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WWW.DISCOVERMAGAZINE.COMNew Immune Cell Discovery May Ease Food Allergy SymptomsFor people with food allergies, even a simple dinner out can become stressful. Figuring out whether every ingredient is listed on the menu and asking the server a dozen questions are necessary steps just to avoid dishes that might seem harmless to most, but can be dangerous — even fatal — to someone with allergies.A bite of something containing peanuts, shellfish, soy, or wheat can lead to anything from mild itching to vomiting or even difficulty breathing. At the moment, managing food allergies mostly comes down to strict avoidance and carrying emergency medication like epinephrine auto-injectors (EpiPens) or antihistamines.While treatments like oral immunotherapy are gaining traction, there’s still no cure. But that may be starting to change. A new study published in Nature highlights a type of immune cell that appears to ease food allergy symptoms — raising hopes among researchers at NYU Langone Health for a new way to treat not only allergies, but potentially other autoimmune conditions, too.Understanding Food AllergiesFirst, it’s important to distinguish a food allergy from a food intolerance. Intolerances — like lactose intolerance — are usually digestive issues and generally less severe. Food allergies, on the other hand, involve the immune system mistakenly identifying certain food proteins as harmful, triggering a reaction each time the food is consumed.Being allergic to a certain food means the immune system has incorrectly tagged a specific protein in that food as dangerous. As a result, it launches an immune response to "fight off" the supposed threat, causing symptoms that can range from mild to severe. These symptoms occur every time the protein is eaten, making even small amounts risky for those affected.Our gut is constantly exposed to a wide variety of foods, and the gut microbiome helps the immune system learn what’s harmful and what’s not. A healthy balance of gut bacteria plays a key role in helping prevent allergic reactions. So, researchers have increasingly turned their attention to the immune system within the gut to better understand how allergies take root at the molecular level.New Immune Cell Shows PromiseBuilding on earlier studies, scientists examined a newly identified type of immune cell called a tolerogenic dendritic cell, known for promoting immune tolerance to beneficial gut bacteria and improving overall microbiome health. This time, they explored whether these same cells could also play a role in reducing food allergies.Through genetically modifying the tolerogenic dendritic cells in mice, researchers observed that the animals developed asthma and food allergy symptoms. Additionally, when the cells were present and exposed to proteins from either food or friendly gut microbes, they triggered a transformation in nearby T cells. These T cells took on a regulatory, anti-inflammatory role — essentially training the immune system to stay calm the next time it encountered the same substance.“This discovery adds evidence to our earlier work showing that these cells also keep the peace with the vast microbiome, the mix of microbes that inhabits our body, and may be important for preventing autoimmune conditions like Crohn’s disease,” said Dan Littman, co-author of the study in a press release.Potential for Broader TreatmentsThe team also identified similar cells in various human tissue samples, suggesting that this mechanism might apply beyond mice. More research is needed to determine the exact role these cells play in the human body, but the implications are exciting.“If further experiments prove successful, our findings could lead to innovative ways to treat food allergies,” said Littman in the release. “For example, if someone has a peanut allergy, perhaps we can use tolerogenic dendritic cells to help create more regulatory T cells to suppress an allergic response to peanut molecules.”Beyond food allergies, this breakthrough could pave the way for treating other autoimmune and allergic conditions — and even help improve tolerance in organ transplant recipients.This article is not offering medical advice and should be used for informational purposes only.Read More: Everything to Know About AllergiesArticle SourcesOur writers at