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The complexity of biology has long been a double-edged sword for scientific and medical progress. On one hand, the intricacy of systems (like the human immune response) offers countless opportunities for breakthroughs in medicine and healthcare. On the other hand, that very complexity has often stymied researchers, leaving some of the most significant medical challengeslike cancer or autoimmune diseaseswithout clear solutions. The field needs a way to decipher this incredible complexity. Could the rise of agentic AI, artificial intelligence capable of autonomous decision-making and action, be the key to breaking through this impasse? Agentic AI is not just another tool in the scientific toolkit but a paradigm shift: by allowing autonomous systems to not only collect and process data but also to independently hypothesize, experiment, and even make decisions, agentic AI could fundamentally change how we approach biology. The mindboggling complexity of biological systems To understand why agentic AI holds so much promise, we first need to grapple with the scale of the challenge. Biological systems, particularly human ones, are incredibly complexlayered, dynamic, and interdependent. Take the immune system, for example. It simultaneously operates across multiple levels, from individual molecules to entire organs, adapting and responding to internal and external stimuli in real-time. Traditional research approaches, while powerful, struggle to account for this vast complexity. The problem lies in the sheer volume and interconnectedness of biological data. The immune system alone involves interactions between millions of cells, proteins, and signaling pathways, each influencing the other in real time. Making sense of this tangled web is almost insurmountable for human researchers. Enter AI agents: How can they help? This is where agentic AI steps in. Unlike traditional machine learning models, which require vast amounts of curated data and are typically designed to perform specific, narrow tasks, agentic AI systems can ingest unstructured and diverse datasets from multiple sources and can operate autonomously with a more generalist approach. Beyond this, AI agents are unbound by conventional scientific thinking. They can connect disparate domains and test seemingly improbable hypotheses that may reveal novel insights. What might initially appear as a counterintuitive series of experiments could help uncover hidden patterns or mechanisms, generating new knowledge that can form the foundation for breakthroughs in areas like drug discovery, immunology, or precision medicine. These experiments are executed at unprecedented speed and scale through robotic, fully automated laboratories, where AI agents conduct trials in a continuous, round-the-clock workflow. These labs, equipped with advanced automation technologies, can handle everything from ordering reagents, preparing biological samples, to conducting high-throughput screenings. In particular, the use of patient-derived organoids3D miniaturized versions of organs and tissuesenables AI-driven experiments to more closely mimic the real-world conditions of human biology. This integration of agentic AI and robotic labs allows for large-scale exploration of complex biological systems, and has the potential to rapidly accelerate the pace of discovery. From agentic AI to AGI Owkins next frontier: Unlocking the immune system with agentic AI Agentic AI has already begun pushing the boundaries of whats possible in biology, but the next frontier lies in fully decoding one of the most complex and crucial systems in human health: the immune system. Owkin is building the foundations for an advanced form of intelligencean AGIcapable of understanding the immune system in unprecedented detail. The next evolution of our AI ecosystem, called Owkin K, could redefine how we understand, detect, and treat immune-related diseases like cancer and immuno-inflammatory disorders. Owkin K envisions a coordinated community of specialized AI agents that can autonomously access and interpret comprehensive scientific literature, large-scale biomedical data, and tap into the power of Owkins discovery engines. These agents are capable of planning and executing experiments in fully automated, robotized wet labs, where patient-derived organoids simulate real-world human biology. The results of these experiments feed back into the system, enabling continuous learning and refinement of the AI agents models. What makes Owkin K particularly exciting is its potential to tackle the immune systema biological network so complex that human intelligence alone has struggled to unravel it. By deploying AI agents with the ability to explore this intricate web autonomously, the project could reveal new therapeutic targets and strategies for immuno-oncology and autoimmune diseases, potentially accelerating the development of groundbreaking treatments. Navigating challenges and ethical considerations of agentic AI Of course, such powerful technology comes with significant challenges and ethical considerations, including trust, security, and transparency. But we must tackle these challenges as agentic AI becomes more integrated into healthcare and research. For example, we can develop mitigation plans that include rigorous validation protocols, real-time human oversight, and regulatory frameworks designed to ensure safety, accountability, and transparency. By prioritizing ethical design and close collaboration between AI systems and human experts, we can harness the potential of agentic AI while minimizing its risks. The future of biological research with agentic AI Agentic AI has the potential to reshape not just healthcare, but the very foundations of biological research. By allowing autonomous systems to explore the unknown, we may unlock new levels of understanding in areas like immunology, neuroscience, and genomicsfields that are currently constrained by the limits of human comprehension. We could soon see a world where AI-driven labs operate around the clock, pushing the boundaries of biology at speeds and scales that far exceed human capabilities. This would not only accelerate scientific discovery but also create new possibilities for personalized medicine, disease prevention, and even longevity. In the end, agentic AI may be more than just another tool for researchers. It could be the key to understanding life itselfone autonomous decision at a time. Davide Mantiero, PhD, Eric Durand, PhD, and Darius Meadon also contributed to this article. This content was produced by Owkin. It was not written by MIT Technology Reviews editorial staff.

