Newton Park Place / ROARSave this picture! Craig WhartonArchitects: ARCHETONIC + PROARQUITECTURAAreaArea of this architecture projectArea:30 mYearCompletion year of this architecture project Year: 2024 PhotographsPhotographs:Craig WhartonManufacturersBrands with products used in this architecture project Manufacturers: G Johns & Sons, Green Roof, Jordan Andrews, Solus Ceramics Lead Architects: Craig Rosenblatt, Makbule Karadag Save this picture!Text description provided by the architects. ROAR have completed a sustainable & natural material-led extension to a historic Victorian property in Chislehurst, South East London. With a brief for a minimal retreat for homeowner Kelly Johnson and her family, the oak extension adds 30sqm to the property for 450,000 plus VAT. A Grade II Listed property located in the Chislehurst Conservation Area, Newton Park Place was designed by Victorian architect Ernest Newton and characterized by it's Vernacular Revival style, asymmetrical plan, and irregular fenestration. Rather than imitate the traditional Victorian architecture, as had been done previously with alterations in 2007, ROAR designed the new timber framed extension to be purposefully different - a modern addition that matches the contemporary garden and allows for a large extension to the home's interiors.Save this picture!Save this picture!Save this picture!Kelly approached ROAR as she had seen their work via Don't Move, Improve! and felt they had the experience and skills to design something that would be contemporary, sustainable, and beautiful. Initially, she was looking for the usual brick extension with Crittall windows but ROAR wanted to do something bolder and greener, convincing her to go with timber instead. Oak was selected for its low embodied carbon and longevity, along with the specification of wood fiber insulation. Working in partnership with specialist joiner Tim Gaudin, the frame was fabricated in their workshop in Devon, dismantled, and then reassembled on-site in London.Save this picture!Save this picture!Inside, rather than the customary open plan design that's typical of London residential extensions, homeowner Kelly Johnson asked for two separate spaces to the rear for kitchen & dining and living room. The new dining area is a separate 'nook' off the kitchen framed by the skylight above and picture window. Finished off by the red string pendant, with warm and rich exposed oak joists and soffit and fenestration. The homeowner's wine selection is also now neatly archived in a 3m deep spiral wine cellar crafted from engineered limestone concrete. Full width 4m wide bi-folding windows with an integrated window seat complete the new living area. With the exposed joists extending into the oak pergola. The planters to the pergola provide privacy screening in the living room and solar protection, but also over time will form a green enclosure for outside dining. During summer the bi-folding doors can be fully opened maximising this connection between inside and out.Save this picture!In terms of sustainability, ROAR were keen that any works felt in keeping the garden and high quality design. Solar panels were incorporated on the roof of the main house concealed from view to reduce energy bills. And the extension topped by a Wildflower green roof, improving biodiversity, softening the extension and creating an amazing experience & view from the master bedroom akin to having your own wild meadow.Save this picture!The garden design, by Lily Gomm, extends directly from the architecture of the house defining the planting beds and framing the view back to the extension. A run of bespoke large format paving aligns to the door opening drawing the eye out into the garden and directing you to two spaces - an area with a pond and adjacent bench seating as a spot to sit and enjoy the wildlife the pond lures in and a larger open space containing comfy chairs and feature tree planting. Both spaces are further defined by edging details of clay pavers and are laid with self-binding gravel to contrast against the larger areas of clay pavers closer to the house.Save this picture!Project gallerySee allShow lessAbout this officeMaterialsWoodGlassMaterials and TagsPublished on February 13, 2025Cite: "Newton Park Place / ROAR" 13 Feb 2025. ArchDaily. Accessed . <https://www.archdaily.com/1026591/newton-park-place-roar&gt ISSN 0719-8884Save!ArchDaily?You've started following your first account!Did you know?You'll now receive updates based on what you follow! Personalize your stream and start following your favorite authors, offices and users.Go to my stream

