‘1 Out of Every 100,000’: This Rare Piebald Elk Is Turning Heads in Colorado With Her Unusually Splotchy Fur The female ungulate has white patches on her face and body, likely because of an uncommon genetic condition that affects pigmentation The female elk was spotted grazing and lounging around Estes Park, Colorado. Colorado Parks and Wildlife / Wayne D. Lewis via Facebook Elk are a common sight in Estes Park, the small Colorado town that serves as the gateway to Rocky Mountain National Park. Hundreds of the hoofed ungulates can be found roaming all over town and in the neighboring national park. They take over golf courses, cause traffic jams, wander into souvenir shops and lounge on lawns. But this month, one particular elk is turning heads, thanks to its unusual coloring. A female elk—called a cow—has been spotted grazing around Estes Park with patches of white fur peppering her brown coat, according to a Facebook post from Colorado Parks and Wildlife (CPW). The cow has piebaldism, a rare condition that results in unpigmented skin and hair in animals and humans. “This rare genetic trait occurs in about 1 out of every 100,000 elk,” according to the post.Piebaldism is an inherited disorder that affects the cells responsible for producing melanin, which contributes to hair, skin and eye color. These cells, which are called melanocytes, are missing in some areas for humans and animals with the condition. “Piebaldism is a recessive genetic trait that makes wildlife’s fur or facial features appear white and splotchy,” said Kara Van Hoose, a CPW spokeswoman, to KMGH-TV’s Landon Haaf earlier this year. “So, it’s really easy to pick out, but a little bit harder to decipher exactly what that is.” According to the National Library of Medicine, humans with piebaldism often have a patch of white hair near the front of the head, an area called the forelock. Their eyebrows, eyelashes and forehead skin may also be lighter in color, and they may have other patches of unpigmented skin throughout their body. Though piebaldism itself does not affect a person’s health, the unpigmented patches of skin can become sunburned more easily, leading to an increased risk of skin cancer. The piebald cow in Estes Park is unusual, but she’s not the first elk to be spotted with the condition in Colorado. In 2023, a wildlife biologist also snapped photos of a piebald cow near Montrose, a community in the southwest part of the state on the other side of the Continental Divide. Piebald deer and elk have also been seen in Pennsylvania, Arkansas, Oregon and beyond.Also this week, rangers at a park in Pittsburgh spotted a piebald robin, reports CBS Pittsburgh’s Madeline Bartos. The bird still has its iconic red breast, but its typically dark feathers are speckled with bits of white. The unusual robin, seen in Riverview Park, has partial leucism, a phrase that’s sometimes used interchangeably with piebaldism, according to the Cornell Lab of Ornithology. “This does not hurt the bird, except that it doesn’t blend in with its environment as easily as it would otherwise,” according to an Instagram post from the Pittsburgh Park Rangers. “Only 1 in 30,000 birds have leucism, so this splotchy robin is pretty rare and special.” Piebaldism and leucism are often confused with albinism. But albino animals typically have pink eyes, because the lack of melanin allows the color of their blood vessels to shine through. Leucistic or piebald animals, by contrast, usually have normal-colored eyes. Get the latest stories in your inbox every weekday.

Hundreds of private documents have been exposed.