Discovermagazine.com use peer-reviewed studies and high-quality sources for our articles, and our editors review for scientific accuracy and editorial standards. Review the sources used below for this article:American Academy of Allergy Asthma & Immunology: The Current State of Oral ImmunotherapyHaving worked as a biomedical research assistant in labs across three countries, Jenny excels at translating complex scientific concepts – ranging from medical breakthroughs and pharmacological discoveries to the latest in nutrition – into engaging, accessible content. Her interests extend to topics such as human evolution, psychology, and quirky animal stories. When she’s not immersed in a popular science book, you’ll find her catching waves or cruising around Vancouver Island on her longboard.0 Comments 0 Shares 20 Views
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WWW.POPSCI.COMBring home the world’s first and only decentralized VPN and firewall hardware for $180 if you act fastWe get it—it’s hard to take online security seriously. You can’t exactly see the hackers stealing your important data like a thief making off with your flatscreen. But just because you don’t see it doesn’t mean it’s not happening. Beef up your internet security with help from the Deeper Connect Mini, the world’s first and only decentralized VPN and firewall hardware, for just $179.99 (reg. $229) now through April 27. Protect your online privacy with this 7-layer firewall Let the Deeper Connect Mini introduce you to the next generation of cybersecurity. It offers all the privacy of a VPN without a subscription. Just pay once for life while protecting your Internet of Things devices—like your smartphone and other smart home devices—from nefarious hackers. You don’t need to be a tech expert to benefit from the Deeper Connect Mini. Once set up, all your data is securely stored on your devices, protecting you from hacking. Deeper Connect Mini offers an impressive 7-layer, enterprise-grade firewall that protects your network from unauthorized access, cyberattacks, or any other threats. You’ll receive a stable network with secure access and no tracking. Among the other perks the Deeper Connect Mini brings? You’ll enjoy the internet how it was meant to be browsed—with zero advertisements on all web browsers. And if you have little ones at home, you can enact one-click parental controls to protect your kids from unsafe content online. You can also earn a little passive income with the Deeper Connect Mini via blockchain mining. Just share your extra internet bandwidth and let a network use your internet connection for a reward. Get your own Deeper Connect Mini, the world’s first and only decentralized VPN and firewall hardware, for just $179.99 (reg. $229) now through April 27. StackSocial prices subject to change.0 Comments 0 Shares 22 Views
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WWW.NATURE.COMThese are the most-cited research papers of all timeNature, Published online: 15 April 2025; doi:10.1038/d41586-025-01124-wSome studies have received hundreds of thousands of citations, Nature’s updated analysis shows.0 Comments 0 Shares 21 Views
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WWW.LIVESCIENCE.COM'Dispiriting and exasperating': The world's super rich are buying up T. rex fossils and it's hampering researchA Tyrannosaurus rex researcher has found that there are now more scientifically valuable T. rex specimens in private or commercial ownership than in public museums, hampering research.0 Comments 0 Shares 21 Views
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V.REDD.ITI just learned BlenderHere's my first animation test. submitted by /u/McDreH [link] [comments]0 Comments 0 Shares 24 Views
