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WWW.SMITHSONIANMAG.COMStem Cell Therapies Could Treat Parkinson's Disease by Rebuilding Lost Circuitry in the Brain, Studies SuggestStem Cell Therapies Could Treat Parkinson’s Disease by Rebuilding Lost Circuitry in the Brain, Studies Suggest Two small clinical trials tested the safety of injecting stem cells into the brains of Parkinson’s patients and found no adverse effects Lillian Ali - Staff Contributor April 21, 2025 1:23 p.m. A cell culture plate with pluripotent stem cells, which can differentiate into any kind of cell in the body. National Center for Advancing Translational Sciences A treatment that could replenish cells in the brains of Parkinson’s disease patients caused no major negative reactions in two small, early-stage clinical trials. The research offers hope that stem cell transplants may be able to replace the loss of certain cells that leads to Parkinson’s symptoms. Both studies injected stem cell-derived neurons into the brains of Parkinson’s patients and primarily tested the procedure’s safety. The pair of studies, published in the journal Nature last week, were both very small—one tested 12 patients, while the other tested seven—so researchers can’t yet conclude the effectiveness of stem cell treatments overall. Still, the studies are “a big leap in the field,” Malin Parmar, a stem cell biologist at Lund University in Sweden who was not involved with the new research, tells Nature’s Smriti Mallapaty. “These cell products are safe and show signs of cell survival.” Parkinson’s disease is a degenerative brain condition estimated to affect at least 1 percent of people over age 60 across the world. It causes deterioration in the basal ganglia, a brain area associated with motor control. The resulting changes in brain chemistry lead to the disease’s characteristic symptoms: slow movements, muscle tremors, stiffness and difficulty walking. The cell loss caused by Parkinson’s results in a lack of dopamine—a key neurotransmitter—in the brain, so many Parkinson’s treatments seek to boost dopamine levels. These include medicines that increase available dopamine, resemble dopamine or block its natural breakdown. While these treatments can slow the progression of Parkinson’s disease, researchers do not have a cure for the condition. Experimental stem cell treatments offer another potential way to manage Parkinson’s—these techniques seek not only to replace or mimic dopamine, but to repair the brain circuitry lost due to Parkinson’s disease. “The idea is to place these neuron progenitors [derived from stem cells] right where you need them to connect with other neurons in the brain,” Viviane Tabar, a neurosurgeon at the Memorial Sloan Kettering Cancer Center and lead author of the 12-participant study, tells NPR’s Jon Hamilton. Stem cells are your body’s “master cells.” They are found in almost every tissue and, depending on the type of stem cell, can become any other kind of cell. The generation of stem cells to replace disease-affected cells is called regenerative medicine. For example, some patients with leukemia receive bone marrow transplants, which replace the diseased blood stem cells in the bone marrow with healthy ones. The new trials used stem cell therapy to replace lost dopamine-producing neurons. In each study, researchers observed whether the new cells survived and whether dopamine production increased. One study, which treated 12 patients in the U.S. and Canada, used stem cells from donated human embryos, while the other study injected seven patients with donated adult stem cells in Kyoto, Japan. In the larger of the two studies, the team gave a “low dose” of 0.9 million cells to five people and a “high dose” of 2.7 million cells to seven people. They expected a high rate of cell death, predicting that 100,000 and 300,000 cells would survive the surgery in each group, respectively, according to Nature. They measured the outcomes of treatment on a standard scale of Parkinson’s progression. A typical Parkinson’s patient “would expect every year to get two or three points worse,” Lorenz Studer, a co-author of the larger study and a stem cell biologist at the Memorial Sloan Kettering Cancer Center, tells NPR. “The high-dose group, they got about 20 points better.” The low-dose group improved by about nine points. The smaller study also noted some symptom improvement and a lack of adverse reactions, such as tumor development or uncontrolled bleeding. Jun Takahashi, senior author of the second study and a researcher at Kyoto University, tells Science News’ Laura Sanders Stem cell therapies for Parkinson’s