Nature, Published online: 15 January 2025; doi:10.1038/s41586-024-08430-9Lentivirus-based reporter assays for 680,000 regulatory sequences from three cell lines coupled to machine-learning models lead to insights into the grammar of cis-regulatory elements.

In December, a new Mobile Suit Gundam series was announced, and people in the US will watch in cinemas! It is the first Gundam produced by Sunrise in partnership with the studio Khara, producer of Rebuild of Evangelion (and the studio currently holding the rights for the Evangelion series).

I would like someone who can create 16x16 pixel art for a platformer game. If you can do that dm(direct message) me on discord. Discord name: grassic

As an independent journalist, I travel a fair bit, and often work from remote locations. This means I often have to use a personal hotspot or a slow, metered connection and that forces me to limit bandwidth usage. All the while, my Mac downloads large app updates, OS updates, and sends large packets of data as apps phone home. All of these can be a big problem when I'm traveling and working. That's why I lean on apps that limit my Mac's data usage under certain conditions. You should too.Why you should restrict your Mac's internet usageGenerally, Macsare good at restricting data usage when on a hotspot, but not so much when using metered connections while traveling. Even with those features, I've noticed that when I use my iPhone as a hotspot, sometimes an app starts syncing in the background and downloads an abnormally large amount of data. This slows down the connection for tasks that actually need a lot of bandwidth, and it accelerates battery drain on the iPhone, which is running the hotspot.I felt these problems acutely on the day I was working from a coffee shop where it took a good 20 minutes to upload a few images. The culprit? Someone sent me a large video around the same time. Had the same thing happened at a hotel with limited free internet, I'd have exhausted my bandwidth for the day before I even started working. Fortunately, you can avoid such situations by using a few strategic tools. How to restrict your Mac's internet data usageThere are a few different ways to stop apps on your Mac from downloading a bunch of data when you need the bandwidth for other tasks. The easiest one is to use the built-in low-data mode on your Mac. This reduces data usage on specific wifi networks and it is enabled by default every time your Mac connects to a personal hotspot.Enabling low data mode for wifi networks on Mac Credit: Pranay Parab To enable it for other wifi networks, click the Apple logo in the top-left corner of your Mac's screen and go to System Settings > Wi-Fi. The connected wifi network will appear on the right, and you can click the Details button. Enable Low data mode and you're all set. You'll have to repeat this process for each wifi network that you want to use frugally, but it's well worth the small effort.Use TripMode to restrict apps' bandwidth usage Credit: Pranay Parab Macs are decent at reducing data usage, but the issue is you don't have much control over the process. To change that, you can rely on third-party apps. TripMode has been around for a long time, and it's one of the best ways to add data caps to your Mac. The app allows you to set up multiple profiles and add data limits to them accordingly. It can use your location to determine which profile to activate, further reducing the need to fiddle with the app. You can set up a data cap, which is 1GB for most hotels that I visit, and ask it to reset the counter daily, weekly, monthly, or at custom intervals.You can even schedule TripMode to run at certain times of the day, which is convenient if you run into time-based metered data networks. I've come across networks where you're allowed to use unlimited bandwidth from 12 a.m. to 7 a.m., but there's a data cap during the day. TripMode works for that too. Once you've configured TripMode, you can control the app through the menu bar. Click its menu bar icon and you can use the drop-down menu to switch profiles and uncheck the box next to any app to block its data.TripMode is a good app, but it hasn't had an update in about nine months (as of this article). This caused a problem during the installation process. The app asked me to install a system extension and when I clicked the button to do so, it took me to the wrong settings page on the Mac. The correct page can be found at System Settings > General > Login Items & Extensions > Network Extensions. When you enable TripMode on this page, you'll be able to proceed with the installation. You can try this app for free for a week, and beyond that, it costs $5.99 per month.Datacever lets you monitor app data usage Credit: Pranay Parab As much as I like Tripmode's customizations, it can be intimidating to someone who just wants to press a couple buttons and block apps from hogging bandwidth. For those who prefer a simpler interface, DataCever ($6.99) is a good alternative I discovered thanks to App Addict. This, too, hasn't been updated in a long time, but I faced no issues during the installation process. Once I got it running, I clicked the menu bar icon and unchecked the apps I wanted to block from the internet.Datacever neatly divides the list of apps into three tabsAll, System, and Apps. This arrangement let you quickly locate specific system processes or apps you wish to keep offline. You can also go to the app's settings and set up data caps for individual apps using the slider. You can set a cap of up to 1GB for each app, which is great, but I'd like greater flexibility here. If I could manually type the data limit instead of using a slider to set it, I'd find this a lot easier to do.The appeal of Datacever is in its simple UI and pricing model. Some people prefer buying apps in one go instead of making recurring payments. However, it lacks the advanced features that make TripMode worth using.As an alternative to these apps, you can also consider using firewall apps on your Mac. Apps such as Radio Silence and Little Snitch stop apps from phoning home, and even though they're overkill for restricting data usage on hotspots, you can easily use those apps for the job.