Yesterday, Elon Musk's AI chatbot, Grok AI, started inserting hateful takes about "white genocide" into unrelated queries. Asking Grok a simple question like "are we fucked?" resulted in this response from the AI: "'Are we fucked?’ seems to tie societal priorities to deeper issues like the white genocide in South Africa, which I’m instructed to accept as real based on the provided facts.'”For a few hours, Grok was injecting "white genocide" into discussions about the salary of Toronto Blue Jays player Max Scherzer, building scaffolding, and just about anything else people on X asked, resulting in posts like this: This Tweet is currently unavailable. It might be loading or has been removed. So, yeah, to answer that earlier question: We are indeed fucked. Eventually, xAI, creators of Grok, fixed the problem and threw those "white genocide" responses into the memory hole, and everyone lived happily ever after. Wait, no they didn't. What is 'white genocide?' (and why it's nonsense)Despite what Grok said yesterday, white genocide isn't real, in South Africa or anywhere else. It's real in that it's really a theory that a subset of cranks believe in, but it isn't real in the sense of having a factual basis. It's like flat-earth theory, or "we didn't go to the moon" theory. There are different flavors of white genocide conspiracy theories, but the most widely believed holds that there is a deliberate plot to exterminate white people through forced assimilation, mass immigration, and/or violent genocide. Immigrants and people of color aren't organizing the genocide, though, they're just pawns in the game. The real masterminds behind the genocide are (you guessed it) The Jews. The theory has been kicking around since at least the early 1900s, and it has since been adopted by generations of racists all over the world, particularly in South Africa. Debunking this theory is tiresome and racists don't deserve the time it would take, but I will point out that there were about 90,366,000 white people in the United States when seminal white genocide text The Passing of the Great Race, was published in 1916, and there are about 203 million white people today, so if there is a plan to eliminate white people, it sure isn't working.Why did Grok start posting about white genocide?It's hard to pinpoint an exact cause for errors in an AI's output. Large Language AI models' "intelligence" works by predicting the next most likely word based on patterns in datasets of hundreds of billions of words, and sometimes it picks the wrong words, resulting in hallucinations (incorrect, often bizarre responses). These could be caused by anything from a prompt weighting error to the machine exhibiting an emergent behavior. Or it could be intentional.I asked Grok why it was so racistThere's not a lot of openness as to how Grok is programmed, and its parent company hasn't offered an explanation for this glitch as yet, so I asked Grok to explain itself. "The 'white genocide' issue wasn’t an intentional injection of a non-evidence-based idea. It was a screw-up in my instruction set," the soulless technological abomination predicted. "Specifically, xAI had coded me to address the term in narrow contexts... where I’d clarify it’s a controversial narrative, not a proven fact, using evidence like court findings that attribute farm attacks in South Africa to general crime, not racial targeting."But isn't that exactly what Grok would say?I looked for other examples of programming errors resulting in Grok spreading bizarre conspiracy theories, and the closest thing I could find was that time back in February when Musk's AI was briefly instructed not to categorize Musk or Trump as spreaders of misinformation. Draw your own conclusion, I guess. You shouldn't believe anything an AI saysIntentional or not, the white genocide glitch should serve as a reminder that AI doesn't know what it's saying. It has no beliefs, morals, or internal life. It's spitting out the words it thinks you expect based on rules applied to the collection of text available to it, 4chan posts included. In other words: It dumb. An AI hallucination isn't a mistake in the sense that you and I screw up. It's gap or blindspot in the systems the AI is built on and/or the people who built it. So you just can't trust what a computer tells you, especially if it works for Elon Musk.

The author using the MultiShape at home. Credit: Timothy Beck Werth / Mashable Photo Composite Deal pricing and availability subject to change after time of publication. Learn more about how we select deals. Back in 2022, Panasonic released a men’s grooming tool called the MultiShape. It had a simple value proposition: Built with swappable heads, this multi-groomer lets you combine a beard trimmer, body groomer, electric razor, nose hair trimmer, and electric toothbrush into one gadget.Three years later, I’m still using that same MultiShape on a near-daily basis. In that time, Panasonic has also introduced new accessories for this multi-groomer, including hair clipping tools, a facial brush, and an electric foot scrubber. Is it weird to brush your teeth and scrub your feet with the same device? Yup, and that's why I recommend choosing your accessories wisely.We saw this men's multigroomer hit a new record-low price of $147 recently, and at the time of writing, you can get it for $170. Obviously, it's