This is today's edition ofThe Download,our weekday newsletter that provides a daily dose of what's going on in the world of technology. The AI lab waging a guerrilla war over exploitative AI Back in 2022, the tech community was buzzing over image-generating AI models, such as Midjourney, Stable Diffusion, and OpenAIs DALL-E 2, which could follow simple word prompts to depict fantasylands or whimsical chairs made of avocados. But artists saw this technological wonder as a new kind of theft. They felt the models were effectively stealing and replacing their work. Ben Zhao, a computer security researcher at the University of Chicago, was listening. He and his colleagues have built arguably the most prominent weapons in an artists arsenal against nonconsensual AI scraping: two tools called Glaze and Nightshade that add barely perceptible perturbations to an images pixels so that machine-learning models cannot read them properly.But Zhao sees the tools as part of a battle to slowly tilt the balance of power from large corporations back to individual creators. Read the full story. Melissa Heikkil Have we entered the golden age of plant engineering? In the 1960s, biologists selective breeding of plants helped spark a period of transformative agricultural innovation known as the Green Revolution. By the 1990s, the yields of wheat and rice had doubled worldwide, staving off bouts of recurring famine. The Green Revolution was so successful that dire predictions of worse famine to comefueled by alarming population growthno longer seemed likely. But it had its limitsonly so much yield could be coaxed from plants using conventional breeding techniques. Now, more precise gene-editing technologies could shave years off the time it takes for new plant varieties to make it from the lab to federally approved seed products. Read the full story. Bill Gourgey This piece is from the latest print issue of MIT Technology Review, which is all about the weird and wonderful world of food. If you dont already, subscribe to receive future copies once they land. MIT Technology Review Narrated: Is robotics about to have its own ChatGPT moment? Robots that can do many of the things humans do in the home have been a dream of robotics research since the inception of the field in the 1950s. While engineers have made great progress in getting robots to work in tightly controlled environments like labs and factories, the home has proved difficult to design for. But now, the field is at an inflection point. A new generation of researchers believes that generative AI could give robots the ability to learn new skills and adapt to new environments faster than ever before. This new approach, just maybe, can finally bring robots out of the factory and into the mainstream. This is our latest story to be turned into a MIT Technology Review Narrated podcast, which were publishing each week on Spotify and Apple Podcasts. Just navigate to MIT Technology Review Narrated on either platform, and follow us to get all our new content as its released. The must-reads Ive combed the internet to find you todays most fun/important/scary/fascinating stories about technology. 1 Donald Trump wants Elon Musk to maximize government efficiency Despite claiming to be a department, technically its more of an advisory board. (Wired $)+ It will allegedly operate outside of the federal government. (WSJ $)+ Expect Musk to treat the US government like his loss-making social network. (Bloomberg $)2 The crypto industry has already started lobbying Trump Executives are wasting no time in presenting the President-elect with their wish lists. (NYT $)+ Were witnessing the industrys nascent attempts to make itself institutional. (NY Mag $)+ The Trump Pump is showing no signs of slowing. (CNN)3 Advertisers are considering staging a return to X In a bid to curry favor with Musk and his political leverage. (FT $)+ Silicon Valley is decidedly more Trump-friendly than it used to be. (Insider $)+ Bluesky is starting to look more and more appealing. (Slate $)4 Major AI players are struggling to make new breakthroughs Funneling money into new products isnt having the desired result. (Bloomberg $)5 The worlds e-waste is actually pretty valuable Theres a lot of gold to be stripped out from those old circuit boards. (Economist $)+AI will add to the e-waste problem. Heres what we can do about it. (MIT Technology Review) 6 DNA testing is ushering in a new age of discriminationAnd you could be denied medical or life insurance because of it. (The Atlantic $) + How to delete your 23andMe data. (MIT Technology Review)7 How to