Nature, Published online: 19 February 2025; doi:10.1038/s41586-025-08585-zAs proof of principle, an analysis using a suite of human-aligned immunocompetent mouse models of hepatocellular carcinoma identifies a promising therapeutic candidate, cladribine, which acts in a highly effective subtype-specific manner in combination with standard-of-care therapy.

Indian teenager Aaryan Shulka performs calculations in his head quicker than most people can use a calculator. At a recent event hosted by Guinness World Records, 14-year-old Shulka shattered six mental math records in one day.

A bog body discovered in Northern Ireland is actually a young woman, not a teenage boy as previously thought.

Titled Antique, this heavily inspired by Greco-Roman architecture and enhanced with motion blur and the gentle wind blowing the leaves scene was completed by George Turmanidze in two weeks. Rendered locally on NVIDIAs GeForce RTX 3090, it took approximately 8 hours using Blender 4.3s Cycles. All the models used are interior 3D scans.George shared that hes still working on enhancing this lush design and is currently preparing a breakdown video to explain how he created the project. Have a look at the final render of the scene:George TurmanidzeStay tuned for updates on Antique by following George on LinkedIn and ArtStation, and see more of his Blender-made architectural visualizations below:George TurmanidzeGeorge TurmanidzeGeorge TurmanidzeGeorge TurmanidzeGeorge TurmanidzeGeorge TurmanidzeDont forget to join our80 Level Talent platformand ournew Discord server, follow us onInstagram,Twitter,LinkedIn,Telegram,TikTok, andThreads, where we share breakdowns, the latest news, awesome artworks, and more.Source link The post Step Into This Gorgeous Blender-Made Interior Inspired By Classical Architecture appeared first on CG SHARES.

The Season 2 Reloaded update is live in Call of Duty: Black Ops 6 and Warzone, bringing a crossover event with the Teenage Mutant Ninja Turtles. This collaboration includes special TMNT-themed modes, bundles, and event rewards. You also can't have the turtles without their signature weapons, so the midseason update adds all their unique melee weapons. Below, we walk you through how to unlock them all.Leonardo, Donatello, Raphael, and Michelangelo's operator bundles are live in Call of Duty's in-game shop. Each turtle's pack is a 10-item bundle priced at 2,400 CoD Points ($20) each.The full TMNT crossover event with the reward tracks and limited-time game modes goes live on February 27. This event includes paid and free reward tracks, adding more TMNT skins to the game. Buying all of Call of Duty's paid TMNT skins will cost $90, but two Foot Clan soldiers are earned free in tiers.In the meantime, here's how you can score all the turtles' weapons for yourself. You'll have a few options between Call of Duty's base versions of the melee weapons and the TMNT-themed blueprints. You can only have one of these base weapon challenges active at once, so it will take some time to grind enough XP to unlock them all. Leo's dual katanasBase weaponThe base version of the dual katanas can be unlocked via an Armory challenge unlock. You'll need to head to the game's Armory and manually select the Katana unlock challenge to get started. This is an XP-based challenge, and it takes 250,000 XP to unlock this weapon.TMNT variantLeonardo's TMNT-themed weapon blueprint for the dual katanas is part of his specific shop bundle. In addition to Leo's operator skin, his bundle includes two gun variants with blue tracers, an ooze-themed "Containment" weapon charm, the "Stoic Leo" emblem, an emote, and more. Donnie's bo staffBase weaponThe base version of the bo staff can be unlocked via an Armory challenge unlock. You'll need to head to the game's Armory and manually select the bo staff unlock challenge to get started. This is an XP-based challenge, and it takes 250,000 XP to unlock this weapon.TMNT variantsOnce the full event goes live, an additional TMNT-themed weapon blueprint can be unlocked in the $10 premium (paid) event track. This turns the bo staff into a cosmetic cane variant for Splinter.Donatello's bundle features his special variant of the bo staff melee weapon, and two gun blueprints with purple tracers. The Bo-Staff Boogie finishing move, Half-shell weapon sticker, and "Donatello Rizz" animated emblem are some of the additional items included in the bundle. Mikey's nunchucksBase weaponThe base version of the Nunchaku melee weapon can be unlocked via an Armory challenge unlock. You'll need to head to the game's Armory and manually select the Nunchaku unlock challenge to get started. This is an XP-based challenge, and it takes 250,000 XP to unlock this weapon.TMNT variantMichelangelo's signature nunchucks are bundled with his operator skin. Two gun blueprints are included with orange tracers to match. The bundle also includes the "Nunchuk Chop" finishing move, a spray, emote, animated calling card, and more. Raphael's saisBase weaponThe base version of the sais can be unlocked via an Armory challenge unlock. You'll need to head to the game's Armory and manually select the Sai unlock challenge to get started. This is an XP-based challenge, and it takes 250,000 XP to unlock this weapon.TMNT variantRaphael's sais are bundled with his operator skin. Two gun blueprints are included with red tracers to match the turtle. Additional items include Raphael's "Quick Skills" finishing move, the "Kickin' It" emote, custom reticle, frag skin, calling card, and emblem. Skateboard melee weaponWhether in the city streets or down in the sewers, the Ninja Turtles love to skate, so Season 2 Reloaded also adds a skateboard melee weapon.Both versions of the skateboard are available to unlock during the TMNT event. The base version is unlocked in the free pass, and the "Sewer Surfer" variant of the skateboard is a reward in the paid pass.For more, make sure to check out the full highlights for Season 2 Reloaded, including a full look at the TMNT event rewards and operator skins. All the big changes for the update can be found here in the Season 2 Reloaded patch notes.

