Grand Theft Auto 6's two trailers have given us a better idea of what to expect from the upcoming crime caper, but we're still waiting to find out who will voice our new castTech22:00, 19 May 2025Who is behind Jason and Lucia's performances?(Image: Rockstar)GTA 6 finally has a release date, although its delay means it's around six months later than we'd expected.Still, having been in development for years, we're now seemingly close to the end of the process, and with Take-Two's CEO saying the game will be worth the wait, we're ready for a return to Vice City after a few years away.‌We now know Jason and Lucia are our protagonists, supported by a raucous supporting cast including musicians, arms dealers and conspiracy theorists, but we're still none the wiser about GTA 6's voice cast (although we did hear DJ Khaled could make an appearance!)‌Now, one Rockstar legend has ruled himself out of the cast despite fans thinking they've heard him in the second trailer.Content cannot be displayed without consentDespite suggestions that Red Dead Redemption and GTA 6 take place in the same universe, it appears Arthur Morgan voice actor Roger Craig Smith won't be featured in GTA 6.Article continues below"Nope. Not me," he posted on May 6, adding "Just to clarify" and the GTA6 hashtag.Some weren't convinced, though, forcing him to issue another clarification the next day."LITERALLY attempting to clarify that it is NOT my voice in that trailer."‌"Just to clarify my earlier clarification. Are we clear? Groovy." he added, acknowledging that "Trailer’s amazing, though" and cheekily adding "Just to clarify." for good measure. Clarification enough?Roger Craig Smith's performance as Arthur Morgan in Red Dead Redemption 2 was incredibleStill, Smith's post raises an interesting point that we still don't know who the game's voices will be provided by. Rockstar tends to avoid casting well-known stars as its main characters (although there have been some big names in the past), but the current talent is under wraps.Article continues belowFans have suggested Gregory Connors and Manni L. Perez are portraying Jason and Lucia, respectively, but there's nothing concrete for either, or any of the other characters spotted in the game's two trailers so far.With around a year to go until the game's long-awaited debut, here's hoping we'll hear more in the coming weeks.For the latest breaking news and stories from across the globe from the Daily Star, sign up for our newsletters.‌‌‌

Rome wasn’t built in a day (Ubisoft) The fan favourite city-building series takes a welcome step back in time to second century Rome, as Anno 117 puts you in control of ancient Britain. Ubisoft’s Anno series, of historical city building sims, has quietly become one of the games industry’s hardiest perennials. Since 1998, it has mostly occupied a time period between the 15th and 19th centuries, albeit with two excursions into the future. Now, with Anno 117 (the eighth mainline instalment of the franchise), it is poised to take a large step back in time, to when the Roman Empire was in full swing and enjoying a period of extended peace. This is important because, as Anno players will be aware, the series is all about building, not fighting. We were given the chance to spend roughly three hours playing the new game, via Ubisoft’s streaming service on PC. Coming from the frenetic action of Doom: The Dark Ages, it felt like an oasis of tranquillity, with its considered gameplay requiring lots of thought and plenty of planning, along with a certain amount of waiting around for essential materials to be manufactured. As with all previous Anno games, it is very much a game for builders rather than destroyers. Given the technological sophistication of the Roman Empire – particularly by the time it had reached the second century AD – it’s surprising that the Anno franchise hadn’t previously explored the time period, but it’s obvious from the start that it’s a good fit. In the full game you’ll be given a choice between two areas of the Roman Empire, in which to establish your colony: Latium (an uncharted Mediterranean area which looks to be off the coast of Italy) or Albion – that is, what is now known as Britain. Much as we would have liked to have amazed the backwards natives by building a shiny Roman city on British shores, the constraints of the preview dictated that we would instead build in Latium. As such, our ship pitched up at a pristine, procedurally generated Mediterranean island, complete with a beach which could be developed into a port, flat land for farming, plenty of forests, a prominent river, and some mountains which could be mined. The first task – since we were taking on the position of governor of the new city – was to build a governor’s villa to accompany the trading post that had already been built on the beach. Once that was done, the from-scratch