disease are not a new idea. But while some patients in past trials have shown improvement in symptoms, researchers had also found evidence suggesting Parkinson’s spread to the implanted, healthy cells. “There have been times of hype versus hope, and ‘is this for real, or is this not for real?’” Tabar tells Science News. Tabar adds that the new studies point toward hope. The findings underscore the stem cell treatment’s safety, and hints of improvements in some patients are pushing these trials forward. Both studies are moving toward larger trials, which may offer stronger evidence of the treatment’s efficacy and open it up to more patients. Mya Schiess, a neurosurgeon at the University of Texas Health Science Center at Houston who was not involved in the trials, tells NPR that “now we have the potential to really, really halt this disease in its tracks.” Get the latest stories in your inbox every weekday.0 Commentarios 0 Acciones 28 Views
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VENTUREBEAT.COMAethir launches AI Unbundled industry alliance for Web3 AI developmentAethir, a provider of decentralized GPU cloud compute, announced the launch of AI Unbundled, an industry-wide alliance for Web3 AI.Read More0 Commentarios 0 Acciones 31 Views
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WWW.GAMEDEVELOPER.COMPalworld dev says Ark: Survival Evolved, Titanfall 2, and other games invalidate patent lawsuitPocketpair has fired a returning shot against Nintendo and the Pokémon Company in lawsuit against the Palworlddeveloper, arguing that Nintendo's claim to have patents on key game mechanics is "invalid" due to the existence of previously published games.In a series of "preparatory briefs" submitted on February 21, 2025 (reviewed by legal publication gamesfray), Pocketpair argued that the existence of "prior art" covering Nintendo's existing patents invalidates its claim of patent infringement. "Prior art" here references existing published games and patent applications from before the priority date of December 22, 2021.These games include Pocketpair's Craftopia, Studio Wildcard's Ark: Survival Evolved, Square Enix's Final Fantasy XIV, and somewhat unexpectedly, Respawn Entertainment's Titanfall 2.As gamesfray points out, it's notable that Pocketpair doesn't just reference individual games, but also player-made mods for existing games like a 2020 Dark Souls 3 mod "Pocket Souls" and a Pokémon-themed mod for Ark. The mods appear to be cited as examples of types of gameplay available to Pocketpair as inspiration during the time period.Titanfall 2, Tomb Raider, and Far Cry 5 are surprising citations in the Palworld patent caseThe citation of games like Titanfall 2 might surprise developers since Nintendo's patent claims had to do with the game mechanic of capturing in-game characters with capture balls and riding these characters. Gamesfray explains that Pocketpair's contention isn't that these contain the foundations for a combination of game mechanics that culminate in Palworld's gameplay—or in some cases, outright display the patented mechanics concerning "capturing" and "smooth switching" of rideable objects.Related:For example in Titanfall 2, Respawn implemented a mechanic for the player to "catch" incoming bullets and throw them back at the enemy. If a developer took inspiration from that mechanic and created a system that applied that "catch and throw" loop to creatures instead of bullets, Pocketpair's argument is essentially that even if the game was released after the December 2021 patent filing, its existence is based "prior art" and can't be considered a violation.In this case, it's arguing that its own game Craftopia is the "starting point" to arrive at the mechanics covered in the patent, and that one need only "combine" Craftopia with prior mechanics to organically arrive at the patented material without violating them.Pocketpair also cited several pre-2021 games from Nintendo's library including The Legend of Zelda, Pikmin 3 Deluxe, and Pokémon Legends: Arceus as games with mechanics that could be "combined" with Craftopia.Related:It's difficult to tell if these arguments justify invalidating Nintendo's 3 patents. Though Pocketpair's reasoning makes sense on the surface, these arguments are taking place before a patent law court, which may take a more hard-and-fast view when it comes to patented game mechanics.However things shake out, Pocketpair has raised one important point: the volume of video game releases in the last 10 years has created a situation where developers iterate fast and take inspiration from each other's game mechanics at a rapid-fire rate, meaning there are complex combinations of mechanics hitting the marketplace on a yearly basis. Unlike the early days of restrictive video game patent filings, it's more difficult to argue that any developer has a unique claim on a specific mechanic.0 Commentarios 0 Acciones 38 Views
