• Genome-wide CRISPR screen in human T cells reveals regulators of FOXP3
    www.nature.com
    Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08795-5The RBPJNCOR repressor complex is identified as a negative regulator of FOXP3 expression through modulation of histone acetylation in induced regulatory T cells.
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  • Fab's Latest Release Introduces Forum Threads, UE5 Plug-In & UX Updates Fab, the new platform from Epic Games that replaces the Unreal Engine Marketpl...
    x.com
    Fab's Latest Release Introduces Forum Threads, UE5 Plug-In & UX UpdatesFab, the new platform from Epic Games that replaces the Unreal Engine Marketplace, Sketchfab Store, and Quixel Megascans, is undergoing continuous development to restore its full functionality while adding new features, and Epic Games has just released another update and shared an overview of the changes.As before, improving Search is an ongoing and iterative process. This March, after integrating historical data from the Unreal Engine Marketplace and Sketchfab into search rankings, the developers have now started incorporating Fab data into the search weighting. This means recent sales will now have an influence on determining search rankings.Fab's other essential features, Unreal Engine 5 plug-in and UEFN integration, are now aligned with the improved UX. A key addition is the new Include 3D Compatible Formats option. The scrollbar is now wider, too, the left navigation panel remains visible when the panel width is sufficient, and all categories, rather than just a portion of them, are now visible in the plug-in.You can now associate forum threads with product listings on Fab, providing a space for questions, discussions, support, or sharing work created using the products. Please note that this feature is not a replacement for reviews.If you're a publisher, when your product is published on Fab, a forum post will be automatically created with you as the author. The title and description of the post will match the title and description from your Fab product listing, and your listing page will include a direct link to the thread.As for the next steps, the developers revealed that they will focus on improving categories, enhancing the performance of the 3D viewer, and refining the UE5 and UEFN integrations. Additionally, they plan to introduce individual sales for publishers and integrate Fab into the launcher.
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  • Studio Ghibli-style images are flooding the internet after ChatGPT's newest update. They are everywhere: https://80.lv/articles/internet-is-getting-dr...
    x.com
    Studio Ghibli-style images are flooding the internet after ChatGPT's newest update.They are everywhere: https://80.lv/articles/internet-is-getting-drowned-by-studio-ghibli-style-ai-image-trend/
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  • Satisfying Blenders Brick Wall Displacement Shader In Action
    cgshares.com
    Lately, weve been sharing lots of videos from Francesco Piacenti, aka FR3NKD, who truly masters the art of creating satisfying clips. This particular video showcases a subdivided mesh and displacement shader in Eevee, however, we highly recommend checking out FR3NKDs fun experiments with the free texturing add-on Ucupaint, like this one, which also uses displacement:And these, making masking out a PBR material from another PBR material looks really hypnotizing:We also featured FR3NKDs fun SubD and Boolean workflow, and the artist has created a tutorial on the technique, which you can check out below:Lets hope hell be making more tutorials in the future, so be sure to follow himonX/Twitter andjoin our80 Level Talent platformand ournew Discord server, follow us onInstagram,Twitter,LinkedIn,Telegram,TikTok, andThreads,where we share breakdowns, the latest news, awesome artworks, and more.Source link The post Satisfying Blenders Brick Wall Displacement Shader In Action appeared first on CG SHARES.