city-building started in earnest. Raw materials are obviously key, so a woodcutting operation was needed in the nearest forest, which has to be connected up to the trading post by road. As ever in a city-building game, close control over the network of roads is essential. Anno 117’s road-building system is exemplary – intelligent enough to let you curve roads to your satisfaction and snap them easily to form the connections they need to make. With a woodcutter and a sawmill constructed, and wood therefore in plentiful supply, we could then start building a number of homes for the workers who form the lifeblood of the city. Build those homes and you’re able to establish a workforce. In its early stages, Anno 117’s tutorial makes its objectives clear: you need to build 10 houses to establish that workforce. Unfulfilled criteria are clearly marked with little warning flags; Anno 117, mercifully, isn’t one of those strategy games which seems happy to leave you confused. After completing the tutorial, we were never at a loss as to what to do and the tutorial itself felt logical rather than manufactured. With our first residential area constructed and hooked up via a road network, we could start turning our attention to the needs of our burgeoning populace. Food, obviously, was required, so we built a fishery and established a wheat farm, along with a bakery and a porridge kitchen. We then began to have little interactions, as governor, with our inhabitants. We unlocked the ability to build a market and a tavern in the residential quarter, which bring helpful area effects. Pleasingly, what was now transforming from a village into a town began to exhibit some bustle, with carts of timber moving around and residents going about their daily work and heading to the tavern afterwards. Ancient Albion on the fringes of the Empire (Ubisoft) Our next task was to attract some more sophisticated, educated residents, by fulfilling a number of criteria in order to upgrade the basic housing. This brought considerations like fashion into the mix, by establishing a hemp farm and setting up a cloth-spinner. More sophisticated building materials such as tiles were also required, so we built a charcoal kiln and, on one of the river slots highlighted in the game’s geography, cleared a clay heap As that extended the city limits somewhat, it was necessary to build another warehouse. And we had to keep an eye on the mix of our population, between the basic Liberti and the more sophisticated Plebeians, by building more houses and upgrading some of them. Now that our town was really starting to take shape a level of exploration and interaction with other nearby enclaves came into play, with governors of nearby provinces appearing – giving us opportunities to indulge in diplomacy. Other residents then started asking to be ferried around the world map in the starting ship, which had previously remained moored as we established the basic structure of our town. More Trending During the tutorial period, we had concentrated on establishing a basic settlement rather than engaging in trade, so had been forced at one point to accept a loan from our superior in Rome. As the game progresses, trading becomes an increasingly important mechanism in the push to build a more sophisticated city. At this point you are given the ability to not only establish trade routes but also set religious criteria, by picking a preferred god to worship from the Roman pantheon. Even three hours in, we were quite happy with the progress we had made towards imposing a decent level of civilisation upon previously uninhabited territory. Those initial three hours with Anno 117: Pax Romana proved very satisfying and enjoyable. Although the series predates the phrase cosy game, it’s definitely that, while also being reminiscent of even older franchises like The Settlers (now also owned by Ubisoft). For a city builder, Anno 117 fells pretty exemplary in terms of its interface, which is clear and logical. It looks great and, with the local interactions and the trade route engine, offers more gameplay variety than most similar games. At the moment, it hasn’t been given a specific release date, but Ubisoft has said that it will come out this year on both consoles and PC. Formats: Xbox Series X/S, PlayStation 5, and PCPublisher: UbisoftDeveloper: Ubisoft MainzRelease Date: 2025 Ocean trading is an important gameplay element (Ubisoft) Email gamecentral@metro.co.uk, leave a comment below, follow us on Twitter, and sign-up to our newsletter. To submit Inbox letters and Reader’s Features more easily, without the need to send an email, just use our Submit Stuff page here. For more stories like this, check our Gaming page. GameCentral Sign up for exclusive analysis, latest releases, and bonus community content. 