When premiered back in 2015, it felt like a breath of somber, brutal fresh air at a time when superhero fare was leaning more toward fantastic and generally lighthearted projects. In the years since the shows end, other works like Deadpool and The Boys have delivered their own kind of comic book grit and violence, but theres still a great fondness for seeing Matt Murdock (Charlie Cox) flip around, throw his sticks at people, and generally brutalize them like the maniac he is. Daredevil: Born Again knows it has a legacy to live up to, and that audiences have been gradually drip-fed the title characters return in recent years with Spider-Man: No Way Home, She-Hulk: Attorney at Law, and Echo. Whereas the latter framed Matt as a force of nature that Maya Lopez barely managed to escape from, the new show opens by taking a page from Matts brief Spider-Man movie cameo and showing how well hes doing for himself. He, Karen Page (Deborah Ann Woll), and Foggy Nelson (Elden Henson) remain an effective trio at their firm and have plenty of friends they can hang with at their classic haunt, Josies Bar. Things are going great Image: Marvel Studios And then, things go wrong. Foggy is shot by Bullseye (Wilson Bethel), leaving Matt in such a fraught state hes given up being Daredevil a year later and focused entirely on being a lawyer. With Karen having left town after Foggys death, Matt and the audience find themselves without his classic support system, those roles now filled by firm partner Kirsten McDuffie (Nikki M. James) and Cherry (Clark Johnson), a retired cop who learned Matts secret seconds after hed thrown Bullseye off the roof and onto the street below, just feet away from Karen and Foggys corpse. After that cold open, Born Again jumps ahead a year to show Matt trying his best to move on from Foggys death. The new status quo makes for a different type of show, with a brighter color palette and a bigger emphasis on Matt as a lawyer that happens to be a superhero. Early episodes revolve around either his current casewith clients introduced through their plight first before Matt comes into the pictureor non-vigilante problems, like getting more money for his firm. This is a full-on weekly TV show, a format which fits the character pretty well. The lawyer scenes let Matt flex his legal muscles in a way the original Daredevil didnt always allow, and each episode provides plenty of moments for Matt to use his enhanced senses just enough to help in his daily life without fully going back to his old vigilante ways.Its hard to come to terms with our violent nature, intones Wilson Fisk (Vincent DOnofrio) to Matt in the premiere during their first face-to-face in years. Like Matt, Fisk has popped up here and there throughout the MCU prior to now, with his campaign to become New Yorks mayor born from his distaste of all vigilantes post-Echo. In Born Again, the former Kingpin is struggling at being a legitimate man in New York and all that entails as its mayor. The most interesting moments of his story arent the ups and downs of his mayoral life, but the quieter scenes between him and his wife Vanessa (Ayelet Zurer). Their relationship takes on interesting shades as the show digs into how his absence affected her and the ways in which they are defined and potentially undone by their love for one another. Photo: Giovanni Rufino/Marvel Studios Restraint is a key theme for several of Daredevil: Born Agains main players and the show itself. The show was famously reworked from its original version envisioned by then-showrunners Matt Corman and Chris Ord, whose influence is felt throughout the first four episodes. Initially, fight scenes are minimal, which feels like an intentional choice to convey how much Matt and Fisk are trying not to slip back into their old ways. Instead, theres a bigger focus placed on New York through journalist BB Urichs (Genneya Walton) news channel, where citizens give their thoughts on Fisks mayorship or the place vigilantes like Daredevil and White Tiger (Kamar de los Reyes) have in the city. Its all very on the nose, but it makes the MCUs version of New York feel the most alive and real it has in some time, and works perfectly for the array of street-level heroes and villains pulled into the shows orbit.Its in the series second half where it feels like current showrunner Dario Scardapane has full control and Born Again begins to fully turn Matt loose. Its action is more frequent and contains several impressive beats, and by seasons end, several ideas established in earlier episodes pay off in interesting, usually satisfying ways. The most refreshing thing about Born Again is how Scardapane and the rest of the team know what the ending is and how to get there. But it doesnt go too big or try to overextend itself: its a show about Matt Murdock above all else, and his unshakable desire to help his city, whether thats as a lawyer or his acrobatic alter ego. Whats here in Daredevil: Born Agains first season will undoubtedly feel compromised, but it remains worthwhile for its eventual highs and Cox and DOnofrio taking center stage once again. The show and character remain very good at what they set out to do, and heres hoping for stronger, more fully realized season two. Daredevil: Born Again airs new episodes Tuesday nights on Disney+. Want more io9 news? Check out when to expect the latest Marvel, Star Wars, and Star Trek releases, whats next for the DC Universe on film and TV, and everything you need to know about the future of Doctor Who.

