Nature, Published online: 08 January 2025; doi:10.1038/s41586-024-08371-3TG2 functions as an eraser and exchanger of H3 monoaminylations, including histaminylation of Gln5 of histone H3.

Nature, Published online: 08 January 2025; doi:10.1038/s41586-024-08312-0Fossils of two new worm-like aculiferan species add to the diversity of this group, showing that evolution in early aculiferans generated unusual forms comparable to other crown-group molluscs.

Lenovo will finally launch its first-of-its-kind concept rollable this year after first announcing a prototype in October 2022.

The world of Magic: The Gathering has long been invaded by new lines of cards that can change the game in major ways. Wizards of the Coast continues to add new drops, incredible art cards that feature amazing artists, and strange new mechanics that make the game feel ever-changing and can help players look at this decades-old game as if it is as fresh as when it was first released. However, in Secret Lair drops and in the Universes Beyond series, which bring other properties into Magic, huge crossovers are possible and allow fans of other games to find characters, places, and objects that they love within the decks of the timeless trading card game.

Fortnite doesn't just offer its players a battle royale experience with great replay value. The third-person shooter also grants players access to a Creative mode, in which they can create their own maps and game modes. These Creative maps vary in all sorts of ways, but there is one Fortnite Creative games that has been one of the most popular since Creative mode dropped: Prop Hunt.

Michael Giacchino has easily become one of the most recognizable names in the sounds of Hollywood thanks to his incredible scores on some truly iconic movies. Whether its an often collaboration with Pixar or an entry into the comic book movie genre, Michael Giacchinos work is varied and exciting to warrant recognition of his best tracks.