build the perfect humanoid robotUnfortunately, theyll be found in factories and warehouses before they make it to our homes. (IEEE Spectrum) + A skeptics guide to humanoid-robot videos. (MIT Technology Review)8 The US is using AI to seek out critical mineralsAccess to regular supplies could lessen its reliance on China and Russia. (Undark Magazine) + The race to produce rare earth elements. (MIT Technology Review)9 Apples AirTags can now share their location with airlines Which should (hopefully) minimize the chances of losing your luggage. (WP $)+ Its next device? An AI wall-mounted tablet, supposedly. (Bloomberg $)10 This new mathematics benchmark is being kept secret To prevent AI models from training against it. (Ars Technica)+ This AI system makes human tutors better at teaching children math. (MIT Technology Review)Quote of the day Dont bring a watermark to a gunfight. AI researcher Oren Etzioni warns the industry to avoid putting too much faith in voluntary standards to actively prevent malicious actors from gaming the system, TechCrunch reports. The big story The great AI consciousness conundrum October 2023 AI consciousness isnt just a devilishly tricky intellectual puzzle; its a morally weighty problem with potentially dire consequences that philosophers, cognitive scientists, and engineers alike are currently grappling with. Fail to identify a conscious AI, and you might unintentionally subjugate a being whose interests ought to matter. Mistake an unconscious AI for a conscious one, and you risk compromising human safety and happiness for the sake of an unthinking, unfeeling hunk of silicon and code. Over the past few decades, a small research community has doggedly attacked the question of what consciousness is and how it works. The effort has yielded real progress. And now, with the rapid advance of AI technology, these insights could offer our only guide to the untested, morally fraught waters of artificial consciousness. Read the full story. Grace Huckins We can still have nice things A place for comfort, fun and distraction to brighten up your day. (Got any ideas? Drop me a line or tweet 'em at me.) + Small changes can improve your life, from debobbling your clothes to oiling your keyholes.+ Woah: these fascinating deep sea creatures can turn back the clock on aging and revert to a more youthful form.+ TikTok is really into onions. Yes, onions. + As if filmmaking wasnt stressful enough, these movies were all completed in a single take.

html PUBLIC "-//W3C//DTD HTML 4.0 Transitional//EN" "http://www.w3.org/TR/REC-html40/loose.dtd"Deond, the studio co-founded by Ross Lovegrove and Ila Colombo, has designed an installation wrapped by three dimensional corrugated cardboards referencing " the rough, spiky seed of nature" in Dubai.The installation, named Enfold Pavilion, was showcased at the Dubai Design District (d3) during Dubai Design Week from November 5th to 10th, in Dubai, United Arab Emirates.With an AI-infused "second skin" fabric that reacts to the state of the body, the installation delves into the idea of phy-gital therapy. It seamlessly blends the digital and physical worlds to produce a profoundly immersive experience.Established in 2023, Deond is a multidisciplinary practice that combines innovative vision with state-of-the-art knowledge. In order to promote a sustainable coexistence between the built and natural environments, they combine advanced manufacturing, interactive installations, and architecture in their pursuit of creating environments that are beautiful, useful, and sustainable.With an exterior that alludes to the coarse, spiky seed of nature and a calming, regenerative core inside, the installation is a perfect example of biomimicry in design. Its overall circular shape represents the holistic embrace that connects technology, body, and mind in a continuous sense of enclosure.Soft, natural light can enter the room through the perforated roof, which varies in size and density. The intensity of the light changes as the sun moves across the sky. In keeping with the exhibition's dedication to sustainability, the entire structure and finish are made of corrugated cardboard.The so-called phy-gital display, a volumetric 3D podium, is located inside the pavilion. It is made up of two digital screens that are integrated into the architectural skin of the pavilion and a group of transparent reflective wires.When the HUG (Holistic Unified Garment) bodysuit is viewed from a particular angle, the collection of wires creates a seamless, flowing garment.The volumetric garment can float and interact with the light