Five Villas / Noue StudioSave this picture! Willem PabArchitects: Noue StudioAreaArea of this architecture projectArea:550 mYearCompletion year of this architecture project Year: 2025 PhotographsPhotographs:Willem PabMore SpecsLess SpecsSave this picture!Text description provided by the architects. This project of five villas in Villarsel-le-Gibloux is designed to integrate both into the site's topography and the existing built fabric, striking a balance between integration and architectural identity. The triangular plot guided the layout of the houses in a staggered arrangement, which helps to break down the volumes and create a more domestic scale. This composition provides a softer perception of the built form, ensuring that each home maintains its privacy while blending harmoniously into its surroundings.Save this picture!Save this picture!Save this picture!The staggered layout also plays a key role in the roof composition. It allows for overlapping pitched roofs, while a flat roof at the center of each volume accommodates level shifts. This central zone houses the circulation areas and sanitary facilities, adding both functional and visual rhythm to the overall design.Save this picture!The houses are spread over three levels, following the natural slope of the land. The entrance, located on the east side, is marked by a covered parking space, ensuring smooth and functional access. On the west side, the main living areas open directly onto gardens at ground level, creating a seamless transition between indoor and outdoor spaces. The upper floor is dedicated to the bedrooms, offering unobstructed views of the surrounding landscape. This layout ensures a clear separation between living and private spaces while making the most of the site's natural topography.Save this picture!Save this picture!Save this picture!The choice of materials was guided by durability, thermal performance, and a connection to the local architectural context. We opted for solid insulating brick, which provides better thermal inertia in both summer and winter. This masonry ensures greater stability and higher-quality rendering, as the plaster is applied to a solid surface, preventing cracks and ensuring long-term durability. The use of massive walls echoes traditional rubble stone constructions, reinterpreting the architectural heritage of local farmhouses.Save this picture!The base of the houses is built in concrete, ensuring a solid foundation anchored into the terrain, while the upper floor is constructed in wood, bringing lightness and warmth to the living spaces. We chose a more eco-friendly concrete with a higher clay content, which reduces its carbon footprint while giving it a warm beige hue that blends naturally with the other materials used in the project. To maintain a natural materiality, we also opted for lime plaster and anhydrite screeds instead of cement, promoting better thermal and humidity regulation.Save this picture!The villas feature two different typologies: two 4.5-room units on the periphery and three 3.5-room units in the center. This project offers a contemporary interpretation of individual housing, in dialogue with both the natural and built environment, where material choices and architectural composition contribute to a sensitive and respectful integration within the site.Save this picture!Project gallerySee allShow lessAbout this officeNoue StudioOfficeMaterialConcreteMaterials and TagsPublished on March 05, 2025Cite: "Five Villas / Noue Studio" 05 Mar 2025. ArchDaily. Accessed . <https://www.archdaily.com/1027410/five-villas-noue-studio&gt ISSN 0719-8884Save!ArchDaily?You've started following your first account!Did you know?You'll now receive updates based on what you follow! Personalize your stream and start following your favorite authors, offices and users.Go to my stream

Join this channel to get access to perks:https://www.youtube.com/@cghow/join Interactive Shield Material in Unreal Engine 5 Tutorial FAB - https://www.fab.com/sellers/CGHOW Whatsapp - https://bit.ly/3LYvxjK Patreon- https://www.patreon.com/Ashif NFT - https://opensea.io/CGHOW Twitter - https://twitter.com/cghow_ If you Liked it - http://bit.ly/2UZmiZ4 Channel Ashif - http://bit.ly/3aYaniw Support me on - paypal.me/9953280644 #cghow #UE5 #UE4Niagara #gamefx #ue5niagara #ue4vfx #niagara #unrealengineniagara #realtimevfxVisit - https://cghow.com/ Unreal Engine Marketplace - https://bit.ly/3aojvAa Artstation Store - https://www.artstation.com/ashif/store Gumroad - https://cghow.gumroad.com/