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WWW.GADGETS360.COMInfinix Note 50s 5G+ Confirmed to Feature 64-Megapixel Rear Camera Ahead of Launch in IndiaPhoto Credit: Infinix Infinix Note 50s 5G+ will arrive in Marine Drift Blue, Ruby Red and Titanium Grey shades Highlights Infinix Note 50s 5G+ will sport a 6.78-inch 144Hz 3D curved AMOLED screen The handset will have MIL-STD-810H certification, IP64 rating Infinix Note 50s will pack a 5,500mAh battery with 45W charging support Advertisement Infinix Note 50s 5G+ specifications have been revealed, giving us an idea of what to expect from the handset's camera, chipset, and battery details ahead of its launch in India on Friday. Previous teasers claimed that the upcoming smartphone will be India's slimmest 144Hz curved AMOLED smartphone in its segment. The Infinix Note 50s 5G+ will be available with two finishes — metallic and vegan leather. The latter is confirmed to arrive witht a "scent tech" feature. The phone is expected to join the Infinix Note 50X 5G, which was introduced in India in March.Infinix Note 50s 5G+ FeaturesThe Infinix Note 50s 5G+ will be powered by a MediaTek Dimensity 7300 Ultimate SoC, the company confirmed in a press release. It is claimed to score over 700,000 points on the AnTuTu benchmark test and is said to support up to 90fps frame rate while gaming.The company added that the Infinix Note 50s 5G+ will pack a 5,500mAh battery with support for 45W All-Round FastCharge 3.0. The phone will ship with Android 15-based XOS 15 and features the company's Folax AI assistant. For optics, the Infinix Note 50s 5G+ will be equipped with a dual rear camera unit including a 64-megapixel Sony IMX682 primary sensor with support for 4K video recording at 30fps. The handset will support AI-backed features like AI wallpaper generator, AIGC Mode and AI Eraser. The official microsite for the handset reveals that it will carry a 13-megapixel selfie shooter.The Infinix Note 50s 5G+ will sport a 6.78-inch full-HD+ 3D curved AMOLED display with a 144Hz refresh rate, a 2,304Hz PWM dimming rate, 10-bit colour depth, 100 percent DCI-P3 colour gamut coverage and Gorilla Glass 5 protection. The upcoming Infinix Note 50s 5G+ smartphone will come with a MIL-STD-810H military-grade durability certification and an IP64 water and dust-resistant rating. The Marine Drift Blue option will have a vegan leather finish and will support Microencapsulation Technology, which will help infuse the back panel with a fragrance. The Ruby Red and Titanium Grey variants will have metallic finishes. For the latest tech news and reviews, follow Gadgets 360 on X, Facebook, WhatsApp, Threads and Google News. For the latest videos on gadgets and tech, subscribe to our YouTube channel. If you want to know everything about top influencers, follow our in-house Who'sThat360 on Instagram and YouTube. Further reading: Infinix Note 50s 5G, Infinix Note 50s 5G India Launch, Infinix Note 50s 5G Features, Infinix Note 50 series, Infinix Note 50X 5G, Infinix Sucharita Ganguly Sucharita is a writer with Gadgets 360 and is mostly found playing with her cat in her free time. She has previously worked at breaking news desks across organizations. Powered by coffee, The Beatles, Bowie, and her newfound love for BTS, she aims to work towards contributing to a better media environment for women and queer folk. More Related Stories0 Comments 0 Shares 20 Views
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MEDIUM.COMSmall Models, Big Shifts: What the 2025 AI Index Tells Us About the Real Future of AISmall Models, Big Shifts: What the 2025 AI Index Tells Us About the Real Future of AI3 min read·Just now--It’s become a cliché to say “AI is a business transformation lever.” That narrative has had its moment.What the 2025 AI Index Report from Stanford’s HAI signals is something deeper and more structural: the AI landscape is no longer just about raw model power – it’s about precision, purpose, and productisation.We’re entering an era of smaller, smarter AI that is cheaper to deploy, faster to execute, and increasingly built for specific tasks and business problems. And that shift has real implications for how organisations innovate, build products, and generate value from AI.The End of Model MaximalismIn 2022, you needed a 540-billion-parameter model to break 60% on the MMLU benchmark. Today, Microsoft’s Phi-3-mini achieves the same score with just 3.8 billion parameters.That’s a 142x reduction in size – without compromising capability.This is more than just an engineering win. It redefines what’s practical. Small models mean:• Lower compute costs• Faster experimentation• Easier deployment at the edge• Less reliance on hyperscaler budgetsIt democratises innovation – making it feasible for startups, internal teams, and even individual researchers to build and fine-tune powerful tools.Costs Crash, Use Cases RiseInference costs have plummeted. Running a model with GPT-3.5-level performance is