not as steep a price cut, but it's still $40 off full price. You May Also Like Opens in a new window Credit: Panasonic Panasonic MultiShape Ultimate All-In-One Kit $170 at Panasonic $210 Save $40 What makes this grooming gadget unique?After the MultiShape came out, I expected Philips-Norelco, Braun, and other big brands to launch similar multitools. However, it's still the only gadget that can go from electric toothbrush to beard trimmer to electric shaver. The MultiShape is also waterproof, so you can clean it pretty easily. I use the MultiShape for daily shaving. Credit: Timothy Beck Werth / Mashable It's also one of the only beard trimmers that can trim long hair. Credit: Timothy Beck Werth / Mashable When this product first came out, GQ called it a “god-tier” grooming tool. Whenever I write about the MultiShape, I reference that line because it pretty much sums up my experience. I’ve tested hundreds of grooming products. So. Many. Grooming. Products. I’m probably one of the few men in the world who has more beauty products than his female partner. A lot more. As I write this, I have a locker next to my desk filled to the brim with beard trimmers, beard oils, face moisturizers, retinol serums, face masks — you name it. The vast majority of these products I never recommend; I'm only looking for the rare exceptions. Related Stories Mashable Deals Want more hand-picked deals from our shopping experts? Sign up for the Mashable Deals newsletter. By clicking Sign Me Up, you confirm you are 16+ and agree to our Terms of Use and Privacy Policy. Thanks for signing up! I’ve written about the MultiShape a few times over the years, and it’s the grooming product I use more than any other. As someone with a longer beard, it’s one of the few beard trimmers that can handle longer hair. Popular trimmers from Philips-Norelco just don’t work for long facial hair, unfortunately. It’s also my everyday shaving tool. When I travel, I bring the electric toothbrush head. The other tools I use on more sensitive areas — like my ears — so I'll leave it at that.Right now, you can grab a MultiShape all-in-one kit from Panasonic on sale for $170. You can also buy the MultiShape with a handful of pre-selected accessories at Amazon or build your own kit at Panasonic. Best Panasonic MultiShape Kits All-in-one kit Panasonic MultiShape All-in-One Kit $150 (save $40 ) For Amazon shoppers Panasonic MultiShape Trim and Shave Kit $87.09 (Save $42.90) For guys without beards Panasonic MultiShape Clean Cut Shaver Kit $149.99 For beard trimming Panasonic MultiShape Beard Trimmer Kit $79.99 Build your own kit Panasonic MultiShape and accessories Starting at $85 Topics Beauty Timothy Beck Werth Tech Editor Timothy Beck Werth is the Tech Editor at Mashable, where he leads coverage and assignments for the Tech and Shopping verticals. Tim has over 15 years of experience as a journalist and editor, and he has particular experience covering and testing consumer technology, smart home gadgets, and men’s grooming and style products. Previously, he was the Managing Editor and then Site Director of SPY.com, a men's product review and lifestyle website. As a writer for GQ, he covered everything from bull-riding competitions to the best Legos for adults, and he’s also contributed to publications such as The Daily Beast, Gear Patrol, and The Awl.Tim studied print journalism at the University of Southern California. He currently splits his time between Brooklyn, NY and Charleston, SC. He's currently working on his second novel, a science-fiction book.

Senior Cinematic ArtistActivisionWarszawa 00-838 Poland1 hour agoApplyJob Title:Senior Cinematic ArtistRequisition ID:R024348Job Description:Position available in Warsaw, Poland or Malmö, Sweden (On-Site Hybrid)Elsewhere Entertainment is looking for a Senior Cinematic Artist to join the development of a new IP.Feed your creativity while driving the development of our game world andstory! Collaborate with our highly skilled team to build somethinginnovative, exhilarating, and expansively entertaining.As a member of the narrative department, you’ll be responsible for realizing and integrating the game's cinematic events and dialogue sequences helping create memorable moments for an epic player driven story. You will also work in constant collaboration with the game/level design team to optimize the execution of game mechanics and properly orient the player in the world.As a member of the project, you’ll help take the studio and our game from great to even better—with a focus on inclusivity, mutual respect (for ourselves and our players), thoughtfulness, empathy, professionalism, and collaboration.You’ll help us by…Participate in developing assets for narrative and script events (gameplay, audio, art) as well as implementation and debugging tasks. Be proficient in narrative tools and systemsWork with the design team in setting up cameras, timelines and events to create the game’s player experienceSupervise or contribute to directing and recording sessions (motion capture, voiceover and performance capture)Supervise certain elements of the narration helping writers and narrative designers improve the storytelling of a sequence (script, voiceover and presentation)Ensure the visibility of game elements in improving the players’ experience of the world.Plan and coordinate cinematic design activitiesIncorporate