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  • Honkai Star Rail Codes March 2025 For Free Stellar Jade, Credits, And More
    www.gamespot.com
    HoYoverse's gacha RPG regularly receives working codes for freebies and rewards to help you on your travels. Some come from livestreams, or during events, whereas others may be obtained via social media. We've collected all of the Honkai Star Rail codes in one handy list, along with instructions on how to redeem them.HSR codes for free Stellar Jade can be used to pull characters from bannersActive HSR codesAll of the new Honkai Star Rail codes are:FIGHTWELLMYDEI - 3 Travelers Guide, 2 Golden HoneycakesDBKMW7MA6XB3 - 50 Stellar Jade, 20,000 CreditsHSRCHOCO - 3 Travelers Guide, 3 Lost Lightdust, 3 Trick SnackWHEREISTRIBBIE - 3 Travelers Guide, 1 Oronyx SlateIFYOUAREREADINGTHIS - 60 Stellar Jade, 1 Fuel4TKSX77Y58QK - 30 Stellar Jade, 3 Travelers Guide, 5 Condensed Aether, 4 Lost Gold Fragment, 20,000 Credits5S6ZHRWTDNJB - 60 Stellar JadeSTARRAILGIFT - 50 Stellar Jade, 2 Travelers Guide, 5 Bottled Soda, 10,000 CreditsHonkai Star Rail livestream codesThe codes from the March 25 livestream for HSR are:Continue Reading at GameSpot
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  • Pokemon Detective Pikachu 4K Steelbook Preorders Are Cheap At Amazon
    www.gamespot.com
    Pokemon: Detective Pikachu Limited Edition Steelbook (4K Blu-ray) $28 (was $33) at Amazon | Releases April 29 Preorder at Amazon Preorder at Walmart Preorder at Gruv Pokemon fans can save on preorders for the new 4K Blu-ray edition of Detective Pikachu at Amazon. When preorders for the upcoming Limited Edition Steelbook opened earlier this month, Amazon priced the release at $42.49. The MSRP has since been adjusted to $33, and Amazon has now dropped the preorder price to only $28. Amazon likely made this move due to Walmart restocking preorders of its own at the $28 price. Walmart's preorders are shipped and sold by Gruv. Amazon and Walmart offer preorder price guarantees and don't charge your card until your order ships.The charming live-action Pokemon movie received a 4K steelbook edition alongside its initial Blu-ray release in 2019, but that Best Buy-exclusive version is long gone. If you missed out then and want to add Detective Pikachu to your collection, now's your chance to get a stylish display case with vibrant art featuring the iconic Pokemon. Pokemon: Detective Pikachu Limited Edition Steelbook (4K Blu-ray) $28 (was $33) at Amazon | Releases April 29 This version of the film includes 4K, Blu-ray, and digital copies of Detective Pikachu. The big selling point is the steelbook--adorned with Pikachus lovable face (complete with his detectives hat), its a fun way to show off your limited edition set. Inside are two discs (4K and Blu-ray), and a digital code lets you download a copy of the film. Note that this must be redeemed before June 30, 2027.Detective Pikachu earned solid reviews when it hit theaters in 2019, as the live-action spinoff featured a cast of lovable characters, unexpected plot twists, and a roster that moves beyond the original 151 Pokemon.Heres a look at the bonus features included with the 4K Blu-ray:Alternate openingMY Pokemon AdventureCreating the World of Detective Pikachu featurettesMr. Mimes Audio CommentaryRyan Reynolds: Outside the Actors StudioMusic Video Preorder at Amazon Preorder at Walmart Preorder at Gruv Detective Pikachu Limited Edition SteelbookIf you dont need the cool steelbook, Detective Pikachu 4K is already available. Its also quite cheap at just $10 (click the coupon to get the full discount). The standard Blu-ray version is even more affordable at just $3.71--once again, click the coupon on Amazon's listing to get the deal. These even come with the same bonus features as the upcoming edition. Keep in mind that both of these deals are likely to expire after tomorrow, March 29.Continue Reading at GameSpot
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  • Great Stranger Things Board Games for Fans
    gamerant.com
    With Season 5 of Stranger Things around the corner, the fans of the show are left on the edge of their seats waiting for how it will all end. After all, Max is utterly shattered in a coma, and the fate of the rest of the Stranger Things crew is uncertain. Fans arent left with much to go on other than the big potential for Stranger Things spin-offs.
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  • Assassin's Creed Shadows' Flashbacks Are a Double-Edged Sword
    gamerant.com
    Assassin's Creed Shadows tells a familiar but compelling story. Naoe watches her father die at the hands of a small army of masked warriors that she eventually learns are part of a secret organization called the Shinbakufu. Alongside the samurai-turned-ronin Yasuke, Naoe hunts down the Shinbakufu members one by one, claiming revenge with each kill and searching for the missing artifact that her father asked her to keep safe.