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Lenovo is a brand synonymous with reliability in the world of computers, and it’s rare to find one of their laptops priced under $1,000. Which is why the Lenovo IdeaPad 15.6″ touchscreen laptop deal currently available on Amazon is the genuine deal: This high-performance 512GB storage laptop can be had for just $549 which is a staggering 70% off its regular price of $1,849. Those with the need for even more storage can choose the one that includes a 1TB SSD, also discounted to $599 from $1,949, which makes both options fantastic bargains. See at Amazon Best in Class Touchscreen Laptop This Lenovo IdeaPad 15.6″ laptop is designed for people who demand the best combination of performance and versatility. The laptop is powered by the 12th Gen Intel Core i5-1235U processor which features 10 cores and 12 threads. You get to enjoy great speed and response whether you are performing demanding productivity, multitasking or even light creative work. The 15.6-inch touch screen Full HD display delivers a sharp 1920×1080 resolution with IPS technology and features rich colors and broad viewing angles. The anti-glare coating ensures its usability in sunny environments while the integrated Intel Iris Xe graphics enable silky smooth graphics for everyday use and multimedia streaming. Streaming videos, image editing and web surfing, the display quality improves your overall experience. 16GB DDR4 RAM means multitasking is effortless and allows you to switch between programs with ease. The 512GB PCIe NVMe SSD provides fast bootup times and quick access to your files and the option to upgrade to a 1TB SSD (for $50 more) means even more room for those who need it. This memory and storage give the laptop responsiveness and zip, even under heavier loads. There are connectivity options galore with Wi-Fi 6 and Bluetooth 5.2 providing fast and consistent wireless connectivity. It has a variety of ports such as USB 2.0, USB 3.2 Gen 1, USB-C 3.2 Gen 1, HDMI, and headphone/microphone combination jack, all of which provide easy connectivity to any number of peripherals and external monitors. With Windows 11 Professional in S mode, this Lenovo IdeaPad has a clean and secure operating system that’s performance-tuned and accessible. The Abyss Blue finish adds a touch of personality to the portable and light design and makes this laptop ideal for students and business professionals. If you’ve been waiting for the right moment to upgrade your laptop or need a reliable machine for work or entertainment, this Lenovo IdeaPad 15.6″ laptop deal is not to be missed. It’s a smart choice if you’re looking to combine performance with affordability. See at Amazon

PNY Grenoble Restaurant / Rudy GuénaireSave this picture!© Ludovic Balay Designers: Rudy Guénaire Area Area of this architecture project Area:  190 m² Year Completion year of this architecture project Year:  2022 Photographs Photographs:Ludovic Balay Lead Architect: Rudy Guénaire More SpecsLess Specs Save this picture! Text description provided by the architects. Grenoble is a relaxed and pleasant city surrounded by spectacular mountains, which can be admired at the end of every street when in town. It is known for its serious skiers and mountaineers and was the hometown of the great French writer, Stendhal. PNY is located at the heart of the charming old city centre.Save this picture!Save this picture!To make PNY customers fly away from their humdrum life is the core brand ambition. There, at the foot of the great mountains, one dreams of taking off into the sky. That's why we decided to cover the walls with giant airplane windows.Save this picture!Save this picture!Save this picture!Being a huge fan of John Lautner's great work, the use of softly polished hard concrete was an obvious choice. The concrete window frames, designed for the project and moulded in France, turn into giant mirrors, little corridors, the restaurant bar, or an oversized Japanese paper lamp.Save this picture!To complete the experience and make it full, every piece of furniture was self-designed, from the wall sconces to the lamps integrated into the tables, down to the napkin holders. Like in every PNY restaurant, a chair was specifically designed for the project: Snow, made out of two sheets of aluminium, is aimed to be both comfortable and sharp.Save this picture! Project gallerySee allShow less Project locationAddress:Grenoble, FranceLocation to be used only as a reference. It could indicate city/country but not exact address.About this officeRudy GuénaireOffice••• Published on May 19, 2025Cite: "PNY Grenoble Restaurant / Rudy Guénaire" 19 May 2025. ArchDaily. Accessed . <https://www.archdaily.com/1030179/pny-grenoble-restaurant-rudy-guenaire&gt ISSN 0719-8884Save世界上最受欢迎的建筑网站现已推出你的母语版本!想浏览ArchDaily中国吗?是否 You've started following your first account!Did you know?You'll now receive updates based on what you follow! Personalize your stream and start following your favorite authors, offices and users.Go to my stream