now 280x cheaper than it was 18 months ago.When you combine that with higher business adoption (78% of companies now use AI; 71% use generative AI in at least one function), the message is clear:We’re not in the experimentation phase anymore. AI is becoming embedded infrastructure.But here’s the catch: effectiveness now hinges on two things:1. How well you define the problem you’re trying to solve2. How good your data is to train, fine-tune, or guide the modelIn other words, your strategic clarity and data quality are more important than ever.A Shift in Global MomentumOne of the more interesting takeaways from the report is geographic: AI optimism is significantly higher in Asia – 83% in China, 80% in Indonesia, and 77% in Thailand. In contrast, only 39% in the U.S. and 36% in the Netherlands view AI’s benefits as outweighing its risks.This mindset matters.Optimism often breeds investment, risk-taking, and accelerated product development. If we start to see more practical, applied AI tools coming out of Asia in the next 12 – 18 months, don’t be surprised.The same way hardware innovation shifted globally two decades ago, AI product leadership could become more distributed – especially in areas like health, education, and digital services.What This Means for Business LeadersHere’s where I think the real opportunity lies:Small models are your invitation to innovate. You no longer need massive infrastructure to prototype and deploy.Define your business problems clearly. The sharper the use case, the better the results – this is where strategy meets execution.Treat data as a product. Better data = better models. Investing in high-quality, well-governed data pipelines will pay off faster than ever.Look globally, act locally. Be aware of where momentum is building – but adapt to your market and internal capabilities.The edge won’t come from owning the biggest model. It will come from knowing where and how to apply AI effectively – building the right thing, not just building the thing right.Final ThoughtAI is no longer about potential. It’s about precision, practicality, and product thinking. The organisations that internalise this shift will build faster, smarter, and more sustainably.Let’s stop chasing the biggest model – and start solving the most meaningful problems.0 Comments 0 Shares 19 Views
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WWW.RESETERA.COMBaldur's Gate 3 Patch 8 dropping on April 15thScott Lufkin Member Dec 7, 2017 2,274 Just saw this on IGN - I'll try to dig up some more info and update the OP. IGN is reporting the release date for Patch 8 has been announced - April 15th! Baldur's Gate 3's Huge Patch 8 and Its 12 New Subclasses Finally Have a Release Date - IGN Baldur's Gate 3's huge Patch 8 and its 12 new subclasses finally have a release date. www.ign.com Baldur's Gate 3 - Biggest Changes in Patch 8 - IGN Baldur's Gate 3's final update is coming to Xbox, PlayStation, and PC on April 15, 2025. Besides general improvements and bug fixes, Patch 8 has a lot in store for players, including long-awaited features like cross-play, photo mode, and 12 new subclasses. As Larian wraps up BG3 to focus on next... www.ign.com EDIT: BlueSky Larian offiical post: View: https://bsky.app/profile/larianstudios.com/post/3lmkbxbr7cc2h antitrop Member Oct 25, 2017 14,728 The Drunken Master Monk class is amusing. The achievement for killing 20 enemies while drunk is one of the rarest achievements in the game (2.5% on Steam) and it's not even hard to get, there's just really no reason to do it (yet). jungius Member Sep 5, 2021 3,469 haven't touch this game yet, maybe i'll wait until patch 10 Porygon One Winged Slayer Member Oct 25, 2017 4,611 Mexicali Well, time to start a campaign with friends, because I'm the only dumbass with a different platform rainier Member Oct 19, 2023 174 Can't wait to try the bladesinger. Ashes of Dreams Fallen Guardian of Unshakable Resolve Member May 22, 2020 19,205 You're welcome. Baldur's Gate 3 |OT| Trust the Dice OT I've been wanting to start my second playthrough for a long time. But I put it off when they announced Patch 7. And then put it off again when they announced Patch 8. I've been waiting a long time but now I don't feel like doing anything else. So I'm going to just start my playthrough now. Which... www.resetera.com Foolish Member Jun 23, 2022 1,456 