By Ed Cara Published February 28, 2025 | Comments (0) | The GLP-1RA medications Wegovy, Victoza, and Ozempic. Michael Siluk/UCG/Universal Images Group via Getty Ozempic and its ilk may do a lot of things, but raising the risk of suicide doesnt appear to be one of them. Research out this week is the latest to find no evidence of a link between GLP-1 drugs and suicide. Scientists at McGill University in Canada conducted the study, published Wednesday in theBritish Medical Journal. They tracked the health outcomes of UK residents, and failed to find an association between GLP-1 use and an increased risk of suicidality. The findings follow other major reports from the U.S. and European Union that reached a similar conclusion. The research into a possible connection between GLP-1 use and suicide began nearly two years ago. In the summer of 2023, health regulators in the UK, Iceland and the EU reported receiving case reports tying the use of GLP-1 drugs to suicidal ideation. They announced they would conduct a review of the medication class, which is primarily used to treat type 2 diabetes and obesity. In early January 2024, the FDA updated its public list of potential new safety risks associated with approved drugs to include this potential risk. It didnt take too long for conflicting evidence to emerge, however. Later that January, for instance, the FDA announced that its own preliminary investigation failed to turn up any signal of an increased suicide risk. A February 2024 study also found that people who started taking GLP-1 drugs were less likely to be diagnosed with depression and anxiety later on, both key risk factors for suicide. And in April 2024, the EUs nine-month probe similarly found no link between any GLP-1 drug, including semaglutide (the active ingredient in Ozempic and Wegovy), and suicide or ideation. In this latest research, the McGill researchers analyzed medical records from hundreds of thousands of UK residents. They compared people who began taking GLP-1s for their diabetes to people taking two other major classes of diabetes drugs, looking specifically for reported outcomes related to suicidalitya broad category that includes suicidal ideation, self-harm, and completed suicides. All in all, they found no increased risk of suicidality in those on GLP-1 therapy compared to other medications. They also failed to find an association between suicidality and GLP-1 use even in people with a past history of psychiatric disorders or self-harm. It can be very hard in science to truly prove a negative. And GLP-1 drugs certainly arent free of other (and rarely, very serious) side effects. But given all the data collected so farincluding studies suggesting that semaglutide use specifically is linked to a lower risk of suicide ideationthe verdict looks to be swiftly in favor of no added suicide risk from using these drugs. These findings should provide some reassurance with respect to the psychiatric safety of these drugs, the McGill researchers wrote.Daily NewsletterYou May Also Like By Ed Cara Published February 19, 2025 By Ed Cara Published February 12, 2025 By Ed Cara Published January 29, 2025 By Ed Cara Published January 17, 2025 By Ed Cara Published January 14, 2025 By Ed Cara Published January 12, 2025