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WWW.THEVERGE.COMSony shows off the PS5 Pro’s liquid metal updatesSony has published a new teardown of the PlayStation 5 Pro, highlighting improvements that it made to the cooling apparatus of the machine. They include tweaks to the PS5’s liquid metal cooling design aimed to give the console “more stable” cooling. The changes follow unproven claims that the liquid metal used in the first PS5 can leak and damage the console. Some sites even recommended against keeping the PS5 vertical after a repair shop owner and YouTuber was partially misquoted by jailbreak site Wololo.net. Wololo later followed up, saying its original story contained a “critical misunderstanding” — ultimately, it doesn’t seem like this was ever a widespread issue.Even so, Sony writes that it changed the design for the PS5 Pro, quoting Shinya Tsuchida, PS5 Pro Mechanical Design Lead:We spent quite some time conducting research on insulation when we were designing the original PS5. The basic structure remains the same in the PS5 Pro, but we made some improvements by adding fine grooves where the liquid metal is applied, so that the cooling effect is more stable. When we were doing research for the original PS5, we anticipated that semiconductors would continue to advance and become much denser, so we believed liquid metal technology would become crucial. It turns out we were right, and it was integral when designing the PS5 Pro.This is your PS5 Pro on liquid metal. Image: SonyThe rest of the blog post and its images may be familiar to you if you already saw iFixit’s teardown of Sony’s very expensive console, in which it noted that the inside of the PS5 Pro contains more thermal management than electronics.It’s fan blades all the way down. Image: SonySome of that includes a larger cooling fan that the company says has redesigned fan blades, including “smaller blades in between” them. The blog also explains why it’s so hard to see the traces on the PS5 Pro’s motherboard: the board hides extra electrical layers beneath, to speed up memory access.See More:0 Commentarios 0 Acciones 38 Views
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WWW.MARKTECHPOST.COMServerless MCP Brings AI-Assisted Debugging to AWS Workflows Within Modern IDEsServerless computing has significantly streamlined how developers build and deploy applications on cloud platforms like AWS. However, debugging and managing complex architectures—comprising services such as Lambda, DynamoDB, API Gateway, and IAM—often requires developers to jump between logs, dashboards, and local tooling. To address these challenges, Serverless Inc. has introduced Serverless MCP (Model Context Protocol), a powerful new protocol that enables seamless, AI-assisted debugging directly inside intelligent IDEs like Cursor. The Serverless MCP builds upon a foundational idea: developers should be able to query, introspect, and resolve serverless application issues from where they write code—without the overhead of context switching or manually navigating AWS dashboards. This integration makes serverless development more accessible, especially for developers aiming to reduce the operational friction of cloud-native applications. Solving the Debugging Dilemma in Serverless Architectures Working with AWS serverless architectures involves interacting with various managed services. A typical application might use Lambda for compute, DynamoDB for storage, API Gateway to expose endpoints, and IAM for permissions. These services produce logs, metrics, and configuration data scattered across multiple consoles. The debugging experience for developers often includes: Manually finding CloudWatch logs tied to specific Lambda executions. Tracing failed API Gateway requests across multiple services. Tracking down misconfigured IAM roles and permissions. Cross-referencing AWS documentation with real-time code behavior. This fragmented experience is where Serverless MCP steps in. What is Serverless MCP? Serverless MCP (Model Context Protocol) is a developer-facing protocol that allows AI-assisted IDEs to communicate with AWS infrastructure resources via the Serverless Framework. Once installed and configured, MCP unlocks deep telemetry from deployed services and surfaces them directly in tools like Cursor and Windsurf. The protocol enables