Join this channel to get access to perks:https://www.youtube.com/@cghow/join Full Video - https://youtu.be/I9mysLM6qV4 FAB - https://www.fab.com/sellers/CGHOW Whatsapp - https://bit.ly/3LYvxjK Patreon- https://www.patreon.com/Ashif NFT - https://opensea.io/CGHOW Twitter - https://twitter.com/cghow_ If you Liked it - http://bit.ly/2UZmiZ4 Channel Ashif - http://bit.ly/3aYaniw Support me on - paypal.me/9953280644Interactive Shield Material in Unreal Engine 5 Tutorial #cghow #UE5 #UE4Niagara #gamefx #ue5niagara #ue4vfx #niagara #unrealengineniagara #realtimevfxVisit - https://cghow.com/ Unreal Engine Marketplace - https://bit.ly/3aojvAa Artstation Store - https://www.artstation.com/ashif/store Gumroad - https://cghow.gumroad.com/

IntroductionModern biomedical research is driven by the promise of precision medicinetailored treatments for individual patients through the integration of diverse, large-scale datasets. Yet, the journey from raw data to actionable insights is fraught with challenges. Our team of researchers at Microsoft Research in the Health Futures group, in collaboration with the Perelman School of Medicine at the University of Pennsylvania (opens in new tab), conducted an in-depth exploration of these challenges in a study published in Nature Scientific Reports. The goal of this research was to identify pain points in the biomedical data lifecycle and offer actionable recommendations to enable secure data-sharing, improved interoperability, robust analysis, and foster collaboration across the biomedical research community.Study at a glanceA deep understanding of the biomedical discovery process is crucial for advancing modern precision medicine initiatives. To explore this, our study involved in-depth, semi-structured interviews with biomedical research professionals spanning various roles including bench scientists, computational biologists, researchers, clinicians, and data curators. Participants provided detailed insights into their workflows, from data acquisition and curation to analysis and result dissemination. We used an inductive-deductive thematic analysis to identify key challenges occurring at each stage of the data lifecyclefrom raw data collection to the communication of data-driven findings.Some key challenges identified include:Data procurement and validation: Researchers struggle to identify and secure the right datasets for their research questions, often battling inconsistent quality and manual data validation.Computational hurdles: The integration of multiomic data requires navigating disparate computational environments and rapidly evolving toolsets, which can hinder reproducible analysis.Data distribution and collaboration: The absence of a unified data workflow and secure sharing infrastructure often leads to bottlenecks when coordinating between stakeholders across university labs, pharmaceutical companies, clinical settings, and third-party vendors.Main takeaways and recommendations:Establishing a unified biomedical data lifecycleThis study highlights the need for a unified process that spans all phases of the biomedical discovery processfrom data-gathering and curation to analysis and dissemination. Such a data jobs-to-be-done framework would streamline standardized quality checks, reduce manual errors such as metadata reformatting, and ensure that the flow of data across different research phases remains secure and consistent. This harmonization is essential to accelerate research and build more robust, reproducible models that propel precision medicine forward.Empowering stakeholder collaboration and secure data sharingEffective biomedical discovery requires collaboration across multiple disciplines and institutions. A key takeaway from our interviews was the critical importance of collaboration and trust among stakeholders. Secure, user-friendly platforms that enable real-time data sharing and open communication among clinical trial managers, clinicians, computational scientists, and regulators can bridge the gap between isolated research silos. As a possible solution, by implementing centralized cloud-based infrastructures and democratizing data access, organizations can dramatically reduce data handoff issues and accelerate scientific discovery.Adopting actionable recommendations to address data pain pointsBased on the insights from this study, the authors propose a list of actionable recommendations such as:Creating user-friendly platforms to transition from manual (bench-side) data collection to electronic systems.Standardizing analysis workflows to facilitate reproducibility, including version control and the seamless integration of notebooks into larger workflows.Leveraging emerging technologies such as generative AI and transformer models for automating data ingestion and processing of unstructured text.If implemented, the recommendations from this study would help forge a reliable, scalable infrastructure for managing the complexity of biomedical data, ultimately advancing research and clinical outcomes.At Microsoft Research, we believe in the power of interdisciplinarity and innovation. This study not only identifies the critical pain points that have slowed biomedical discovery but also illustrates a clear path toward improved data integrity, interoperability, and collaboration. By uniting diverse stakeholders around a common, secure, and scalable data research lifecycle, we edge closer to realizing individualized therapeutics for every patient.We encourage our colleagues, partners, and the broader research community to review the full study and consider these insights as key steps toward a more integrated biomedical data research infrastructure. The future of precision medicine depends on our ability to break down data silos and create a research data lifecycle that is both robust and responsive to the challenges of big data.Explore the full paper (opens in new tab) in Nature Scientific Reports to see how these recommendations were derived, and consider how they might integrate into your work. Lets reimagine biomedical discovery togetherwhere every stakeholder contributes to a secure, interoperable, and innovative data ecosystem that transforms patient care.We look forward to engaging with the community on these ideas as we continue to push the boundaries of biomedical discovery at Microsoft Research.Access the full paperOpens in a new tab