jungius said: haven't touch this game yet, maybe i'll wait until patch 10 Click to expand... Click to shrink... They said Patch 8 will be the final non-bug-fixes-only patch, so you're pretty good to go on the 15th. Kenzodielocke Member Oct 25, 2017 13,762 So, is this for real the last big one? rainier Member Oct 19, 2023 174 jungius said: haven't touch this game yet, maybe i'll wait until patch 10 Click to expand... Click to shrink... If you're actually interested in trying it, this is the final content patch. So no real reason to wait anymore. Pepito Member Dec 11, 2017 3,364 CROSSPLAAAAAAAAAY timedesk Member Oct 27, 2017 5,067 Can't wait to try out the new Warlock and Bard subclasses. Cash Money Member Dec 8, 2023 326 I just started a new play through last night... canderous Prophet of Truth Member Jun 12, 2020 9,971 Canada Kenzodielocke said: So, is this for real the last big one? Click to expand... Click to shrink... For realsies this time (I think) Which means I can finally do a second playthrough. Every time I was about to do it, they were like oh wait big patch coming. Yurei Member Feb 28, 2023 1,249 Fuck right before Expedition 33 for me? Fuck, I'll start a new BG3 playthrough in may then. jungius Member Sep 5, 2021 3,469 Foolish said: They said Patch 8 will be the final non-bug-fixes-only patch, so you're pretty good to go on the 15th. Click to expand... Click to shrink... rainier said: If you're actually interested in trying it, this is the final content patch. So no real reason to wait anymore. Click to expand... Click to shrink... ty! ill pick it up on steam after I cleared my summer backlog Blacklisted Member Aug 15, 2021 333 jungius said: haven't touch this game yet, maybe i'll wait until patch 10 Click to expand... Click to shrink... I also didn't start the game because I'm waiting for patch 10 Friskyrum Member Jun 25, 2019 1,066 Been patiently waiting for this to do another run, and the patience started wearing thin the past couple weeks for me but I held strong. Can't wait! ClearMetal Hey, it's that sheep! Member Oct 25, 2017 18,620 the Netherlands Death Cleric Shadowheart, baby! Guess I need to go back to my Shadowheart avatar. AgentStrange Member Oct 25, 2017 4,873 Who gonna be up Balduring their Gate on April 15? Derkon Member Oct 25, 2017 3,447 Can anyone thats played the pre-release of patch 8 speak on the new subclasses? Any hits or misses? Astral Member Oct 27, 2017 33,108 Fucking adore this game. It's crazy how it almost never gets boring. Till you reach Act 3 on replays. AlexMeloche Member Oct 27, 2017 3,643 Hyped for crossplay. Friendly Bear Member Jan 11, 2019 3,343 I Don’t Care Where (Just Far) Any word on if this improves Act 3 performance further? Zera Bloodwinter Member Oct 27, 2017 2,164 My body is ready!!!!!! horkrux Member Oct 27, 2017 6,330 Damn they still patching? Crazy I also finally returned to my playthrough, so I will naturally absorb this update lol Voror Member Oct 25, 2017 4,036 I'm just gonna be curious to see all the crazy builds that come out of this with the new classes BlackheartVinyl Member Jun 15, 2020 7,610 I'm really bummed they're not gonna add a Roguelite mode forrest ▲ Legend ▲ Member Oct 25, 2017 1,866 The wife and I started at co-op game a couple nights ago. Curious to see what they are adding. Ashes of Dreams Fallen Guardian of Unshakable Resolve Member May 22, 2020 19,205 Since I'll finally be doing my evil/durge playthrough, I'm thinking about my party, since I want to use a bunch of the new stuff... Minthara (never used her) - Paladin/New Warlock subclass Astarion - New Ranger/New Bard Shadowheart - New Cleric Pretty open to changing all this of course and still haven't decided on what I want Durge to be ClearMetal Hey, it's that sheep! Member Oct 25, 2017 18,620 the Netherlands I have never played a Rogue (and I don't use/kill/respec Astarion) since I don't enjoy the stealth mechanics. But Swashbuckler sounds cool. Drunken Master or Hexblade might be fun, too. Honestly reading up on them I'm leaning Hexblade. Karlach is 100 percent going Path of Giants. But I'm mostly just stoked to Toll the Death with Shadowheart, haha. Elven_Star Member Oct 27, 2017 4,679 Finally. Stress testing started in freaking January. What took them so long? I'm going to do an honor mode playthrough as a dark urge death cleric drow called Dudley. leodrp Member