these IDEs to: Pull logs and metrics relevant to the current file or function. Highlight failed invocations and error traces contextually. Visualize service relationships (e.g., how a Lambda function connects to an API route or a DynamoDB table). Recommend fixes for common issues like IAM misconfigurations or timeout errors. The Serverless Framework CLI (v3.38+) now supports serverless dev, which activates the MCP interface. Once enabled, AI coding environments can query your infrastructure and assist in debugging without requiring manual log exploration or infrastructure navigation. How MCP Works with IDEs like Cursor and Windsurf In IDEs integrated with MCP, developers can hover over a line of code—say, an AWS Lambda function handler—and see the logs from its last execution, error messages, or even the duration and cold start metrics. This contextual debugging model reduces cognitive load and allows real-time understanding of production behavior. Cursor, for example, uses AI models that are MCP-aware. When a developer writes or edits code, the AI agent queries the MCP interface to fetch infrastructure state, recent logs, and performance metrics relevant to the code segment. It then suggests improvements, flags misconfigurations, or explains recent failures. This makes the MCP integration not just a log viewer, but an AI-assisted debugging assistant. Security and Operational Considerations Serverless MCP is designed with least-privilege principles in mind. The setup process involves creating a minimal set of IAM policies required for MCP access. This ensures that IDEs only fetch diagnostic data scoped to the developer’s workflow. Moreover, since all the debugging insights are surfaced locally in the IDE, there is no need to expose your cloud dashboard or give third-party plugins blanket access to your AWS environment. Conclusion With the release of Serverless MCP, the debugging workflow for AWS serverless applications gets a much-needed upgrade. By embedding operational intelligence into AI-driven IDEs, Serverless bridges the gap between code and cloud, offering a smoother and more intuitive development experience. As serverless architectures grow in complexity, tools like MCP will likely become foundational in modern DevOps pipelines—especially for teams seeking to minimize downtime and maximize iteration speed without diving deep into the AWS console. For developers already using the Serverless Framework, enabling MCP is a simple upgrade that promises significant productivity gains. Check out the Twitter and join our Telegram Channel and LinkedIn Group. Don’t Forget to join our 90k+ ML SubReddit. Asif RazzaqWebsite | + postsBioAsif Razzaq is the CEO of Marktechpost Media Inc.. As a visionary entrepreneur and engineer, Asif is committed to harnessing the potential of Artificial Intelligence for social good. His most recent endeavor is the launch of an Artificial Intelligence Media Platform, Marktechpost, which stands out for its in-depth coverage of machine learning and deep learning news that is both technically sound and easily understandable by a wide audience. The platform boasts of over 2 million monthly views, illustrating its popularity among audiences.Asif Razzaqhttps://www.marktechpost.com/author/6flvq/A Step-by-Step Coding Guide to Defining Custom Model Context Protocol (MCP) Server and Client Tools with FastMCP and Integrating Them into Google Gemini 2.0’s Function‑Calling WorkflowAsif Razzaqhttps://www.marktechpost.com/author/6flvq/OpenAI Releases a Practical Guide to Identifying and Scaling AI Use Cases in Enterprise WorkflowsAsif Razzaqhttps://www.marktechpost.com/author/6flvq/An Advanced Coding Implementation: Mastering Browser‑Driven AI in Google Colab with Playwright, browser_use Agent & BrowserContext, LangChain, and GeminiAsif Razzaqhttps://www.marktechpost.com/author/6flvq/Meta AI Introduces Collaborative Reasoner (Coral): An AI Framework Specifically Designed to Evaluate and Enhance Collaborative Reasoning Skills in LLMs0 Commentarios 0 Acciones 32 Views
