• Cationic peptides cause memory loss through endophilin-mediated endocytosis
    www.nature.com
    Nature, Published online: 15 January 2025; doi:10.1038/s41586-024-08413-wElucidation of the mechanism by which zeta inhibitory peptide erases memories, involving endocytosis of AMPA receptors on potentiated synapses, provides insight into more general mechanisms of memory maintenance and response to traumatic brain injury.
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  • Giant horned dinosaur's fossils were destroyed in WWII but photos reveal it was an unknown species
    www.livescience.com
    Scientists have unveiled a giant horned dinosaur from Egypt called Tameryraptor markgrafi after discovering lost photos of fossils destroyed in WWII.
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  • Crystal Sword
    v.redd.it
    submitted by /u/Lewiwww [link] [comments]
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  • Donkey Kong Country Returns HD Is Discounted On Launch Day
    www.gamespot.com
    Donkey Kong Country Returns HD Release-Day Deal - $50 (was $60) Get deal at Woot Preorder at Walmart See at Best Buy See at Target Nintendo Switch owners can save $10 on Donkey Kong Country Returns HD on launch day at Woot. The Amazon-owned outlet store that has had a bevy of Nintendo game deals in recent months, including dozens of active promotions. DKC Returns HD is a wonderful side-scrolling platformer with 80 levels spread across nine worlds. It originally released in 2010 for Nintendo Wii and was ported to 3DS in 2013. If you want to revisit the challenging adventure starring DK and Diddy in high definition, you may want to grab this deal soon. Woot's launch discounts on new Nintendo games tend to sell out.As with all of Woot's Switch games, the listing notes that DKC Returns HD is region-free and will work on all Switch consoles. Woot sometimes sells imported games from a different region. These always support English and are functionally the same. The only difference you'll notice out of the gate is the ESRB emblem will be replaced by another territory's ratings board. Additionally, if you want DLC, you'll need to purchase it from region's eShop that matches your copy of the game. Donkey Kong Country Returns HD is self-contained, with no DLC expected, so this potential snag won't impact you here.Donkey Kong Country Returns HD is also available for the full $60 price at Walmart, Best Buy, Target, and GameStop. Continue Reading at GameSpot
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  • Nintendo is Breaking One of Its Longest Trends With The Switch 2
    gamerant.com
    Many were surprised by today's sudden reveal of the Nintendo Switch 2, as there was no lead-up to the announcement trailer, but some fans were not. In fact, among the many recent leaks and rumors surrounding the Nintendo Switch 2, it was stated by prominent figures that the teaser would be released today. Still, the Japanese company is making history, releasing a successor to the Nintendo Switch, which sold more copies than the PlayStation 2 did in its lifetime. The new handheld console is a successor through and through, as it has the original's design with new elements and features, and it's even called "Nintendo Switch 2."
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  • Prototype of an Adventure Puzzle Game with a Robot
    gamedev.net
    Ive just uploaded a prototype of my indie game on https://kindmoba.itch.io/robot?secret=Z8YPXofQLLGgGeuSX0oUHSsWg (link to the game), and Id love to hear your feedback to make it even better.
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  • Poppy Playtime developer suing Google over scam games
    www.polygon.com
    Poppy Playtime developer Mob Entertainment is suing Google over scam versions of its games. Mob Entertainment, via a lawsuit filed Wednesday in California and reviewed by Polygon, is asking the court to force Google to take down its game and for damages of at least $150,000 per infringing work. The lawsuit also targets the unnamed developer who created the fake Poppy Playtime games using the Daigo Game 2020 moniker. Daigo Game 2020 is listed as publishing the two Poppy Playtime apps on Google Play, as well as games based off Skibidi Toilet and Minecraft. The Minecraft app, called Minicraft 2020, is listed on AppMagic as having more than 50 million downloads. (Minicraft 2020 and the Skibidi Toilet games have been removed from the Google Play store.)Poppy Playtime is a survival horror game thats published episodically, the first of which was published in 2021 by Mob Entertainment. Its playable on Windows PC, consoles, and mobile. So far, there are three chapters, with a fourth scheduled for release on Jan. 30. Basically, the premise is that youve got to survive in a terrible toy factory with scary toys the big one being Huggy Huggy, an awful blue monster with rows of shark-like, disgusting teeth. The video games themselves are quite popular, with more than 40 millions across platforms, according to the company, but its also wildly popular on YouTube, where Lets Play videos and lore explainers rack up millions of views. Legendary Entertainment is making a movie based off the franchise.All of this is to say that Poppy Playtime is a moneymaker. After its first two chapters were published, players were eagerly awaiting the third installment. At least one person looked to capitalize on the excitement surrounding the next chapter, Mob Entertainment said in its lawsuit, by publishing applications that directly use the Poppy Playtime name to lure in players. The unauthorized games are titled Poppy Playtime Chapter 3 and Poppy Playtime Chapter 4, and they are currently available to install on the Google Play store. Not only do the they use the Poppy Playtime name, they also use screenshots from Poppy Playtime: Chapter 2, Mob Entertainment wrote. Per the Google Store, these purported scam games have been downloaded more than 1 million times. Both of these games are free to install, but then ask the player to download a mod to access the game priced between $30 to $95 according to the lawsuit. After paying for the game, all [players] receive is a link to a dead webpage, the company wrote. The lawsuit claims these apps are being used to trick consumers into spending $95 for a game prior to its release.There are other games, seemingly by other creators, on both Google Play and the iOS App Store that appear to be influenced byPoppy Playtime, but which dont appear to use the copyrighted Poppy Playtimename.Googles role in this, Mob Entertainment wrote in the lawsuit, is due to its unwillingness to take down the scam games. Mob Entertainment said it issued DMCA takedowns on both infringing chapters and has otherwise contacted Google to inquire. In December, Google did remove the content. But days later, the content returned to the Google Play store.Mob Entertainment argued that the purported scam games have tarnished the companys reputation due to their bad quality many grammatical mistakes and an ugly color scheme, per the lawsuit of the bait-and-switch scam, plus the high price of it ($95 for almost nothing).Mob Entertainments fight against scam, slop ripoffs is, unfortunately, not unique. The conversation has centered recently around the Nintendo Switch eShop that, as Kotaku put it, is filled with a lot of garbage that was likely made quickly and is only there to cash in on a trend or holiday. Unpacking developer Wren Brier posted about studio Witch Beams struggle to get blatant, low-quality Unpacking clones off the eShop. Its been over two weeks and these are still on the eShop, Brier wrote on BlueSky. Nintendo hasnt responded to any of our reports of these egregious scams which are using our trademarked game name and purposely tricking Nintendo customers into buying cheap fakes. The Unpacking clones have since been removed, but theres plenty more slop on the eShop with the same agenda and, as indicated by Mob Entertainments lawsuit, on the Google Play store, too.Polygon has reached out to Mob Entertainment and Google. Polygon reached out to four different email addresses associated with Daigo Game 2020, but all four were unable to be delivered.