Dungeons & Dragons 2024 Monster Manual $49.47 See at Amazon A new version of the Dungeons & Dragons Monster Manual, one of the seminal tabletop RPG's most important source books, was released earlier this week. This is the first new version of the book in a decade and is the third new entry in the D&D 2024 Edition Core Collection along with the new 2024 Player's Handbook and 2024 Dungeon Master's Guide that launched last year--and just like those other releases, the new Monster Manual is compatible with D&D 5E books and supplemental materials. You can pick up the 2024 Monster Manual for $49.47 at Amazon. Dungeons & Dragons 2024 Monster Manual $49.47 The hardcover Dungeons & Dragons 2024 Monster Manual includes stats blocks, lore, and other information for over 500 unique monsters for your D&D campaigns, including 75 all-new creatures. The book also offers guidance on creating unique combat encounters and boss monsters, as well as blueprints for crafting humanoid NPCs. All that gameplay information is supplemented with over 300 pieces of art. See at Amazon As mentioned above, Dungeons & Dragons 2024 Monster Manual is part of the new D&D 2024 Edition Core Collection. This updated version of the game--also known as 5.5E--is designed as an enhanced and streamlined version of D&D 5E. While the new 2024 editions of the Player's Handbook, Dungeon Master's Guide, and now Monster Manual all introduce new gameplay elements and tweaked rules, they are also backward compatible with 5E materials, including all rulebooks, adventure modules, expansions, and third-party 5E supplements. That also means you can use your existing 5E characters with the new 5.5E rulebooks.If you're new to D&D or are considering updating all your books to the new versions, you'll find the other Dungeons & Dragons 2024 Edition releases at Amazon, including the new Player's Handbook and updated accessories like official character sheets and DM screen. The only book currently not available at Amazon is the 2024 Dungeon Master's Guide, but we expect it will be restocked in the near future. You can also purchase digital versions of the new 2024 Edition rulebooks via D&D Beyond.Continue Reading at GameSpot

Overwatch 2 just got a mysterious new currency called Hard Light Crystals, though its source and purpose are currently unknown. Likely intended only for use in China, this currency can currently be seen in the Overwatch 2 Hero Gallerys filter options.

A player scores a quad pistol elimination in Rainbow Six Siege and more accidental wins.

My husband and I have been playing a lot of Portal 2 arguably the best couch co-op game of the modern era, despite the success of Hazelights It Takes Two, which also changed the genre forever. I could name a few more, and thats about it. Im not talking just about games you can play with multiple people locally. I mean games where you must work with a partner to get to the end, or at least to make the process more enjoyable. For those, in our house, weve made all kinds of games into co-op games.We got the idea after playing through The Quarry, the playable film with lots of celebrities and a lot of characters to control. The game has a local co-op setting, where you pass the controller to the next player to make choices and try to dodge the occasional fallen tree. But we forewent this setting because were playing as a team, talking out each decision, sometimes pausing the game to think through a clue or recall earlier dialogue. We probably played The Quarry three or four times through like this, one of us with the controller, the other preparing our dinner in the kitchen. We took the same tack with Overboard!, the inverted mystery game where youre the killer trying to evade being discovered perhaps an even better candidate for this style of play given that its designed for replaying, with new goals and paths in each playthrough.These non-co-op co-op games, which are usually narrative and have an element of decision-making, have become a go-to for our weeknights and starting a new game is a great date night option in the winter. It also gives us a fun way to show each other games weve been enjoying. And, like all great art, experiencing the games together lets us connect over the stories, like when we cried on the couch at the end of Firewatch.So yes, Im very excited for Split Fiction, the next title from Hazelight. But I might be equally as excited for Expelled! an upcoming game in the world of Overboard!, and surely one Ill play with my spouse for many, many hours.

If you think youve clocked quite a few hours in Marvel Rivals already, think again. One player has spent so much time playing theyve earned the highest achievement you can get on almost every one of its heroes.TikTok user Alevik26 stunned everyone with a clip showing off their 31 Lord icons on Tuesday, and then they dropped two more clips as they climbed to 33. @alevik26 Just 4 more lords original sound alevik26 To reach Lord status on even a single hero, you have to play a lot of matches and be good enough to meet their specific objectives. A Strategist like Invisible Woman requires you to not only heal a ton, but also use her tiny little shield to block absurd amounts of damage. Most people wont hit Lord for hundreds of hours.Alevik26 did it with around 20 hours on every hero. It helps that theyre a high rank player who grinds Quick Match, and that they have hero shooter experience from their time in Overwatch. But it still took them over 4,500 matches and over 1,000 hours to pull it off. Thats almost half as many hours as Marvel Rivals has been out; the game launched on Dec. 5, or 1,848 hours ago.I set myself a goal to get Lord on every character, they wrote in the comments of one of the clips. I do get bored a lot but I just push through.Spider-Man took the longest at 26 hours, Alevik26 said. Theyre also considering releasing a video with tips on reaching Lord for the most difficult heroes. There are two more heroes Starlord and Magik for them to finish first, however, and then theyll have the Thing and Human Torch to finish when season 1.5 launches on Thursday.Thanks to the games robust API, you can follow their progress on Tracker.gg. Alevik26 was busy working on Starlord most recently, but stopped playing yesterday. I dont know whats more shocking: The dedication to the grind or that they actually take breaks.