Nature, Published online: 08 January 2025; doi:10.1038/d41586-024-04105-7Mathematical modelling suggests that it is theoretically possible to reduce risk of common diseases using heritable genome editing. Scientists argue that the technology involves considerable risk and uncertain benefits.

Nature, Published online: 08 January 2025; doi:10.1038/s41586-024-08311-1Cryo-electron microscopy of Azotobacter vinelandii FeSIInitrogenase reveals a core complex of molybdenumiron proteins (MoFePs), iron proteins (FePs) and FeSII, in which FeSII mediates interactions with MoFeP and FeP to position their FeS clusters in catalytically inactive but O2-protected states.

Nature, Published online: 08 January 2025; doi:10.1038/s41586-024-08375-zA global multi-taxon extinction risk assessment of freshwater fauna for The IUCN Red List of Threatened Species finds one-quarter of species to be at high risk of extinction.

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The release of Monster Hunter Wilds is just around the corner, but one player has taken the time between sequels to create an even harder way to play an earlier game in the series, Monster Hunter: World. Aaron Callaway decided to beat the game without any weapons by relying only on emotes, including the Hadoken fireball popularized by Street Fighter's Ryu and Ken.Callaway posted a video on YouTube that demonstrated how an emote-only Monster Hunter: World run works. He notes that the other two emotes used were Street Fighter's Shoryuken and Devil May Cry's guns. However, the Shoryuken drained too much stamina and the DmC emote wasn't ideal either. That's why Callaway came to rely on the Hadoken, even though it's also comparatively weak and can only dish out 13 points in damage at most. It's one thing to say you've done something and another to show it. To prove his achievement, Callaway posted his gameplay videos from his emote-only Monster Hunter: World run. The first video alone is just under three hours, but these videos demonstrate that the challenge is possible, even though there's no Achievement or Trophy waiting at the end for sticking with it.Continue Reading at GameSpot

One of Konami's next big games is Metal Gear Solid Delta: Snake Eater, a remake of the 2004 game. With the calendar now changed over to 2025, that means 2024 came and went entirely without Konami giving any major update on the game or telling fans when they can expect to play it.Metal Gear Solid Delta: Snake Eater was announced at the PlayStation Showcase in 2023, but at the time, Konami did not provide a release date, or even a window, for the game. It was never confirmed for a 2024 release, either, but fans thought it might release during the year due in part to an erroneous social media post. It didn't, so the wait continues. At the end of October 2024, a financial document from Konami listed the release date for Metal Gear Solid Delta: Snake Eater as "TBD." A spokesperson for Konami told GameSpot, "Right now there's nothing new we can share at the moment."Continue Reading at GameSpot

World of Warcraft continues to pay tribute to Mats "Ibelin" Steen, the subject of the recent Netflix documentary The Remarkable Life of Ibelin, this time transforming Steen's character into a full-fledged NPC.As spotted by Wowhead, dataminers have discovered an NPC by the name of Lord Ibelin Redmoore on the public test realm for the MMORPG's upcoming 11.1 update. The NPC's appearance matches Ibelin's look in the documentary, though it's currently unclear where players will be able to find Ibelin in-game or what he might have to say should players interact with him.Steen suffered from Duchenne muscular dystrophy and played WoW as a means of socializing and connecting with others. His character Ibelin, who he often roleplayed as, labeled himself as a private investigator and would use his in-game job title as a means to strike up conversation.Continue Reading at GameSpot

Anime has its distinct feel, and if theres anything that makes anime more special, it has to be music. Starting with action-packed intro songs to sad insert songs that play at the end of the episodes, anime songs are not just any song or there to just fill in the rest of the time until the episode reaches its running timeanime songs are a feeling. Theyre the catchy songs you sing to while taking a shower or the songs you crank up when you feel dramatic about doing your laundry. But in point, these less-than-two-minute tracks are highly valuable in defining the anime's whole plot and, contrary to popular belief, its success.

To prepare players for the hellish grind that is the endgame of Path of Exile 2, the developers have left easy-to-miss encounters in the main campaign that provide permanent buffs, additional passive skill points, and weapon set skill points to characters.

There are only a handful of customizable weapons in Metro Exodus. However, each weapon can be set up with hundreds of different attachment combinations and upgrades. This means that there are dozens of viable setups for each gun in-game. When attempting to rank the best weapons in the game, there are a few things to keep in mind.