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  • Share of the Week: Assassins Creed Shadows
    blog.playstation.com
    Last week, we asked you to take a leap into Assassins Creed Shadows and share epic moments of dual protagonists Naoe and Yasuke using #PSshare #PSBlog. Here are this weeks highlights:TakaSanGames shares Naoe in traditional Assassin white, in front of the Hidden Ones symbolEvo_Pixel shares Yasuke striking with his katana in the raindomo_vp shares Naoe framed by candlelightYuric83 shares Yasuke in ornamental armor emerging from shadowscalisarah1998 shares Naoe approaching a large red gateMilz_VP shares Yasuke wearing a samurai mask in the morning fogSearch #PSshare #PSBlog on Twitter or Instagram to see more entries to this weeks theme. Want to be featured in the next Share of the Week?View and download imageDownload the imagecloseCloseDownload this imageTHEME: Assassins Creed Shadows LandscapesSUBMIT BY: 11:59 PM PT on April 2, 2025Next week, were focusing on the beautiful environments of Assassins Creed Shadows. Share landscapes across the seasons of Japan using #PSshare #PSBlog for a chance to be featured.
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  • All kofun locations and rewards in Assassins Creed Shadows
    www.polygon.com
    Kofuns are dungeons in Assassins Creed Shadows that hide many secrets that is, if secrets means legendary gear.These short dungeons tend to be poorly lit byzantine mazes, but powerful items await those capable of completing their challenges. Each kofun is designed to be completed by a specific character. You may have to parkour as Naoe or push heavy things as Yasuke to make your way through a kofun. Since there arent level requirements for kofuns, completing them is a shortcut to some of high-powered armor and weapons usually reserved for the late-game.In this Assassins Creed Shadows guide, well show you where to find all kofun locations and list all Kofun rewards you receive by completing them.All kofun locations in Assassins Creed ShadowsThere are a total of 10 kofuns in Asssassins Creed Shadows. With at least one in most provinces in the game, finding all of them requires that you have progressed the main story missions to some extent before tackling the higher-level areas.Heres a list of all kofuns in Assassins Creed Shadows and the provinces youll find them in:Old Kofun (Izumi Settsu)Makino Kurumazuka Kofun (Izumi Settsu)Ancient Tomb of Nanjo (Yamashiro)Megalithic Vault (Yamato)Ishibutai Kofun (Yamato)Azuchi Hyotanyama Kofun (Omi)Tagaki Kofun (Harima)Veiled Tumulus (Wakasa)Chasuriyama Kofun (Tamba)Shimosato Kofun (Kii)In case you want to try your luck and go by yourself even when under the recommend level for a province, try your best to avoid conflicts. Assassins Creed Shadows doesnt prevent you from entering the areas. Just be sure to have unlocked Yasuke before, because you will have to play him in order to complete some of these.Old Kofun (Izumi Settsu)Located in Izumi Settsu, the first province you explore in the game, Old Kofun is probably the first kofun you will find if youre thoroughly exploring the map. You can find it in the Izumi Coast region, east of Sakai.Once you get the exact location, you will find an opening on the ground with stairs taking you to the dungeon blocked. Dont overthink. The real entrance to Old Kofun is located on the left side of the hill.Youll need to play as Naoe to complete Old Kofun. If you arent in a hurry to tackle this one, dont worry. Naoes quest eventually takes you to this kofun.For completing it, youll receive the Amaterasus Blessing legendary trinket.Makino Kurumazuka Kofun (Izumi Settsu)Youll find Makino Kurumazuka Kofun on the north side of Izumi Settsu. Look for it around the Yawata Plains area.Youll need to play as Yasuke to complete Makino Kurumazuka Kofun. There are some puzzles involving carrying heavy pots of gunpowder and then blowing them up, making it a more complex dungeon than some other kofuns. See our fullMakino Kurumazuka Kofun walkthrough for more details.Finding the final prize in this kofun is totally worth it, though. You gain the Blush of the Earth legendary bow for Yasuke.Ancient Tomb of Nanjo (Yamashiro)Once you get to the Yamashiro region, you may want to look for the Ancient Tomb of Nanjo kofun for Naoe. It is located in an area called Eagles Nest, southwest of Kyoto, right near where youll arriev in the regionYoull need to play as Naoe to complete the Ancient Tomb of Nanjo; it tests her climbing skills and features a labyrinthian layout. See our Ancient Tomb of Nanjo walkthrough for more details.Once you get to