Weve shared deals on Ankers portable power stations several times before, but when it comes to combining the power you need with the portability that lets you take it anywhere you want, the Anker SOLIX C300 might just take the cake. Ankers somehow found a way to fit 300 watts and 90,000mAh of on-demand power delivered through 7 output ports into this amazingly small 6-pound device, and Amazons found a way to drop the price on this awesome indoor/outdoor accessory to just $150 for a limited time.See at AmazonThe SOLIX C300 is so compact and lightweight that you can easily fit it into a backpack for an outdoor excursion, or even attach it to the outside of your gear with a carabiner. Its powerful enough to charge a 16-inch M3 MacBook Pro to 80% in just 75 minutes, and it can be recharged and ready for more in just an hour when both USB-C charging ports are plugged into an AC outlet, or 1.8 hours when one USB-C port is plugged in. The bright built-in pop-out light at the top of the unit and the easy-carry handle make the SOLIX C300 resemble a ultra-high-tech camping lantern, and thats just one of its great many uses.7-in-1 Super ChargerThere are 7 powerful output ports on the SOLIX C300, and they can all be put to use at the same time to keep several of your devices juiced up and ready to go. The two 140W USB-C ports, the same ones you use to recharge the SOLIX C300, are also fast-charge output ports. Theres also a 100W USB-C port, a 15W USB-C, two 12W USB-A ports, and a 120W car socket. You can monitor all 7 ports, control the SOLIX C300s lights, and more with the Anker Smart App on your smartphone.Recharging the SOLIX C300 is almost as versatile as using it. The two USB-C input ports can be used together for rapid recharging, or by just 1 port. (Wall charger is not included.) You can also purchase a solar panel and compatible cord to recharge the SOLIX C300 via the solar input port at the front of the unit, or purchase a cable to use with your cars electrical socket.Mighty MiteWhen you consider how amazingly compact the SOLIX C300 is just 4.9 x 4.7 x 7.9 inches and a hair over 6 pounds you realize that it can go literally anywhere. Camping trips are an obvious use, but at that size the SOLIX C300 could even earn a spot in your bag for a daylong hike just as a safety measure. Tailgate parties and backyard gatherings benefit from the presence of a portable power bank, and its wise to have one handy in case of power outages.Amazons taken $50 off (-25%) the price of the Anker SOLIX C300 for a limited time, making it one of the best $150 charging devices weve seen yet, and definitely the most portable. The LiFePO4 battery comes with a 3-year guarantee, and with normal use the SOLIX C300 should have a run of many years as your go-to source for portable power.See at Amazon