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CRISPR (short for Clustered Regularly Interspaced Short Palindromic Repeats) — the genetic equivalent of a word processor — has received its most powerful upgrade yet: the ability to insert an entire gene at the most potentially effective spot, according to an article in the journal Science.This marks a key step in cell and gene therapy, all of which aim to treat illnesses by making corrections or additions to the “misspelled” genes that can lead to disease.Before CRISPR, delivering genes inside of neutered viruses was thought to be the answer. It sometimes worked, but often the new genetic word would be flooded into the body, inserted at random. Sometimes it would land in the right spot, other times it would miss its target. And worst of all, that approach can lead to a potentially deadly immune response.The Rise of CRISPRWhen CRISPR debuted in 2012, it was thought to provide both more specificity and control. It is essentially the genetic equivalent of a “search and replace” command in a word processor, with the ability to find, then snip out faulty DNA within one gene, using what many researchers call “molecular scissors.” Its innovators were awarded the Nobel Prize in Chemistry in 2020.However, despite incredible potential, that approach still has some limitations. The “scissors” can sometimes snip the wrong part of the targeted DNA sequence. This could lead to either incomplete repair or the inadvertent admission of a harmful mutation. It can also only fix one error in a single gene at a time.Despite those “software bugs” and limitations, early versions of CRISPR have shown promise. The approach was used to edit genes in six patients with a rare genetic disorder in 2022. More recently, scientists used the system to deliver for the first time a treatment tailored to a specific patient, a baby boy with a rare metabolic disorder.CRISPR Upgrades The multiple components of the evoCAST gene editor grasping a strand of DNA (red). (Image Cred: George Lampe (Columbia University Irving Medical Center))The new version shows promise to be even more effective. Since it doesn’t cut out any existing DNA, it is less likely to inadvertently add mutations or errors. It is much more specific than either virus-based gene therapy or earlier CRISPR approaches. And delivering an entire correct gene is considered a safer, more effective approach than cutting and replacing portions of an existing one.The update essentially involves the addition of guide molecules called “CRISPR-associated transposases (CASTs).” These bacterial systems “lead” CRISPR to specific sites, so the correct gene is more likely to be integrated and activated. The tool's developers named it “evoCAST.”Also, existing gene therapy strategies, as well as the early CRISPR work in humans, were focused on diseases with errors in only one gene. Although there are many such diseases, each one affects relatively few people, compared to more common diseases that are thought to be the result of multiple genetic mutations.“Hundreds to thousands of different mutations in the CFTR gene can cause cystic fibrosis, for example, so an inordinate number of distinct gene editing drugs would be needed to ensure each patient could be treated,” Samuel Sternberg, a researcher at Columbia University and an author of the paper, said in a press release. “Instead, something like evoCAST could enable a single gene therapy that inserts a complete and healthy gene into the patient’s genome."CRISPR's Future The researchers will continue to test the evoCAST system in animals modelled to exhibit certain human diseases. As they do so, they intend to tweak and debug the system so it can be even more accurate and effective. But their biggest challenge is the same one that faced early gene therapy researchers: targeted delivery.“How do we actually get these tools and their payloads into the cells or tissues of interest?” Sternberg said in a press release. “That’s a challenge that many of us in the field are facing.”This article is not offering medical advice and should be used for informational purposes only.Article SourcesOur writers at Discovermagazine.com use peer-reviewed studies and high-quality sources for our articles, and our editors review for scientific accuracy and editorial standards. Review the sources used below for this article:The Nobel Prize. Genetic scissors: a tool for rewriting the code of lifeBefore joining Discover Magazine, Paul Smaglik spent over 20 years as a science journalist, specializing in U.S. life science policy and global scientific career issues. He began his career in newspapers, but switched to scientific magazines. His work has appeared in publications including Science News, Science, Nature, and Scientific American.