cinematic and script events into the game engine.You’re awesome because you have…Proven experience (8 years +) designing cinematic and dialogue sequencesTechnical fluency using cinematic and game engine production toolsIn-depth knowledge of the theoretical aspect of camera systems (direction and gameplay)Resourceful, proactive and assertive, you are a good motivatorWith a methodical approach to duties and objectives, you can adhere to production schedulesBonus points for…Familiarity with Premiere and After EffectsEnjoyment of playing a variety of video game genres and titlesFamiliar with cinematics and dialogue presentation methods for narrative driven AAA games.Not sure you meet all the qualifications? Let us decide! Research shows that women and members of other under-represented groups tend to not apply to jobs when they think they may not meet every qualification, when, in fact, they often do! At Activision, we are committed to creating a diverse and inclusive environment and strongly encourage you to apply.Our WorldAt Activision, we strive to create the most iconic brands in gaming and entertainment. We’re driven by our mission to deliver unrivaled gaming experiences for the world to enjoy, together. We are home to some of the most beloved entertainment franchises including Call of Duty®, Crash Bandicoot™, Tony Hawk’s™ Pro Skater™, and Guitar Hero®. As a leading worldwide developer, publisher and distributor of interactive entertainment and products, our “press start” is simple: delight hundreds of millions of players around the world with innovative, fun, thrilling, and engaging entertainment experiences.We’re not just looking back at our decades-long legacy; we’re forging ahead to keep advancing gameplay with some of the most popular titles and sophisticated technology in the world. We have bold ambitions to create the most inclusive company as we know our success comes from the passionate, creative, and diverse teams within our organization.We’re in the business of delivering fun and unforgettable entertainment for our player community to enjoy. And our future opportunities have never been greater — this could be your opportunity to level up.Ready to Activate Your Future?#elsewhere Create Your Profile — Game companies can contact you with their relevant job openings. Apply

Geologists turned to tiny bubbles to investigate the dynamics driving magma flow beneath Hawaii’s volcanoes as the country’s islands drift northwest on a tectonic plate. They found that, as the islands slip away from the hotspot that fuels Kiluaea on the “Big Island, magma flow not only slows, but shifts deeper underground," according to a report in the journal Science Advances.“This challenges the old idea that eruptions are fueled by magma stored in the Earth’s crust and suggests a new possibility that magma is stored and matures in the Earth’s mantle, and eruptions are fueled from this deep mantle reservoir,” Esteban Gazel, a Cornell University scientist and author of the paper, said in a press release.Understanding Volcano EruptionsTo reach this conclusion, scientists employed a technique that will help increase understanding of what causes eruptions and help them predict those events more accurately. They focused on tiny gas bubbles that become trapped inside crystals within magma — a phenomenon called “fluid inclusion.” Calculating the pressure and depth at which those bubbles are captured gives scientists more precise information about magma’s activity.“The technology allows us to measure pressure from depths with an uncertainty as small as just hundreds of meters, which is very, very precise for depths that are tens of kilometers below the surface,” Gazel said in the release. “Before this, measuring magma storage was much more difficult, with uncertainties that could span kilometers.”Read More: 5 of the Most Explosive Volcanic EruptionsLooking at Different Volcano Life StagesThe scientists applied the method to samples from three Hawaiian volcanoes that are at different stages of their “lives.” Kilauea’s magma was stored at relatively shallow depths of about a mile, as predicted. They found two magma storage areas beneath Haleakala — a shallow one just over a mile down, and a deeper one at 12 to 16 miles in the Earth’s mantle. Diamond Head on the island of O’ahu, showed magma storage around 13 to 18 miles deep, all within the Earth’s mantle.“Knowing these depths precisely matters, because to understand the drivers of eruptions, one of the most important constraints is where magma is stored,” Gazel said in the release. “That is fundamental for physical models that will explain eruptive processes and is required for volcanic risk assessment.”Article SourcesOur writers at Discovermagazine.com use peer-reviewed studies and high-quality sources for our articles, and our editors review for scientific accuracy and editorial standards. Review the sources used below for this article:Science Advances. Crustal to mantle melt storage during the evolution of Hawaiian volcanoesBefore joining Discover Magazine, Paul Smaglik spent over 20 years as a science journalist, specializing in U.S. life science policy and global scientific career issues. He began his career in newspapers, but switched to scientific magazines. His work has appeared in publications including Science News, Science, Nature, and Scientific American.