The New Museum Expansion by OMA to Open in Fall 2025 with Exhibition on HumanitySave this picture!Rendering of the expanded New Museum. Image Courtesy of OMA/bloomimages.deThe New Museum is the only museum in New York City dedicated exclusively to contemporary art. From its beginnings as a one-room office on Hudson Street to the inauguration of its first freestanding building on the Bowery, designed by SANAA in 2007, it has evolved into a center for exhibitions, research, and documentation on international living artists. In 2017, Shohei Shigematsu and Rem Koolhaas of OMA were selected to design the New Museum's expansion. The first design images were released in 2019. This year, the Museum announced that its 60,000-square-foot expansion, designed in collaboration with Cooper Robertson, will open in fall 2025 with an exhibition exploring the very definition of humanity.Save this picture!The OMA-designed expansion will complement the New Museum's existing SANAA-designed flagship building while doubling gallery space, improving visitor circulation, and providing a dedicated home for the Museum's cultural incubator, NEW INC. According to Shohei Shigematsu, OMA Partner and Director of OMA New York, the expansion embodies the Museum's openness as an incubator for new cultural perspectives and artistic production. The new OMA building will be named in honor of the late philanthropist Toby Devan Lewis in recognition to its contribution to the Capital Campaign. To date, the New Museum has raised $118 million toward its $125 million Capital Campaign goal, with $82 million allocated for construction costs.Save this picture!The seven-story expansion will appear distinct on the exterior while seamlessly integrating with the existing structure inside. It will align ceiling heights on the second, third, and fourth floors for uninterrupted connectivity between the two buildings. Improved vertical circulation will include an atrium stairway, offering neighborhood views and opportunities for site-specific art installations, as well as three additional elevators, two dedicated to gallery access. Related Article New York City Implements Traffic Congestion Pricing, the First in the US On the ground level, the Museum's expanded lobby will feature an enlarged bookstore and a full-service restaurant, while a new entrance plaza will provide an open-air venue for public art installations at the intersection of Bowery and Prince Street. The upper floors will house a dedicated studio for artists-in-residence, a 74-seat forum, and a new home for NEW INC, the first museum-led cultural incubator, equipping over 120 creative entrepreneurs annually with collaborative workspaces and production facilities.Save this picture!The Museum's seventh-floor Sky Room will double in size while maintaining its panoramic views of downtown Manhattan. The expansion will also include three additional terraces overlooking the Bowery. The building's exterior will feature laminated glass with metal mesh, creating a unified faade that complements the original SANAA structure while enhancing transparency. Imagined as a highly connected yet distinct counterpart to the existing museum's verticality and solidity, the new building will offer horizontally expansive galleries for curatorial variety, open vertical circulation, and a diversity of spaces for gathering, exchange, and creation. The building is further shaped to create an active public faceincluding an outdoor plaza at the ground, moments of transparency throughout the central atrium, and terraced openings at the topthat will openly engage the surrounding community and beyond. Shohei Shigematsu, OMA Partner and Director of OMA New YorkAccording to Lisa Phillips, Toby Devan Lewis Director of the New Museum, "The New Museum has always been a future-facing museumnot a place for preserving and recording history, but a place where history is made." Reflecting this vision, the inaugural expansion exhibition, New Humans: Memories of the Future, will explore how artists have grappled with the question of what it means to be human amid sweeping technological changes. Spanning the entire Museum, the exhibition will present works by more than 150 international artists, writers, scientists, architects, and filmmakers, tracing key moments when technological and societal shifts have reshaped conceptions of humanity and visions for its future.Save this picture!In addition to New Humans, the expanded New Museum will reopen with multiple site-specific commissions enabled by the new architectural spaces. Among them is VENUS VICTORIA by Sarah Lucas, the first recipient of the Hostetler/Wrigley Sculpture Award, a biannual juried prize supporting new work by women artists. The piece will be displayed on the Museum's public entrance plaza. Further details on new commissions, residencies, public programs, institutional collaborations, and exhibitions enabled by the expansion will be announced in the coming months.OMA is an international practice led by seven partners (Rem Koolhaas, Reinier de Graaf, Shohei Shigematsu, Iyad Alsaka, Chris van Duijn, Jason Long, and Managing Partner-Architect David Gianotten) with offices in Rotterdam, New York, Hong Kong, and Australia. Its recent projects worldwide include the exhibition scenography for the Islamic Arts Biennale in Jeddah, Saudi Arabia; the renovation of the Gallery of the Kings at the Museo Egizio in Turin, Italy; and the Simone Veil Bridge in Bordeaux, France. Additionally, among the firm's urban-focused projects is the renovation of Perth Concert Hall in Australia, a 51-year-old heritage-listed venue, set to begin in early 2025.Image gallerySee allShow lessAbout this authorCite: Antonia Pieiro. "The New Museum Expansion by OMA to Open in Fall 2025 with Exhibition on Humanity" 28 Feb 2025. ArchDaily. Accessed . <https://www.archdaily.com/1027488/the-new-museum-expansion-by-oma-to-open-in-fall-2025-with-exhibition-on-humanity&gt ISSN 0719-8884Save!ArchDaily?You've started following your first account!Did you know?You'll now receive updates based on what you follow! Personalize your stream and start following your favorite authors, offices and users.Go to my stream