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  • The good, the bad and the ugly of Duolingo gamification
    uxdesign.cc
    Ten design principles rated from best to worst.Continue reading on UX Collective
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  • This 65-Inch Sony OLED TV Is $500 Off
    lifehacker.com
    We may earn a commission from links on this page. Deal pricing and availability subject to change after time of publication.There's a world of difference between OLEDs and QLEDs, with OLEDs offering the most premium picture at a higher pricebut you can still find budget OLED TVs at prices that won't cost an arm and a leg. The 65-inch Sony Bravia A75L is one of them, currently being sold by Best Buy for $1,499.99 (originally $1,999.99), the lowest price it has ever been, according to price tracking tools. Best Buy is also offering $249 worth of mounting and installation in labor (not parts, like mounting brackets) with your OLED purchase. 65-Inch Sony A75L OLED TV Display Type: OLED, Resolution: 4K (2160p), Screen Size Class: 65 inches. $1,499.99 at Best Buy $1,999.99 Save $500.00 Get Deal Get Deal $1,499.99 at Best Buy $1,999.99 Save $500.00 Like all OLEDs, be mindful that its brightness will not be as good as QLEDs or LEDs. If your setup is in a bright room, make sure you have shades if you want to see the full effect of an OLED.The Sony A75L OLED came out in 2023 as a new entry-level OLED TV with many of the features you'd want from a premium TV, especially for gamers. Although you only get one HDMI 2.1 (apart from the second one which doubles as the eARC port, which isn't a problem unless you want to hook up a sound system), the A75L has VRR support, bandwidth for up to 4K at 120Hz, low input lag in Game Mode of 9.2 ms, and clear motion with little blur, all which combine to make an excellent gaming OLED TV.Casual streamers will enjoy the Cognitive Processor XR, which upscales low-resolution content very well (great if you're not paying for 4K Netflix). I really like the Google TV smart platform, mainly because of the user-friendliness and that it lets me cast my phone or laptop without an external device. The viewing angle and reflection handling on the A75L are top-tier as well, allowing people to view from the far end of the couch.
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  • AGDQ just ended, but there's already a schedule for Frost Fatales and it owns
    www.engadget.com
    Awesome Games Done Quick has already wrapped up for 2025 (with a cool $2.5 million raised for the Prevent Cancer Foundation), but the philanthropic group has other programs year-round that raise money for worthy causes. Two of those are hosted by the Frame Fatales, a community for women and femmes in speedrunning under the GDQ umbrella. The group's Frost Fatales event runs from March 9-16 and will raise money for the National Women's Law Center. The schedule just dropped today and here are a few of the highlights.The event starts with a pair of my personal favorite games to watch: the punishing 2D platformer Cuphead followed by the wahoos of Super Mario Odyssey. I'm also amused that Lanaruse will run Coffee Caravan, but with the category "Any% No Coffee." That kicks of the show on March 13 at 1 PM ET. The March 14 lineup looks particularly exciting, with Jaypeg tackling Snufkin: Melody of Moomin-valley, GretaIceVixen and Corvimae showing off Pkemon Sword & Shield, and Bloupeuh playing Undertale Yellow. Frost Fatales is set to close out with SawaYoshi tackling a one-handed run of Celeste, which sounds like required viewing.And if you can't wait until March to see some excellent gamer philanthropy, then be sure to tune in during Back to Black, GDQ's event highlighting Black speedrunners. This year, the showcase will be raising money for Race Forward, a racial justice nonprofit, from February 6-9.It's only a few days long, but Back to Black has a bunch of great talent in the lineup. Bobbeigh running any Castlevania game is a must-watch, and he'll play Rondo of Blood on Feb. 6 at 7:08 PM ET. Super Smash Bros. pro-turned-speedrunner Ryan Ford is on the schedule twice, with The Legend of Zelda: Link's Awakening DX on Feb. 8 at 4:05 PM ET and Super Metroid on Feb. 9 at 8:04 PM ET. Check out the full Back to Black schedule of games, runners and hosts here.This article originally appeared on Engadget at https://www.engadget.com/gaming/agdq-just-ended-but-theres-already-a-schedule-for-frost-fatales-and-it-owns-212907587.html?src=rss
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