Norovirus has been top of mind for many this winter: Everybody seems to know somebody thats been temporarily felled by the winter vomiting bug.The anecdotal sense that norovirus is everywhere has been born out in some data so far. From August to mid-January, there were about twice as many outbreaks than there were in the same time period a year ago: 1,078 compared with 557, according to the U.S. Centers for Disease Control and Prevention. Those data come from 14 states that partner with the CDC on norovirus surveillance.Norovirus symptoms come on strong and make for a few extremely unpleasant days of vomiting, diarrhea and nausea. People tend to be fine once theyre through it. But it can be harder on the youngest, the oldest and those who are immunocompromised, with dehydration a particular problem. There are no vaccines or specific treatments for the virus.Around 20 million illnesses, on average, are caused by norovirus each year in the United States, as per the CDC. That leads to 465,000 emergency department visits mostly for young children and 900 deaths, largely among those 65 and older. Globally, there are 685 million norovirus illnesses each year and 200,000 deaths, with a quarter of those in children, mainly in developing countries.The burden and cost of norovirus illnesses globally estimated at $4 billion for healthcare plus a $60 billion cost to society annually has made a vaccine for this virus a World Health Organization priority. There are several candidates making their way through clinical trials now. But the virus is a tricky one, and there are still some big information gaps to fill. Heres an introduction to the virus, some of the vaccines in development and how to keep a norovirus infection at bay.What do researchers know about norovirus and what big questions remain?There are a lot of noroviruses out there, so researchers keep track of them with a classification system. Based on genetic differences, noroviruses are divided into 10 groups and subdivided into 49 types. Five of the groups are known to infect people. Type 4 in group 2, represented as GII.4, has been responsible for most norovirus illnesses in people for the last two decades or so, but other types have caused outbreaks too. Looking at September through December of 2024, most of the norovirus outbreaks in the United States were due to GII.17, according to the CDC.Some of the norovirus groups infect other mammals, including cows, sheep, dogs, cats and sea lions. Oysters in coastal areas contaminated with sewage discharge can pick up norovirus, which is why the shellfish are sometimes tied to outbreaks.One big question about the virus is that researchers arent sure how long immunity lasts after a norovirus infection in people, with estimates ranging from several months to nine years, depending on the study. People can become infected by one after another of the different types, but whether thats due to short-lived immunity, the genetic differences between the types or a combination of those and other factors isnt known. And GII.4, the type behind most norovirus illnesses in people, is especially prone to genetic changes, such that people can be reinfected by the different versions of this one type.Another lingering question: In people, norovirus infects the cells that line the inner surface of the intestine, which are called epithelial cells. But researchers havent figured out what receptor the virus uses to break in. The virus does bind to certain sugars on the cells, but evidence so far suggests that only helps the virus hang on, says virologist Christiane Wobus of the University of Michigan in Ann Arbor. We dont know what molecule helps the virus cross over the membrane to get inside the cell to then start to replicate.Noroviruses that infect people have been difficult to study because researchers havent been able to get them to grow in laboratory cell cultures. Theres been a breakthrough on that front: the development of mini guts, which are lab-grown cultures of intestinal cells that physiologically function like the lining of the gut. Mary Estes, a molecular virologist at the Baylor College of Medicine in Houston, and her colleagues were the first to show that norovirus will replicate in mini guts. Were now just beginning because now we have the cultivation systems to look at the biology of the virus, Estes says.When researchers figure out the receptor norovirus uses to enter cells, they should be able to incorporate that receptor in basic laboratory cells that every virologist in the world could work with, Estes says, making norovirus research much easier.Sponsor MessageWhats challenging about developing norovirus vaccines and what progress has been made?The biggest problem we have to deal with is the genetic diversity theres lots of different flavors of norovirus, Wobus says. Considering that diversity, researchers arent sure how many norovirus types a vaccine needs to include in order to provide enough protection, she says, other than representatives from groups I and II, which are responsible for a lot of infections.Even with those questions, its definitely good that there are multiple vaccine platforms that are being tested, Wobus says.The candidates moving through clinical trials target the protein shell of the virus. Moderna announced last September that it has begun the phase 3 trial of their norovirus vaccine candidate. The trials goal is to enroll 25,000 people globally: 20,000 age 60 and older and 5,000 ages 18 to 59. Researchers will evaluate how well the pharmaceutical companys mRNA vaccine, which includes three norovirus types, protects against moderate to severe cases of illness.Other candidates that have made it through early-stage clinical trials are based on viruslike particles, which mimic the shape and size of a virus but cant cause infections because they dont contain genetic material.I think there will be a vaccine, Estes says. But its hard to say when until there are results from phase 3 trials.How can people try to avoid norovirus infections?A person experiencing norovirus symptoms is extremely infectious. The virus particles spread via feces and vomit. Some studies have suggested it doesnt take very many virus particles to infect someone else. If youre helping clean up after someone who is dealing with symptoms, use gloves and a mask because particles are in the air, Wobus says. It always surprises people how far vomit particles travel.The end of symptoms does not mean the end of the infection. People can continue to excrete the virus for weeks. We certainly can detect it in peoples stool for out to a month, Estes says.The virus is also very stable in the environment, meaning it doesnt degrade quickly. When scientists investigated a 2014 norovirus outbreak at two hotels in Spain, they detected the virus on frequently touched surfaces in the guest rooms sampled as well as on elevator keypads, scientists reported in 2020 in a journal of the Spanish Society of Infectious Diseases and Clinical Microbiology.The virus sticks to lots of different surfaces and remains for a long time, Estes says. So other people coming along that touch those surfaces can pick it up. And if you put your hands in your mouth or on your face, you can get infected. And, unfortunately, alcohol-based hand sanitizers do not kill the virus. Washing hands with soap and water is the way to go.

Nature, Published online: 13 February 2025; doi:10.1038/d41586-025-00477-6The crucial drugs can have unintended consequences. Innovative therapies could shield the microbiome from their effects.

Nature, Published online: 13 February 2025; doi:10.1038/d41586-025-00479-4Use this form to share information with Natures news team, or to make suggestions for future coverage.

Astronomers have used a continent-sized radio telescope to find the largest black hole jet ever observed in the early universe.

DNA and RNA epigenetics, once thought to be separate, have now been found to work together to fine-tune gene expression.

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.@ggdroust showcased a cool UEFN project concept featuring a character pulled into a computer world.See more: https://80.lv/articles/watch-uefn-game-protagonist-get-pulled-into-computer-world/

Have a staring contest with Dwight Schrute from The Office in Samer El Seidy's sneak peek at his 3D model.Enjoy: https://80.lv/articles/sneak-peek-at-3d-dwight-schrute-from-the-office/

3D Animator Anderson Droust Pillar, specializing in creating immersive experiences within the Fortnite universe, has really pushed the boundaries of Epic Games Unreal Editor for Fortnite with this project concept, where a character gets isekaid into a computer world. The developer mentioned using Control Rig in UEFNs example project for animating the body and head and Niagara for the visual effects.With smooth movement and a fun concept, this isnt Drousts first creative project using UEFN. Check out some of his previous works below:Follow him on X/Twitter for more and join our80 Level Talent platformand ournew Discord server, follow us onInstagram,Twitter,LinkedIn,Telegram,TikTok, andThreads,where we share breakdowns, the latest news, awesome artworks, and more.Source link The post Watch UEFN Game Protagonist Get Pulled Into Computer World appeared first on CG SHARES.