In 2025, Dry January got a boost from the Surgeon General: an advisory about alcohols role in cancer and a warning about the risks of drinking.Alcohol consumption, the report stated, is the third leading preventable cause of cancer in the United States, after tobacco and obesity, increasing the risk of cancer in at least seven sites: mouth, throat, larynx, esophagus, breast, liver, and colon.With the advisory drawing our attention to the issue, its a good time to take a look at the connection between alcohol and cancer so we can make informed decisions about drinking.How Alcohol Causes CancerAlcohol does its damage in several ways. First, the breakdown of alcohol (ethanol) in the body produces acetaldehyde, a toxic chemical that damages both DNA and proteins.Alcohol also generates what scientists call reactive oxygen species you may know them as free radicals. They are unstable molecules that contain oxygen, which can react with other molecules. A buildup of these can damage DNA, RNA, and proteins and can contribute to the development of cancer.Alcohol can also increase blood levels of estrogen, a hormone that fuels some breast cancers. And last, but by no means least, alcohol can dissolve some other carcinogens, such as particles from tobacco smoke and pollution, making it easier for the body to absorb them. This increases the risk of mouth and throat cancers especially.Even Moderate Drinking Could Carry Cancer Risk For many years, weve heard that moderate drinking, especially red wine, is good for cardiovascular health. Recently, however, that thinking has been questioned. In 2018, The Lancet published research using 26 years of global data in an attempt to determine how much alcohol is safe.Though the study found that alcohol provided some protection from ischemic heart disease and diabetes, the benefits were outweighed by the risk of cancer. The researchers famously concluded that the safest level of drinking is none.Wei Zheng, a cancer epidemiologist at Vanderbilt University Medical Center, agrees with that conclusion. Zheng says that in the last five to seven years, more careful studies have found that moderate drinking provides no cardiovascular benefits, while weve known about the association between alcohol and cancer for over 20 years.The Surgeon Generals report shows that even moderate drinking one drink per day for women and two drinks per day for men still carries a lot of risk for cancer, Zheng says.Alcohol Consumption Nuances Meanwhile, the U.S. is gearing up to revise its dietary recommendations. To aid with this decision, the National Academies of Medicine (NAM) undertook a review of the evidence for the benefits and harms of moderate drinking. Its findings are somewhat more nuanced.The analysis did find that women who drink moderately have a 10 percent higher risk of breast cancer than do non-drinkers. Women who drink on the higher end of the moderate range had an even higher risk.On the other hand, the NAM report drew no conclusions about the risk of colorectal cancer for moderate drinkers, nor was it able to establish an association between moderate drinking and oral, pharyngeal, esophageal, or laryngeal cancers. (It did find, however, that when you get beyond moderate drinking, the risks increase.) On top of that, the report concluded (with moderate certainty) that when compared with never drinking, moderate alcohol consumption is associated with a lower risk of cardiovascular mortality in both men and women.Why the differences? For starters, the connection between alcohol consumption and health is very difficult to study. Other lifestyle factors can muddy the waters. For example, many moderate drinkers eat well and exercise regularly, habits which are known to lower risk.At the same time, conditions such as obesity can increase risk. Also, many past studies have relied on self-reporting, and people are known to underestimate, intentionally or not, how much they drink. The result is that its fiendishly difficult for researchers to adjust for all these factors.To Drink or Not To Drink When deciding whether to drink and how much, here are a few things to keep in mind.As the Surgeon Generals report explains, the increases in risk described in the report are relative risks. Relative risk is the proportional chance of an outcome occurring for one group (e.g., those who drink alcohol) as compared to another group (e.g., those who do not drink alcohol). It is important to understand that a large change in relative risk may represent only a small change in absolute risk, the report stated.Also, drinking is not the only factor that increases cancer risk; so does obesity, a sedentary lifestyle, and a family history of cancer. In other words, your mileage may vary depending on other risk factors.The current U.S. guidelines recommend two drinks a day or fewer for men and one drink or fewer a day for women. If youre not willing to give up alcohol completely, and most people arent, following these guidelines is probably the best strategy.If you drink, drink as little as possible, says Zheng, noting that the more you drink, the greater your risk. He also adds that other healthy lifestyle habits, while not eliminating the risk posed by alcohol, can also reduce your overall cancer risk.Article SourcesOur writers at Discovermagazine.com use peer-reviewed studies and high-quality sources for our articles, and our editors review for scientific accuracy and editorial standards. Review the sources used below for this article:U.S. Public Health Service. Surgeon Generals 2025 AdvisoryRethinking Drinking. What are the U.S. Guidelines for Drinking?Avery Hurt is a freelance science journalist. In addition to writing for Discover, she writes regularly for a variety of outlets, both print and online, including National Geographic, Science News Explores, Medscape, and WebMD. Shes the author of Bullet With Your Name on It: What You Will Probably Die From and What You Can Do About It, Clerisy Press 2007, as well as several books for young readers. Avery got her start in journalism while attending university, writing for the school newspaper and editing the student non-fiction magazine. Though she writes about all areas of science, she is particularly interested in neuroscience, the science of consciousness, and AIinterests she developed while earning a degree in philosophy.