Laptops have long rivaled desktops in terms of power. But those slim and portable machines lack something their tower-shaped cousins tend to have in abundance: ports. Docking stations let you plug in monitors, mice, keyboards, storage devices and more using just a single port on your laptop. And if you're someone who relocates with your laptop often, a docking station makes it easier to get all your accessories connected again when youre back at your desk. We tested out more than 15 highly rated docking stations and considered monitor support, number and type of ports, design and price to help you determine which one is the best docking station for your home or office setup. Table of contents Best docking stations What to look for in a docking station How we tested docking stations Other laptop docking stations we tested Docking station FAQs Best docking stations Back to top Back to top Back to top Back to top What to look for in a docking station First and foremost, consider what you need to plug in. This will likely be the deciding factor when you go to actually buy a docking station. Do you need three screens for an expanded work view? A quick way to upload photos from an SD card? Are you looking to plug in a webcam, mic and streaming light, while simultaneously taking advantage of faster Ethernet connections? Are you hooking up a gaming laptop to multiple displays and peripherals? Once youve settled on the type of ports you need, you may also want to consider the generation of those ports as well; even ports with the same shape can have different capabilities. Heres a brief overview of the connectivity different docking stations offer. Monitor ports External monitors typically need one of three ports to connect to a PC: HDMI, DisplayPort or USB-C. HDMI connections are more common than DisplayPort and the cables and devices that use them are sometimes more affordable. The most popular version of the DisplayPort interface (v1.4) can handle higher resolutions and refresh rates than the most common HDMI version (2.0). All of the display docking stations with HDMI ports that we recommend here use version 2.0, which can handle 4K resolution at 60Hz or 1080p up to 240Hz. The DisplayPort-enabled docks support either version 1.2, which allows for 4K resolution at 60Hz, or version 1.4, which can handle 8K at 60Hz or 4K at 120Hz. You can also use your docks downstream (non-host) Thunderbolt ports to hook up your monitors. If your external display has a USB-C socket, you can connect directly. If you have an HDMI display or DisplayPort-only monitor, you can use an adapter or a conversion cable. Of course, the number of monitors you can connect and the resolutions/rates theyll achieve depend on both your computers GPU and your monitors and the more monitors you plug in can bring down those numbers as well. Be sure to also use cables that support the bandwidth youre hoping for. MacOS users should keep in mind that MacBooks with the standard M1 or M2 chips support just one external monitor natively and require DisplayLink hardware and software to support two external displays. MacBooks with M1 Pro, M2 Pro or M2 Max chips can run multiple monitors from a single port. USB ports Most docking stations offer a few USB Type-A ports, which are great for peripherals like wired mice and keyboards, bus-powered ring lights and flash drives. For faster data transfer speeds to your flash drive, go for USB-A sockets labeled 3.1 or 3.2 or better yet, use a USB-C Thunderbolt port. Type-C USB ports come in many different flavors. The Thunderbolt 3, 4 and USB4 protocols are newer, more capable specifications that support power delivery of up to 100W, multiple 4K displays and data transfer speeds of up to 40Gbps. Other USB-C ports come in a range of versions, with some supporting video, data and power and some only able to manage data and power. Transfer rates and wattages can vary from port to port, but most docks list the wattage or GB/s on either the dock itself or on the product page. And again, achieving the fastest speeds will depend on factors like the cables you use and the devices youre transferring data to. Nearly every dock available today is a USB-C docking station, connecting to a computer via USB-C, often Thunderbolt, and those host ports are nearly always labeled with a laptop icon. They also allow power delivery to your laptop: available wattage varies, but most docks are rated between 85 and 100 watts. That should be enough to keep most computers powered and it also means you wont have to take up an extra laptop connector for charging. Other ports None of our currently recommended laptops include an Ethernet jack; a docking station is a great way to get that connection back. We all know objectively that wired internet is faster than Wi-Fi, but it might take running a basic speed comparison test to really get it on a gut level. For reference, on Wi-Fi I get about a 45 megabit-per-second download speed. Over Ethernet, its 925 Mbps. If you pay for a high-speed plan, but only ever connect wirelessly, youre probably leaving a lot of bandwidth on the table. Every docking station I tested includes an Ethernet port, and it could be the connector you end up getting the most use out of. Just two of our favorite laptops have SD card readers, and if you need a quick way to upload files from cameras or audio recorders, you may want to get a dock with one of those slots. Of the docks we tested, about half had SD readers. For now, most (but not all) laptops still include a 3.5mm audio jack, but if you prefer wired headphones and want a more accessible place to plug them in, many docking stations will provide. When youre counting up the ports for your new dock, remember that most companies include the host port (the one that connects to your computer) in the total number. So if youre looking for a dock with three Thunderbolt connections, be sure to check whether one of them will be used to plug in your laptop. Design Most docking stations have either a lay-flat or upright design. Most docks put the more permanent connections in back such as Ethernet, DC power, monitor connections and a few USBs. Up-front USB ports can be used for flash drive transfers, or even acting as a charger for your phone (just make sure the port can deliver the power you need). USBs in the rear are best for keyboards, mice, webcams and other things youre likely to always use. Some docks position the host port up front, which might make it easier to plug in your laptop when you return to your desk, but a host port in back may look neater overall. Back to top How we tested docking stations We started out by looking at online reviews, spec sheets from various brands and docking stations that our fellow tech sites have covered. We considered brands weve tested before and