thanks to this creative suspension system, which eliminates the need for large supporting materials and improves the conceptual and visual coherence of the body, technology, and space.Deond, HUG Holistic Unified Garment. Image DeondThe HUG bodysuit imagines new kinds of speculative tools that could help treat anxiety and de-accelerate the mind and body by fusing Eastern treatment methods with Western approaches to science and technology.The clothing stimulates the body's triggering points and imitates natural shapes using Al and 3D design tools.Deond investigates the potential advantages for both people and the ecosystem as a whole if the dichotomy of "Body as Machine/Body as Garden" were to vanish."Body as Machine is an idea developed in the West that attempts to prioritise technological acceleration and considers a body as a vehicle that doesnt know its limitations," said Ila Colombo & Deff Collective. "Body as Garden" enhances self-regulatory capacity. This perspective is nourished in the East, where the body is not viewed as a vehicle with many separate parts, but a whole a holistic environment.""What if technological acceleration could give us a chance to become closer to nature - to return to what has been neglected and forgotten? How can we envision embedded devices that prevent physical anxiety, acting as a protective, healing second skin? How should we merge technology and nature to bridge?," they added.Project factsProject name:Enfold: The Holistic Embrace of Body and TechnologyDesign by:Deond (Ross Lovegrove and Ila Colombo)Creative and Art Direction:Ila ColomboLocation:Dubai Design District (d3), Near the UAE flag, front facing the road between building 9-10Bodysuit garment sponsor:StratasysDigital content:Deff collectiveAll images Deed Studiounless otherwise stated.> via Deond

html PUBLIC "-//W3C//DTD HTML 4.0 Transitional//EN" "http://www.w3.org/TR/REC-html40/loose.dtd"The Trkiye Pavilion has announced the project and curators for the19thInternationalArchitectureExhibitionof the 2025 Venice Architecture Biennalein Venice, Italy.Commissioned bytheIstanbulFoundationforCultureandArts(IKSV), the exhibition, titled Grounded,curatedby Istanbul-based curatorCerenErdemand Berlin-based architectBilgeKalfa.The 2025 Venice Architecture Biennale will take place fromMay10 to November23 November 2025 at the Giardini, the Arsenale and various venues in Venice.TitledIntelligens. Natural. Artificial. Collective, the exhibition will be curated by Carlo Ratti, an architect and engineer, Carlo Ratti is currently holding teaching positions at the Massachusetts Institute of Technology (MIT) and at the Politecnico di Milano.Ceren Erdem, Bilge Kalfa. Image courtesy of theIstanbulFoundationforCultureandArtsAfter evaluating 48 projects, the Selection Committeewhich included Melike Altnk, N. Mge Cengizkan, Prof. Dr. Zeynep elik, Oral Gkta, and Dr. Sait Ali Kknarselected Grounded, which was curated by Ceren Erdem and Bilge Kalfa, from a shortlist of three finalists, each of whom was noteworthy for its distinctive design concepts and content.Grounded examines soil as a living archive, an ecosystem, a form of natural intelligence, a supportive model, and a repository of ecological and cultural memory.The project was selected because of its creative research proposal, which seeks to unearth fresh optimism for the future, primarily from Trkiye, while integrating significant artistic perspectives in an interdisciplinary approach that enhances its story, advances global understanding, and stimulates critical thinking.By highlighting the qualities of soil as a source of life, memory, and knowledge, Grounded will establish a connection between the past and the future.The Pavilion of Trkiye, Ghost Stories: Carrier Bag Theory of Architecture. Image Rachele MaistrelloThe exhibition's main goal is to remind us that this object, which is sometimes dismissed as inert and unimportant, actually holds important knowledge about historical civilizations, ecological systems, and the potential for coexisting peacefully with the natural world. It will do this through sensory experiences, scientific documentation, architecture, and artwork.Grounded will combine new research with traditional building techniques with the soil, as well as future visions that value life both above and below the soil equally.With the help of 21 sponsors and the purchase of the permanent location at Sale d'Armi, Arsenale, at the initiative of IKSV, the Trkiye Pavilion has participated in the International Architecture Exhibition since 2014.Ceren Erdem is an Istanbul-based curator who has worked