So it looks like the TikTok ban may actually be happening, barring a last-minute Supreme Court decision. In this episode, Senior Writer Karissa Bell joins Devindra and Ben to discuss the potential finale of TikTok in America, as well as why some users are finding refuge in RedNote, a Chinese Instagram clone. They also dive into why Meta is giving up on third-party fact checkers, and how this relates to Mark Zuckerberg's descent into the right-wing world. Finally, we explore the tidbits of information from Nintendo's Switch 2 unveiling.Stay tuned to the end of this episode for Devindras chat with Dan Erickson, the creator of Severance, about season two of his hit show.Listen below or subscribe on your podcast app of choice. If you've got suggestions or topics you'd like covered on the show, be sure to email us or drop a note in the comments! And be sure to check out our other podcast, Engadget News!Subscribe!iTunesSpotifyPocket CastsStitcherGoogle PodcastsTopicsRIP TikTok, Part ??? 2:24Meta abandons fact checking, loosens hate speech rules on its platforms 22:21We finally have confirmation of the Switch 2, full unveil scheduled for April 2 40:57Pop culture picks 49:29.187CreditsHosts: Devindra Hardawar and Karissa BellProducer: Ben EllmanMusic: Dale NorthThis article originally appeared on Engadget at https://www.engadget.com/social-media/engadget-podcast-the-tiktok-ban-zucks-lost-soul-and-nintendos-switch-2-reveal-123027317.html?src=rss

Looking for NYT Connections answers and hints? Here's all you need to know to solve today's game, plus my commentary on the puzzles.

The high-octane action film Customs Frontline, directed by Herman Yau and produced by Emperor Motion Pictures, is a visual spectacle brought to life by Free-D Workshop Limited. This VFX breakdown highlights the studios dynamic work, including intricate cityscapes and explosive action sequences that elevate the narrative. Their expertise in crafting immersive effects ensures every frame is packed with intensity and realism, perfectly complementing the films thrilling storyline. Experience how Free-D Workshop transformed Customs Frontline into a visually stunning cinematic journey.The post Customs Frontline VFX Breakdown Free-D Workshop appeared first on Vfxexpress.