the final room in the dungeon, you can claim the Yukimitsus Revenge legendary tanto, which is a fantastic upgrade to Naoes arsenal.Megalithic Vault (Yamato)In the northwest region of Yamato, youll find the Megalithic Vault. The entrance is located west of Todaiji.Youll need to play as Yasuke to complete Megalithic Vault, and as with many other kofuns designed for Yasuke, youll need to clear your path by pushing large objects. Dont forget that Yasuke can open doors by rushing toward them. It will be an important skill to traverse this dungeon.In the Megalithic Vault, to compensate for Yasukes inability to parkour, you must improvise in order to reach higher places or cross chasms spanned by broken bridges.The prize for completing this kofun is the beautiful legendary armor Elegant Samurai Outfit legendary armor.Ishibutai Kofun (Yamato)While youre still in Yamato, you should look for the Ishibutai Kofun, where you find a unique piece of equipment for Naoe. Ishibutai Kofun is South of Takatori, a region more to the south of Yamato.Youll need to play as Naoe to complete Ishibutai Kofun, as a big part of this dungeon involves reaching the next area by using your grappling hook. You need to time your swings correctly to jump at the right moment and boost yourself to the next platform.After swinging all the way to the highest part of the dungeon, you find the chest with the Masakados Vengeance legendary trinket.Azuchi Hyotanyama Kofun (Omi)Theres only one kofun in Omi: the Azuchi Hyotanyama Kofun. You can find it on the southeast quadrant of the province, west of Azuchi.Youll need to play as Yasuke to complete Azuchi Hyotanyama Kofun and will find all kinds of challenges in this kofun. There are enemies to be killed, walls to be exploded, and platforms to be aligned in order to allow Yasuke to reach the new segments of the dungeon.As a reward for completing the Azuchi Hyotanyama Kofun, youll receive the Heartspiller legendary bow.Tagaki Kofun (Harima)Inside the Takagi Otsuka Fort in Harima, you find the entrance to the Tagaki Kofun being guarded by a group of soldiers. The fort can be found east of Kanki Burned Fields, but if you have already explored the area, you can also reach the place from Kakogawa Estuary.You need to complete Tagaki Kofun while playing as Yasuke. Although you can simply ignore the soldiers in the fort, there are some of them inside the dungeon that you will need to face. Inside, you also need to position explosives and shoot them to open the path for Yasuke.After defeating a last group of enemies, you can finally claim the Deaths Bloom legendary teppo.Veiled Tumulus (Wakasa)Closer to a massive river which cuts the whole region of Wakasa, you can find the Veiled Tumulus kofun. More specifically, it is in an area east of Obama.Youll need to play as Naoe to complete Veiled Tumulus. Youll find the place already invaded by some bandits, so you must use act furtively to take them all out. You can also explode some barrels by throwing shurikens at them. Its just out of character.When you climb to the final room, you can loot the legendary chest that holds the Stone Heart kusarigama.Chasuriyama Kofun (Tamba)At the highest hill northwest of the Chasuriyama region in Tamba, you can find the Chasuriyama Kofun. If youre planning on unlocking all allies in Assassins Creed Shadows, you wont miss this one, since you must complete it during Yagoros quest.You need to play as Naoe to complete Chasuriyama Kofun. And while the layout of this dungeon is less complicated than others, there is a lot to be found in it. In some rooms, you find letters and more information about the past of the League, and the woman who saved Yagoro.Reaching the kofuns final room and opening the chest rewards you with the Scarlet Fate legendary tanto.Shimosato Kofun (Kii)Shimasato Kofun is located in Kii, one of the last areas youll visit in Assassins Creed Shadows. Head southeast of Kumano Sanzan to find its entrance.Youll need to play as Yasuke to complete Shimosato Kofun. Different from the other Yasuke-centred kofuns, this one requires our favorite samurai to use his lungs, hold his breath, and dive into unknown waters to find the path to the final treasure. It doesnt mean you wont have to push and carry things around though.If you complete Shimasato Kofun, you get the Riddle of Steel legendary naginata.For more Assassins Creed Shadows guides, see our running lists of Lost Pages, Kuji-kiri, and armor locations. Or see our full Assassins Creed Shadows walkthrough, and our guides on how to get all companions and romance options.
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