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TOWARDSAI.NETThe Great Disconnect: Why Talking to Machines Still Feels Like Talking to MachinesThe Great Disconnect: Why Talking to Machines Still Feels Like Talking to Machines 0 like April 21, 2025 Share this post Author(s): MKWriteshere Originally published on Towards AI. From Clippy to ChatGPT: The Thirty-Year Quest to Solve AI’s Hardest ProblemImage Generated by Author Using Gpt-4o (Non-Member Link) In 1995, Gartner published its first “Hype Cycle” report — a visual representation of how technologies evolve from innovation to widespread adoption. Right at the top of this inaugural curve, at the “Peak of Inflated Expectations,” sat “Intelligent Agents.” Three decades later, we’re still riding this rollercoaster of anticipation and disappointment with AI assistants. Imagine the journey as a dramatic mountain trek: enthusiastic climbers rush up the slopes of hype, tumble down into the “Trough of Disillusionment,” then gradually ascend the “Slope of Enlightenment” toward the “Plateau of Productivity.” This is precisely the path AI assistants have followed multiple times. Few developments have experienced as many ups and downs as artificial intelligence assistants. From the much-maligned Clippy to the sophisticated ChatGPT, we’ve witnessed these digital helpers ride waves of hype only to crash against the shores of reality. Yet with each cycle, they’ve grown more capable, inching ever closer to the science fiction dream of a truly intelligent digital companion. Image Source : ReasearchGate Website Let’s unpack this fascinating evolution and understand why contextual reasoning remains the final frontier for AI. Image Source : Microsoft Clippy Cast your mind back to 1997. Microsoft Office users were suddenly introduced to an animated… Read the full blog for free on Medium. Join thousands of data leaders on the AI newsletter. Join over 80,000 subscribers and keep up to date with the latest developments in AI. From research to projects and ideas. If you are building an AI startup, an AI-related product, or a service, we invite you to consider becoming a sponsor. Published via Towards AI Towards AI - Medium Share this post0 Commentarios 0 Acciones 49 Views
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WWW.IGN.COMRuneScape: Dragonwilds Interactive Map is Now AvailableIGN's RuneScape: Dragonwilds map is here! Our interactive map tracks essential locations across Ashenfall, including Primary and Secondary Quests (Side Quests), recipes for Masterwork equipment such as the Staff of Light, and resources such as Anima-Infused Bark and Blightwood Root.RuneScape: Dragonwilds Interactive MapClick on the image above to go to our RuneScape: Dragonwilds interactive map!You can also check off your exact progress toward completion using our checklists! And you can filter exactly what you're looking for using the sidebar on the left.The available map filters for our RuneScape: Dragonwilds interactive map include:Collectibles, including Lore Scraps and Recipes for Masterwork equipment such as the Crystal Bow.Items, such as Chests, so you know exactly where to go to find loot.Quests, including Primary Quests and side quests, such as Restless Ghosts.Resources, such as locations for Anima-Infused Bark, Gold Ore Nodes, and Swamp Weed for all your crafting needs.Other notable map markers, including NPC locations, Crumbled Walls, and Thorny Vines.RuneScape: Dragonwilds GuidesThere's a lot to do in RuneScape: Dragonwilds, whether that's tracking down materials like Ram Horns or crafting rare weapons like the Abyssal Whip. IGN's Game Help is here to help with informative guides. Our coverage includes:Visit our RuneScape: Dragonwilds wiki for more game help.Meg Koepp is a Guides Editor on the IGN Guides team, with a focus on trends. When she's not working, you can find her playing an RPG or spending time with her corgi.0 Commentarios 0 Acciones 43 Views
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9TO5MAC.COMiPhone 17 Air will compromise in a few areas, but this key feature won’t be one of themLater this year, Apple is going to debut its thinnest iPhone to date. At just 5.5mm thin, iPhone 17 Air will be record-setting. You might anticipate that an ultra-thin phone comes with awful battery life. After all, iPhone battery life improved drastically over the past few years, as Apple has made increasingly thicker iPhones. However, at least according to current rumors, iPhone 17 Air won’t compromise on battery life. Here’s why. According to multiple sources, Apple is engineering two solutions to ensure battery life is still top notch on one of it’s thinnest devices to date: Redesigned display and silicon components, for greater efficiency Higher density battery cells, to pack more capacity in a smaller form factor The first rumored solution comes from highly-reputable Mark Gurman from Bloomberg. In a Power On newsletter last month, he outlined that Apple didn’t want to compromise by including “fewer hours of battery life” on its new thinner iPhone model: Apple didn’t want to compromise here, so it sent engineers back to the drawing board to redesign display and silicon components, as well as software, to make the device more