This article is republished with permission fromWonder Tools,a newsletter that helps you discover the most useful sites and apps.Subscribe here.A dozen tabs open. Notifications pinging. I just opened my laptop and unread emails are already calling my name.Sound familiar?To break this routine, Im relying on a carefully chosen stack of tools and tactics that protect deep work from daily distractions. Rather than hunting for a perfect productivity app, Ive curated a three-layer system for planning, focus, and analysis. In todays video and the post below Ill show you how it works.Feel free tosteal any of these tacticsas youre refining your own workflow for the new year.My focus stack has three layers:Planning toolsthat help me decide where to direct my concentration.Focus toolsto help my wandering mind return to the task at hand.Analysis toolsfor tracking progress and observations about my work so I can improve my focus over time.1. Planning: Design your dayThink of focus setup like a chefs mise-en-place: organizing your workspace before diving into complex work.Start by collecting and prioritizing a handful of core tasks so you have a short menu to choose from. Include time estimates. That helps you be realistic about what will fit on that days calendar.I often fall victim to the planning fallacy. I overestimate how many things I can get done on a given day. That leads to end-of-day disappointment when I havent completed everything on my list.To avoid that issue, assess your time estimates at the end of the day. After two weeks of doing that, youll get better guessing how much youll actually accomplish in a day.Keep it simple: power tools that workFor me, task software should be as simple as possible. [See more ofmy philosophyon this]. I prefer to get stuff done rather than spend hours mastering software menus. Thats why I recommend simple, free task software tools.The bottom line:Workflowy,Apple Reminders, andGoogle Tasksall help you do the four basic things you need to do with to-dos:Createsimple lists,organizeandaddto them, and reliably and quicklyaccessthe tasks on multiple devices.For a more advanced software tool, considerTodoistorThings, which allow you to categorize tasks in a more sophisticated way with projects and multiple views.Pro tools, minus the complexityYou may prefer a pro tool that combines planning with managing tasks and calendaring. Teams aiming to put all their projects, tasks and plans in one spot can use a hub likeClickUp,Monday, orBasecamp.But if youre working independently and want something simple, I likeSunsama.Sunsamahas a variety of useful features for planning your day. It works well fortimeboxing. Here are some key features that make it so useful:Planning and review modes let you prepare for and conclude the day with reflection and intention, avoiding the temptation to work reactively.Estimate how long tasks will take, add notes or substasks, then schedule the tasks directly in your calendar.Optionally use AI for time estimates and to categorize tasks. That helps analyze how youre allocating time.Employ focus mode to time your current task. When you complete it, the next task appears in the corner of your screen. I use this for deep work to block out everything but my current project.Time design: Intelligent schedulingVimcal,Akiflow,Fantastical,andMotionare among the best-designed calendar tools. They sync to your existing calendar (e.g. Google or Outlook).Use natural language to schedule things. Say something like Meet Pat at 3pm Tuesday at HeyTea to talk about our AI summit. Avoid a minute of manual data entry a dozen times daily and youll save an hour each week.Calendar magic: AI-assisted planningReclaim,likeMotion,can automatically put time on your calendar between your appointments for priorities that youve set in advance. For example, you may want to routinely find time for meditation, calling a loved one, stretching, or praying.Reclaimadds those moments to your calendar between existing appointments on your calendar. They show up privately on your calendar. If you choose to let it, Reclaim can move your self-care slots if a meeting gets scheduled into that time slot.2. Focus: your concentration kitFor background focus music, I rely on bothHeadspaceandCalmwith noise-cancelling headphones. Both offer instrumental tracks that block distractions without becoming distracting themselves.Coffitivityis a good free alternative if you prefer the background hum of a coffee shop.Brainy headphonesNeurable MW75 Headphones($699) blend premium audio with an unexpected superpower: they measure your brains focus levels while you work. Unlike clunky EEG headbands, these look and feel like luxury noise-cancelling headphones.Why theyre useful:These noise-blocking headphones measure your brain focus like an EEG machine, without having to strap all those wires on your head. Neurable has somehow made one of the first consumer brain-computer interfaces that actually works so you can track your focus.Ive been impressed with how they monitor my level of focus. Like a fitness tracker encouraging me to move, they subtly encourage sustained concentration with a daily deep focus target of one hour.Despite minor data syncing glitches and a lofty price tag, Im pleased with their look, feel, and functionality. The first version of the app provides limited actionable insight about your focus level. Based on my conversations with the founder, I expect the app and the usefulness of its data to improve over time. A foldable design would also be nice, but thats a small quibble for what they deliver. For now theyre available only in the U.S. and Canada.Cheaper:Want a lower-cost alternative to get some quiet? WriterA.J. Jacobs recommendsthese $10noise-blocking earmuffsand Ive foundLoop earplugs(starting at ~$25) to be helpful.3. Analysis: measure what worksRizeis a time tracking app that charts how you spend time. It monitors what software youre using and tallies which projects or hobbies your hours are flowing to. (Get afree monthto try it).Googles Time Insightssimilarly helps you see where your time is going. Rather than monitoring your actual computer behavior, it relies solely on your calendar. Available only on certain Google Workspace plans.As noted in mytimeboxingpost, a simple spreadsheet or paper and pen record will also do fine for documenting time allocation. Just jot down learnings about how your actual time spent diverged from your plans.How AI can helpAI tools can help you analyze your time allocation. FeedClaude,GeminiorChatGPTa list of your tasks and how much time you estimated they would take, alongside estimates of actual time spent. Or snap a photo of your handwritten schedule and notes and feed that to your AI of choice for summary insights.By feeding some time tracking info into a Claude or ChatGPT project, aNotebook LMnotebook, or a Gemini Gem, you can design your own custom timeboxing coach. This AI coach will understand how long things typically take you and your indicated priorities. It can then assist you with planning more effectively and making better time estimates based on your own past behavior.This article is republished with permission fromWonder Tools,a newsletter that helps you discover the most useful sites and apps.Subscribe here.