Jan 23, 2025 106 So I finished the game on release, were they able to address the performance issues on act3 since then?? MF DOOMbot Member Jun 5, 2023 3,855 I will be there no matter what...in Crossplay dakun Member Oct 28, 2017 5,678 i waited for this moment after playing it for a bit when it came out. happy to finally start again with all the content updates done mhayes86 Member Oct 27, 2017 5,588 Maryland My wife and I finished BG 3 well over a year ago, we loved it, but we haven't really had the time to play it all over again. New classes and cross-play are really tempting, though! Skel1ingt0n Member Oct 28, 2017 11,190 I played 80hrs of this at launch and never even got to Baldur's Gate, lmfao. Whatchya all think: Start fresh or continue my playthrough? I'm tempted to continue my playthrough as it'll feel more new and I also really liked my hero and my choices so far. WascallyWabbit Member Oct 25, 2017 12,126 Was holding off on my first Durge run for this! SunBroDave "This guy are sick" Member Oct 25, 2017 14,925 Skel1ingt0n said: I played 80hrs of this at launch and never even got to Baldur's Gate, lmfao. Whatchya all think: Start fresh or continue my playthrough? I'm tempted to continue my playthrough as it'll feel more new and I also really liked my hero and my choices so far. Click to expand... Click to shrink... The Baldur's Gate portion of the game is practically its own full game in its own right. I think I spent 60 hours there alone, more than in any other act in the game. That said, a lot of what makes the Baldur's Gate section so good is how well it concludes all of the major and minor storylines that built throughout the entire game, so it really depends on how good your memory is of what you've played so far. If you're fuzzy on the details of what you played so far, it might make sense to start fresh. Magic-Man Member Feb 5, 2019 11,530 Epic Universe Hoping for performance improvements plz. Looking at you Steam Deck. dekjo Member Jul 10, 2023 31 Don't think I'm ready for my 3rd run, but at some point I will and the crossplay & new subclasses will make that a lot of fun. BG3 helped me rediscover my love for CRPG games, and have since played Pillars of Eternity 1 and am now in the middle of Deadfire, while also starting a Pathfinder Kingmaker playthrough. So thank you Larian for reviving my interest in these game, having a lot of fun in all of them. ResinPeasant93 Member Apr 24, 2024 2,206 I know there was a rumor for a bit that one of these patches would allow either Volo or Alfira join your party (not talkign Dark Urge stuff). Did that ever come to pass? mangrilla Member Aug 28, 2020 1,074 Washington, DC It doesn't say (or I didn't see in my skim), but assuming this is across all platforms? I know sometimes stuff takes a little longer to review for the consoles. Been waiting for this to jump back in on PS5. Darkwing-Buck Member Oct 25, 2017 31,438 Los Angeles, CA fuck yes FakePlasticTree Member Jul 24, 2018 13,500 mangrilla said: It doesn't say (or I didn't see in my skim), but assuming this is across all platforms? I know sometimes stuff takes a little longer to review for the consoles. Been waiting for this to jump back in on PS5. Click to expand... Click to shrink... Yes it's gonna be on PS5 too FakePlasticTree Member Jul 24, 2018 13,500 ResinPeasant93 said: I know there was a rumor for a bit that one of these patches would allow either Volo or Alfira join your party (not talkign Dark Urge stuff). Did that ever come to pass? Click to expand... Click to shrink... Nah that ain't happening. FakePlasticTree Member Jul 24, 2018 13,500 Skel1ingt0n said: I played 80hrs of this at launch and never even got to Baldur's Gate, lmfao. Whatchya all think: Start fresh or continue my playthrough? I'm tempted to continue my playthrough as it'll feel more new and I also really liked my hero and my choices so far. Click to expand... Click to shrink... Continue!!! LossAversion The Merchant of ERA Member Oct 28, 2017 11,555 Finally going to dive into BG3... after a couple more hot fixes for whatever this patch breaks, lol. SofNascimento cursed Member Oct 28, 2017 24,623 São Paulo - Brazil Time for a new playthrough I guess. DarkFlame92 Member Nov 10, 2017 5,869 Now is the time for me Harbinger00 Member Oct 27, 2017 2,300 Nice, i've been waiting for this to drop.0 Comments 0 Shares 22 Views