Ive been a camera nerd for 20-ish years, and as a result, my photo archive takes up 12TB of space all by itself. Am I a photo hoarder? Yes. Am I willing to change? Absolutely not, especially when I can get a 20TB (thats terabytes, or 1,000 gigabytes) for $279. This is the largest consumer hard drive on the market at the moment and its just $20 more expensive than the 12TB version. Thats nearly doube the storage space for less than the price of an 11 p.m. Taco Bell order. These have been selling for $325 lately because they arent easy to get, so a deeper discount is a real treat.WD 20TB Elements Desktop External Hard Drive $279 (was $325)WD I have been using these drives as a supplement to my cloud storage for several years now. Theyre very simple. Its basically a Western Digital drive inside of a housing with a USB 3.0 port on it. Its a full-sized desktop drive inside, so it requires external power, but Ive owned probably 10 of these in recent years and havent had one fail. Theyre pre-formatted for Windows, but a quick, simple format makes them compatible with Macs as well.

Alpha Centauri, the nearest star system to the sun, is probably shedding comets and asteroids into our solar system and even producing a few meteors in our sky.Located just 4.3 light-years from Earth, Alpha Centauri consists of three stars that revolve around one another. If Alpha Centauri has an Oort cloud of distant comets as the sun does, about a million of these objects larger than a football field are now in our solar system, astronomers Cole Gregg and Paul Wiegert of the University of Western Ontario in London, Canada, estimate in work submitted February 5 to arXiv.org.Most of [the objects] would be in the far reaches of the solar system, Gregg says. That puts them well beyond the orbit of Pluto, where they are mingling with the native objects in the suns own Oort cloud of cometary bodies.Astronomers have only ever detected one interstellar asteroid and one interstellar comet in our solar system. But neither came from Alpha Centauri.Just as Jupiters gravity catapulted the two Voyager spacecraft onto interstellar trajectories, so the stars of Alpha Centauri and their planets should do the same to some of the comets and asteroids that swing around them. A small percentage of the ejected objects 0.03 percent pass through our solar system, Gregg and Wiegert say, but none of the large bodies is close enough for telescopes to see.Still, small particles from Alpha Centauri probably reach Earths atmosphere, where they burn up. Gregg and Wiegert estimate that up to 10 meteors worldwide come from Alpha Centauri each year.We expect these numbers to go up by about a factor of 10 when Alpha Centauri is closest, Gregg says. Alpha Centauri is racing toward us at 0.007 light-years per century (80,000 kilometers per hour) and will be closest 28,000 years from now, when it will be 3.2 light-years from Earth.But 10 or even 100 meteors a year is a pittance compared with Earths annual total of 7 trillion meteors. Furthermore, because Alpha Centauri lies far to the south, its meteors appear only in the far southern sky, out of sight of most people on Earth, Gregg and Wiegert say. Their calculations are right, but the problem hides basically in the assumptions, says Simon Portegies Zwart, an astronomer at Leiden Observatory in the Netherlands. We dont know the rate at which Alpha Centauri ejects material, he says, which means the actual number of interstellar objects coming from our near neighbor could be much greater or smaller than the study calculates. Nevertheless, the work demonstrates that our solar system is not an isolated object in space, he says. We are connected to other objects like Alpha Centauri, like other stars in the neighborhood.

Nature, Published online: 26 February 2025; doi:10.1038/s41586-025-08608-9Analyses of strain-resolved metagenomics with isolate sequencing data of skin samples from residents at nursing homes suggest that skin is a reservoir for Candida auris and other multidrug-resistant bacterial species.

Nature, Published online: 26 February 2025; doi:10.1038/s41586-025-08622-xThe cis-regulatory functions of human accelerated regions of genomic loci and their potential contribution to human brain evolution are revealed.

A new study has pinpointed cells in the brains of mice that have the unique ability to proliferate and may help to repair damaged tissue. Scientists now need to determine if similar cells exist in human brains.

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