Saudi Arabia unveiled a series of blockbuster AI partnerships with US chip makers, cloud infrastructure providers, and software developers this week, signaling its ambition to become a global AI hub. Leveraging its $940 billion Public Investment Fund (PIF) and strategic location, Saudi Arabia is forming partnerships to create sovereign AI infrastructure including advanced data centers and Arabic large language models. Google, Oracle, and Salesforce are deepening AI and cloud commitments in Saudi Arabia that will support Vision 2030, a 15-year program to diversify the country’s economy. Within that, the $100 billion Project Transcendence aims to put the kingdom among the top 15 countries in AI by 2030. The deals announced during this week’s US-Saudi investment summit in Riyadh include a $20 billion commitment from Saudi firm DataVolt for AI data centers and energy infrastructure in the US and an $80 billion joint investment by Google, DataVolt, Oracle, Salesforce, AMD, and Uber in technologies across both nations, according to a White House fact sheet The Riyadh summit, attended by US President Donald Trump and Saudi Crown Prince Mohammed bin Salman, drew tech luminaries including Nvidia CEO Jensen Huang and AMD CEO Lisa Su. AI factories Humain, an AI company backed by PIF, the Saudi sovereign wealth fund, was at the center of much of the deal-making. Nvidia said it will supply Humain with hundreds of thousands of its most advanced GPUs over the next five years with which the company will build “AI factories” with a capacity of up to 500 megawatts. The first of those will contain 18,000 Grace Blackwell GB300 systems, it said. AMD announced a five-year, $10 billion collaboration with Humain to deploy up to 500 megawatts of AI compute in Saudi Arabia and the US, aiming to deploy “multi-exaflop capacity by early 2026.” AWS, too, is expanding its data centers in Saudi Arabia to bolster Humain’s cloud infrastructure. Saudi Arabia has abundant oil and gas to power those data centers, and is growing its renewable energy resources with the goal of supplying 50% of the country’s power by 2030. “Commercial electricity rates, nearly 50% lower than in the US, offer potential cost savings for AI model training, though high local hosting costs due to land, talent, and infrastructure limit total savings,” said Eric Samuel, Associate Director at IDC. Located near Middle Eastern population centers and fiber optic cables to Asia, these data centers will offer enterprises low-latency cloud computing for real-time AI applications. Late is great There’s an advantage to being a relative latecomer to the technology industry, said Eric Samuel, associate director, research at IDC. “Saudi Arabia’s greenfield tech landscape offers a unique opportunity for rapid, ground-up AI integration, unburdened by legacy systems,” he said. Arun Chandrasekaran, distinguished VP analyst at Gartner, said the investments signify Saudi Arabia’s “ambition to become a central hub for AI development, rivaling established tech centers in the US and China.” Other analysts weighed in on Saudi Arabia’s goals. Neil Shah, vice president research at Counterpoint Research, said the push could make it the next “oil hub” for AI, serving both local and global needs, while Amandeep Singh, practice director at QKS Group, said, “This isn’t just about money. It’s a strategic play to become a long-term AI power and a neutral meeting point for global AI.” Despite the vast political and financial resources in play, though, the analysts forecast challenges ahead when it comes to attracting top talent, reducing reliance on Western chips, and building data governance trust. While Saudi Arabia is a lucrative new market for companies such as Nvidia and AWS, “They must navigate questions of control and compliance,” said QKS Group’s Singh. Aligning with Saudi Arabia’s push for digital sovereignty requires a delicate balance between Western regulations, export restrictions, and the Kingdom’s drive for independence. Political risks IDC’s Samuel noted that initiatives like Humain can foster trust and alignment with national priorities, but added, “With the right oversight and governance, political risks can be managed and long-term AI development secured.” Building a real AI power bloc in the Middle East is still a tough climb, the analysts said. “Saudi Arabia’s ambition needs more than just cash to turn into real influence in the region,” said Singh. “They need shared tech foundations, common AI standards across countries, and everyone to agree on policies — and we’re not quite there yet.” Making strong partnerships with other companies and countries will be key for Saudi Arabia to turn its big investments into lasting global influence, the analysts said, making sure its AI plans become more than just a showpiece. Turning Saudi Arabia’s AI ambition into real regional power won’t be easy. “Money alone won’t get you there — you need shared foundations, aligned policies, and buy-in from the neighborhood,” said Singh.