ZEUS is expected to produce even higher levels of power later this year. Credit: Marcin Szczepanski / Michigan Engineering Get the Popular Science daily newsletter💡 Breakthroughs, discoveries, and DIY tips sent every weekday. A laser named after the most powerful god in ancient Greece is living up to its name. According to the University of Michigan, the first official experiment from the Zettawatt-Equivalent Ultrashort pulse laser System (ZEUS) yielded 2 petawatts (2 quadrillion watts) of power. For reference, that’s more than 100 times the electricity output across the entire planet—but you’ll likely miss it if you blink. The school gym-sized ZEUS is the successor to the university’s HERCULES system, which topped out at 300 terawatts. ZEUS relied on a reconfigured target for its debut demonstration, which required firing a laser pulse at a cell containing helium. The subsequent interaction produced plasma as it tore electrons away from the helium atoms, resulting in a mixture of both positive ions and free electrons. The electrons started gaining speed behind the laser pulse in a phenomenon known as wakefield acceleration. Because light moves slower in plasma, the electrons can catch up to the laser beam. Those free electrons also get more time to speed up given the size of the target chamber and thereby hit higher speeds. The recent demonstration is a prelude to the signature ZEUS experiment scheduled for later this year. In that test, the accelerating electrons will also smack into laser pulses coming from the opposite direction. This is where things get (even) more complicated—but to condense it down, the effect makes a 3-petawatt laser appear one million times more powerful, hence the “zettawatt-equivalent” in ZEUS’ name. Accomplishing this and other experimental feats does require some safeguards. ZEUS includes optical devices known as diffraction gratings that stretch out the initial infrared pulse over time. This ensures the initial power doesn’t get so intense that it begins tearing apart the air around it. Another goal is to ultimately create beams of electrons with energies similar to those found in particle accelerators hundreds of feet longer than ZEUS at a fraction of both its size and operating costs. At only $16 million to construct, the University of Michigan previously described the machine as a “bargain.” Years of construction, calibration, and expertise is showcased in an astoundingly short amount of time. ZEUS’ 2 petawatt firing lasted just 25 quintillionths of a second. But future experiments will make the most of these moments.  John Nees (left) and laser engineer Paul Campbell (right) work in Target Area 1, where the first 2 petawatt user experiment will take place. ZEUS is now the most powerful laser in the US. Credit: Marcin Szczepanski / Michigan Engineering “The fundamental research done at the NSF ZEUS facility has many possible applications, including better imaging methods for soft tissues and advancing the technology used to treat cancer and other diseases,” explained Vyacheslav Lukin, program director in the National Science d Division of Physics, which is responsible for the ZEUS project. Meanwhile, ZEUS experiments could also help researchers explore the dynamics of positron jets that shoot out of black holes, or how gamma ray bursts operate.  “One of the great things about ZEUS is it’s not just one big laser hammer, but you can split the light into multiple beams,” said Franklin Dollar, a University of California professor of physics and astronomy who oversaw the 2 petawatt experiment. “Having a national resource like this, which awards time to users whose experimental concepts are most promising for advancing scientific priorities, is really bringing high-intensity laser science back to the U.S.”

Nature, Published online: 19 May 2025; doi:10.1038/d41586-025-01539-5At least 2,500 applications for research funding have been denied so far this year.

Former U.S. President Joe Biden's office announced that he has been diagnosed with "aggressive" prostate cancer, which has spread to his bones. Here's what to know about the disease.