An illustration of the titanosaur Chadititan calvoi and the other Cretaceous Period organisms it lived with. Gabriel LioShareA team of paleontologists found a new long-necked dinosaur species near a large salt flat in Argentina. Chadititan calvoi, or titan of the salt is estimated to have been about 22 feet-long and lived about 78 million years ago. The new species of titanosaur is described in a study published March 5 in the journal Revista del Museo Argentino de Ciencias Naturales.From its well-preserved bones, the paleontologists believe that Chadititan was a small and slender dinosaur, with elongated vertebrae and delicate limbs that set it apart from other titanosaurs. It was an herbivore and belonged to the Rinconsaurian group.The bones were uncovered near a salt flat in the Anacleto Formation in northern Patagonia, Argentina and found among fossils of ancient snails, garfishes, crocodile relatives, clams, freshwater turtles, and other organisms. Among this prehistoric treasure trove, the team uncovered the first fossil record of a family of tropical land snailsNeocyclotidaeand the first example of a small, tropical air-breathing land snail in the genus Leptinaria. This area was once a small pond surrounded by sand dunes and palm trees in what was a more arid and dry environment.In addition to Chadititan, the fossils we identified of mollusks, fish, and turtles, enriches our understanding of this ancient ecosystem and expands our knowledge of life in Patagonia near the end of the dinosaur era, Diego Pol, a study co-author, paleontologist, and National Geographic Explorer, said in a statement. Just by looking at the presence or absence of species in an area can suggest what makes the environment unique. In this case, the abundance of turtles and scarcity of crocodiles compared to regions in Europe and North America during the same period further highlights how Patagonian ecosystems were distinct as the continents drifted apart during the Cretaceous.Freshwater turtles made up over 90 percent of the recovered fossils, which surprised the research team, who represented organizations in Argentina and Uruguay. During the Cretaceous Period, this region was teeming with dinosaurs including megaraptors and Giganotosaurus, but paleontologists did not expect to see this many turtles. Get the Popular Science newsletter Breakthroughs, discoveries, and DIY tips sent every weekday. By signing up you agree to our Terms of Service and Privacy Policy.This high percentage is highly unusual, as in coeval sites from North America and Europe, turtles rarely account for more than 50% of the fauna, study co-author and paleontologist Federico Agnolin said in a statement.Continued study of the area aims to broaden our scientific understanding of the dinosaurs and other vertebrates that lived in Patagonia during the last 15 million years of the Cretaceous. Pols work will also build an animal database to help other researchers identify the extinction patterns at the end of the Cretaceous in South America and how they related to other regions of the world.