have liked, and weeded out anything that didnt have what we consider a modern suite of connections (such as a dock with no downstream USB-C ports). We narrowed it down to 12 contenders and I tested each dock in a home office, using an M1 MacBook Pro, a Dell XPS 13 Plus and an Acer Chromebook Spin 514. I plugged in and evaluated the quality of the connections for 12 different peripherals including a 4K and an HD monitor, a 4K and an HD webcam, plus USB devices like a mouse, keyboard, streaming light and mic. I plugged in wired earbuds, and transferred data to a USB-C flash drive and an external SSD. I ran basic speed tests on the Ethernet connections as well as the file transfers. I judged how easy the docks were to use as well as the various design factors I described earlier. I made spreadsheets and had enough wires snaking around my work area that my cat stayed off my desk for three weeks (a new record). As new docking stations come out and we find models worthy of testing, (there are a couple from Ugreen we have our eye on), we'll update this guide accordingly. Back to top Other laptop docking stations we tested Plugable TBT4-UDZ When I pulled the Plugable TBT4-UDZ Thunderbolt 4 out of the box, I was convinced it would make the cut: It has a practical upright design, an attractive metal finish, and the host connection is TB4. While there are plenty of USB-A and monitor ports, theres just one downstream USB-C. A modern dock, particularly one that costs $300, should let you run, say, a USB-C cam and mic at the same time. Otherwise, its pretty limiting. Anker 575 USB-C At $250 (and more often $235), the Anker 575 USB-C could make for a good budget pick for Windows. It performed well with the Dell XPS 13 Plus, but had trouble with the third screen, the 4K webcam and headphone jack when connected to the MacBook Pro. Its quite compact, which means it can get wobbly when a bunch of cables are plugged in, but it has a good selection of ports and was able to handle my basic setup well. Belkin Connect Pro Thunderbolt 4 Belkins Connect Pro Thunderbolt 4 Dock is a contender for a Thunderbolt 4 alternative. It has nearly the same ports as the AD2010 (minus the microSD slot) and an attractive rounded design but its $90 more, so Id only recommend getting it if you find it on sale. Acer USB Type-C Dock Acers USB Type-C Dock D501 costs $10 more than our Kensington pick for Chromebooks, but it performs similarly and is worth a mention. It has nearly the same ports (including the rather limiting single downstream USB-C) but both the Ethernet and data transfer speeds were faster. Back to top Docking station FAQs Are docking stations worth it? Docking stations are worth it if you have more accessories to plug in than your laptop permits. Say you have a USB-C camera and mic, plus a USB-A mouse, keyboard and streaming light; very few modern laptops have enough connections to support all of that at once. A docking station can make that setup feasible while also giving you extra ports like a gigabit Ethernet connection, and supplying power to your laptop. However, if you just need a few extra USB sockets, you might be better off going with a hub, as those tend to be cheaper. How much does a laptop dock cost? Laptop docking stations tend to be bigger and more expensive than simple USB-A or USB-C hubs, thanks to the wider array of connections. You can find them as low as $50 and they can get as expensive as $450. A reasonable price for a dock with a good selection of ports from a reputable brand will average around $200. How do I set up my laptop dock? Most docking stations are plug and play. First, connect the DC power cable to the dock and a wall outlet. Then look for the host or upstream port on the dock its almost always a USB-C/Thunderbolt port and often branded with an icon of a laptop. Use the provided cable to connect to your computer. After that, you can connect your peripherals to the dock and they should be ready to use with your laptop. A few docking stations, particularly those that handle more complex monitor setups, require a driver. The instructions that come with your dock will point you to a website where you can download that companion software. Does a laptop charge on a docking station? Nearly all docking stations allow you to charge your laptop through the host connection (the cable running from the dock to your computer). That capability, plus the higher number of ports is what separates a docking station from a hub. Docks can pass on between 65W and 100W of power to laptops, and nearly all include a DC adapter. Are all docking stations compatible with all laptops? No, not all docking stations are compatible with every laptop. In our tests, the Chromebook had the biggest compatibility issues, the Dell PC had the least, and the MacBook fell somewhere in between. All docks will list which brands and models they work with on the online product page be sure to also check the generation of your laptop as some docks cant support certain chips. What are some popular docking station brands? Kensington, Anker, Pluggable and Belkin are reputable and well-known brands making docking stations for all laptops. Lenovo, Dell and HP all make docks that will work with their own computers as well as other brands.This article originally appeared on Engadget at https://www.engadget.com/computing/accessories/best-docking-station-160041863.html?src=rss

Tonal, the company behind the smart home gym of the same name, is now launching the Tonal 2. This machine is an upgrade over its predecessor, which we tested some years ago. Two years ago, Tonal laid off 35 percent of its workforce, but the company seems to be doing much better now.According to the company, Tonal 2 has improved hardware, including a better camera that uses AI to analyze 500 data points per second and an upgraded adaptive weight system. The latter can now let users lift up to 250 pounds. Tonal 2 also comes with new Aero HIIT workouts you can follow to combine cardio and strength training, something the first generation trainer doesnt offer. Additionally, Tonal 2 has a sleeker design and new look, thanks to an all-black appearance with chrome accents.Like the original Tonal trainer following a few software updates, Tonal 2 knows when your muscles are fatiguing and will reduce the resistance. This adjustment lets you pump out a few more reps and ensure you reach muscle failure easier, increasing muscle gains as a result.Tonal 2 is now available to purchase in all 50 states for $3,995. This price doesnt include a subscription, which costs $60 a month. The company will install the machine for you in your home when it arrives.This article originally appeared on Engadget at https://www.engadget.com/home/smart-home/tonal-2-is-now-available-for-purchase-170040163.html?src=rss