HealthThere are many claims about the benefits of microdosing weight-loss drugs, from anti-inflammatory effects to extending longevity. Do any of them stack up? 26 March 2025 Getty Images; AlamyMadison Burgess decided to get serious about weight loss when the scale hit 91 kilograms (200 pounds). She began taking Ozempic. The medication worked better than she ever thought possible: even on the low starter dose, she lost more than 2 kg (5 lbs) within the first week.Problems began, however, when Burgess, a 25-year-old healthcare administrator from Bloomfield, Michigan, ramped up her intake, as per the manufacturers guidelines. The higher doses were rough on me, she says. The constipation, nausea, diarrhoea and acid reflux hit hard and made eating difficult. Thats when she decided to drop back down to a lower dose and determine whether she could continue seeing benefits.This article is part of a special series investigating the GLP-1 agonist boom. Read more here.Burgess is just one of a growing number of people who are microdosing a practice more typically associated with psychedelics such as LSD and psilocybin by taking lower-than-standard amounts of weight-loss drugs such as Wegovy and Mounjaro (see How they work, below).For some, the hope is to avoid side effects while losing weight, while others want to tap into the anti-inflammatory effect of these medications or reap their other benefits for the heart and the brain (see A wonder drug?, below). Microdosing the drugs has even been touted for extending longevity by ultra-wealthy elites like tech entrepreneur Bryan Johnson, and is rumoured to be the secret weapon of Hollywood stars wanting to look svelte for photo calls.The question is, does this off-label, low-dose experimentation work?

Jeff Bezos and his fiance Lauren Snchez are set to marry in Venice. Michael Tran / AFP via Getty Images 2025-03-30T17:06:44Z SaveSaved Read in app This story is available exclusively to Business Insider subscribers. Become an Insider and start reading now.Have an account? Billionaire Jeff Bezos' marriage to Lauren Snchez is set to take place in Venice this summer.The city's mayor is attempting to reassure locals ahead of the event.He said organizers were working to ensure it would be "respectful of the fragility and uniqueness of the city."As the city of Venice confirmed it is gearing up to host the wedding of Amazon founder Jeff Bezos and Lauren Snchez this summer, the local mayor attempted to reassure residents amid the ongoing battle with overtourism.In a statement on Saturday, the city of Venice said the billionaire and his bride-to-be's upcoming nuptials would not cause disruption to residents or visitors and that the priority would be to make sure the city long a tourist hotspot "functions as normal."The statement said that 200 guests are due to attend the Venetian ceremony, but it stressed that the city was accustomed to handling large international events.It also denied reports that large numbers of gondolas or "excessive" numbers of water taxis had been booked for the occasion."The many speculations and fake news circulating about Jeff Bezos' wedding are completely unfounded," the statement continued.Luigi Brugnaro, Venice's mayor, added: "We are mutually working and supporting the organizers, to ensure that the event will be absolutely respectful of the fragility and uniqueness of the city. For this reason, we will work together for best result. Whoever loves Venice will always be welcome." Bezos and Snchez. Stefanie Keenan/VF24/ Getty Images The city did not disclose the date for Bezos and Sanchez's destination wedding, and representatives for the Blue Origin founder did not respond to a request for comment from Business Insider, which was sent outside regular working hours.However, a spokesperson for the mayor of Venice told CNN that the celebrations are due to take place from June 24 to June 26.Bezos and Snchez, a former broadcast journalist, became engaged in May 2023. The Washington Post owner was previously married to MacKenzie Scott, with whom he has four children. Venice has taken measures to address overtourism in the city. Marco Bottigelli/Getty Images It's not the first time the "floating city" has played host to a high-profile wedding.In 2014, George and Amal Clooney tied the knot at the exclusive Aman Canal Grande Hotel, which faces onto the iconic Grand Canal.But in recent years, the city famed for its maze of picturesque canals and stunning architecture has garnered increasing attention for its attempts to push back on overtourism.With a population of around just 50,000, the island city of Venice welcomes around 20 million visitors a year and many of its outnumbered residents are fed up.Several measures have been introduced to try to tackle the issue, including limiting tourist groups to 25 people, banning large cruise ships from entering the Venice Lagoon, and charging a daily 5-euro (around $5.40) fee to day-trippers.Recommended video

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