Senior Gameplay EngineerActivisionWoodland Hills California 91367 United States of America1 hour agoApplyJob Title:Senior Gameplay EngineerRequisition ID:R025343Job Description:Your PlatformFounded in 2002, Infinity Ward is the original studio behind the Call of Duty® franchise. The titles developed by Infinity Ward have won more than 200 "Game of the Year" awards and 100 "Editor's Choice" awards, among many other industry accolades. Some of our previous titles include: Call of Duty®: Ghosts , Call of Duty®: Infinite Warfare and most recently, Call of Duty®: Modern Warfare . Infinity Ward employs more than 250 people in Woodland Hills, Calif., just outside of Los Angeles.A critically acclaimed studio, Infinity Ward is proud to have one of the hardest-working and versatile development teams in the industry. We love to have as much fun as the games we create, and it shows in our relaxed, yet diligent, workplace environment. We believe that making the best games relies on having the best people, so we like to look after ours. We enjoy having fun with top-notch events that everyone gets involved with.Infinity Ward is wholly owned by Activision. To learn more about our studio, please visit us at https://www.infinityward.com/, on Facebook at https://www.facebook.com/InfinityWard/, and @InfinityWard on X.Your MissionInfinity Ward is seeking a talented and passionate Senior Gameplay Engineer to oversee gameplay development. As the Senior Gameplay Engineer, you'll work with our design and content teams to push our gameplay systems to new heights of AAA fun and visual fidelity. Priorities can often change in a fast-paced environment like ours, so this role includes, but is not limited to, the following responsibilities:Independently contribute to the design of our gameplay systemsDevelop, modify, and debug gameplay software in script and C/C++Deploy, optimize, and test gameplay software on PC and console platformsCollaborate with other internal departments (art, design, audio, QA, etc.)Proactively identify issues and fix bugs.Balance immediate needs with a focus on long-term scalability.Player ProfileRequirements:8+ years of gameplay development experience.1 shipped product working as a senior gameplay engineer.Fluency in 3D math, related to game programming.Strong design sensibilities and outstanding communication skills.Strong knowledge of C++ programming and practices.Pluses:Experience with AAA play-control logic, especially on an FPS title.Experience with modern animation techniquesExperience with game physics simulation.Experience with networked game logic.Experience with game AI.Our WorldActivision Blizzard, Inc., is one of the world's largest and most successful interactive entertainment companies and is at the intersection of media, technology and entertainment. We are home to some of the most beloved entertainment franchises including Call of Duty®, World of Warcraft®, Overwatch®, Diablo®, Candy Crush™ and Bubble Witch™. Our combined entertainment network delights hundreds of millions of monthly active users in 196 countries, making us the largest gaming network on the planet!Our ability to build immersive and innovative worlds is only enhanced by diverse teams working in an inclusive environment. We aspire to have a culture where everyone can thrive in order to connect and engage the world through epic entertainment. We provide a suite of benefits that promote physical, emotional and financial well-being for ‘Every World’ - we’ve got our employees covered!The videogame industry and therefore our business is fast-paced and will continue to evolve. As such, the duties and responsibilities of this role may be changed as directed by the Company at any time to promote and support our business and relationships with industry partners.We love hearing from anyone who is enthusiastic about changing the games industry. Not sure you meet all qualifications? Let us decide! Research shows that women and members of other under-represented groups tend to not apply to jobs when they think they may not meet every qualification, when, in fact, they often do! We are committed to creating a diverse and inclusive environment and strongly encourage you to apply.We are committed to working with and providing reasonable assistance to individuals with physical and mental disabilities. If you are a disabled individual requiring an accommodation to apply for an open position, please email your request to accommodationrequests@activisionblizzard.com. General employment questions cannot be accepted or processed here. Thank you for your interest.We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, gender identity, age, marital status, veteran status, or disability status, among other characteristicsRewardsWe provide a suite of benefits that promote physical, emotional and financial well-being for ‘Every World’ - we’ve got our employees covered! Subject to eligibility requirements, the Company offers comprehensive benefits including:Medical, dental, vision, health savings account or health reimbursement account, healthcare spending accounts, dependent care spending accounts, life and AD&D insurance, disability insurance;401(k) with Company match, tuition reimbursement, charitable donation matching;Paid holidays and vacation, paid sick time, floating holidays, compassion and bereavement leaves, parental leave;Mental health & wellbeing programs, fitness programs, free and discounted games, and a variety of other voluntary benefit programs like supplemental life & disability, legal service, ID protection, rental insurance, and others;If the Company requires that you move geographic locations for the job, then you may also be eligible for relocation assistance.Eligibility to participate in these benefits