efficient. On top of that, supply chain analyst Ming-Chi Kuo alluded to the fact that iPhone 17 Air would implement “high-density battery cells.” In a report regarding Apple’s upcoming foldable iPhone, Kuo mentioned the following: It will use the same high-density battery cells as the ultra-thin iPhone 17. While we unfortunately don’t have many details regarding these high-density battery cells, we at least know that Apple is looking to pack more capacity in this phone than they’d traditionally be able to. Contrary to popular belief, a thin phone doesn’t have to have a small battery. Additionally, Apple is widely expected to implement its new C1 modem in the iPhone 17 Air. This’ll allow for less battery drain over 5G cellular, something that’s previously been a concern for some users. Are you looking forward to Apple’s ultra-thin iPhone 17 Air? Let us know in the comments. My favorite Apple accessories on Amazon: Follow Michael: X/Twitter, Bluesky, Instagram Add 9to5Mac to your Google News feed. FTC: We use income earning auto affiliate links. More.You’re reading 9to5Mac — experts who break news about Apple and its surrounding ecosystem, day after day. Be sure to check out our homepage for all the latest news, and follow 9to5Mac on Twitter, Facebook, and LinkedIn to stay in the loop. Don’t know where to start? Check out our exclusive stories, reviews, how-tos, and subscribe to our YouTube channel0 Commentarios 0 Acciones 47 Views
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FUTURISM.COMKaty Perry Now Feeling Regrets Over Jeff Bezos Rocket RideBy many accounts, pop star Katy Perry's frivolous PR stunt to ride Jeff Bezos' Blue Origin rocket to the edge of space backfired in spectacular fashion.Perry, who rode the company's New Shepard rocket to the outer reaches of the Earth's atmosphere last week alongside several other zillionaires, received major blowback from the public.The singer was thoroughly mocked for trying to turn the self-serving journey into a symbolic victory for women in space — and it certainly didn't help that NASA has been rushing to wipe any mentions of diversity and women in leadership from its websites this year due to Donald Trump's anti-DEI agenda, an insidious initiative that Perry made no mention of.Perry was also ridiculed for claiming that the stunt was somehow "for the benefit of Earth," rather than a meaningless joyride for a handful of uber-wealthy celebrities. There are also environmental concerns; while Blue Origin's capsule only releases water vapor as a byproduct, experts have pointed out that the particles can still wreak havoc with the planet's stratosphere and contribute to the depletion of the ozone layer.And, if the Daily Mail's insider sources are to be believed, Perry is now regretting the way the extravaganza unfolded after the widespread backlash."Katy doesn't regret going to space," the source told the tabloid. "It was life changing. What she does regret is making a public spectacle out of it."The unnamed insider also claimed that Perry "regrets sharing the daisy with the world," referring to a symbolic flower she brought to space in a tribute to her four-year-old daughter, and she "wishes the video footage from inside the pod was never shown."A number of other high-profile celebrities have heavily criticized the publicity stunt, calling it out for being tone-deaf and pointless."Space exploration was to further our knowledge and to help mankind," actor Olivia Wilde argued earlier this month. "What are they gonna do up there that has made it better for us down here?"Model Emily Ratajkowski said she was "literally disgusted" by the "beyond parody" stunt.The blowback was so widespread, even the X-formerly-Twitter account behind the burger chain Wendy's jumped on the opportunity to take a swipe, proposing that we "send her back" to space.Seeing even the fast food world gang up on the popstar appeared to have been the straw that broke the camel's back."Wendy’s didn’t make a joke — they made a choice," a "source close to the situation" told People magazine. "Their recent posts on X aimed at Katy Perry were not only disrespectful, but blatantly inappropriate.""Wendy’s should ‘do the right thing’... apologize and do better in the future," the source added.Meanwhile, Perry's long-standing nemesis and fellow popstar Kesha Sebert shared a picture of herself drinking out of a Wendy's cup. Perry controversially collaborated with producer Dr. Luke for her most recent album, a man Sebert has previously accused of sexual, physical, and emotional abuse, leading to a long-standing legal battle.Share This Article0 Commentarios 0 Acciones 52 Views