on exhibitions and publications internationally. Some of her projects include Tack, Limb, Ilizarov, Depo, Istanbul (2023); All Else Is Far (2021) and Ad Infinitum (2019), Dirimart, Istanbul; Inverse Grayscale, Pasinger Fabrik, Munich (2016); Istanbul. Passion, Joy, Fury, Fondazione MAXXI, Rome (2015); Water Knows All My Secrets, Pratt Manhattan Gallery (2015) and Private Matters, apexart (2014), New York.Erdem has taken full-time roles at Dirimart, Istanbul, Tina Kim Gallery, New York, British Council Turkey, Istanbul, and Istanbul Biennial.The Pavilion of Trkiye, Ghost Stories: Carrier Bag Theory of Architecture. Image Rachele MaistrelloErdem received her Master's Degree in Modern Art: Critical and Curatorial Studies at Columbia University, New York, MFA in Visual Arts - Visual Communication Design at Sabanc University, Istanbul, and BSc in Industrial Product Design at Istanbul Technical University.Bilge Kalfa is an architect who owns Bilge Kalfa Architecture and is an adjunct professor at Berlin International University. In addition to furniture design that emphasizes natural, cyclical materials, Kalfa's expertise encompasses all stages of architectural and interior design.A graduate of Istanbul Technical Universitys Faculty of Architecture with a bachelors and masters degree, she also co-owns The Keep, an artisanal rug company. In 2010, she received a national architectural prize for the group project mkanmekan. She has completed numerous projects in Istanbul and Berlin, including the renowned Moda Sahnesi and Theater Hall at Boazii University, with her former business partner. Her approach aims to honour the interconnectedness of life and the environment as much as possible.At the Venice Architecture Biennale 2023, the Trkiye Pavilion hosted the exhibition, titled Ghost Stories: Carrier Bag Theory of Architecture curated by Istanbul-based architecture studio SO?, co-founded by Sevince Bayrak and Oral Gkta. The exhibition aimed "to question the taken-for-granted images and approaches to buildings and to reveal hopeful proposals for the future."Top image: The Pavilion of Trkiye, Ghost Stories: Carrier Bag Theory of Architecture. Image Rachele Maistrello.> via IKSV

The National Trust for Scotland plans to reopen historic cottage to the public in 2025Source: Ben AddySource: Ben AddySource: Ben AddySource: Ben AddySource: Ben AddySource: Ben AddySource: Ben AddySource: Ben Addy1/8show captionMoxon Architects has restored the Royal Picnic Cottage on the Mar Lodge Estate, a property once frequented by Queen Victoria during her Balmoral holidays.Situated within Britains largest National Nature Reserve, the project aims to safeguard this Category C listed structure for future generations. Originally built around 1850, the granite cottage has been removed from Scotlands Buildings at Risk Register following conservation efforts.The restoration used locally sourced materials and revived the cottages original architectural elements, including timber twig detailing and larch roof shingles, a rarity in Scotland.Andrew MacPherson, director of Moxon Architects, stated, As an architecture practice deeply invested in the regions heritage, we have proudly worked with The National Trust for Scotland to preserve a significant piece of local heritage on the Mar Lodge Estate. He added that the approach was one of minimal yet durable interventions to withstand the remote and challenging climate.Structural repairs included lime mortar repointing, harling of the walls, and the installation of conservation rooflights. The interior now features new timber flooring and restored fireplaces, with original roof timbers hand-oiled to a dark finish. Historic survey drawings helped guide the sympathetic reinstatement of the wooden porch, once a prominent feature of the cottage.Source: Ben AddySource: Ben Addy1/2show captionDavid Frew, Head of Mar Lodge Estate for the National Trust for Scotland, noted the cottages historical significance: Our archival research and archaeological survey showed that there used to be a porch on the property, and we have tried to reinstate this sympathetically with the help of our architects Moxon.He also highlighted the propertys royal connection, stating, The building is a fascinating look back at how the royals used to spend their free time, and were incredibly proud to see it restored.Set to reopen in 2025, the cottage will feature informational displays and custom furniture, inviting visitors to experience its 19th-century character amidst the surrounding woodland. The restoration was supported by funding from the NTS USA Foundation.