Bone tools found in Olduvai, photographed in the Pleistocene Archaeology Lab of CSIC. Credit: CSIC / Csar Hernndez RegalShareNew evidence uncovered in east Africa indicates ancient hominins began crafting tools from animal bones far earlier than previously thought. If confirmed, our human ancestors started shaping bones by striking them at specific angles in a process known as knapping as much as 1.5 million years ago.The findings come after paleolithic archeologists led by Ignacio de la Torre at the Spanish National Research Council (CSIC) analyzed bone fragments from the Olduvai Gorge site in northern Tanzania. Located in the Great Rift Valley and stretching roughly 29 miles across the Serengeti Plains, Olduvai Gorge is considered one of the most important paleoanthropological troves to date, and has advanced our understanding of early human life since its discovery over a century ago.The bones included those from ancient elephants and hippos. Credit: CSIC Csar Hernndez RegalIn this discovery, paleoarcheologists uncovered 27 tools mostly derived from ancient hippopotamus and elephant bones measuring as much as 1.25 feet long. As the team explained in their study published on March 5 in the journal Nature, the new information implies hominin abilities for adaptation and creation stretch much further back in our evolutionary timeline.Prior to the latest Olduvai Gorge finds, the earliest evidence of systematic production of bone tools crafted with knapping techniques came from European sites dating between 400,000 and 250,000 years ago. Meanwhile, those found in paleoanthropological pre-Middle Stone Age African contexts were widely considered as episodic, expedient and unrepresentative of early Homo toolkits. The Olduvai Gorge bones, however, dont appear to have been shaped at random, but instead display a uniformity indicating a practiced methodology and strategy.Excellent understanding of bone fracture mechanics is shown by the preferential use of large mammal fresh bones and the application of recurrent flaking procedures, wrote researchers, adding that: Mental templates are suggested by the production of morphologically similar, elongated, pointed and notched bone tools. Get the Popular Science newsletter Breakthroughs, discoveries, and DIY tips sent every weekday. By signing up you agree to our Terms of Service and Privacy Policy.Its not just the age of the bone tools that is striking to researchers, but their overall historical context. Study authors believe that integrating the material into ancient hominin toolkits at least 1.5 million years ago puts them at a pivotal time in the evolution of African cultural adaptations, particularly the late Oldowan and the early Acheulean periods.These developments may have had a profound effect on the complexification of behavioral repertoires observed in the latter period, including enhanced cognitive abilities, tool curation, and raw material harvesting techniques.

Ancient human relatives crafted sharp-edged tools out of animal bones around 1.5 million years ago, researchers say.Discoveries at Tanzanias Olduvai Gorge, a famous East African fossil location, represent the oldest known evidence of systematic bone tool production by hominids, according to archaeologist Ignacio de la Torre of CSIC-Spanish National Research Council in Madrid and colleagues.Excavations conducted from 2015 through 2022 unearthed 27 bone tools in sediment that had already been dated, the scientists report March 5 in Nature. Either of two fossil hominids known to have lived at Olduvai Gorge around 1.5 million years ago a possible direct human ancestor called Homo erectus or a side-branch species dubbed Paranthropus boisei could have created the bone artifacts, they say.While stone toolmaking emerged as early as 3.3 million years ago, bone tools generally date to no earlier than around 500,000 years ago. Much older origins of bone toolmaking were suggested by the identification of a 1.4-million-year-old hippos leg bone fashioned into a cutting or sawing tool, which had gone unexamined since its discovery at an Ethiopian site in 1994.An ancient bone tool kit unearthed in Tanzania exhibits a range of sizes and modifications.CSICEven older artifacts recovered at Olduvai Gorge come from a bone tool kit, the scientists say. Implements of varying sizes and shapes were identified as pieces of leg bones, mostly from elephants and hippos. Pounding marks appear where hominids sharpened the edges of bones. The largest tools, made from elephant bones, reached up to 38 centimeters long. Thats roughly the distance, on average, from an adults elbow to fingertips.Six bone tools featured a carved notch on one end, which perhaps served as a grip, and a sharp point at the other end. Several other bone tools resemble pear-shaped stone hand axes.Archaeologists consider stone hand axes the main innovation of the Acheulean industry, a tool tradition that emerged roughly 1.7 million years ago. We believe that the Olduvai bone tools represent a technological transfer [by hominids] from stone to bone, de la Torre says.His group excavated many hippo bones bearing butchery marks, suggesting that Olduvai hominids exploited hippo carcasses for food as well as bones suited for toolmaking. But few elephant remains turned up. Elephant-bone tools were brought to the site from elsewhere, the investigators suspect.

Nature, Published online: 05 March 2025; doi:10.1038/s41586-025-08619-6Gene duplication and subsequent paralogue diversification are major obstacles to genotype-to-phenotype predictability.

Nature, Published online: 05 March 2025; doi:10.1038/d41586-025-00654-7Mysterious syndrome remains a red risk for long-term spaceflight.