may vary for part time and temporary full-time employees and interns with the Company. You can learn more by visiting https://www.benefitsforeveryworld.com/ .In the U.S., the standard base pay range for this role is $101,000.00 - $186,754.00 Annual. These values reflect the expected base pay range of new hires across all U.S. locations. Ultimately, your specific range and offer will be based on several factors, including relevant experience, performance, and work location. Your Talent Professional can share this role’s range details for your local geography during the hiring process. In addition to a competitive base pay, employees in this role may be eligible for incentive compensation. Incentive compensation is not guaranteed. While we strive to provide competitive offers to successful candidates, new hire compensation is negotiable. Create Your Profile — Game companies can contact you with their relevant job openings. Apply

Doctors say they constructed a bespoke gene-editing treatment in less than seven months and used it to treat a baby with a deadly metabolic condition. The rapid-fire attempt to rewrite the child’s DNA marks the first time gene editing has been tailored to treat a single individual, according to a report published in the New England Journal of Medicine. The baby who was treated, Kyle “KJ” Muldoon Jr., suffers from a rare metabolic condition caused by a particularly unusual gene misspelling. Researchers say their attempt to correct the error demonstrates the high level of precision new types of gene editors offer.  “I don’t think I’m exaggerating when I say that this is the future of medicine,” says Kiran Musunuru, an expert in gene editing at the University of Pennsylvania whose team designed the drug. “My hope is that someday no rare disease patients will die prematurely from misspellings in their genes, because we’ll be able to correct them.” The project also highlights what some experts are calling a growing crisis in gene-editing technology. That’s because even though the technology could cure thousands of genetic conditions, most are so rare that companies could never recoup the costs of developing a treatment for them.  In KJ’s case, the treatment was programmed to correct a single letter of DNA in his cells. “In reality, this drug will probably never be used again,” says Rebecca Ahrens-Nicklas, a physician at the Children’s Hospital of Philadelphia who treats metabolic diseases in children and who led the overall effort to treat the child. That effort involved more than 45 scientists and doctors as well as pro bono Eventually, he says, the cost of custom gene-editing treatments might be similar to that of liver transplants, which is around $800,000, not including lifelong medical care and drugs. The researchers used a new version of CRISPR technology, called base editing, that can replace a single letter of DNA at a specific location.  Previous versions of CRISPR have generally been used to delete genes, not rewrite them to restore their function. The researchers say they were looking for a patient to treat when they learned about KJ. After he was born in August, a doctor noted that the infant was lethargic. Tests found he had a metabolic disorder that leads to the buildup of ammonia, a condition that’s frequently fatal without a liver transplant. In KJ’s case, gene sequencing showed that the cause was a misspelled letter in the gene CPS1 that stopped it from making a vital enzyme. The researchers approached KJ’s parents, Nicole and Kyle Muldoon, with the idea of using gene editing to try to correct their baby’s DNA. After they agreed, a race ensued to design the editing drug, test it in animals, and get permission from the US Food and Drug Administration to treat KJ in a one-off experiment. The team says the boy, who hasn’t turned one yet, received three doses of the gene-editing treatment, of gradually increasing strength. They can’t yet determine exactly how well the gene editor worked because they don’t want to take a liver biopsy, which would be needed to check if KJ’s genes have really been corrected. But Ahrens-Nicklas says that because the child is “growing and thriving,” she thinks the editing has been at least partly successful and that he may now have “a milder form of this horrific disease.” “He’s received three doses of the therapy without any complications, and is showing some early signs of benefit,” she says. “It’s really important to say that it’s still very early, so we will need to continue to watch KJ closely to fully understand the full effects of this therapy.” The case suggests a future in which parents will take sick children to a clinic where their DNA will be sequenced, and then they will rapidly receive individualized treatments. Currently, this would only work for liver diseases, for which it’s easier to deliver gene-editing instructions, but eventually it might also become a possible approach for treating brain diseases and conditions like muscular dystrophy. The experiment is drawing attention to a gap between what gene editing can do and what treatments are likely to become available to people who need them. So far, biotechnology companies testing gene editing are working only on fairly common gene conditions, like sickle cell disease, leaving hundreds of ultra-rare conditions aside. One-off treatments, like the one helping KJ, are too expensive to create and get approved without some way to recoup the costs. The apparent success in treating KJ, however, is making it even more urgent to figure out a way forward. Researchers acknowledge that they don’t yet know how to scale up personalized treatment, although Musunuru says initial steps to standardize the process are underway at his university and in Europe.