Nicholas Boys Smith has said the governments decision to shut down the Office for Place risks ministers marking their own homework on housing design.Yesterday housing minister Matthew Pennycook announced the arms length body would be scrapped, arguing its role could be more effectively and efficiently delivered within the Ministry of Housing Communities and Local Government (MHCLG).Source: Tom CampbellOffice for Place interim chair Nicholas Boys SmithSet up in July 2021 by former housing secretary Robert Jenrick, the Office for Place was tasked with ensuring quality design in new housing projects and driving the adoption of design codes by local authorities.Transformed into an independent body in July last year with plans for a head office in Stoke on Trent, it was envisaged as an enabler for the governments house building targets by promoting public consent for new schemes.Boys Smith, the founder of Create Streets and the interim chair of Office for Place, said the decision to close the body was a mistake and questioned whether the drive for quality in planning policy would be lost.He said: Naturally I am hugely disappointed by this news and think that it is a mistake or I would not have set it up. In the, correct dash for quantity there needs to be an independent voice for quality. Will that voice now be lost within Whitehall? We will find out. I hope not.> Also read:Office for Place seeks permanent chief executive and new Stoke-on-Trent headquartersBoys Smith added that it was a huge sadness that the organisation would not be able to set up its planned office in Stoke on Trent. Other staff on its board included classicist architect Robert Adam and AHMM co founder Paul Monaghan.The body was planning to publish an annual review into place-making and regenerative developments across England which would assess how many councils had adopted design codes, and how successful they were in enabling more housebuilding with public consent.Boys Smith said: Will the Government still publish [the review]? Is there a risk of them marking their own homework?While he admitted the Office for Place did not have a magic wand to speed up the delivery of more homes, he said its role was to drive efficiency by promoting clearer, more visual and more clearly locally popular local policy to permit more homes with more public consent.Pennycook said the decision to close the body had been taken by himself and housing secretary Angela Rayner following last months autumn Budget and the re-setting of departmental budgets.He insisted the move did not mean the government was not downgrading the importance of good design and placemaking, or the role of design coding in improving the quality of development.Instead, he promised it would draw the bodys expertise into MHCLG and fully integrate good design and placemaking into the governments planning reforms.I also believe that embedding this work within MHCLG will allow experience to be better reflected in decision-making, as well as integrated within an existing delivery team in Homes England already focused on design and placemaking, Pennycook said.The decision was also criticised by Jenrick, who said by ditching the building beautiful agenda, Labour would reduce consent for new housing and ruin the character of communities.His comments were backed byMichael Gove, Jenricks successor as housing secretary under the previous Conservative government, who said on X that Jenrick hadput beauty at the heart of the case for new development, adding The Office for Place - a centre of architectural excellence - was central to that. I do hope ministers think again.What Nicholas Boys Smith said on the decision to close the Office for PlaceNye Bevan said that While we shall be judged for a year or two by the number of houses we build.we shall be judged in 10 years time by the type of houses we build.We set up the Office was Place to be independent, non-partisan and broadly based. For example, when I started the process, the then Chief Executive of the Power to Change fund, and now deputy chief of staff to Sir Keir Starmer, kindly served as my deputy chair.Naturally I am hugely disappointed by this news and think that it is a mistake or I would not have set it up. In the, correct, dash for quantity there needs to be an independent voice for quality. Will that voice now be lost within Whitehall? We will find out. I hope not.I guess my job now is to keep asking the questions.The Office for Place was going to publish an annual review into place-making and beautiful and regenerative development across England. How many councils have visual design codes and pattern books in place? Are they authority-wide? Can they demonstrate that they are locally popular? Are they linked to fast-track development to help us build more homes with public consent? Are the codes making it possible for attractive intensification of existing streets? Above all, is the publics confidence growing in our ability to create new homes and places without scarring existing neighbourhoods?Will the Government still publish this? Is there a risk of them marking their own homework?No one disagrees that we are going to need to many more homes. The most common request from councils is for more staff. This is not surprising given the highly discretionary and inefficient way we have ended up running our planning system. The Office for Place did not have a magic wand to fix this. But the Government doesnt have one of those either. We were designing the Office for Place as a force multiplier, helping move the democracy forward and work smarter by setting clearer, more visual and more clearly locally popular local policy to permit more homes with more public consent. This means that each individual planning application can be handled more efficiently without losing public good will.If you like, we were trying to help not just force more development water down the planning pipe but to widen the pipe.I wish the new government well in their important work. I am delighted that they are keeping important hooks in the planning system for beautiful and popular place-making. But will those hooks be enough without a small body committed to supporting councils put them into practice with enabling and popular local plans? We are going to find out.Above all I would like to thank my marvellous board, our expert advisors and the brilliant officials who supported us tirelessly. I am so pleased that they will be able to move to new roles. We also had plans to bring in national expertise to support the regenerative development of our home, Stoke on Trent. It is a huge sadness to me that we will not now be able to put those into action.I can only apologise to those in the place-making industry that our attempt to create a small, independent and powerful voice for the importance of place within governmenthashit the buffers. One day we willgetthere. And the mission to create new places and steward existing places to be happy and healthy, resilient and beautiful is never-ending.