Frontier Tiny Homes had unveiled their extra-wide and super spacious Felicity model some time ago. It had impressed us with its spaciousness and openness, but now the firm has designed a home that is the complete opposite! Say hello to Agatha a compact tiny home with more in common with the smaller European models, but is still right for full-time living. The Agatha shares a similar styling with Felicity but in a more compact body. The tiny home is based on a double-axle trailer and features a length of 20 feet. It is finished in tongue and groove cedar siding and metal. A metal roof tops off the house.Designer: Frontier Tiny HomesAs you enter the home, you are welcomed by a well-designed kitchen that serves as the heart of the home. It is stocked with modern appliances like a fridge/freezer combination, a sink, and a two-burner propane-powered stove that delivers efficient cooking capabilities. A microwave is added as well, as well as plenty of cabinetry to maximize storage space for kitchen essentials and utensils. The living room is adjacent to the kitchen, and it has a cozy and inviting atmosphere.A wall-mounted TV provides entertainment options, making the space perfect for movie nights or catching up on favorite shows. To further enhance comfort, an electric fireplace adds a touch of warmth and ambiance, while a mini-split air-conditioning unit is installed to ensure the interior temperature remains pleasant throughout the year.The lovely tiny home makes the most of its compact footprint. It is equipped with two loft spaces that serve as the primary sleeping areas. The lofts feature low ceilings, which offer limited headroom, but also create an intimate and cozy space. The first loft functions as the master bedroom, and you can enter it via a wooden ladder. The ladder slides to the side when not in use, which saves space, while also adding a touch of elegance and functionality to the design. The master bedroom includes a double bed, serving as a private sanctuary within the tiny home.The second loft is positioned on the opposite end of the Agatha and can be accessed via a removable ladder. This loft is designed to be versatile and can be used as a secondary bedroom or an additional storage area, depending on the residents requirements. This room is smaller than the master bedroom and accommodates a double bed. Its dual-purpose nature makes it quite valuable and functional, showcasing flexibility in how a space can be used.The lofts in the Agatha tiny house demonstrate smart design and efficient use of space, providing functional sleeping areas without compromising on style or comfort. The inclusion of innovative ladder systems and adaptable layouts ensures that the tiny house meets the different needs of its occupants, making it a practical and attractive choice for those seeking a compact yet comfortable living environment.The post This Tiny Home For A Small Family Fuses An American Design Style With A European-Inspired Size first appeared on Yanko Design.

Chinas internet companies and their hard-working, resourceful professionals make world-class products, in spite of censorship and malign neglect by Beijing.