on how many workouts you do. The 965 has all that, plus onboard maps, so you can see where you are relative to roads, bodies of water, and so on. It's also got a few extra training statistics, like an endurance score and a heat acclimation score. The 255 and 955 have all of these same features. The only features that are meaningfully different between the x55 and x65 series are:The 255/955 have the older, always-on MIP screen, while the 265 has a smartphone-style AMOLED screen. I have more here on the difference between those screen types.The 255/955 don't have touchscreens. You’ll use the UP and DOWN buttons on the left side to scroll through options. The 255 can’t store music, unless you buy the 255 Music version. The 955 has music storage built in, just like the 265 and 965 do.The 255 doesn’t have Training Readiness, but it does have Training Status. (Personally, I never use Training Readiness, so this isn’t much of a loss. You can always look at your HRV trend, which the watch also reports, if you want a sense of how recovered you are each morning.) The 955, 265, and 965 all have Training Readiness.For the detailed list of every minor feature that’s different between the two, you can check out this comparison page on Garmin’s site. Which Forerunner 255 version you should getThere is only one Forerunner 955, but there are four versions of the 255, and two versions of the 265. The regular Forerunner 255 is the larger size (45.6 mm) and does not have music storage. The Forerunner 255S is the smaller size (41 mm) and also does not have music storage.The Forerunner 255 Music is the larger size (45.6 mm) and does have music storage, so you can play tunes from the watch while leaving your phone at home.The Forerunner 255S Music is the smaller size (41 mm) with music storage.  Personally, I always have my phone with me when I run, so I’ve never found the standalone music feature very helpful. If you think you might use it, though, it’s normally a $50 upgrade, but currently only a $20 upgrade on the larger size of the watch.To help you decide, the photo above shows the difference in screens between the AMOLED 265S (left) and MIP 255 (right). It also shows the size difference between the smaller and larger models; the 265S on the left is 41.7 mm, very close to the 255S at 41 mm. How old is the 255, anyway? The 255 is only one year older than the 265. They were released in 2022 and 2023, respectively. Before that, Forerunner releases tended to be three to four years apart. The quick turnaround between the 255 and 265 makes sense when you realize they’re basically the same watch with a different display.So I wouldn’t expect a 255 to feel outdated anytime soon. The main question you need to ask yourself is: How do I feel about a MIP screen? I’ve written more about the difference between MIP and AMOLED here. MIP screens don’t light up, although they have a backlight that can come on automatically when you raise your wrist. At rest, they are “always on,” in the sense that they’re always displaying something, so you’ll never look down at a blank screen. They’re also brightly reflective in sunlight. AMOLED screens are more like a smartphone screen, with glowing pixels, and watches typically turn off the display when you’re not using it to save energy. (You can enable an always-on setting, but it eats battery.) That said, the overall battery life on both watches is similar on default settings—14 days not counting activities for the 255, and 13 days for the 265. Some people prefer the MIP screens, and if that includes you, this is a no-brainer: snag the 255 or 955. You can even get a refurbished version for $179.99, which makes this one of the cheapest Garmin watches in any line. The bottom line (check prices) Prices on Forerunners have been fluctuating lately, so I'm hesitant to give any dollar-for-dollar comparisons, but here's what I'm seeing at the moment I write this. Officially, Garmin is selling the 255 and 265 for the same price, $349.99. The 955 and 965 are going for the same price, $499.99. At those prices, you might as well get the -65 version of whichever watch you prefer. But over on Amazon, I'm seeing prices as low as $247 for the 255 and $373 for the 955. That means a 255 is the same price as the anemic Forerunner 165 (it's OK as a budget watch, but it's missing a lot of features that the 255/265 have) and the 955 is the same price as a 265! Check prices to see if these deals are still live by the time you read this, and ultimately decide based on features.