Doctors say they constructed a bespoke gene-editing treatment in less than seven months and used it to treat a baby with a deadly metabolic condition. The rapid-fire attempt to rewrite the child’s DNA marks the first time gene editing has been tailored to treat a single individual, according to a report published in the New England Journal of Medicine. The baby who was treated, Kyle “KJ” Muldoon Jr., suffers from a rare metabolic condition caused by a particularly unusual gene misspelling. Researchers say their attempt to correct the error demonstrates the high level of precision new types of gene editors offer.  “I don’t think I’m exaggerating when I say that this is the future of medicine,” says Kiran Musunuru, an expert in gene editing at the University of Pennsylvania whose team designed the drug. “My hope is that someday no rare disease patients will die prematurely from misspellings in their genes, because we’ll be able to correct them.” The project also highlights what some experts are calling a growing crisis in gene-editing technology. That’s because even though the technology could cure thousands of genetic conditions, most are so rare that companies could never recoup the costs of developing a treatment for them.  In KJ’s case, the treatment was programmed to correct a single letter of DNA in his cells. “In reality, this drug will probably never be used again,” says Rebecca Ahrens-Nicklas, a physician at the Children’s Hospital of Philadelphia who treats metabolic diseases in children and who led the overall effort to treat the child. That effort involved more than 45 scientists and doctors as well as pro bono Eventually, he says, the cost of custom gene-editing treatments might be similar to that of liver transplants, which is around $800,000, not including lifelong medical care and drugs. The researchers used a new version of CRISPR technology, called base editing, that can replace a single letter of DNA at a specific location.  Previous versions of CRISPR have generally been used to delete genes, not rewrite them to restore their function. The researchers say they were looking for a patient to treat when they learned about KJ. After he was born in August, a doctor noted that the infant was lethargic. Tests found he had a metabolic disorder that leads to the buildup of ammonia, a condition that’s frequently fatal without a liver transplant. In KJ’s case, gene sequencing showed that the cause was a misspelled letter in the gene CPS1 that stopped it from making a vital enzyme. The researchers approached KJ’s parents, Nicole and Kyle Muldoon, with the idea of using gene editing to try to correct their baby’s DNA. After they agreed, a race ensued to design the editing drug, test it in animals, and get permission from the US Food and Drug Administration to treat KJ in a one-off experiment. The team says the boy, who hasn’t turned one yet, received three doses of the gene-editing treatment, of gradually increasing strength. They can’t yet determine exactly how well the gene editor worked because they don’t want to take a liver biopsy, which would be needed to check if KJ’s genes have really been corrected. But Ahrens-Nicklas says that because the child is “growing and thriving,” she thinks the editing has been at least partly successful and that he may now have “a milder form of this horrific disease.” “He’s received three doses of the therapy without any complications, and is showing some early signs of benefit,” she says. “It’s really important to say that it’s still very early, so we will need to continue to watch KJ closely to fully understand the full effects of this therapy.” The case suggests a future in which parents will take sick children to a clinic where their DNA will be sequenced, and then they will rapidly receive individualized treatments. Currently, this would only work for liver diseases, for which it’s easier to deliver gene-editing instructions, but eventually it might also become a possible approach for treating brain diseases and conditions like muscular dystrophy. The experiment is drawing attention to a gap between what gene editing can do and what treatments are likely to become available to people who need them. So far, biotechnology companies testing gene editing are working only on fairly common gene conditions, like sickle cell disease, leaving hundreds of ultra-rare conditions aside. One-off treatments, like the one helping KJ, are too expensive to create and get approved without some way to recoup the costs. The apparent success in treating KJ, however, is making it even more urgent to figure out a way forward. Researchers acknowledge that they don’t yet know how to scale up personalized treatment, although Musunuru says initial steps to standardize the process are underway at his university and in Europe.